Article
Public, Environmental & Occupational Health
Julika Loss, Juliane Wurm, Gianni Varnaccia, Anja Schienkiewitz, Helena Iwanowski, Anne-Kathrin Mareike Loer, Jennifer Allen, Barbara Wess, Angelika Schaffrath Rosario, Stefan Damerow, Tim Kuttig, Hanna Perlitz, Anselm Hornbacher, Bianca Finkel, Carolin Krause, Jan Wormsbaecher, Anna Sandoni, Ulrike Kubisch, Kiara Eggers, Andreas Nitsche, Aleksandar Radonic, Kathrin Trappe, Oliver Drechsel, Kathleen Klaper, Andrea Franke, Antje Huether, Udo Buchholz, Walter Haas, Lothar H. Wieler, Susanne Jordan
Summary: In daycare centres, close contact between children and employees increases the risk of infection transmission. This study aimed to investigate the role of daycare centres in the SARS-CoV-2 pandemic and the spread of the virus to associated households. The results showed that the secondary attack rate varied among daycare groups, and the household secondary attack rate was high. Additionally, children in daycare centres were less likely to be infected with SARS-CoV-2 compared to employees.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Multidisciplinary Sciences
Chloe Dimeglio, Jean-Michel Loubes, Marcel Miedouge, Fabrice Herin, Jean-Marc Soulat, Jacques Izopet
Summary: The study utilized an adapted statistical model to predict SARS-CoV-2 spread in France, with assumed seroprevalence in Occitania at 4.2% post-first lockdown, later measured at 2.4%. The discrepancy implies a lower than expected virus transmission rate, potentially influenced by varying infectivity with patient symptoms or uneven population geographical distribution.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Giorgio Guzzetta, Flavia Riccardo, Valentina Marziano, Piero Poletti, Filippo Trentini, Antonino Bella, Xanthi Andrianou, Martina Del Manso, Massimo Fabiani, Stefania Bellino, Stefano Boros, Alberto Mateo Urdiales, Maria Fenicia Vescio, Andrea Piccioli, Silvio Brusaferro, Giovanni Rezza, Patrizio Pezzotti, Marco Ajelli, Stefano Merler
Summary: Italy imposed a national lockdown on March 11, 2020 to curb the spread of SARS-CoV-2. The net reproduction number dropped below 1 14 days after lockdown and remained stable at approximately 0.76 in all regions for at least 3 weeks.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Fabrice Carrat, Xavier de Lamballerie, Delphine Rahib, Helene Blanche, Nathanael Lapidus, Fanny Artaud, Sofiane Kab, Adeline Renuy, Fabien Szabo de Edelenyi, Laurence Meyer, Nathalie Lydie, Marie-Aline Charles, Pierre-Yves Ancel, Florence Jusot, Alexandra Rouquette, Stephane Priet, Paola Mariela Saba Villarroel, Toscane Fourie, Clovis Lusivika-Nzinga, Jerome Nicol, Stephane Legot, Nathalie Druesne-Pecollo, Younes Esseddik, Cindy Lai, Jean-Marie Gagliolo, Jean-Francois Deleuze, Nathalie Bajos, Gianluca Severi, Mathilde Touvier, Marie Zins
Summary: During May-June 2020, the seropositivity to anti-SARS-CoV-2 antibodies in the French adult population was around 10%, varying across different regions. Younger age, having children or adolescents in the household, and being a non-smoker were associated with higher seropositivity rates.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Shay Reicher, Ronit Ratzon, Shay Ben-Sahar, Sharon Hermoni-Alon, David Mossinson, Yotam Shenhar, Michael Friger, Yaniv Lustig, Sharon Alroy-Preis, Emilia Anis, Siegal Sadetzki, Ehud Kaliner
Summary: The first local spread of COVID-19 in Israel was detected in March 2020, and a nationwide seroprevalence study conducted between June and September showed an overall seroprevalence of 3.8%. Males had a higher prevalence than females, with adolescents showing the highest prevalence. Participants who had undergone RT-PCR testing had a tenfold higher risk to be seropositive.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Sylvain Ladoire, Vincent Goussot, Emilie Redersdorff, Adele Cueff, Elise Ballot, Caroline Truntzer, Siavoshe Ayati, Leila Bengrine-Lefevre, Nathalie Bremaud, Bruno Coudert, Isabelle Desmoulins, Laure Favier, Clea Fraisse, Jean-David Fumet, Roxana Hanu, Audrey Hennequin, Alice Hervieu, Silvia Ilie, Coureche Kaderbhai, Aurelie Lagrange, Nils Martin, Irina Mazilu, Didier Mayeur, Remi Palmier, Anne-Laure Simonet-Lamm, Julie Vincent, Sylvie Zanetta, Laurent Arnould, Charles Coutant, Aurelie Bertaut, Francois Ghiringhelli
