Article
Environmental Sciences
Qiaofeng Ai, Peixuan Zhang, Lirong Gao, Xin Zhou, Yang Liu, Di Huang, Lin Qiao, Jiyuan Weng, Minghui Zheng
Summary: This study investigated the concentrations, congener group profiles, and air-soil exchange of short-chain and medium-chain chlorinated paraffins in a contaminated area in Zhoushan, China. The results showed that CPs were found at higher concentrations in soil samples near shipyards, with chlorinated decane and undecane and penta-, hexa-, and hepta-chlorinated CPs being enriched in the air samples. SCCPs and MCCPs dominated the air-soil exchange.
Article
Engineering, Environmental
Thomas J. McGrath, Yukiko Fujii, Yunsun Jeong, Jasper Bombeke, Adrian Covaci, Giulia Poma
Summary: This study examines the presence and distribution of short-and medium-chain chlorinated paraffins (SCCPs and MCCPs) in edible insects from Asia and Europe. The findings show higher levels of chlorinated paraffins in edible insects purchased from Asia compared to Europe. The study concludes that adverse health outcomes are unlikely from consuming edible insects contaminated with chlorinated paraffins, but monitoring of insect farming and processing practices is still necessary.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Wenjie Ding, Zixuan Zhao, Yudan Zheng, Rui Wang, Zeyao Zhang, Ziyang Zhang, Xiangdong Wang, Shali Yu, Lei Liu, Rongrong Huang, Xinyuan Zhao, Qiyun Wu
Summary: In this study, SCCP exposure was shown to induce astrocyte proliferation and activation via the JAK2/STAT3 signaling pathway. These findings contribute to the understanding of the molecular mechanism underlying SCCP-induced neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Chi Xu, Kunran Wang, Lirong Gao, Minghui Zheng, Jingguang Li, Lei Zhang, Yongning Wu, Lin Qiao, Di Huang, Shuang Wang, Da Li
Summary: A study conducted in China in 2017 revealed a continuous increase in the presence of chlorinated paraffins (CPs) in both urban and rural areas, with a decrease in short-chain chlorinated paraffins (SCCPs) levels in urban areas. The significant health risks posed to infants through the intake of SCCPs and MCCPs via breastfeeding should be a cause for concern.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jingwen Huang, Lei Zhao, Yumeng Shi, Xiaowen Zeng, Wenwen Sun, Xianglong Zhao, Ruqing Liu, Qizhen Wu, Guanghui Dong, Da Chen, Xiaotu Liu
Summary: The present study quantified and profiled short-chain chlorinated paraffins (SCCPs), medium-chain chlorinated paraffins (MCCPs), and long-chain chlorinated paraffins (LCCPs) in PM2.5 samples collected from 96 schools in the Pearl River Delta of South China. The concentrations of SCCPs, MCCPs, and LCCPs ranged from 0.832-109, 1.02-110, and 0.173-17.4 ng/m3, respectively, with a detection rate over 90%. The dominant congener groups were C13Cl6-8, C14Cl7-8, and C18Cl7-9 for SCCPs, MCCPs, and LCCPs, respectively. Seasonal and spatial variations were observed, with higher concentrations of SCCPs and MCCPs in summer and higher concentrations of LCCPs in winter. Exposure risk assessment suggested no significant health risk from exposure to PM2.5-associated chlorinated paraffins.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Applied
Marie Meziere, Philippe Marchand, Frederic Larvor, Elisabeth Baeza, Bruno Le Bizec, Gaud Dervilly, Ronan Cariou
Summary: The distribution of CPs in biota varies, with different chain lengths and chlorine contents showing different retention patterns in tissues. Additionally, there is potential for biotransformation based on mass balance analysis.
