Article
Biochemistry & Molecular Biology
Tauseef Alam, Samina Naseem, Farha Shahabuddin, Subuhi Abidi, Iqbal Parwez, Farah Khan
Summary: This study evaluates the protective efficacy of orally administered Nigella sativa oil (NSO) against arsenic-induced cytotoxic and genotoxic alterations in rat intestine and elucidates its underlying mechanism of action. The results demonstrate that NSO significantly alters the ability of the intestine to protect against free radical-mediated arsenic toxicity by improving antioxidant status and energy metabolism. Therefore, NSO may have excellent potential in managing gastrointestinal distress in arsenic intoxication.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Nutrition & Dietetics
Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Hend F. Alharbi, Hoda A. Ali
Summary: This study assessed the protective effects of Nigella sativa floral honey (NS floral honey) and multi-floral honey (M-floral honey) compared to Nigella sativa oil (NS oil) against azathioprine-induced testicular degeneration in rats. Both NS floral honey and NS oil partially restored testicular function and improved sperm quality, while the effects of M-floral honey were inconclusive. Further clinical studies are needed to investigate the bioactive constituents of these substances.
Article
Environmental Sciences
Doaa A. Madkour, Mohamed M. Ahmed, Sahar H. Orabi, Samy M. Sayed, Reda M. S. Korany, Hanem K. Khalifa
Summary: The study demonstrated that Nigella sativa oil (NSO) has a protective effect against emamectin benzoate (EMB) induced neurotoxicity through its antioxidant, anti-inflammatory, and anti-apoptotic activities. The findings suggest NSO as a potential therapeutic agent for EMB-induced neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Mohamed A. Al-Griw, Suliman M. Shalabi, Rabia O. Alghazeer, Abdul H. Elnfati, Soad A. Treesh, Ahmeda E. Benjama, Ghalia Shamlan, Mahmmoud M. Habibullah, Areej A. Eskandrani, Afnan M. Alnajeebi, Nouf A. Babteen, Wafa S. Alansari
Summary: This study explored the therapeutic potential of Nigella sativa (NS) seed extract on testis and sperm abnormalities in BPA-exposed mice and characterized the underlying mechanism. The results demonstrate that NS oil protects mice against BPA-induced sperm and testis abnormalities, likely by suppressing levels of the oxidative stress marker, MDA, and enhancing the levels of the antioxidant marker, GSH.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Agnieszka Daca, Adam Kokotkiewicz, Maria Luczkiewicz, Jacek Maciej Witkowski, Katarzyna Aleksandra Lisowska
Summary: The study examines the effects of black seed oil on T cells in patients with Hashimoto's thyroiditis (HT). The results show that black seed oil can inhibit the proliferation of CD4(+) and CD8(+) T cells and induce cell death in HT patients and healthy women. It also reduces the concentration of certain cytokines.
Article
Biochemistry & Molecular Biology
Safialdin Alsanosi, Ryan A. Sheikh, Sultan Sonbul, Hisham N. Altayb, Afnan S. Batubara, Salman Hosawi, Kaltoom Al-Sakkaf, Omeima Abdullah, Ziad Omran, Mahmoud Alhosin
Summary: Nigella sativa oil, commonly known as black seed oil (BSO), contains the active compound thymoquinone (TQ) which inhibits cell proliferation and induces apoptosis by targeting epigenetic factors and proteins. This study compared the effects of BSO and pure TQ on cancer cells and found that both had similar inhibitory and apoptotic effects. Molecular docking and simulation showed that TQ had good binding affinity to UHRF1 and HDAC1, suggesting it as a promising strategy for epigenetic therapy.
Article
Public, Environmental & Occupational Health
Samina Ikram, Sadia Suleman, Syeda Nadia Ahmad, Mehwish Nasir, Muhammad Ali Kanwal, Kausar Raees, Iram Inayat, Saira Saddique, Asma Younis, Basharat Ali Saleem, Khawaja Raees Ahmad
Summary: This study examined the potential of NsO to ameliorate renal histopathologies induced by Bf exposure in mice and found that NsO could potentially have a nephroprotective role.