Summary: A study conducted at a large cancer center showed low seroprevalence of SARS-CoV-2 antibodies among both staff and patients, despite more high-risk factors among patients. None of the tested risk factors were statistically associated with seroprevalence in either group. Only fever, loss of smell, and loss of taste were significantly more frequent among seropositive patients.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Pierre Gallian, Nathanael Hoze, Nadege Brisbarre, Paola Mariela Saba Villarroel, Elif Nurtop, Christine Isnard, Boris Pastorino, Pascale Richard, Pascal Morel, Simon Cauchemez, Xavier de Lamballerie
Summary: We conducted a cross-sectional study on SARS-CoV-2 anti-S1 IgG prevalence in French blood donors, finding an overall increase in seroprevalence over the study period. By January 2021, we estimated that 15% of the French population had been infected. The infection/hospitalization ratio increased with age, and half of the IgG-S1 positive individuals showed no detectable antibodies after 4 to 5 months.
Article
Multidisciplinary Sciences
Marie-Kathrin Breyer, Robab Breyer-Kohansal, Sylvia Hartl, Michael Kundi, Lukas Weseslindtner, Karin Stiasny, Elisabeth Puchhammer-Stoeckl, Andrea Schrott, Manuela Foedinger, Michael Binder, Markus Fiedler, Emiel F. M. Wouters, Otto C. Burghuber
Summary: Analysis of a large Viennese cohort revealed that early governmental lockdown measures contributed to a low SARS-CoV-2 seroprevalence, with higher infections than officially reported PCR-positive cases. Children and elderly individuals had lower infection risks, with half of antibody-positive subjects displaying no or only mild symptoms. Taste and smell disturbances were the most strongly related symptoms to SARS-CoV-2 positivity.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Stephane Le Vu, Gabrielle Jones, Francois Anna, Thierry Rose, Jean-Baptiste Richard, Sibylle Bernard-Stoecklin, Sophie Goyard, Caroline Demeret, Olivier Helynck, Nicolas Escriou, Marion Gransagne, Stephane Petres, Corinne Robin, Virgile Monnet, Louise Perrin de Facci, Marie-Noelle Ungeheuer, Lucie Leon, Yvonnick Guillois, Laurent Filleul, Pierre Charneau, Daniel Levy-Bruhl, Sylvie van der Werf, Harold Noel
Summary: The study reports the estimated seroprevalence in the French population during the first wave of COVID-19, as well as the proportion of infected individuals who developed neutralising antibodies at three points throughout this period. The results show a gradual increase in nationwide seroprevalence, with approximately 70% of seropositive individuals having neutralising antibodies, and an infection fatality rate that increases exponentially with age.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Naif Khalaf Alharbi, Suliman Alghnam, Abdullah Algaissi, Hind Albalawi, Mohammed W. Alenazi, Areeb M. Albargawi, Abdullah G. Alharbi, Abdulaziz Alhazmi, Ali Al Qarni, Ali Alfarhan, Hosam M. Zowawi, Hind Alhatmi, Jahad Alghamdi, Fayhan Alroqi, Khalid Batarfi, Yaseen M. Arabi, Anwar M. Hashem, Mohammed Bosaeed, Omar Aldibasi
Summary: This study reports the national serological prevalence of SARS-CoV-2 in Saudi Arabia during the COVID-19 pandemic to be 11%, with apparent disparities between regions, indicating the presence of asymptomatic or mild unreported COVID-19 cases.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Microbiology
Marie Pouquet, Dorine Decarreaux, Pol Prevot-Monsacre, Corentin Herve, Andreas Werner, Brigitte Grosgogeat, Helene Blanche, Pascaline Rabiega, Julien Laupie, Fabienne Kochert, Nathalie Abraham, Jean-Marc Sebaoun, Xavier de Lamballerie, Remi Charrel, Cecile Souty, Ibrahima Camara, Jeanne Pergeline, Harold Noel, Caroline Guerrisi, Sylvie van der Werf, Fabrice Carrat, Thomas Hanslik, Thierry Blanchon, Alessandra Falchi
Summary: This study focuses on the seroprevalence of IgG antibodies against SARS-CoV-2 in primary health care workers and their household contacts in metropolitan France, achieved through vaccination and/or natural protection. It will be conducted in two phases using ELISA and virus neutralization tests to estimate seroprevalence.