Article
Environmental Sciences
Kerstin Kraetschmer, Alexander Schaechtele, Walter Vetter
Summary: This study assessed dietary exposure for consumers in Southern Germany regarding SCCPs and MCCPs, finding that CPs were present in food, with highest amounts in extra virgin olive oils and fish. Different dietary samples showed consistent CPs levels, but vegetarian meal plans contained higher levels of CPs than other diets.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jakub Tomasko, Ondrej Parizek, Jana Pulkrabova
Summary: This study selected clothing as the research object because it is produced in large quantities worldwide and is worn for long periods in direct contact with human skin. Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) were found in all samples, with higher concentrations in garments with a substantial proportion of synthetic fibers. The effect of washing in the washing machine varied among individual samples.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Environmental
Xue-Tong Wang, Cheng-Lin Wang, Ying Zhou, Guo-Fa Ren, Rui Fu, Jing An
Summary: This study investigated the concentrations, spatial distribution, possible sources, and health risks of SCCPs and MCCPs in urban road dust collected from Shanghai, China. The results showed that MCCPs were the dominant component in all road dust, accounting for an average of 82.8% of total CPs. The concentrations of CPs in dust from traffic and commercial areas were significantly higher than those from other areas.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Environmental Sciences
Lixin Yang, Yinping Liu, Ze Cui, Yongmao Zhang, Jianbo Zhang, Kaoqi Lian
Summary: This study used a metabolomics approach to investigate the toxicity of SCCPs in rats, finding that high-dose SCCP exposure resulted in liver and kidney injury, affecting pathways related to energy metabolism, amino acid metabolism, glycerophospholipid metabolism, nucleotide metabolism, and vitamin B metabolism. Fluctuating levels of phospholipids and nucleotides may contribute to the neurotoxicity of SCCPs, while down regulation of folic acid induced by SCCPs may lead to malformations during early development in laboratory animals.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Yi Liu, Xiumei Han, Nan Zhao, Xinxin Fang, Shiwen Zhang, Shixue Li, Wei Jiang, Lei Ding
Summary: This study evaluated the associations between serum short-chain CP (SCCP) or medium-chain CP (MCCP) concentrations and liver enzymes in 197 residents in Jinan, China. The findings suggested that chlorinated paraffins are associated with disturbed liver biomarker levels in humans, indicating hepatotoxicity of SCCPs and MCCPs.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Huijuan Li, Hui Li, Shishan Zhang, Huizhi Li, Yanfang Zhao, Xiangfeng Chen, Zongwei Cai
Summary: This study investigated the contamination levels and risks associated with the dietary intake of SCCPs and MCCPs in commonly used TCM herbs. The concentrations varied among different herbs and were mainly associated with environmental contamination levels. The estimated daily intake and margin of exposure were below health risk levels, indicating the acceptable dietary intake of SCCPs and MCCPs in the studied TCMs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Yadan Luo, Juan Li, Wei Gao, Lirong Gao, Runhui Ke, Chunyan Yang, Yingjun Wang, Yan Gao, Yawei Wang, Guibin Jiang
Summary: This study investigated the exposure to chlorinated paraffins in infant foods in the Chinese market, with a focus on the less studied long-chain chlorinated paraffins (LCCPs). Differences in chlorinated paraffin profiles were observed between imported and Chinese infant foods. While no significant health concerns were identified, variations in CP concentrations and excessive feeding practices may pose potential health threats to infants. This study provides important data on infant exposure to chlorinated paraffins, especially LCCPs.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Shuang Yu, Yuan Gao, Xiuhua Zhu, Haoran Yu, Yichi Zhang, Jiping Chen
Summary: Short and medium chain chlorinated paraffins (SCCPs and MCCPs) are gaining attention due to their persistence and long-range transport capacity. This study investigated the environmental levels of SCCPs and MCCPs in both outdoor and indoor air samples using passive air samplers. The results showed high concentrations of SCCPs in the chlorination workshop and nearby outdoor samples, indicating release during production. Gas/particle partitioning was determined by adsorption and absorption processes. Occupational exposure to MCCPs was found to be higher than SCCPs, with no observed adverse effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Weifang Chen, Xingwang Hou, Xiaowei Mao, Suning Jiao, Linfeng Wei, Yaotian Wang, Jiyan Liu, Guibin Jiang
Summary: This study elaborates the comprehensive environmental transformation of short-chain chlorinated paraffins (SCCPs) in a rice seedling exposure system. The selected congener of SCCPs, CP-4, was quickly absorbed, translocated, and phytovolatilized by seedlings. The transformation of CP-4 was mainly attributed to degradation by rhizosphere microorganisms, root exudates, and abiotic factors, with a majority being phytotransformed by rice seedlings. A total of 61 transformation products were identified through complex pathways.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Lei Zhang, Jiahuai Zhang, Sai Fan, Yuxin Zhong, Jingguang Li, Yunfeng Zhao, Song Ni, Jiaying Liu, Yongning Wu
Summary: This case-control study investigated the associations between urinary concentrations of bisphenols and the risk of papillary thyroid cancer (PTC). The results showed significant positive associations between bisphenol F (BPF) concentration and PTC risk, but negative associations between bisphenol A (BPA) and bisphenol S (BPS) concentrations and PTC risk in the overall population. However, the significant associations were only observed in non-smoking women after stratification by age and smoking.
