Article
Materials Science, Multidisciplinary
Di Chuan, Huan Hou, Yuelong Wang, Min Mu, Jinglun Li, Yangmei Ren, Na Zhao, Bo Han, Haifeng Chen, Gang Guo
Summary: Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H2O2 in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qiang Yang, Luen Xu, Jingjing Wang, Xinghong Cai, Shi-Yu Lu, Qiuye Zhang, Yifan Duan, Min Wang, Hui Liu
Summary: Integration of Fenton-induced chemodynamic therapy (CDT) and near-infrared (NIR) laser-mediated photothermal therapy (PTT)/photodynamic therapy (PDT) into a nanocomposite enables effective tumor cell killing. The nanocomposite composed of an iron (Fe) ions-decorated polypyrrole (PPy) core, IR820 payload, and bovine serum albumin (BSA) coating demonstrates superior PTT/PDT/CDT synergistic effect, achieving significant tumor cell killing under laser irradiation. The up-regulation of calreticulin expression activates immunogenic cell death, promising complete tumor elimination.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Shuang Chao, Ziyan Shen, Jiaming Ren, Zhilin Zhang, Xiaolin Chen, Yuxin Pei, Zhichao Pei
Summary: A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic l-arginine-modified photosensitizer NBS-l-Arg and DOX in the presence of Cu(2+)via the synergy of coordination, hydrophobic, and pi-pi stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.
CHEMICAL COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Limin Wang, Keke Kang, Yajie Ma, Feng Zhang, Wei Guo, Kai Yu, Kai Wang, Fengyu Qu, Huiming Lin
Summary: In this paper, simple nitrated carbon dots (CDs-NO) were synthesized as a nanoparticle that combines gas therapy and phototherapy therapy. Under near-infrared irradiation, the generated ROS combines with NO to form highly cytotoxic radicals, effectively inhibiting cancer cells. The synergistic NO therapy and photothermal/dynamic therapy not only have a significant therapeutic effect on tumor-bearing mice but also efficiently inhibit metastasis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Dihai Gu, Zhikun Liu, Hongshuai Wu, Peijing An, Xu Zhi, Yujie Yin, Wen Liu, Baiwang Sun
Summary: A new nano-platform PBMO-GH for multi-modal therapy was developed in this study, which effectively inhibited the growth of tumor cells through the synergistic effect of ST/CDT/PTT.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Qiuhong Zhang, Meijuan He, Xiaodong Zhang, Hongwei Yu, Jiawei Liu, Yi Guo, Junmin Zhang, Xiangzhong Ren, Han Wang, Yanli Zhao
Summary: This study reports the development of a tumor microenvironment-activable ROS-generating system using a protein-based nanomedicine that undergoes multistage self-assembly. The system offers effective self-protection for normal tissues and achieves tumor-specific therapy, providing a powerful strategy for nanomedicine design and precise cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Correction
Chemistry, Multidisciplinary
Qiang Cheng, Yuyan Li, Wei Huang, Ke Li, Minhuan Lan, Benhua Wang, Jianxiu Wang, Xiangzhi Song
Summary: This article proposes the use of copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Mingze Lu, Haoan Wu, Di Liu, Fei Wang, Yan Wang, Mengjun Wang, Qiannan Cui, He Zhang, Fengchao Zang, Ming Ma, Jun Ma, Fangfang Shi, Yu Zhang
Summary: This study designs a camouflaged nano-reactor that combines chemodynamic therapy and radiotherapy, effectively inhibiting malignant tumors. Experimental results demonstrate that the nano-reactor damages tumor cells through multiple mechanisms and addresses the limitations of chemodynamic therapy and radiotherapy.
Article
Biochemical Research Methods
Zhongping Su, Haiying Xu, Hui Zhang, Siran Jin, Ziqing Yang, Rui Yan, Zhiqiang Wang, Xiaodan Wu, Yingxue Jin
Summary: In this study, CuPPaCC conjugate was synthesized for ROS-mediated cancer therapy. CuPPaCC continuously produced cytotoxic ROS and oxygen through a photo-chemocyclo reaction, alleviated hypoxia, and inhibited HIF-1α expression. The results showed that CuPPaCC has excellent antitumor activity.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Huang Yang, Yuan Ding, Zongrui Tong, Xiaohui Qian, Hao Xu, Fenghao Lin, Guoping Sheng, Liangjie Hong, Weilin Wang, Zhengwei Mao
Summary: This study developed a versatile and biocompatible nanoplatform using iron-gallic acid coordination polymer nanodots and pH-responsive platelet-based hybrid membrane for specific delivery and responsible release of ultrasmall nanoparticles. The nanoplatform exhibited high penetration efficiency in acidic environment and demonstrated excellent antitumor and antimetastatic effects on orthotropic breast cancer.
