Article
Agriculture, Dairy & Animal Science
C. Farmer, S. A. Edwards
Summary: Newborn piglets have a high mortality rate associated with low birth weights and intra-uterine growth restriction. Nutritional strategies during gestation and assistance in the transition period can improve fetal development and increase piglet survival. Optimizing the farrowing environment, supervising and assisting newborn piglets, cross-fostering, providing nurse sows, and artificial milk are effective approaches to enhance piglet survival.
Article
Agriculture, Dairy & Animal Science
Kaitlyn M. Sommer, Julianna C. Jespersen, Loretta T. Sutkus, Youngsoo Lee, Sharon M. Donovan, Ryan N. Dilger
Summary: Oral supplementation of encapsulated tributyrin can increase the concentration of butyrate in the colon, but it is unable to mitigate the negative effects of DSS-induced colitis. It also affects the growth performance of young pigs.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
Keylla Helena Nobre Pacifico Pereira, Karita da Mata Fuchs, Jaqueline Valenca Correa, Simone Biagio Chiacchio, Maria Lucia Gomes Lourenco
Summary: This review discusses the factors affecting the health of puppies and kittens during pregnancy, birth, and the first few weeks of life. It emphasizes the importance of both veterinarians and breeders having knowledge of maternal and neonatal care. Knowledge in neonatology is crucial for effective breeding management and higher neonatal survival rates.
Article
Biology
Xiaoyu Feng, Zhifang Wu, Junji Xu, Yipu Xu, Bin Zhao, Baoxing Pang, Xingmin Qu, Liang Hu, Lei Hu, Zhipeng Fan, Luyuan Jin, Dengsheng Xia, Shimin Chang, Jingsong Wang, Chunmei Zhang, Songlin Wang
Summary: Nitrate has shown to effectively prevent and treat radiation-induced hypofunction of the parotid gland, by maintaining the function of irradiated tissue and enhancing cell proliferation through the nitrate-sialin feedback loop and the EGFR-AKT-MAPK signaling pathway. This suggests that dietary nitrate supplementation may be a novel and effective way to address radiation-induced xerostomia in head and neck cancer patients.
Article
Agriculture, Dairy & Animal Science
T. A. Sutton, H. V. Masey O'Neill, M. R. Bedford, K. McDermott, H. M. Miller
Summary: This study found that xylanase (XYL) and xylo-oligosaccharide (XOS) had limited effects on pig performance, while faecal bacterial community composition significantly changed over time without an overall impact from the treatments.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Santi D. Upadhaya, Sang Seon Lee, Young Hwa Kim, Zhenlong Wu, In Ho Kim
Summary: This study evaluated the impact of supplementing glutamic acid to reduced protein diets on the growth performance of weanling pigs. The results showed that supplementing glutamic acid enhanced the body weight, average daily gain, and gain-to-feed ratio of the weanling pigs. The study also observed a linear increase in these growth parameters with increasing levels of glutamic acid. Additionally, the supplementation of glutamic acid had an effect on ammonia and methyl mercaptans emissions.
Article
Cardiac & Cardiovascular Systems
Victor Nauffal, Ludovic Trinquart, Asishana Osho, Thoralf M. Sundt, Steven A. Lubitz, Patrick T. Ellinor
Summary: In patients with post cardiac surgery AF, the use of NOACs compared to warfarin is associated with a shorter postoperative length of stay without excess bleeding or other short-term complications. These findings support the broader use of NOACs as a safe alternative to warfarin in this patient population.
ANNALS OF THORACIC SURGERY
(2021)
Review
Veterinary Sciences
Jixiang Ma, Weikang Huangfu, Xu Yang, Junying Xu, Yan Zhang, Zhichang Wang, Xiaoyan Zhu, Chengzhang Wang, Yinghua Shi, Yalei Cui
Summary: Alfalfa, a high-quality feed with rich nutrients, has been found to have positive effects on pigs. Research has shown that supplementing dietary alfalfa improves intestinal health, growth performance, and pork quality.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Maiken N. Engelsmann, Niels Morten Sloth, Tina S. Nielsen, Jan Norgaard
Summary: Increasing the level of threonine in pig feed did not reduce the probability of diarrhoea from 2 to 7 weeks post-weaning on a commercial pig farm.
Article
Cell Biology
Mohammad Amin Fayaz, Fahar Ibtisham, Tat-Chuan Cham, Ali Honaramooz
Summary: The effects of basic fibroblast growth factor, glial cell line-derived neurotrophic factor, and leukemia inhibitory factor on the in vitro propagation of neonatal porcine gonocytes were tested. It was found that media supplemented with 10 ng/mL bFGF and 10 ng/mL bFGF + 100 ng/mL GDNF + 1500 U/mL LIF resulted in the highest numbers of gonocytes and largest colonies. The resultant gonocytes and colonies expressed both germ cell- and pluripotency-specific markers.
CELL AND TISSUE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Pengsheng Li, Fan Li, Ling Tang, Wenjing Zhang, Yan Jin, Haiwei Gu, Wuqiang Zhu
Summary: The study revealed distinct differences in the metabolic profiles of pig hearts at different postnatal stages. P1 hearts showed active anabolism of nucleotide and proteins, while P28 hearts demonstrated active posttranslational protein modification, metabolic switch from glucose to fatty acids, and reduced collagen to total protein ratio.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Agronomy
Hongmei Xie, En Yu, Huamei Wen, Bayi Jiang, Guihua Fu, Haitao Sun, Jun He
Summary: The main purpose of this study was to evaluate the effects of varying levels of powdered DA inclusion in maternal diet on the growth performance and intestinal health of neonatal rabbits. The results showed that dietary DA supplementation increased individual body weight and average daily gain in neonatal rabbits, and improved antioxidative capacity and immunity. Additionally, DA supplementation also had positive effects on the intestinal structure and health of neonatal rabbits.
Review
Biochemistry & Molecular Biology
Enrique Antonio Alfonso-Munoz, Raquel Burggraaf-sanchez de las Matas, Jorge Mataix Boronat, Julio Cesar Molina Martin, Carmen Desco
Summary: The review suggests that antioxidant supplementation in adult Type 1 and Type 2 diabetes mellitus patients without retinopathy or mild-to-moderate nonproliferative DR and without diabetic macular edema has a IIB level of recommendation as a complementary therapy with standard medical care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Yasuhiro Kurasawa, Akihiko Iida, Kaya Narimatsu, Hideki Sekiya, Yutaka Maruoka, Yukihiro Michiwaki
Summary: This study found that perioperative oral management (POM) can reduce the risk of postoperative pneumonia in certain cancer patients, especially in lung and pancreatic cancer patients. POM has also been shown to lower mortality in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Leticia Dzierva, Marley Conceicao dos Santos, Leopoldo Malcorra de Almeida, Chayane da Rocha, Lucas Schmidt Bassi, Keysuke Muramatsu, Alex Maiorka
Summary: The objective of this study was to evaluate the effects of diet particle size and amylase supplementation on nutrient digestibility and performance of nursery pigs. The results showed that finer diet particle size reduces feed conversion ratio (FCR) and increases fat digestibility. Coarser diet particle size increases average daily feed intake (ADFI) and average daily weight gain (ADWG). The supplementation of amylase improves growth performance, nutrient digestibility, and digestible energy (DE).
Article
Reproductive Biology
Anastasia Weyrich, Markus Frericks, Michael Eichenlaub, Steffen Schneider, Thomas Hofmann, Steven Van Cruchten, Bennard van Ravenzwaay
Summary: This study compared the expression levels of xenobiotic transporters in liver, kidney, and placenta of human, Wistar rat, and New Zealand White rabbit during pre- and postnatal development, revealing significant differences in transporter expression in development and between species.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Kevin Van Tichelen, Sara Prims, Miriam Ayuso, Celine Van Kerschaver, Mario Vandaele, Jeroen Degroote, Steven Van Cruchten, Joris Michiels, Chris Van Ginneken
Summary: This study evaluated the effects of orally supplementing different bioactive compounds on the resilience and survival of low birth weight piglets. The results showed that the evaluated compounds, at the given dosages, were unable to improve the parameters and even had a negative effect on survival in piglets supplemented with short-chain fructo-oligosaccharides.