Article
Engineering, Environmental
Feng Han, Jiaying Liu, Yuxin Wang, Jingguang Li, Bing Lyu, Yunfeng Zhao, Yongning Wu
Summary: The mechanism of blood to milk transfer of PFOS and Cl-PFESAs was studied using 145 paired maternal serum and human milk samples. The transfer efficiency was found to be influenced by the physicochemical properties and primary components of human milk. Results suggest that passive diffusion through the paracellular route may be the main transfer pathway for PFOS and Cl-PFESAs from blood to milk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yizhong Shen, Yunlong Wei, Xiang Gao, Chao Nie, Jianlong Wang, Yongning Wu
Summary: Scientists successfully synthesized a novel blue fluorescence nanozyme CeO2@TPE with high peroxidase-like activity. By embedding aggregation-induced emission (AIE) tetraphenylethene (TPE) into hollow CeO2 nanospheres and combining ethanol oxidase (AOX) and o-phenylenediamine (OPD), they developed an enzymatic cascade activation ratiometric fluorescence-colorimetric dual-mode system for detecting methyl mercaptan (CH3SH). This study provides a new insight into designing target-responsive enzymatic cascade activation systems and enables real-time point-to-point detection of environmental health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Infectious Diseases
Danxia Gu, Zelin Yan, Chang Cai, Jiaping Li, Yanyan Zhang, Yuchen Wu, Jiaxing Yang, Yonglu Huang, Rong Zhang, Yongning Wu
Summary: In this study, the efficacy of three different methods for the rapid detection of carbapenemases (KPC, NDM, IMP, OXA-48, and VIM) was evaluated. The NG-test Carba 5, colloidal gold immunoassay (CGI) test, and Xpert Carba-R assay showed reliable performances in carbapenemase detection, with Xpert Carba-R being recommended for the detection of KPC variants.
Article
Chemistry, Analytical
Xu Zhang, Chaochen Sun, Ruiling Li, Yongning Wu, Xin Jin, FengFu Fu
Summary: This study presents a reusable magnetic enzyme-loading nanoplatform with enhanced peroxidase-like activity for developing colorimetric sensors. It demonstrates stable and enhanced peroxidase-like activity, good enzyme-loading capacity, and magnetic separation capability, which enables the fabrication of sensitive and simple colorimetric sensors. It also successfully detects glucose and cholesterol with high recovery and low relative standard deviation.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Feifei Huang, Lei Zhang, Moqin Zhou, Jianwen Li, Qing Liu, Bo Wang, Ke Deng, Pingping Zhou, Yongning Wu
Summary: Polycyclic aromatics hydrocarbons (PAHs) are commonly found in foods and the environment and have carcinogenic and mutagenic potential. A study in China determined the concentrations of 16 PAHs in commonly consumed food items. Edible vegetable oils had the highest concentration of PAHs, while fruits had the lowest. PAH4 was identified as a suitable indicator for PAH contamination, and the overall dietary exposure for PAHs in the Chinese population was estimated to be within safe limits.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Agriculture, Multidisciplinary
Chi Zhang, Heli Li, Huijing Shen, Bing Lyu, Shaohua Li, Jingguang Li, Yunfeng Zhao, Dawei Chen, Yongning Wu
Summary: This study is the first nationwide study in China on the chronic health risks of chlorothalonil and its metabolite (4-OH-chlorothalonil) for Chinese adults and breastfed infants. The study found that chlorothalonil and 4-OH-chlorothalonil were detected in dietary samples, with higher levels in Northwest China and Shandong regions. Other exposure routes besides dietary intake were also identified. The study concluded that the chronic health risks from dietary exposure to chlorothalonil and 4-OH-chlorothalonil are low for Chinese adults and breastfed infants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Allergy
Hua Feng, Jiangdong Zhou, Yuanan Lu, Qian Zhao, Zifei Yang, Xiujuan Xiong, Nan Luo, Yan Chen, Lianglu Wang, Yongning Wu
Summary: The prevalence of self-reported food allergy among adults in China is approximately 4.0%, with 3.1% in men and 4.8% in women. The most common allergic symptom is skin reaction, reported by 63.9% of participants with self-reported food allergy. Shrimp, mollusks, and mango are the most common allergenic foods, accounting for 39.8%, 20.8%, and 18.7% of cases respectively. Gender, age, and other allergic conditions are associated factors with food allergy in adults.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Engineering, Environmental
Xin Liu, Lei Zhang, Jiaying Liu, Gerili Zaya, Yuxin Wang, Qian Xiang, Jingguang Li, Yongning Wu
