Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songuel Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci Ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study aimed to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1 alpha,25 dihydroxy vitamin D [1,25( OH)(2)D] levels in cord blood of newborn babies. The results showed that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but there is no correlation between BPA levels and vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songul Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study investigated the association between BPA, 25(OH)D, and 1,25(OH)(2)D levels in cord blood of newborn babies. The study found that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but BPA levels were not correlated with vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, General & Internal
Luis Arboleya, Ignacio Brana, Estefania Pardo, Marta Loredo, Ruben Queiro
Summary: Osteomalacia is a series of disorders characterized by altered mineralization of the skeleton, which can be caused by various genetic or acquired disorders, including nutritional deficiencies. It is important to differentiate osteomalacia from other bone diseases to avoid misdiagnosis and incorrect treatment. Clinicians should be aware of the subtle manifestations and radiological features of osteomalacia, and consider it as a possible cause of therapeutic failures in patients with other bone diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Yap-Hang Chan, C. Mary Schooling, Jie Zhao, Shiu-Lun Au Yeung, Jo Jo Hai, G. Neil Thomas, Kar-Keung Cheng, Chao-Qiang Jiang, Yuen-Kwun Wong, Ka-Wing Au, Clara S. Tang, Chloe Y. Y. Cheung, Aimin Xu, Pak-Chung Sham, Tai-Hing Lam, Karen Siu-Ling Lam, Hung-Fat Tse
Summary: The study demonstrated through Mendelian randomization that vitamin D has a protective effect on the recurrence of ischemic vascular events in individuals with prior ischemic stroke or myocardial infarction. The genetic risk score predicted improved event-free survival from recurrent ischemic stroke or MI, supporting a causal relationship between genetically predicted lower vitamin D levels and the recurrence of ischemic vascular events.
Article
Nutrition & Dietetics
Hye Ran Shin, Hyeon Ju Park, Sun Yung Ly
Summary: Vitamin D deficiency is prevalent among young Korean women. This study aimed to determine the optimal vitamin D intake level for maintaining adequate serum 25-hydroxyvitamin D (25[OH]D) levels in young Korean women throughout different seasons. The study identified seasonal factors influencing 25(OH)D levels, calculated the necessary vitamin D intake for sufficient levels, and analyzed the relationship between 25(OH)D and intact parathyroid hormone (iPTH) levels. The results showed that 25(OH)D levels were higher in summertime compared to wintertime, and an increase in vitamin D intake led to a corresponding increase in 25(OH)D levels. The study suggests that increasing UV irradiation time in summertime and consuming vitamin D supplements and foods throughout the year is beneficial for maintaining sufficient levels of 25(OH)D in young Korean women.
Review
Nutrition & Dietetics
Madhura Joshi, Suma Uday
Summary: Vitamin D is crucial for regulating calcium and phosphate metabolism and maintaining bone health. Deficiency can lead to rickets in children and osteomalacia in adults. Recent studies have shown that vitamin D also has effects on multiple biological processes beyond bone health. Chronic childhood conditions affecting various systems can increase the prevalence of vitamin D deficiency. Screening and treating deficiency is important for these children and young people with chronic diseases.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Agnieszka Radom, Andrzej Wedrychowicz, Stanislaw Pieczarkowski, Szymon Skoczen, Przemyslaw Tomasik
Summary: Maintaining optimal vitamin D levels after breast cancer treatment is important for reducing recurrence risk and extending survival time. A study in Polish women after mastectomy found that vitamin D deficiency was more common in this group compared to the general population, highlighting the importance of vitamin D supplementation and monitoring. By providing recommendations and increasing awareness about vitamin D supplementation, there was a significant increase in the number of patients who started supplementing and the average dose of supplements.
Article
Neurosciences
Suhalika S. Sahni, Shruti Kakkar, Ruchika Kumar, Jatinder S. Goraya
Summary: This study described a cohort of 26 children and adolescents with osteomalacic myopathy, most of whom presented with progressive walking difficulty and signs of rickets. Laboratory and radiographic findings were consistent with vitamin-D deficiency in all cases, and response to vitamin-D treatment was good.
Article
Nutrition & Dietetics
Chiara Tuma, Arne Schick, Nele Pommerening, Hans Braun, Mario Thevis
Summary: Vitamin D is crucial for athletes, and personalized supplementation is more effective than standardized supplementation in helping athletes achieve adequate vitamin D levels.
Article
Nutrition & Dietetics
Roger Bouillon, Leen Antonio, Oscar Rosero Olarte
Summary: Vitamin D deficiency has adverse effects on both skeletal and extra-skeletal health. The optimal level of vitamin D remains a subject of debate. Observational studies suggest a link between low vitamin D levels and increased infection risk and cardiovascular events, but intervention studies have not shown clear benefits on these outcomes. Pregnancy supplementation with vitamin D reduces the risk of certain complications. The role of vitamin D in neurodegenerative diseases is still unclear. Vitamin D supplementation may have a marginal effect on overall mortality risk, particularly in elderly individuals with low vitamin D levels.
