Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment

Leukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well-characterised. However, our understanding of these interactions and their regulation has expanded substantially in recent years to include novel lectins and regulatory pathways. In this review, we discuss the role of glycans and glycan-binding proteins, mediating the interactions between endothelium and leukocytes both directly and indirectly. We also highlight recent findings of key enzymes involved in glycosylation which affect leukocyte recruitment. Finally, we investigate the potential of glycans and glycan binding proteins as therapeutic targets to modulate leukocyte recruitment and transmigration in inflammation.

Automated summary

The recruitment of leukocytes is a complex process involving interactions between proteins expressed by the endothelium and circulating leukocytes. Recent research has expanded our understanding of these interactions, identifying novel lectins and regulatory pathways. Targeting glycans and glycan-binding proteins could offer new therapeutic strategies for modulating leukocyte recruitment and transmigration during inflammation.