Article
Multidisciplinary Sciences
Amit G. Singal, Andrew Masica, Kate Esselink, Caitlin C. Murphy, Jill A. Dever, Annika Reczek, Matthew Bensen, Nicole Mack, Ellen Stutts, Jamie L. Ridenhour, Evan Galt, Jordan Brainerd, Noa Kopplin, Sruthi Yekkaluri, Chris Rubio, Shelby Anderson, Kathryn Jan, Natalie Whitworth, Jacqueline Wagner, Stephen Allen, Alagar R. Muthukumar, Jasmin Tiro
Summary: The study aimed to estimate the prevalence of COVID-19, risk factors of infection, and related attitudes and behaviors in an urban population. The results showed that over 10% of the population in the city had been infected with COVID-19, and there were differences in attitudes and behaviors among different races and ethnicities.
Article
Infectious Diseases
Florence Poizeau, Emmanuel Oger, Sebastien Barbarot, Yannick Le Corre, Mahtab Samimi, Emilie Brenaut, Helene Aubert, Estel Chambrelan, Catherine Droitcourt, Valerie Gissot, Christopher Heslan, Claire Laurent, Ludovic Martin, Laurent Misery, Pierre Tattevin, Alexis Toubel, Vincent Thibault, Alain Dupuy
Summary: This case-control study reveals an association between chilblains occurring during the lockdown and household exposure to SARS-CoV-2.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Abbas Hoballah, Rana El Haidari, Ghina Siblany, Fadi Abdel Sater, Samir Mansour, Hamad Hassan, Linda Abou-Abbas
Summary: The study aimed to evaluate the prevalence of SARS-CoV-2 antibodies in Lebanon and compare it with the officially registered number of confirmed cases. The results indicate that the Lebanese population is still susceptible to SARS-CoV-2 infection and far from achieving herd immunity.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Dien M. Vu, Diep T. B. Vu, Thuy T. T. Do, Allison E. Olmsted, Bach H. Dao, Truc T. Thai, Chi L. Nguyen, Nhung T. T. Le, Tuan A. Le, Hien T. T. Bui, Thach N. Pham, Matthew R. Moore
Summary: This study investigated the immune response to ChAdOx1 nCoV-19 vaccine in healthcare workers in Vietnam. The findings showed that the vaccine induced antibodies within 3 months of the second dose, regardless of the dosing interval.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Maelle Le Goff, Eric Kendjo, Marc Thellier, Renaud Piarroux, Pierre Yves Boelle, Stephane Jaureguiberry
Summary: This study analyzed the impact of chemoprophylaxis on the outcomes of Plasmodium vivax and Plasmodium ovale infections in civilian travelers. It found that travelers using blood-stage drugs were at a higher risk of delayed-onset illness. This calls for new chemoprophylaxis acting on liver stages.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Infectious Diseases
Robert Cohen, Federico Martinon-Torres, Inga Posiuniene, Bernd Benninghoff, Kyu-Bin Oh, Dirk Poelaert
Summary: The SARS-CoV-2 pandemic has caused healthcare systems to be overwhelmed, making it crucial to prioritize high levels of pediatric vaccination against vaccine-preventable diseases like rotavirus gastroenteritis. Evidence shows that currently available rotavirus vaccines in Europe are highly effective, reducing hospitalizations and deaths. Additionally, there is no overall increase in intussusception and may even be a reduction in cases with high rotavirus vaccine coverage in the first year of life.