Article
Materials Science, Multidisciplinary
Meifang Wang, Wenyin Zhang, Binbin Ding, Pin'an Ma, Jun Lin
Summary: A photodynamic/chemodynamic synergistic therapeutic nanoagent, DCI, was synthesized to overcome the obstacles in tumor microenvironment by regulating the levels of H2O2, O2, and GSH. The DCI nanoagent can also be used for MRI imaging and achieve enhanced antitumor efficacy.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Physical
Nannan Zheng, Yitong Chen, Lei Jiang, Hongchao Ma
Summary: This study successfully achieved the synergistic effect of photothermal therapy, photodynamic therapy, and chemodynamic therapy by designing and synthesizing dBHI nanoparticles, thus solving the problem of severe hypoxia in the tumor microenvironment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Materials Science, Multidisciplinary
Yuehan Gong, Xianwen Wang, Fei Gong, Guangqiang Li, Yuqi Yang, Linqian Hou, Qiao Zhang, Zhuang Liu, Liang Cheng
Summary: Sonodynamic therapy (SDT) is a promising non-invasive treatment method for cancer, but the low efficiency of sonosensitizers limits its effectiveness. In this study, FePc-PEG NDs were developed as a safe and highly efficient sonosensitizer for enhanced SDT. The modified FePc-PEG NDs demonstrated excellent biocompatibility and stability, and showed significant cell killing efficiency and tumor suppression without causing adverse effects in mice.
SCIENCE CHINA-MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jiawei Zhu, Chenxi Wang, Qinglin Wei, Yan Su, Xinyu Qu, Wenjun Wang, Xuejiao Song, Xiaochen Dong, Yu Cai
Summary: By modulating the energy band structure of PtMo with Au nanoparticles, a PtMo-Au metalloenzyme sonosensitizer is synthesized, which effectively improves the quantum yield of reactive oxygen species (ROS) under ultrasound. The PtMo-Au metalloenzymes also alleviate hypoxia tumor microenvironment and enhance ROS generation. Moreover, PtMo-Au can induce ferroptosis through the depletion of glutathione and the accumulation of lipid peroxides, and inhibit ATP production and induce tumor cell starvation through glucose oxidase mimic activity.
Article
Engineering, Biomedical
Han Huang, Xiaorui Wang, Weili Wang, Xinyu Qu, Xuejiao Song, Yewei Zhang, Liping Zhong, Da-peng Yang, Xiaochen Dong, Yongxiang Zhao
Summary: A light-activated injectable hydrogel has been developed to inhibit tumor growth, treat bacterial infection, and promote wound healing. Through photothermal and chemodynamic effects, the hydrogel can eliminate tumors and multidrug-resistant bacteria, as well as accelerate wound healing during treatment.
Article
Chemistry, Physical
Jiajia Meng, Yanyan Cui, Yaling Wang
Summary: Lanthanide-doped nanoparticles have been widely used in biophotonics due to their unique luminescent properties. In this study, a new type of nanoparticle that can simultaneously emit efficient visible and near-infrared luminescence was developed. The photosensitizer in the nanoparticle can be triggered by visible light, making it suitable for biotherapeutic applications, while the near-infrared light emission allows for better penetration in bioimaging.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Physical
Tanbo Gao, Yurong Jiang, Shengyi Yang, Jinming Hu, Zhenheng Zhang, Peiyun Tang, Yanyan Cui, Muhammad Sulaman, Libin Tang, Bingsuo Zou
Summary: This study presents a template-free synthesis of perovskite nanowires using ion intercalation processing, and demonstrates their applications in single-nanowire based photodetectors. The fabricated photodetectors show low dark current and high responsivity, indicating that this synthesis method is promising for low-cost, high-performance nanowire optoelectronics.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Crystallography
Navid Hussain Shah, Mengke Li, Ping Zhang, Yanyan Cui, Yaling Wang
Summary: The S-scheme photocatalyst system, using two semiconductor photocatalysts with different bandgap energies, has gained popularity in degrading pollutants. A nanocomposite of Ag2WO4/Ag6Si2O7 p-n heterojunction was successfully developed and showed enhanced photocatalytic degradation performance of organic dyes. Through physical and chemical property analysis, a comprehensive p-n heterojunction S-scheme process was proposed to explain the improved photocatalytic performance of the nanocomposite.
Article
Instruments & Instrumentation
Tianyu Fu, Yan Wang, Kai Zhang, Jin Zhang, Shanfeng Wang, Wanxia Huang, Yaling Wang, Chunxia Yao, Chenpeng Zhou, Qingxi Yuan
Summary: This study proposes a new ring artifact correction method based on the residual neural network (ResNet) for X-ray tomography. The method uses complementary information of each wavelet coefficient and a residual mechanism of the residual block to obtain high-precision artifact correction through low operation costs. It also accurately extracts stripe artifacts in sinograms using a regularization term, which helps preserve image details while separating artifacts.