Review
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Anna Wardowska, Katarzyna Aleksandra Lisowska
Summary: Background: Nigella sativa has been traditionally used for medicinal purposes and has known antibacterial, virucidal, fungicidal, and antiparasitic properties. However, studies on its immunomodulatory effects are limited. This review examines in vitro and in vivo research supporting the role of Nigella sativa in modulating immune responses. The results suggest its potential as a therapeutic agent for regulating immune reactions.
Article
Medicine, Research & Experimental
Hilal Alkis, Elif Demir, Mehmet Resit Taysi, Suleyman Sagir, Seyithan Taysi
Summary: Ionizing radiation leads to the release of free radicals into the systemic circulation, causing oxidative stress in distant organs. Naturally occurring antioxidant agents such as Nigella sativa oil (NSO) and thymoquinone (TQ) exhibit protective and antioxidant effects against oxidative damage in the kidney tissue of rats exposed to cranial irradiation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Masoumeh Fadishei, Mahboobeh Ghasemzadeh Rahbardar, Mohsen Imenshahidi, Ahmad Mohajeri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: The study found that BPA can lead to abnormalities in blood pressure, lipid profile, hepatic enzymes, and insulin, while supplementation with NSO or TQ can reduce these abnormalities and increase the level of glutathione, providing a certain control over metabolic disorders.
PHYTOTHERAPY RESEARCH
(2021)
Article
Veterinary Sciences
Sayed Soliman Abdel Ghfar, Montaser Elsayed Ali, Maha Abdullah Momenah, Fatimah A. Al-Saeed, Amin A. Al-Doaiss, Yasser Sabry Mostafa, Ahmed Ezzat Ahmed, Mohamed Abdelrahman
Summary: This study found that garlic, Nigella sativa, or their combination had positive effects on reducing aluminum toxicity and restoring normal function in the liver, kidneys, and testes. Additionally, garlic and Nigella sativa showed protective effects against aluminum-induced changes in blood parameters.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Ilknur Undag, Hasan Huseyin Donmez
Summary: This study aimed to evaluate the protective effects of Nigella sativa oil against acrylamide-induced toxicity in the rat hippocampus. The findings showed that Nigella sativa oil supplementation increased the number of neurons in the hippocampus and improved gait abnormalities.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Kristian Leisegang, Walid Almaghrawi, Ralf Henkel
Summary: Obesity is a significant risk factor for male reproductive dysfunction and infertility. Nigella sativa seed oil and metformin show potential positive effects on obesity, but further research is needed on their impact on male fertility.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemical Research Methods
Ikenna Kingsley Uchendu, Henshaw Uchechi Okoroiwu
Summary: The study aimed to evaluate the protective effect of methanolic extracts of Nigella sativa against cadmium-induced blood oxidative stress and testicular toxicity in albino rats. The results showed that N. sativa seed extract can protect testicular cells and tissues from oxidative damage caused by harmful substances like cadmium.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Engineering, Biomedical
Cansu Aras, Elif Tumay Ozer, Gokhan Goktalay, Gulbahar Saat, Esra Karaca
Summary: Polyurethane/Nigella sativa oil nanofibrous mat has significant antibacterial activity and promotes wound healing effectively. The release of NSO from the mat is controlled, and it shows no cytotoxicity.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Pharmacology & Pharmacy
Essam Abdel-Sattar, Eman T. Mehanna, Sabah H. El-Ghaiesh, Hala M. F. Mohammad, Hanan A. Elgendy, Sawsan A. Zaitone
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Medicine, Research & Experimental
Rabie E. Elshaer, Mona K. Tawfik, Nermine Nosseir, Sabah H. El-Ghaiesh, Eman A. Toraih, Nehal M. Elsherbiny, Sawsan A. Zaitone
Article
Medicine, Research & Experimental
Hala M. F. Mohammad, Manal M. Sami, Samy Makary, Eman A. Toraih, Amany O. Mohamed, Sabah H. El-Ghaiesh
Article
Neurosciences
Nehal M. Elsherbiny, Yousra Abdel-Mottaleb, Amany Y. Elkazaz, Hoda Atef, Rehab M. Lashine, Amal M. Youssef, Wessam Ezzat, Sabah H. El-Ghaiesh, Rabie E. Elshaer, Mohamed El-Shafey, Sawsan A. Zaitone
FRONTIERS IN NEUROSCIENCE
(2019)
Review
Pharmacology & Pharmacy
Thomas Antony, Sharifa Y. Alzaharani, Sabah H. El-Ghaiesh
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Article
Immunology
Alshimaa Aboalsoud, Sabah H. El-Ghaiesh, Fleur F. Abd Elmonem, Mohammed L. Salem, Mohamed N. Abdel Rahman
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Neurosciences
Sabah H. El-Ghaiesh, Hoda Bahr, Afaf T. Ibrahiem, Doaa Ghorab, Suliman Y. Alomar, Noha E. Farag, Sawsan A. Zaitone
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Review
Immunology
Raghad D. Alamri, Mazen A. Elmeligy, Ghadeer A. Albalawi, Sarah M. Alquayr, Samaher S. Alsubhi, Sabah H. El-Ghaiesh
Summary: Leflunomide inhibits the DHODH enzyme and depletes pyrimidine nucleotides in cells, resulting in immunosuppression and antiproliferative effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Ahmed S. Ahmed, Ehab M. Hantash, Soha S. Zakaria
Summary: The study found that amantadine can reverse the structural changes induced by glutamate in the rat brain cortex and increase the activity of protein phosphatase 2A subunit B. Additionally, the administration of amantadine led to a decrease in the apoptotic index in the treated individuals. This indicates the potential of amantadine as a therapeutic agent.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell Biology
Ahmed S. Ahmed, Hoda A. Ibrahim, Ehab M. Hantash
Summary: The study found that fish oil has a protective potential against DIP, preserving the histological architecture, tight junction, and cell cycle of the colon in rats. Further examination is suggested to fully understand the molecular basis of this potential for future clinical applications.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2021)
Article
Neurosciences
Ahmed S. Ahmed, Marwa M. Mona, Rasha A. Elsisy, Ehab M. Hantash
Summary: The study found that under chronic mild stress, administration of HSD can decrease hippocampal amyloid beta and malondialdehyde levels, protect cognitive functions, and preserve hippocampal histological structure.
NEUROTOXICITY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ahmed S. Ahmed, Marwa M. Mona, Rasha A. Elsisy, Ehab M. Hantash
Summary: This study aimed to investigate the potential palliative role of ascorbic acid supplements on the harmful effects induced hyperuricemia on the hippocampus of albino Wistar rats. The results showed that ascorbic acid strongly preserved the histological architecture and maintained normal hippocampal functions in the hyperuricemic group. Discussion/Conclusion: The anti-inflammatory and antioxidant properties of ascorbic acid can protect the hippocampus of albino Wistar rats against the hazardous impact of hyperuricemia.
NEUROENDOCRINOLOGY
(2023)
Article
Oncology
Othman R. Alzahrani, Rashid Mir, Hanan E. Alatwi, Yousef M. Hawsawi, Amnah A. Alharbi, Abdulrahman H. Alessa, Elham Saleh Albalawi, Imadeldin Elfaki, Yousef Alalawi, Laila Moharam, Sabah H. El-Ghaiesh
Summary: A case-control study in Saudi Arabia revealed a strong association between gene variants of PI3K-AKT signaling pathway, KLF 14-AA, MDM4-GA, miR27a-GG, and miR-196a-CT, with the susceptibility and progression of breast cancer. The study also provided valuable insights into the disease mechanisms through whole-exome sequencing.