Article
Chemistry, Multidisciplinary
Patrick O. Saboe, Lorenz P. Manker, Hanna R. Monroe, William E. Michener, Stefan Haugen, Eric C. D. Tan, Ryan L. Prestangen, Gregg T. Beckham, Eric M. Karp
Summary: Bio-based carboxylic acids are established as adaptable precursors to renewable biofuels and chemicals, but their separation poses significant energy and cost challenges. The use of weak-base adsorption processes shows promising results in reducing operating costs, energy consumption, and greenhouse gas emissions compared to conventional methods.
Article
Chemistry, Multidisciplinary
Andressa Neves Marchesan, Jean Felipe Leal Silva, Rubens Maciel Filho, Maria Regina Wolf Maciel
Summary: Lactic acid production is highly influenced by fermentation pH, and alternative downstream processing designs play a crucial role in the economic performance. Low-pH fermentation shows economic potential, but salt decomposition significantly impacts economic performance.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Green & Sustainable Science & Technology
Pongtorn Charoensuppanimit, Boonraksa Chaiapha, Suttichai Assabumrungrat, Bunjerd Jongsomjit
Summary: This research aims to design the conversion process of ethanol into a more valuable product, such as diethyl ether (DEE). Experimental results show that using anhydrous ethanol for DEE production is more profitable compared to using hydrous ethanol, which results in acetaldehyde formation. By implementing the right technology for acetaldehyde removal, the process using hydrous ethanol can also become profitable.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Engineering, Chemical
Andrew M. Elias, Andreza A. Longati, Harikishan R. Ellamla, Felipe F. Furlan, Marcelo P. A. Ribeiro, Paulo R. F. Marcelino, Julio C. dos Santos, Silvio S. da Silva, Roberto C. Giordano
Summary: Research proposed two processes for producing biosurfactants from sugarcane bagasse, with the second process showing superior economic and environmental performance. Global sensitivity and uncertainty analyses indicated the need to focus on the performance and scaleup of bioreactors and ultrafiltration processes.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Thermodynamics
Anna Nova, Kristiano Prifti, Francesco Negri, Flavio Manenti
Summary: This study investigates the thermal splitting of H2S at different scales and validates a kinetic scheme through experimental and modeling approaches. The results are used for process design and scale-up, estimating a production rate of 590.8 kg/h of hydrogen with a cost of 2.23 $/kg.
Article
Agricultural Engineering
Yongjie Zhang, Jinjun Dong, Guochao Xu, Ruizhi Han, Jieyu Zhou, Ye Ni
Summary: A semi-continuous fermentation process was developed to improve the production efficiency of hyaluronic acid, resulting in a titer of 14.60 g/L and a productivity of 1.01 g/L/h. Addition of recombinant hyaluronidase SzHYal further enhanced the titer to 29.38 g/L with a productivity of 1.13 g/L/h after 24 h. This newly developed fermentation process provides a promising strategy for industrial production of hyaluronic acid and related polysaccharides.
BIORESOURCE TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Ruschoni Ucm, Mera Aem, Zamudio Lhb, Vinod Kumar, Mohammad J. Taherzadeh, Vijay Kumar Garlapati, Anuj Kumar Chandel
Summary: The growing demand for low-cost and high-quality hyaluronic acid (HA) can be met by producing HA from harmless microorganisms, leading to economic and environmentally friendly production. Various fermentation modes and downstream processing techniques have been explored to optimize HA production at different molecular weights.
Article
Green & Sustainable Science & Technology
Femi Peter Alege, Xiangyu Gu, Haiying Tao, Gilbert J. Miito, Pius M. Ndegwa
Summary: The study examined the techno-economic feasibility of pelletizing dairy manure compost, finding that labor costs were the most important factor influencing the minimum selling price. It is recommended to optimize the product for improved marketability, particularly for bioenergy applications.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Thermodynamics
Thapanat Chuenphan, Tarabordin Yurata, Teerawat Sema, Benjapon Chalermsinsuwan
Summary: In this study, a potassium carbonate (K2CO3) solution-based carbon dioxide (CO2) absorption process was improved and optimized using Aspen Plus. Sensitivity analysis revealed that the liquid-to-gas (L/G) mass ratio and CO2 concentration in sour gas were the most important parameters affecting CO2 removal efficiency and reboiler specific heat duty. Additionally, a pilot-scale CO2 capture process using K2CO3 and monoethanolamine (MEA) solutions was compared, with K2CO3 solution showing higher CO2 removal efficiency, lower reboiler specific heat duty, and lower CO2 capture cost.
Article
Energy & Fuels
Maria Martinez, Alejandra Rodriguez, Teresa Gea, Xavier Font
Summary: This study explores the production of SLs using sustainable resources and provides an economic evaluation of the solid-state fermentation process. The results highlight the significant impact of the physical properties of substrates and supports on process costs.
Review
Biochemistry & Molecular Biology
Priya Shukla, Rupika Sinha, Shubhankar Anand, Pradeep Srivastava, Abha Mishra
Summary: This article discusses the manufacture, purification, and applications of hyaluronic acid (HA). To meet the growing demand for affordable and high-quality HA, it is important to explore diverse production techniques that use renewable resources and have minimal risk of cross-contamination. Various fermentation techniques, such as continuous, batch, fed-batch, and repeated batch culture, have been investigated to optimize HA production, particularly from specific strains of Streptococci. The development of new procedures to produce HA with increased productivity, specific molecular weights, and purity is necessary to meet the anticipated growth in trade and application opportunities.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Yuneng Tang, Shenyong Li, Cheng Liu, Yu Qi, Yunpeng Yu, Kaibing Zhang, Bin Su, Jianglong Yu, Lian Zhang, Baiqian Dai
Summary: In order to reduce CO2 emissions in the FCC process, the post-combustion carbon capture and storage (CCS) technology has been applied for its ease of retrofit. However, it is a high-cost method due to the required chemicals and high energy consumption. Oxy-fuel combustion, with the use of different advanced air separation units (ASU), has the potential to be a cost-effective technology for carbon capture in the FCC system.