JOURNAL OF SYNCHROTRON RADIATION
(2023)
Editorial Material
Multidisciplinary Sciences
Yaling Wang, Chunying Chen
Article
Environmental Sciences
Jiangxue Li, Liuxiang Wang, Shilin Li, Xiaoyu Liang, Yiming Zhang, Yaling Wang, Ying Liu
Summary: We established a subchronic exposure mouse model to investigate the toxicity of nano-iron oxide in the food industry. The results showed that oral intake of nano-iron oxide can disrupt the small intestinal epithelial barrier, induce hepatic lipid metabolism disorders through the gut-liver axis, and cause hepatic damage accompanied with hepatic iron deposition. This study highlights the importance of the gut-liver axis in the hepatotoxicity of nano-iron oxide.
Article
Green & Sustainable Science & Technology
P. Chen, P. Zhang, Y. Cui, X. Fu, Y. Wang
Summary: Environmental pollution and energy crisis are two inevitable problems hindering sustainable development. Photocatalysis technology can convert solar energy into usable energy to solve depletion of energy resources and environmental deterioration. Copper-based inorganic nanostructure photocatalysts have attracted extensive attention due to their excellent band structures and photocatalytic activities under visible light. Strategies, preparation methods, and applications of copper-based photocatalysts are summarized, and future prospects are discussed.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Energy & Fuels
Qixiang Kang, Xinghua Zhang, Yanyan Cui, Xuelai Zhao, Wuyu Wang, Jiapeng Zhang, Qi Zhang, Longlong Ma
Summary: Cycloalkanes jet fuel derived from biomass is the perfect alternative to fossil fuel. The Mannich-Michael reaction of cyclopentanone and formaldehyde followed by hydrodeoxygenation (HDO) is a promising method for producing high-density jet fuel. The combination of pyrrolidine and acetic acid showed high catalytic activity in the one-pot Mannich-Michael reaction under mild conditions. By using the enamine catalytic pathway, a high yield of condensed products and conversion of cyclopentanone was achieved. The alkali-treated H beta 25-1 catalyst combined with Pd/C effectively catalyzed the hydrodeoxygenation of the condensed products, resulting in a high yield of dicyclopentylmethane with desirable density and heating value. This work provides a new route for producing high-density jet fuel from lignocellulosic compounds.
Review
Biochemistry & Molecular Biology
Peng Chen, Ping Zhang, Navid Hussain Shah, Yanyan Cui, Yaling Wang
Summary: Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method with deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Inorganic sonosensitizers play a crucial role in SDT and show great potential due to their high stability and longer circulation time. This review discusses the possible mechanisms of SDT, summarizes the latest research progress on inorganic sonosensitizers, and introduces strategies for optimizing treatment efficacy. The challenges and future prospects of sonodynamic therapy are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Ziwei Chen, Mengke Li, Yanyan Cui, Yaling Wang
Summary: The AgVO3/Ag6Si2O7 nanocomposite, prepared through the coprecipitation method, showed suitable bandgap for strong absorption of visible light. The heterojunction nanostructure formed by these two nanostructures exhibited higher photogenerated carrier transfer efficiency and stability. Among them, AgSV-12 demonstrated the best photocatalytic activity and showed good photodegradation activity towards other organic dyes.
MATERIALS TODAY SUSTAINABILITY
(2023)
Review
Chemistry, Analytical
Xinyi Lu, Xin Wang, Susu Gao, Ziwei Chen, Ru Bai, Yaling Wang
Summary: Hypoxia imaging of tumors plays a crucial role in prognosis and recurrence rate. Magnetic resonance imaging (MRI) has advantages in accurate tumor imaging but requires better contrast agents for enhanced clinical safety. The development of bioparameter-directed nanoformulations as MRI contrast agents for accurate tumor diagnosis is important and promising.
Article
Chemistry, Physical
Navid Hussain Shah, Muhammad Abbas, Muhammad Qasim, Muhammad Sulman, Muhammad Imran, Sohail Azmat, Yanyan Cui, Yaling Wang
Summary: Perovskites, particularly alkaline earth stannates, have attracted significant interest due to their favorable properties. In this study, the researchers enhanced the photocatalytic performance of calcium tin oxide by incorporating silver silicate. The resulting heterostructure exhibited improved carrier separation and enhanced absorption in the visible light range. The Ag6Si2O7/CaSnO3 catalyst demonstrated high efficiency and recyclability in the degradation of RhB, making it a promising candidate for visible-light-driven catalysts.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