Review
Biochemistry & Molecular Biology
Chris Van Ginneken, Miriam Ayuso, Lieselotte Van Bockstal, Steven Van Cruchten
Summary: Intrauterine growth restriction (IUGR) is commonly observed in pig production, resulting in differences in organ growth. Insufficient uteroplacental nutrient transfer is the main cause of IUGR. Supplementing arginine and glutamine in the sow's diet improves placenta growth and reduces IUGR incidence. IUGR piglets have higher mortality rates and morbidity. Surveillance during farrowing and individual nutrient supplementation can reduce mortality rates. However, long-term consequences of IUGR, including persistent structural deficits in organs, cannot be reversed.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Agriculture, Dairy & Animal Science
Kevin Van Tichelen, Sara Prims, Miriam Ayuso, Lieselotte Van Bockstal, Celine Van Kerschaver, Mario Vandaele, Jeroen Degroote, Steven Van Cruchten, Joris Michiels, Chris Van Ginneken
Summary: The increase in litter sizes of sows over the past three decades has resulted in higher proportions of low birth weight piglets and increased pre-weaning mortality. This study investigated the use of a dense milk replacer to improve the performance of low birth weight piglets. The results showed no significant effect of the milk replacer on the survival or performance of the piglets, suggesting that perinatal management is more important for their survival than supplementation.
Article
Multidisciplinary Sciences
Sara Prims, Xaveer Van Ostade, Miriam Ayuso, Martin Dom, Geert Van Raemdonck, Steven Van Cruchten, Christophe Casteleyn, Chris Van Ginneken
Summary: Monitoring chronic stress in pigs is important for animal welfare and farmers. This study investigated the use of saliva as a non-invasive tool for monitoring chronic stress in pigs. The results showed that chronic stress alters the porcine salivary proteome, and the affected proteins could be potential biomarkers for optimizing rearing conditions and identifying welfare issues.
Article
Pharmacology & Pharmacy
Laura Buyssens, Allan Valenzuela, Sara Prims, Miriam Ayuso, Thomas Thymann, Chris Van Ginneken, Steven Van Cruchten
Summary: Despite progress in understanding drug metabolism in human pediatric population, data remains scarce in preterm neonates. This study assessed the ontogeny of CYP3A and UGT enzyme activity in the liver of preterm and term-born domestic piglets. Results showed that postconceptional age affects porcine CYP3A and UGT enzyme ontogeny. These findings contribute to the characterization of the preterm piglet as a translational model for hepatic drug metabolism in the preterm human neonate.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pediatrics
Marina-Stefania Stroe, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, Chris Van Ginneken, Steven Van Cruchten
Summary: Animal models provide valuable information on human disease mechanisms and (patho)physiological factors affecting drug development. Nonclinical data is critical for understanding pediatric disease conditions and developing new drug therapies. This study aimed to develop a neonatal Gottingen Minipig model for investigating the impact of systemic hypoxia and therapeutic hypothermia on drug disposition in perinatal asphyxia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Allan Valenzuela, Miriam Ayuso, Laura Buyssens, Chloe Bars, Chris Van Ginneken, Yann Tessier, Steven Van Cruchten
Summary: This study evaluated the effects of various ASO sequences and modifications on platelets in adult and juvenile Gottingen minipigs. The results were compared to human data and showed remarkable similarities, validating the use of Gottingen minipigs for ASO safety testing. The differential abundance of GPVI and PF4 in minipigs provides insight into ASO-induced thrombocytopenia in pediatric patients.
Review
Biochemistry & Molecular Biology
Karen Leys, Marina-Stefania Stroe, Pieter Annaert, Steven Van Cruchten, Sebastien Carpentier, Karel Allegaert, Anne Smits
Summary: Perinatal asphyxia (PA) continues to have significant morbidity and mortality rates. Therapeutic hypothermia (TH) is the only effective treatment for neonates with moderate to severe hypoxic-ischemic encephalopathy after PA. Additional pharmacotherapy may be necessary for these neonates, and both PA and TH can affect physiology and, consequently, pharmacokinetics (PK) and pharmacodynamics (PD).
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)