INFECTIOUS DISEASES AND THERAPY
(2023)
Review
Infectious Diseases
Didier Pinquier, Pascal Crepey, Pierre Tissieres, Astrid Vabret, Jean-Christophe Roze, Francois Dubos, Fabienne Cahn-Sellem, Etienne Javouhey, Robert Cohen, Catherine Weil-Olivier
Summary: The highly contagious respiratory syncytial virus (RSV) is responsible for a significant number of hospitalizations in children under 5 years old in France. Strategies such as maternal vaccination and administration of long-acting monoclonal antibodies are being investigated to protect young children from RSV infection.
INFECTIOUS DISEASES AND THERAPY
(2023)
Correction
Infectious Diseases
Robert Cohen, Federico Martinon-Torres, Inga Posiuniene, Bernd Benninghoff, Kyu-Bin Oh, Dirk Poelaert
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Infectious Diseases
Francesco Bonacina, Pierre-Yves Boelle, Vittoria Colizza, Olivier Lopez, Maud Thomas, Chiara Poletto
Summary: A global decline in influenza circulation during the COVID-19 pandemic was observed, but the magnitude varied across regions and time. COVID-19 incidence and pandemic preparedness were the most important predictors of the decline.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Pediatrics
Gottfried Huss, Shimon Barak, Laura Reali, Christine Magendie, Angel Carrasco-Sanz, Eli Somekh, Robert Cohen, Corinne Levy, Leyla Namazova-Baranova, Mehmet Vural, Massimo Pettoello-Mantovani
JOURNAL OF PEDIATRICS
(2023)
Article
Infectious Diseases
Deidre Wilkins, Annefleur C. Langedijk, Robert Jan Lebbink, Christopher Morehouse, Michael E. Abram, Bahar Ahani, Anastasia A. Aksyuk, Eugenio Baraldi, Tyler Brady, Albert Tian Chen, Hsin Chi, Eun Hwa Choi, Robert Cohen, Daria M. Danilenko, Vancheswaran Gopalakrishnan, Anne Greenough, Terho Heikkinen, Mitsuaki Hosoya, Christian Keller, Elizabeth J. Kelly, Leyla Kragten-Tabatabaie, Federico Martinon-Torres, Abiel Homero Mascarenas de los Santos, Marta C. Nunes, Maria Angelica Palomino, Jesse Papenburg, Jeffrey M. Pernica, Peter Richmond, Renato Stein, Kevin M. Tuffy, Charl Verwey, Mark T. Esser, David E. Tabor, Louis J. Bont, INFORM RSV Study Grp
Summary: This study evaluated the geotemporal distribution of RSV A and RSV B between 2015 and 2021 and functionally characterized the nirsevimab binding-site substitutions during this period. The results showed that the nirsevimab binding site remained highly conserved, with only a few rare mutations affecting nirsevimab neutralization emerging between 2016 and 2021. The genetic diversity of RSV fusion protein was lower compared to influenza hemagglutinin and SARS-CoV-2 spike proteins.
LANCET INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Morgane Jaloustre, Robert Cohen, Valerie Biran, Fabrice Decobert, Richard Layese, Etienne Audureau, Nolwenn Le Sache, Marie Chevallier, Mohamed Riadh Boukhris, Pascal Bolot, Laurence Caeymaex, Manon Tauzin
Summary: This study aims to identify factors associated with severe morbidity and mortality after healthcare-associated primary bloodstream infections (BSIs) in neonates in neonatal intensive care units (NICUs). The results showed that corrected gestational age <28 weeks, fetal growth restriction, and proven pathogen-related BSI were associated with severe morbidity/mortality. In possible BSIs, a lower risk of severe morbidity was associated with S. epidermidis compared to other CoNS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Infectious Diseases
Alexis Rybak, Corinne Levy, Naim Ouldali, Stephane Bonacorsi, Stephane Bechet, Jean-Francois Delobbe, Christophe Batard, Isabelle Donikian, Marie Goldrey, Jessica Assouline, Robert Cohen, Emmanuelle Varon
Summary: Epidemiological surveillance of nasopharyngeal pneumococcal carriage is important for monitoring serotype distribution and antibiotic resistance. A surveillance study in France analyzed pneumococcal carriage, antibiotic susceptibility, and serotype distribution in children with acute otitis media. The study found stable overall carriage rates and a rebound of penicillin non-susceptibility during the late PCV13 period. Non-PCV13 serotypes accounted for the majority of strains and the next generation PCVs may help decrease antibiotic resistance.
