Journal
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
Volume 33, Issue 2, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jksus.2020.101297
Keywords
COVID-19; Molecular docking; Potent inhibitor; ACE-2; Sulawesi propolis
Categories
Funding
- DRPM Universitas Indonesia through Grant Publikasi Terindeks Internasional (PUTI) Q2 2020 [NKB-1713/UN2.RST/HKP.05.00/2020]
- King Saud University, Riyadh, Saudi Arabia [RSP-2020/283]
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This study investigated the potential of Sulawesi propolis compounds in inhibiting ACE-2, a receptor of SARS-CoV-2. Molecular docking analysis revealed five compounds with high docking scores that are promising inhibitors of the ACE-2 and SARS-CoV-2 binding interaction.
Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fighting to control virus transmission. Yet, at the same time, Indonesia has a rich biodiversity of natural medicinal products that potentially become an alternative cure. Thus, this study examined the potency of a natural medicinal product, Sulawesi propolis compounds produced by Tetragonula sapiens, inhibiting angiotensin-converting activity enzyme-2 (ACE-2), a receptor of SARS-CoV-2 in the human body. In this study, molecular docking was done to analyze the docking scores as the representation of binding affinity and the interaction profiles of propolis compounds toward ACE-2. The results illustrated that by considering the docking score and the presence of interaction with targeted sites, five compounds, namely glyasperin A, broussoflavonol F, sulabiroins A, (2S)-5,7-dihydroxy-4'-methoxy-8-prenylflavanone and isorhamnetin are potential to inhibit the binding of ACE-2 and SARS-CoV-2, with the docking score of -10.8, -9.9, -9.5, -9.3 and -9.2 kcal/mol respectively. The docking scores are considered to be more favorable compared to MLN-4760 as a potent inhibitor. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
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