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Luisella Cianferotti
Summary: Mineralization plays a pivotal role in determining the stiffness and toughness of bones. Vitamin D deficiency is a major cause of altered mineralization, leading to inadequate absorption of calcium and phosphate. Assessment of alkaline phosphatase levels is important for diagnosing osteomalacia. The prevalence of different forms of osteomalacia and the effectiveness of treatment still require further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mehmet Emin Arayici, Sila Ovgu Korkut-Uysal, Asim Leblebici, Zeynep Akcali, Deniz Tuna Edizer, Seher Kabul, Dilek Cimrin, Ender Berat Ellidokuz
Summary: The aim of this study was to evaluate the change in 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. The study found that restrictions, partial or complete closures, and curfews can significantly affect individuals' 25(OH)D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support the results.
Article
Biology
Ioan-Alexandru Minciuna, Gabriel Cismaru, Mihai Puiu, Radu Rosu, Denis Amet, Daniela Anghelina, Alexandra Gica, Raluca Tomoaia, Marius Andronache, Dana Pop
Summary: In patients with cor triatriatum sinister and atrial fibrillation, accurate exploration and thorough understanding of the left atrial anatomy is crucial for successful catheter ablation. Anatomical variations, such as the left common pulmonary vein, may influence the approach and outcome of the procedure.
Article
Nutrition & Dietetics
Bogdana Adriana Nasui, Patricia Talaba, Gabriel Adrian Nasui, Dana Manuela Sirbu, Ileana Monica Borda, Anca Lucia Pop, Viorela Mihaela Ciortea, Laszlo Irsay, Anca Ileana Purcar-Popescu, Delia Cinteza, Madalina Gabriela Iliescu, Florina Ligia Popa, Soimita Mihaela Suciu, Rodica Ana Ungur
Summary: The present study aimed to assess the oxidative status in relation to diet and physical activity in patients with osteoarthritis (OA). The study found that most patients were overweight or obese, had above recommended levels of physical activity, but low intake of vegetables and fruit. The marker of oxidative stress, malonyl dialdehyde (MDA), was inversely associated with vegetable consumption.
Article
Medicine, General & Internal
Diana Andrada Irimie, Adela Viviana Sitar-Taut, Bogdan Caloian, Florina Fringu, Gabriel Cismaru, Radu Rosu, Mihai Puiu, Ioan Alexandru Minciuna, Gelu Simu, Dumitru Zdrenghea, Dana Pop
Summary: Catheter ablation for women with ischemic heart disease and atrial fibrillation is performed later and involves trying more antiarrhythmic drugs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Alina Gabriela Negru, Anda Pastorcici, Simina Crisan, Gabriel Cismaru, Florina Georgeta Popescu, Constantin Tudor Luca
Summary: The importance of magnesium in maintaining normal heart rhythm is still controversial. Magnesium supplementation has been shown to reduce the recurrence of ventricular arrhythmias and improve ventricular response. It also has beneficial effects on the occurrence of polymorphic ventricular tachycardia and supraventricular tachycardia. However, the use of magnesium in the treatment of atrial fibrillation and after cardiac surgery remains controversial.
Article
Medicine, General & Internal
Nicu Catalin Draghici, Daniel-Corneliu Leucuta, Dana Mihaela Ciobanu, Adina Dora Stan, Tudor Dimitrie Lupescu, Dafin Fior Muresanu
Summary: Diabetic polyneuropathy (DPN) is a common complication of diabetes, while carpal tunnel syndrome (CTS) is a common neuropathy characterized by compression of the median nerve at the wrist. This study aimed to compare the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and the six-item CTS symptoms scale (CTS-6) with nerve conduction studies (NCS) for detecting CTS in patients with DPN. The results showed that both the BCTQ and CTS-6 had significant differences in clinical evaluation between patients with and without CTS. Patients with DPN had higher chances of detecting CTS using these questionnaires.
Article
Biochemistry & Molecular Biology
Gelu Radu Simu, Raluca Tomoaia, Radu Ovidiu Rosu, Gabriel Gusetu, Mihai Puiu, Gabriel Cismaru, Bogdan Caloian, Andreea Terec, Teodor Buliga, Armand Boer, Ioan Alexandru Minciuna, Gyorgy Bodizs, Dumitru Zdrenghea, Dana Pop
Summary: Atrial high-rate episodes (AHREs) are common in patients with cardiac implantable electronic devices (CIEDs). Galectin-3 may provide additional data in predicting the occurrence of AHREs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Oana Pinzariu, Carmen Emanuela Georgescu
Summary: Despite advances in medical and surgical techniques, the therapeutic response to acromegaly still varies among patients, making personalized medicine necessary. Metabolomics can uncover the molecular mechanisms behind this response variability and identify new pathways for therapeutic management. A systematic review of metabolomic studies on acromegaly revealed that choline levels were negatively correlated with somatostatin receptors type 2 expression and positively correlated with MRI T2 signal and Ki-67 index in growth hormone-secreting pituitary adenomas (PAs). Metabolomic profiling also highlighted alterations in glucose metabolism, linoleic acid, sphingolipids, glycerophospholipids, arginine/proline, and taurine/hypotaurine. Matrix-assisted laser desorption/ionization coupled with mass spectrometry imaging accurately distinguished PAs from healthy pituitary tissue.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria-Evelina Bordean, Rodica Ana Ungur, Dan Alexandru Toc, Ileana Monica Borda, Georgiana Smaranda Martis, Carmen Rodica Pop, Miuta Filip, Mihaela Vlassa, Bogdana Adriana Nasui, Anamaria Pop, Delia Cinteza, Florina Ligia Popa, Sabina Marian, Lidia Gizella Szanto, Sevastita Muste
Summary: This study aimed to investigate the antioxidant and antibacterial activities of leaf and stem ethanolic extracts of Artemisia absinthium L. and Artemisia annua L. The results showed that the leaf extract of Artemisia annua L. had the highest total phenolic content and the strongest antioxidant capacity, while both Artemisia annua L. and Artemisia absinthium L. leaf extracts exhibited low minimum inhibitory concentration and minimum bactericidal concentration against various bacteria.
Review
Pediatrics
Alexandru Cristian Bolundut, Cecilia Lazea, Carmen Mihaela Mihu
Summary: Congenital heart defects (CHD) are the most common congenital abnormality, with a global birth prevalence of 9.41 per 1000 live births. The etiology of CHDs is complex and still poorly understood, with environmental factors accounting for about 10% of cases. Transcription factors and signaling molecules are potential genetic markers for CHDs. This review provides an overview of the current knowledge on genetic mechanisms and associations between transcription factors, signaling molecules, and congenital heart defects.
Review
Cardiac & Cardiovascular Systems
Simina Crisan, Ruxandra-Maria Baghina, Silvia Ana Luca, Alina-Ramona Cozlac, Alina-Gabriela Negru, Cristina Vacarescu, Mihai-Andrei Lazar, Constantin-Tudor Luca, Dan Gaita
Summary: Currently, various imaging techniques play a crucial role in the comprehensive evaluation of patients with suspected pulmonary hypertension (PH), providing important diagnostic information and facilitating early detection of the disease. Transthoracic echocardiography is the primary method for assessing right ventricle pressure overload and dysfunction, while right heart catheterisation is considered the gold standard assessment. Other imaging modalities such as chest radiography, CT, and CT pulmonary angiography are equally important for evaluating lung parenchyma and pulmonary arteries. Advanced techniques like dual-energy CT and cardiac MRI provide accurate diagnostic information for specific subtypes of PH.
Article
Medicine, Research & Experimental
Diana-Carina Iovanovici, Alina-Gariela Negru, Carmen Delia Nistor Cseppento, Calin Florin Bochis, Bombonica Gabriela Dogaru, Anamaria Jurcau, Babes Elena Emilia, Nicoleta Anamaria Pascalau, Timea Claudia Ghitea, Alexa Florina Bungau, Simona Gabriela Bungau
Summary: The aim of this prospective study was to assess the incidence of physical frailty in patients with HF and the role of physical exercise in improving physical performance. The study found that 20.56% of patients enrolled in the study had mild and moderate frailty, and 2.83% had severe frailty. The prevalence of mild and moderate frailty was significantly higher in the HF group compared to the non-HF group. Exercise-based rehabilitation was found to improve physical performance and increase independence in daily activities and functional performance in HF patients.
Article
Medicine, General & Internal
Horatiu Comsa, Gabriel Gusetu, Gabriel Cismaru, Bogdan Caloian, Radu Rosu, Dumitru Zdrenghea, Adina David, Bogdan Dutu, Raluca Tomoaia, Florina Fringu, Diana Irimie, Dana Pop
Summary: This study aimed to investigate the influence of gender on post-angioplasty prognosis in patients with peripheral arterial disease (PAD). The results showed no significant difference in the incidence rates of major adverse limb events (MALE) between men and women undergoing peripheral angioplasty. The ankle-brachial index (ABI) was found to be an independent predictor for MALE.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Simona Turcanu, Gabriel Gusetu, Dana Mihaela Ciobanu, Sabina Istratoaie, Radu Rosu, Minciuna Ioan Alexandru, Lucian Muresan, Cecilia Lazea, Dana Pop, Dumitru Zdrenghea, Gabriel Cismaru, Cristian Barsu, Alina Gabriela Negru, Andrei Cismaru, Simona Sorana Cainap
Summary: Previous research has established normal limits for children's heart rates based on age. However, children of the same age can have significantly different heart rates depending on their weight, height, and body size. Our study aimed to create Z scores for heart rate based on various body size factors and compare them to the normal age-related heart rate limits.
Meeting Abstract
Biochemistry & Molecular Biology
Botezatu Alina, Adina Chis, Calin Deleanu, Cecilia Lazea, Gabriella Horvath, Melinda Baizat, Ligia Blaga, Simona Bucerzan, Alina Nicolescu, Romana Vulturar
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)