Summary: Growing toxicologic evidence suggests that emerging perfluoroalkyl substances (PFASs), like chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA), may be as toxic or more toxic than perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA). This study examined the effects of these substances on newborn thyroid homeostasis and found that 6:2 Cl-PFESA has a more pronounced impact on newborns' thyroid homeostasis compared to PFOS. The findings suggest the importance of comparing the thyroid disruption caused by emerging and legacy PFASs in human health risk assessment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Yajie Wang, Jing Cao, Guanzhao Wang, Tao Wei, Kexin Hu, Wenqi Yi, Pingyang Zeng, Huifang Li, Yongning Wu, Qinghua He
Summary: Three ZIFs materials were synthesized and applied to the adsorption and detoxification of gossypol in cottonseed oil. The materials exhibited good crystal structure, thermal stability, and high specific surface area. The adsorption processes followed pseudo-second-order kinetics and were better described by the Langmuir model. The ZIFs materials showed high detoxification rates in both spiked and real cottonseed oil samples.
Article
Food Science & Technology
Hui -Ming Chen, Quan Zhou, Li-Jun Huang, Jun Lin, Jia-Fei Liu, Zi-Yong Huang, Rong-Lin Zhang, Jing-Jing Wang, Yong Zhao, Yong-Ning Wu, Xing-Fen Yang, Wei-Liang Wu
Summary: This study aimed to evaluate the effects of curcumin-mediated photodynamic treatment (PDT) on the shelf-life quality of ready-to-eat salmon fillets. The results showed that PDT had outstanding bacterial inhibition and extended the shelf-life of salmon fillets. Additionally, PDT was able to maintain the physicochemical indicators and freshness of the salmon fillets, and improve the sensory scores.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Guojian Wu, Abudoushukeer Dilinaer, Peng Nie, Xin Liu, Zhi Zheng, Pengjie Luo, Wenjuan Chen, Yongning Wu, Yizhong Shen
Summary: Developing efficient meat freshness assays is crucial for ensuring food safety. In this study, a bimetallic nanozyme Fe@CeO2 with high peroxidase-like activity was synthesized, and a self-supplying enzymatic cascade catalytic system was developed for colorimetric and photothermal detection of meat freshness. The assay showed both reliability and sensitivity, providing new insights for onsite visual monitoring of meat freshness.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun, Michal Tomczyk
Summary: It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. This study aimed to explore the mechanism of action of MF and EC against immunosuppression using network pharmacology, molecular docking, molecular dynamics simulations, and animal experiments. The results obtained from network pharmacology identified important components, hub targets, and signaling pathways involved in the treatment of immunosuppression. Molecular docking and dynamics simulations confirmed the stable binding of certain critical components to hub targets. Animal experiments also demonstrated the significant effect of MF and EC in treating immunosuppression. These findings suggest that MF and EC may have a multi-component, multi-target, and multi-pathway mode of action in treating immunosuppression.
Article
Biochemistry & Molecular Biology
Luyao Zhang, Jialu Liu, Bufan Xu, Di Wu, Yongning Wu, Guoliang Li
Summary: In this study, the effects of exposure to different concentrations of beta-carbolines norharman and harman on the survival rate and behaviors of C. elegans were assessed. The changes in antioxidant system, neurotransmitter levels, and acetylcholinesterase activity were evaluated. RNA-seq analysis identified potential molecular mechanisms underlying the toxic effects of norharman and harman. The results suggest that long-term exposure to low doses of beta-carbolines in food poses a risk of neurotoxicity.
Review
Chemistry, Analytical
Jin Liu, Guoliang Li, Jianghua Liu, Panxue Wang, Di Wu, Xianlong Zhang, Yongning Wu
Summary: PCBs, a class of synthetic organochlorine chemicals, had been widely used in industrial and commercial applications in the last century. However, PCBs have significant impacts on human health and the ecosystem, including neurotoxicity and carcinogenicity. This review mainly focuses on the recent progress in the toxicity and detection techniques of PCBs in the environment and food, covering classification, source, distribution, and toxicity, as well as sample preparation and analytical determination technologies.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)