Journal
MATERIALS TODAY COMMUNICATIONS
Volume 26, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtcomm.2020.101948
Keywords
PLGA-PEG; Riboflavin; Microfluidic; Molecular dynamics; Cancer
Categories
Funding
- Academy of Finland [317316]
- Academy of Finland (AKA) [317316, 317316] Funding Source: Academy of Finland (AKA)
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This study revealed the significant impact of MoSe2 on the stability and size of RF-targeted micelles, and demonstrated that the microfluidic method is the most effective way to synthesize nano carriers. The use of MoSe2 monolayer, micelle containing RF, and microfluidic method were believed to be the best approach in order to improve the quality of micelles for cancer treatment.
The rate of Riboflavin (RF) consumption in cancerous cells is interestingly high and this might imply the use of RF ligand in nanocarriers in order to target anticancer drugs into cancer cells. This study aimed to develop a hybrid drug carrier of Doxorubicin (DOX) loaded on RF targeted micelles composed of hydrophobic polylacticglycolic acid (PLGA) and hydrophilic polyethylene glycol (PEG). In this regard, a simultaneous encapsulation of DOX and in-situ micellization as well as the self-assembly of PLGA-PEG-RF molecules were investigated. Moreover, the effects of microfluidic environment and transition metal dichalcogenide (TMD) nanolayers on the micellization properties (e.g., stability, size, and self-assembly interaction energies) of nanocarriers were simulated for the first time. To this purpose, the simulations were performed using two non-microfluidic methods as well as a novel microfluidic one. The molecular simulations revealed that all of the selected TMDs, especially MoSe2, had a great impact on the stability and size of nanocarriers. MoSe2 significantly enhanced the loading capacity as well as the stability of RF-targeted micelles and reduced the size of nanocarriers. Likewise, the results of various analyses demonstrated that the microfluidic method is the most effective way to synthesize nano carriers with higher stability and smaller particle size. Hence, the use of MoSe2 monolayer, micelle containing RF, and microfluidic method were believed to be the best approach in order to improve the quality of micelles. The present work sheds new light on the use of TMDs in the synthesis of smart carriers for cancer treatment.
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