Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of “Nitazene” 2-Benzylbenzimidazole Synthetic Opioids

Isotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland

(2021) F. Mueller et al.   FORENSIC SCIENCE INTERNATIONAL

DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles

(2021) István Ujváry et al.   ACS Chemical Neuroscience

Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework

(2020) Alex J Krotulski et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

(2020) Alexander Gillis et al.   Science Signaling

In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances

(2020) Marthe M. Vandeputte et al.   ARCHIVES OF TOXICOLOGY

Assessment of biased agonism at the A3 adenosine receptor using β-arrestin and miniGαi recruitment assays

(2020) Eline Pottie et al.   BIOCHEMICAL PHARMACOLOGY

Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform

(2020) Lakshmi Vasudevan et al.   BIOCHEMICAL PHARMACOLOGY

Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative Diphenpipenol

(2020) Annelies Cannaert et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

First report on brorphine: the next opioid on the deadly new psychoactive substances’ horizon?

(2020) Nick Verougstraete et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Intrinsic efficacy of opioid ligands and its importance for apparent bias, operational analysis and therapeutic window

(2020) Alexander Gillis et al.   MOLECULAR PHARMACOLOGY

Etazene (N,N-diethyl-2-{[(4-ethoxyphenyl)methyl]-1H-benzimidazol-1-yl}-ethan-1-amine (dihydrochloride)): a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization

(2020) Marta Siczek et al.   Forensic Toxicology

Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor

(2020) Alexander Gillis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of psychedelic new psychoactive substances (NPS) showing biased agonism at the 5-HT2AR through simultaneous use of β-arrestin 2 and miniGαq bioassays

(2020) Eline Pottie et al.   BIOCHEMICAL PHARMACOLOGY

Activity-based reporter assays for the screening of abused substances in biological matrices

(2019) Annelies Cannaert et al.   CRITICAL REVIEWS IN TOXICOLOGY

Hide and Seek: Overcoming the Masking Effect of Opioid Antagonists in Activity-Based Screening Tests

(2019) Annelies Cannaert et al.   CLINICAL CHEMISTRY

Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists

(2019) Elise Wouters et al.   BIOCHEMICAL PHARMACOLOGY

Report on a novel emerging class of highly potent benzimidazole NPS opioids: chemical and in vitro functional characterization of isotonitazene

(2019) Peter Blanckaert et al.   Drug Testing and Analysis

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

(2019) Besma Benredjem et al.   Nature Communications

DARK Classics in Chemical Neuroscience: Morphine

(2018) Andrea L. Devereaux et al.   ACS Chemical Neuroscience

Activity-Based Concept to Screen Biological Matrices for Opiates and (Synthetic) Opioids

(2018) Annelies Cannaert et al.   CLINICAL CHEMISTRY

Activity-Based Detection of Cannabinoids in Serum and Plasma Samples

(2018) Annelies Cannaert et al.   CLINICAL CHEMISTRY

Oxidation-assisted structural elucidation of compounds containing a tertiary amine side chain using liquid chromatography mass spectrometry

(2018) Tamar Shamai Yamin et al.   JOURNAL OF MASS SPECTROMETRY

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Validation of Activity-Based Screening for Synthetic Cannabinoid Receptor Agonists in a Large Set of Serum Samples

(2018) Annelies Cannaert et al.   CLINICAL CHEMISTRY

Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists

(2016) David Winpenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural identification of compounds containing tertiary amine side chains using ESI-MS3 combined with fragmentation pattern matching to chemical analogues – Benzimidazole derivatives as a case study

(2016) Avi Weissberg et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse

(2013) Pauline Charbogne et al.   NEUROPHARMACOLOGY

NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity

(2012) Paul Renton et al.   ACS Medicinal Chemistry Letters

Copper-Catalyzed, One-Pot, Three-Component Synthesis of Benzimidazoles by Condensation and C–N Bond Formation

(2011) Yong Kim et al.   JOURNAL OF ORGANIC CHEMISTRY

Quantifying Ligand Bias at Seven-Transmembrane Receptors

(2011) S. Rajagopal et al.   MOLECULAR PHARMACOLOGY

On the analysis of ligand-directed signaling at G protein-coupled receptors

(2008) Frederick J. Ehlert   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY