Article
Medicine, General & Internal
Milenko Bogdanovic, Ivan Skadric, Tatjana Atanasijevic, Oliver Stojkovic, Vesna Popovic, Slobodan Savic, Zoran Mihailovic, Bojana Radnic, Tijana Acimovic, Irina Damjanjuk, Sanja Despotovic, Aleksandra Barac
Summary: The first case of retrospective detection of SARS-CoV-2 in post-mortem vitreous humor in Europe on February 5th, 2020, proves that the virus was spreading faster and earlier than previously thought, indicating that COVID-19 may have been the cause of reported pneumonia of unknown origin in January and February 2020.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Cordilia Maria Himwaze, Viktor Telendiy, Fred Maate, Songwe Mupeta, Chanda Chitalu, Duncan Chanda, Peter Julius, Chibamba Mumba, Clemence Marimo, Amos Hamukale, Llyod Mulenga, Aaron Lunda Shibemba, Alimuddin Zumla, Luchenga Adam Mucheleng'anga
Summary: This study examined the gross pathology and histological features of COVID-19 in sub-Saharan Africa, specifically in Zambia. The majority of COVID-19 deaths in this study were below 55 years old and had comorbidities such as HIV and tuberculosis. The findings of this study were consistent with those reported in China, Europe, and the USA, but highlighted the importance of further investigation into the impact of HIV and TB co-infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Yuichiro Hirata, Harutaka Katano, Shun Iida, Sohtaro Mine, Sayaka Nagasawa, Yohsuke Makino, Ayumi Motomura, Seiya Ozono, Yuko Sato, Tsuyoshi Sekizuka, Makoto Kuroda, Rutsuko Yamaguchi, Go Inokuchi, Suguru Torimitsu, Shinji Akitomi, Daisuke Yajima, Hisako Saitoh, Tadaki Suzuki, Hirotaro Iwase
Summary: This study conducted genomic analyses of SARS-CoV-2 in 18 forensic autopsy cases and identified the distribution of the virus primarily in the respiratory organs. In one case of death due to COVID-19, intrahost genomic diversity of the virus was found. The study suggests the feasibility of genomic analysis in forensic autopsy cases and the potential for uncovering important information in COVID-19 deaths.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Nicolo Musso, Luca Falzone, Stefano Stracquadanio, Dafne Bongiorno, Monica Salerno, Massimiliano Esposito, Francesco Sessa, Massimo Libra, Stefania Stefani, Cristoforo Pomara
Summary: The limited number of post-mortem analyses during the COVID-19 pandemic has led to inaccuracies in counting COVID-19 deaths. A study proposed the possibility of performing confirmatory analyses on exhumed bodies after a long period of burial to assess the presence of SARS-CoV-2 RNA. The results showed successful detection of viral RNA in lung samples from buried COVID-19 patients, indicating the persistence of the virus even after a long post-mortem interval.
Article
Cardiac & Cardiovascular Systems
Ana Ferrer-Gomez, Hector Pian-Arias, Irene Carretero-Barrio, Antonia Navarro-Cantero, David Pestana, Raul de Pablo, Jose Luis Zamorano, Juan Carlos Galan, Belen Perez-Mies, Ignacio Ruz-Caracuel, Jose Palacios
Summary: This study reported the pathological findings in cardiac samples of 30 patients who died due to Sars-Cov-2 infection, revealing that most patients had modest cardiac pathology and the direct effect of SARS-CoV-2 on cardiac lesions remains to be established.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Melanie C. Bois, Nicholas A. Boire, Andrew J. Layman, Marie-Christine Aubry, Mariam P. Alexander, Anja C. Roden, Catherine E. Hagen, Reade A. Quinton, Christopher Larsen, Young Erben, Ramanath Majumdar, Sarah M. Jenkins, Benjamin R. Kipp, Peter T. Lin, Joseph J. Maleszewski
Summary: This study provides a detailed evaluation of cardiac pathology in individuals with COVID-19, revealing that nonocclusive fibrin microthrombi are common in active COVID-19 cases but do not typically result in acute ischemic injury. Myocarditis is present in a significant percentage of patients with active and cleared COVID-19, while histological features of resolved infection are variable. Additionally, cardiac amyloidosis may be an added risk factor for severe disease.
Article
Cell Biology
Daniele Colombo, Laura Falasca, Luisa Marchioni, Antonella Tammaro, Ganiyat Adenike Ralitsa Adebanjo, Giuseppe Ippolito, Alimuddin Zumla, Mauro Piacentini, Roberta Nardacci, Franca Del Nonno
Summary: COVID-19 infection has a wide range of neurological manifestations, affecting both the central and peripheral nervous system, leading to smell and taste disturbances, cerebrovascular disease, and long-lasting neurological symptoms in surviving patients. Post-mortem neuropathological studies have shown vascular changes, inflammation, and hypoxic neuronal injury in the cerebral cortex of COVID-19 patients, highlighting the role of microvascular injury in neurological manifestations.
Review
Critical Care Medicine
Luke Milross, Joaquim Majo, Nigel Cooper, Paul M. Kaye, Omer Bayraktar, Andrew Filby, Andrew J. Fisher
Summary: Post-mortem lung tissue analysis reveals a high degree of heterogeneity in COVID-19 lung disease, with different phenotypes and pathophysiological processes. This understanding is crucial for patient management and the development of treatment strategies.
LANCET RESPIRATORY MEDICINE
(2022)
Review
Medicine, General & Internal
Aniello Maiese, Paola Frati, Fabio Del Duca, Paola Santoro, Alice Chiara Manetti, Raffaele La Russa, Marco Di Paolo, Emanuela Turillazzi, Vittorio Fineschi
Summary: This systematic review analyzed the potential impacts of COVID-19 on the heart, revealing that SARS-CoV-2 can cause irreversible changes in the heart, increasing cardiac risks in surviving patients. Postmortem analysis is an essential tool to understand the pathological changes caused by COVID-19.
Article
Cell Biology
Jasmin Dionne Haslbauer, Valeria Perrina, Matthias Matter, Athanassios Dellas, Michael J. Mihatsch, Alexandar Tzankov
Summary: The study found that there was no early lethal community spread of COVID-19 in Basel before its initial reported emergence in Switzerland in March 2020. Analysis showed a significant increase in pulmonary causes of death in March 2020, with a rise in fatal bronchopneumonia observed between December 2019 and January 2020.
Review
Radiology, Nuclear Medicine & Medical Imaging
Laura Filograna, Guglielmo Manenti, Garyfalia Ampanozi, Antonello Calcagni, Colleen Patricia Ryan, Roberto Floris, Michael John Thali
Summary: This narrative review explores the potentials of post-mortem CT (PMCT) and its ancillary techniques in the analysis of suspected or confirmed SARS-COV-2 deaths. PMCT findings suggestive of pulmonary COVID-19 in SARS-COV-2 positive cadavers are reported in the literature. Further studies are needed to determine the value of PMCT in determining COVID-19 as the cause of death without autopsy histopathological confirmation.
Review
Immunology
Yebei Li, Meiying Rao, Gaosi Xu
Summary: The emergence of acute kidney disease (AKD) following COVID-19 vaccination has raised concerns. This review summarizes hypotheses and pathogenesis of AKD caused by COVID-19 vaccines, aiming to assist clinical assessment and management of this condition.
Review
Biochemistry & Molecular Biology
Hanfei Chen, Qiang Chen
Summary: COVID-19, caused by SARS-CoV-2, has had a detrimental impact on global health and economy. Its association with MAFLD has become a topic of interest, as MAFLD is a potential risk factor for severe COVID-19 symptoms. This review provides an update on the interactions between COVID-19 and MAFLD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Josefina B. Parodi, Agustin Indavere, Pamela Bobadilla Jacob, Guillermo C. Toledo, Ruben G. Micali, Gabriel Waisman, Walter Masson, Eduardo D. Epstein, Melina S. Huerin
Summary: This study analyzed the relationship between COVID-19 vaccination and the prevalence of post-COVID cardiac complications. The study found that vaccination was associated with a lower incidence of cardiac injury and a lower prevalence of persistent long-COVID cardiac symptoms compared to unvaccinated individuals.
Article
Critical Care Medicine
Luke Flower, Pradeep R. Madhivathanan, Matyas Andorka, Olusegun Olusanya, Ashraf Roshdy, Filippo Sanfilippo
JOURNAL OF CRITICAL CARE
(2021)
Article
Health Care Sciences & Services
Paul R. Mouncey, Alvin Richards-Belle, Karen Thomas, David A. Harrison, M. Zia Sadique, Richard D. Grieve, Julie Camsooksai, Robert Darnell, Anthony C. Gordon, Doreen Henry, Nicholas Hudson, Alexina J. Mason, Michelle Saull, Chris Whitman, J. Duncan Young, Francois Lamontagne, Kathryn M. Rowan
Summary: This study aimed to evaluate the clinical effectiveness and cost-effectiveness of reduced vasopressor exposure through a lower mean arterial pressure target in older critically ill patients. The results showed that the group with lower mean arterial pressure targets did not significantly reduce 90-day mortality compared to usual care, but did lead to a reduction in exposure to vasopressors for patients.
HEALTH TECHNOLOGY ASSESSMENT
(2021)
Article
Critical Care Medicine
A. Roshdy, A. S. Elsayed, A. S. Saleh
Summary: This article explores the practice of infectious diseases in the Intensive Care Unit (ICU) and identifies gaps and opportunities. The findings indicate that there are variations in practice across ICUs and antimicrobial stewardship programs are not universally implemented. The study highlights the need for improvement in infectious disease training and knowledge.
MEDICINA INTENSIVA
(2022)
Letter
Anesthesiology
L. Flower, P. Parulekar, A. Roshdy
Review
Critical Care Medicine
Ashraf Roshdy, Ahmad Samy Elsayed, Ahmad Sabry Saleh
Summary: This study examined the evidence for the use of APRV in patients with COVID-19. It found that APRV was associated with improved gas exchange but did not significantly improve mortality or ventilator free days compared to conventional mechanical ventilation. However, the results were limited by low study quality and a small number of patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Emergency Medicine
M. H. Elwan, A. Roshdy, E. M. Elsharkawy, S. M. Eltahan, T. J. Coats
Summary: The objective of this study was to evaluate the accuracy of passive leg raise (PLR) monitored by a non-invasive cardiac output monitor in predicting fluid resuscitation response in the emergency department (ED). The study found that PLR test was a better predictor of fluid responsiveness than commonly used parameters, suggesting the potential for a clinical trial comparing PLR-directed fluid management with standard care.
BMC EMERGENCY MEDICINE
(2022)
Article
Critical Care Medicine
Sean M. Bagshaw, Ary Serpa Neto, Orla Smith, Matthew Weir, Haibo Qiu, Bin Du, Amanda Y. Wang, Martin Gallagher, Rinaldo Bellomo, Ron Wald
Summary: The study aimed to assess the impact of chronic kidney disease (CKD) on the relationship between renal-replacement therapy (RRT) initiation strategy and clinical outcomes. The findings showed that an accelerated strategy of RRT initiation increased the risk of 90-day RRT dependence among patients with pre-existing CKD.
INTENSIVE CARE MEDICINE
(2022)
Review
Critical Care Medicine
Ashraf Roshdy
Summary: With the increased use of mechanical ventilation, there is a need for effective monitoring to prevent adverse effects. Over the past two decades, various monitoring tools and modalities have been introduced, providing insight into asynchrony, lung and chest wall mechanics, and respiratory effort and drive. However, formulating the appropriate monitoring strategy is challenging due to the complexity and cost involved. Intensivists should be aware of the advantages and limits of each tool to interpret the data effectively. This review provides a simplified narrative of commonly used respiratory monitors and discusses their limitations and future prospects.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Correction
Critical Care Medicine
Sean M. Bagshaw, Ary Serpa Neto, Orla Smith, Matthew Weir, Haibo Qiu, Bin Du, Amanda Y. Wang, Martin Gallagher, Rinaldo Bellomo, Ron Wald
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Niccolo Buetti, Alexis Tabah, Ambre Loiodice, Stephane Ruckly, Abdullah Tarik Aslan, Giorgia Montrucchio, Andrea Cortegiani, Nese Saltoglu, Bircan Kayaaslan, Firdevs Aksoy, Akova Murat, Ozlem Akdogan, Kemal Tolga Saracoglu, Cem Erdogan, Marc Leone, Ricard Ferrer, Jose-Artur Paiva, Yoshiro Hayashi, Mahesh Ramanan, Andrew Conway Morris, Francois Barbier, Jean-Francois Timsit
Summary: This study describes the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) among COVID-19 and non-COVID-19 critically ill patients. The results show differences in the characteristics of HABSI between the two groups, with COVID-19 patients having a higher risk of mortality.
Letter
Respiratory System
Federico Angriman, Bruno L. Ferreyro, Natalia Angeloni, Bruno R. da Costa, Ron Wald, Sean M. Bagshaw, Neill K. J. Adhikari
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Critical Care Medicine
Fernando G. Zampieri, Bruno R. da Costa, Suvi T. Vaara, Francois Lamontagne, Bram Rochwerg, Alistair D. Nichol, Shay McGuinness, Danny F. McAuley, Marlies Ostermann, Ron Wald, Sean M. Bagshaw
Summary: The reanalysis using Bayesian framework of the STARRT-AKI trial found that an accelerated strategy of kidney-replacement therapy initiation did not offer clinically important benefits compared to a standard strategy. Patients receiving the accelerated strategy may have fewer days alive and free from kidney-replacement therapy.
Meeting Abstract
Respiratory System
Yasser Ahmed, Niranjan Babu Ananda Setty, Ashraf Roshdy, Duncan Powrie, Dora Amran, Alguili Elsheikh, Sriya Gokaraju, Anne Tear, Maryam Noeman, Maria Darda, Iman El Sayed, Vijayalakshmi Karunanithi, Aarani Mahalingam, Muhammad Shafiq, Iman Abdulkhalik, Johnson Samuel
EUROPEAN RESPIRATORY JOURNAL
(2021)