FUEL PROCESSING TECHNOLOGY
(2023)
Article
Engineering, Chemical
Chloe Simchick, Brooke Zidek, Devin Moder, Dustin Madson, Michael Payne, Jonathon Kelsey, Faisal Shaikh, Serdar Ozturk
Summary: The MixAlco process utilizes fermentation to convert organic wastes into carboxylic acid salts, with the new design focusing on optimizing and commercializing mixed carboxylic acid salts as the final product. Sensitivity analyses show that biomass feed rate and population size have the most significant impact on process economics. Overall, the new design is flexible in supporting populations of varying sizes and different biomass feed rates and compositions.
Article
Biotechnology & Applied Microbiology
Priya Shukla, Shubhankar Anand, Pradeep Srivastava, Abha Mishra
Summary: Hyaluronic acid has unique applications in the cosmetics and medical industries, and fermentation of Streptococcus zooepidemicus is the best method for its production. Utilizing cane molasses as a carbon source can optimize the fermentation conditions for hyaluronic acid.
Article
Chemistry, Multidisciplinary
Xin Zhou, Hao Yan, Xiang Feng, Hui Zhao, Yibin Liu, Xiaobo Chen, De Chen, Chaohe Yang
Summary: By optimizing the novel VDG process, glycerol can be efficiently oxidized to glyceric acid, achieving high purity product separation at low temperatures, which reduces production costs and energy consumption.
Article
Biochemistry & Molecular Biology
Andre D. D. Cavalcanti, Bruna A. G. Melo, Rhelvis C. Oliveira, Maria H. A. Santana
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2019)
Review
Chemistry, Applied
C. C. Mandu, D. Barrera-Arellano, M. H. A. Santana, G. D. Fernandes
Article
Biotechnology & Applied Microbiology
Jens O. Kromer, Rafael G. Ferreira, Demetri Petrides, Norbert Kohlheb
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Rodrigo A. Costa, Alexandre S. Cunha, Jose Carlos G. Peres, Adriano R. Azzoni, Enzo Laurenti, Ardson S. Vianna
Review
Biotechnology & Applied Microbiology
Rafael G. Ferreira, Adriano R. Azzoni, Sindelia Freitas
Summary: Lignocellulose is the most abundant renewable material on Earth, but the high production cost of enzymes degrading lignocellulose remains a major challenge for its utilization as raw material. By comparing the production costs of enzymes from different process designs, it is found that raw materials and capital-related costs are generally the main drivers of enzyme production cost, and production parameters play a significant role in the process economics of enzyme production.
BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
(2021)
Article
Biochemistry & Molecular Biology
Alexandro Barbosa de Souza, Marco Vinicius Chaud, Thais Francine Alves, Juliana Ferreira de Souza, Maria Helena Andrade Santana
Review
Biochemical Research Methods
Camila Hiromi Chiba, Marcos Camargo Knirsch, Adriano Rodrigues Azzoni, Antonio R. Moreira, Marco Antonio Stephano
Summary: Biopharmaceutical products play a crucial role in treating or preventing diseases, with a growing market share globally. Cell-free protein synthesis (CFPS) technology has shown promise in overcoming obstacles faced by traditional cell-based expression methods, successfully producing various biologics. While CFPS offers scalability, there are still significant limitations to consider.
Article
Engineering, Chemical
Rafael G. Ferreira, Neal F. Gordon, Rick Stock, Demetri Petrides
Summary: The COVID-19 pandemic has led to the rapid development of various vaccines, with some successful ones based on the adenoviral vector platform. This study designed, simulated, and economically evaluated two baseline processes for producing COVID-19 adenoviral vector vaccines, and found that perfusion cell culture was more cost-effective and required less capital investment than batch cell culture. The results suggest that adenoviral vector vaccines can be practically mass-produced at low cost.
Article
Biochemistry & Molecular Biology
Sara Cardoso, Fani Sousa, Pedro A. Pessoa Filho, Adriano R. Azzoni
Summary: This study investigates the adsorption of plasmid DNA and RNA molecules onto arginine-agarose resin, showing that adsorption conditions can be tuned to enhance separation between pDNA and RNA, a crucial factor for nucleic acid purification in vaccine production.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Thales Thiago Ferreira Godoi, Bruno Lima Rodrigues, Stephany Cares Huber, Maria Helena Andrade Santana, Lucas Furtado da Fonseca, Gabriel Silva Santos, Gabriel Ohana Marques Azzini, Tomas Mosaner, Chris Paulus-Romero, Jose Fabio Santos Duarte Lana
Summary: Platelet-rich plasma (PRP) is an autologous product with immunomodulatory and anabolic properties that has been used in combination with hyaluronic acid (HA) and a new product called plasma gel for enhanced tissue repair and wound healing in musculoskeletal conditions. Plasma gels, formed by polymerizing plasmatic proteins, are considered a rich source of growth factors and have chemotactic, migratory, and proliferative properties. This regenerative approach, named PRP-HA cellular gel matrix (PRP-GM), may contribute to the optimization of regenerative protocols for the treatment of degenerative musculoskeletal diseases.
BIOENGINEERING-BASEL
(2022)
Meeting Abstract
Cell & Tissue Engineering
A. C. Juraski, A. R. Azzoni
TISSUE ENGINEERING PART A
(2022)