Review
Biochemistry & Molecular Biology
Agusti Alentorn, Giulia Berzero, Harry Alexopoulos, John Tzartos, German Reyes Botero, Andrea Morales Martinez, Sergio Muniz-Castrillo, Alberto Vogrig, Bastien Joubert, Francisco Garcia A. Jimenez, Dagoberto Cabrera, Jose Vladimir Tobon, Carolina Delgado, Patricio Sandoval, Monica Troncoso, Lorna Galleguillos, Marine Giry, Marion Benazra, Isaias Hernandez Verdin, Maelle Dade, Geraldine Picard, Veronique Rogemond, Nicolas Weiss, Marinos C. Dalakas, Pierre-Yves Boelle, Jean-Yves Delattre, Jerome Honnorat, Dimitri Psimaras
Summary: Anti-NMDAR encephalitis is associated with multiple antigenic triggers and this study aimed to explore if geographic and climatic factors may influence disease risk. Through a systematic review and meta-analysis, they found that the incidence of anti-NMDAR encephalitis varies among countries, with higher rates in Oceania and South America compared to Europe and North America. Regression models confirmed a strong negative correlation with latitude and seasonal analyses showed a peak of cases during warm months. Exposure-lag-response models revealed a positive correlation between extreme hot temperatures and disease incidence in France.
Editorial Material
Infectious Diseases
Didier Pinquier, Pascal Crepey, Pierre Tissieres, Astrid Vabret, Jean-Christophe Roze, Francois Dubos, Fabienne Cahn-Sellem, Etienne Javouhey, Robert Cohen, Catherine Weil-Olivier
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Infectious Diseases
Jeremie F. Cohen, Alexis Rybak, Andreas Werner, Fabienne Kochert, Fabienne Cahn-Sellem, Nathalie Gelbert, Frankois Vie Le Sage, Christophe Batard, Stephane Bechet, Hippolyte Corbaux, Bruno Frandji, Corinne Levy, Robert Cohen
Summary: This study evaluated the burden of noninvasive group A Streptococcus (GAS) infections in ambulatory pediatrics before and during the COVID-19 pandemic in France. The incidence of GAS diseases significantly decreased after the implementation of COVID-19 mitigation measures in March 2020 and significantly increased after the relaxation of these measures in March 2022. This highlights the important impact of COVID-19 control measures on the epidemiology of noninvasive GAS infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Robert Cohen, Emmanuelle Varon, Philippe Bidet, Jeremie F. Cohen, Stephane Bechet, Vincent Couloigner, Anne Sylvestre Michot, Cecile Guiheneuf, Stephane Bonacorsi, Corinne Levy
Summary: Group A Streptococcus is a leading cause of otorrhea. Rapid antigen tests showed excellent sensitivity, 97.3% (95% confidence interval: 90.7%-99.7%), and specificity, 100% (95% confidence interval: 98.0%-100%), in 256 children with otorrhea. Early diagnosis could be useful during a period of increasing group A Streptococcus infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Cell Biology
Ye Fan, Cedric Pionneau, Federico Cocozza, Pierre-Yves Boelle, Solenne Chardonnet, Stephanie Charrin, Clotilde Thery, Pascale Zimmermann, Eric Rubinstein
Summary: This study reveals that CD9, CD81, and CD63, commonly used as protein markers for extracellular vesicles (EVs), have little impact on the protein composition of EVs released by MCF7 breast cancer cells. Knocking out CD9 and CD81 only significantly decreases the levels of CD9P-1 and EWI-2 in EVs. This suggests a marginal role of CD9, CD81, and CD63 in determining the protein composition of EVs and highlights the regulation of CD9P-1 and EWI-2 expression level and/or trafficking by CD9 and CD81.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Letter
Infectious Diseases
Robert Cohen, Philippe Bidet, Emmanuelle Varon, Stephane Bechet, Jeremie F. Cohen, Stephane Bonacorsi, Corinne Levy
INFECTIOUS DISEASES NOW
(2023)