Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers

Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression

(2020) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Plasma kynurenines and prognosis in patients with heart failure

(2020) Anders Lund et al.   PLoS One

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

(2019) Christopher P. Stanley et al.   NATURE

Opening of ATP-sensitive potassium channels causes migraine attacks: a new target for the treatment of migraine

(2019) Mohammad Al-Mahdi Al-Karagholi et al.   BRAIN

Systematic Review on the Involvement of the Kynurenine Pathway in Stroke: Pre-clinical and Clinical Evidence

(2019) Gabriela D. Colpo et al.   Frontiers in Neurology

Cerebrovascular effects of endothelin-1 investigated using high-resolution magnetic resonance imaging in healthy volunteers

(2019) Anders Hougaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kynurenines and the Endocannabinoid System in Schizophrenia: Common Points and Potential Interactions

(2019) Ferenc Zádor et al.   MOLECULES

Systemic administration of l -kynurenine sulfate induces cerebral hypoperfusion transients in adult C57Bl/6 mice

(2017) Dániel Péter Varga et al.   MICROVASCULAR RESEARCH

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

(2017) Francesco Fazio et al.   Frontiers in Pharmacology

Altered serum levels of kynurenine metabolites in patients affected by cluster headache

(2016) Martina Curto et al.   JOURNAL OF HEADACHE AND PAIN

Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat

(2012) Virginie Chauvel et al.   EXPERIMENTAL NEUROLOGY

Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography–tandem mass spectrometry

(2011) Wentao Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The L-kynurenine signalling pathway in trigeminal pain processing: A potential therapeutic target in migraine?

(2011) Song Guo et al.   CEPHALALGIA

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Improvement of the Closed Cranial Window Model in Rats by Intracarotid Infusion of Signalling Molecules Implicated in Migraine

(2009) S Gupta et al.   CEPHALALGIA

The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

(2009) Eniko Vamos et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

(2008) Helen J. Ball et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL