Biologia Futura: Emerging antigen-specific therapies for autoimmune diseases

Tackling autoimmunity with nanomedicines

(2020) Xiangru Feng et al.   Nanomedicine

In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells

(2020) Bo Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

(2020) Jinmin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Antigen-Specific Tolerance in T Cell Mediated Diseases

(2020) Laura Passerini et al.   Frontiers in Immunology

Therapeutic Cytokine Inhibition Modulates Activation and Homing Receptors of Peripheral Memory B Cell Subsets in Rheumatoid Arthritis Patients

(2020) Zafar Mahmood et al.   Frontiers in Immunology

Antigen-specific therapeutic approaches for autoimmunity

(2019) Pau Serra et al.   NATURE BIOTECHNOLOGY

Evolving Therapy for Celiac Disease

(2019) Shakira Yoosuf et al.   Frontiers in Pediatrics

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis

(2018) Geoffrey D. Keeler et al.   MOLECULAR THERAPY

Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis

(2018) Jeremy Chataway et al.   NEUROLOGY

Engineered T Regulatory Type 1 Cells for Clinical Application

(2018) Silvia Gregori et al.   Frontiers in Immunology

Nanoparticles for the Induction of Antigen-Specific Immunological Tolerance

(2018) Takashi Kei Kishimoto et al.   Frontiers in Immunology

Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells

(2018) Sang-Hyun Kim et al.   YONSEI MEDICAL JOURNAL

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance

(2018) Qunfang Zhang et al.   Frontiers in Immunology

Human regulatory B cells in health and disease: therapeutic potential

(2017) Claudia Mauri et al.   JOURNAL OF CLINICAL INVESTIGATION

Antigen-specific immunotherapies in rheumatic diseases

(2017) Judit Pozsgay et al.   Nature Reviews Rheumatology

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

(2017) Mohammad Alhadj Ali et al.   Science Translational Medicine

On Peptides and Altered Peptide Ligands: From Origin, Mode of Action and Design to Clinical Application (Immunotherapy)

(2016) Martín Candia et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes

(2015) Ezio Bonifacio et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regulatory dendritic cells in autoimmunity: A comprehensive review

(2015) Juan Liu et al.   JOURNAL OF AUTOIMMUNITY

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

(2015) Anja Ten Brinke et al.   MEDIATORS OF INFLAMMATION

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man

(2015) Verena K. Raker et al.   Frontiers in Immunology

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Beneficial Effect of Tolerogenic Dendritic Cells Pulsed with MOG Autoantigen in Experimental Autoimmune Encephalomyelitis

(2014) María José Mansilla et al.   CNS Neuroscience & Therapeutics

Red blood cells as innovative antigen carrier to induce specific immune tolerance

(2013) Magali Cremel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exploiting Apoptosis for Therapeutic Tolerance Induction

(2013) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

(2012) Grazia Andolfi et al.   MOLECULAR THERAPY

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

(2011) S. Fourlanos et al.   DIABETES

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Reversal of type 1 diabetes by a new MHC II-peptide chimera: “Single-epitope-mediated suppression” to stabilize a polyclonal autoimmune T-cell process

(2010) Marvin Lin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

No Effect of the Altered Peptide Ligand NBI-6024 on  -Cell Residual Function and Insulin Needs in New-Onset Type 1 Diabetes

(2009) M. Walter et al.   DIABETES CARE

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis

(2008) Hideki Garren et al.   ANNALS OF NEUROLOGY