The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation

Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design

(2020) Christoph Portier et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation: Influence of process and formulation variables on granule quality attributes of model formulations

(2020) Christoph Portier et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

(2020) L. Vandevivere et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modeling of semi-continuous fluid bed drying of pharmaceutical granules with respect to granule size

(2019) Michael Ghijs et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding

(2019) Fanny Stauffer et al.   AAPS PHARMSCITECH

Managing API raw material variability in a continuous manufacturing line – Prediction of process robustness

(2019) F. Stauffer et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Breakage and drying behaviour of granules in a continuous fluid bed dryer: Influence of process parameters and wet granule transfer

(2018) F. De Leersnyder et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A novel approach to support formulation design on twin screw wet granulation technology: Understanding the impact of overarching excipient properties on drug product quality attributes

(2018) N. Willecke et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

On the modelling of granule size distributions in twin-screw wet granulation: Calibration of a novel compartmental population balance model

(2018) Daan Van Hauwermeiren et al.   POWDER TECHNOLOGY

Twin Screw Granulation: Effects of Properties of Primary Powders

(2018) Sushma Lute et al.   Pharmaceutics

In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding

(2017) Maxim Verstraeten et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation

(2017) N. Willecke et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a continuous direct compression platform for low-dose drug products

(2017) B. Van Snick et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Twin screw granulation: Understanding the mechanism of granule formation along the barrel length

(2016) Sushma V. Lute et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Continuous twin screw granulation of controlled release formulations with various HPMC grades

(2016) V. Vanhoorne et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Use of a continuous twin screw granulation and drying system during formulation development and process optimization

(2015) J. Vercruysse et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Impact of microcrystalline cellulose material attributes: A case study on continuous twin screw granulation

(2015) Margot Fonteyne et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them May 20–21 2014 Continuous Manufacturing Symposium

(2015) Stephen Byrn et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Development of drying-induced stresses in pharmaceutical granules prepared in continuous production line

(2014) Maksim Mezhericher   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets

(2014) Margot Fonteyne et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

(2014) Margot Fonteyne et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Granulation of increasingly hydrophobic formulations using a twin screw granulator

(2014) Shen Yu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms

(2014) Michael Leane et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Granulation rate processes in the kneading elements of a twin screw granulator

(2013) A. S. El Hagrasy et al.   AICHE JOURNAL

Stability and repeatability of a continuous twin screw granulation and drying system

(2013) J. Vercruysse et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Continuous twin screw granulation: Influence of process variables on granule and tablet quality

(2012) J. Vercruysse et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Twin screw granulation: Steps in granule growth

(2012) Ranjit M. Dhenge et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Inline Real-Time Near-Infrared Granule Moisture Measurements of a Continuous Granulation–Drying–Milling Process

(2011) Lipika Chablani et al.   AAPS PHARMSCITECH

Twin screw wet granulation: Effect of powder feed rate

(2011) Ranjit M. Dhenge et al.   ADVANCED POWDER TECHNOLOGY

Real-time assessment of critical quality attributes of a continuous granulation process

(2011) Margot Fonteyne et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY