Article
Chemistry, Physical
Janice Caroline Hardt, Michelly Cristina Galdioli Pella, Ana Caroline Reis Meira, Andressa Giombelli Rosenberger, Josiane Caetano, Douglas Cardoso Dragunski
Summary: This study evaluated the potential application of silver sulfadiazine loaded PBAT/PCL microfibers as wound dressings, which exhibited antimicrobial activity and controlled release. The results showed that the fiber diameter and crystallinity were concentration-dependent on the silver sulfadiazine, and the release profile was biphasic with both fast and sustained release.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Semen Goreninskii, Nadezhda Danilenko, Evgeniy Bolbasov, Anastasia Evtina, Mikhail Buldakov, Nadezhda Cherdyntseva, Muhammad Saqib, Natalia Beshchasna, Joerg Opitz, Victor Filimonov, Sergei Tverdokhlebov
Summary: The PVP-containing PCL/PVP scaffolds fabricated using HFIP showed an enhanced strengthening effect and hydrophilicity, making them suitable for drug delivery systems.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Textiles
Rezvan Mohamadinooripoor, Soheila Kashanian, Kobra Omidfar
Summary: Electrospun composite mats of PCL/PEE were used to fabricate PCL-PEE sutures with desirable mechanical and antibacterial properties. The sutures showed promising characteristics including sustained drug release, high tensile strength, antifungal effects, and accelerated wound healing.
FIBERS AND POLYMERS
(2023)
Article
Materials Science, Multidisciplinary
Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom
Summary: In this research, a periodontal membrane with nanoporous structure and tetracycline drug loading was designed and fabricated to improve periodontal regeneration and anti-inflammatory effect.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jian Zeng, Qiaolin Ji, Xinxin Liu, Minglong Yuan, Mingwei Yuan, Yuyue Qin
Summary: A controlled-release antibacterial active food packaging film was prepared using electrospinning technique. The film showed improved water vapor barrier performance, UV resistance, and antioxidant activity, while maintaining the antibacterial properties of thymol. The study suggests that the developed film has potential for food active packaging applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Pharmacology & Pharmacy
Nikolaos D. Bikiaris, Ioanna Koumentakou, Georgia Michailidou, Margaritis Kostoglou, Marilena Vlachou, Panagiotis Barmpalexis, Evangelos Karavas, George Z. Papageorgiou
Summary: In this study, nanofibrous patches were successfully fabricated via electrospinning for the sustained release of leflunomide's active metabolite, teriflunomide. The results showed that teriflunomide was incorporated in an amorphous form inside the nanofibers and exhibited significant molecular interactions with the polyester. The nanofibers demonstrated a biphasic release profile, with an initial burst release followed by sustained release.
Article
Chemistry, Multidisciplinary
Alena Opalkova Siskova, Maria Buckova, Zuzana Kronekova, Angela Kleinova, Stefan Nagy, Joanna Rydz, Andrej Opalek, Monika Slavikova, Anita Eckstein Andicsova
Summary: Nanofiber mats loaded with Diclofenac sodium salt on the base of poly(epsilon-caprolactone) were studied for their biocompatibility and ability to inhibit bacterial infections. The mats demonstrated good viability with human cells culture and showed significant activity against cancer cells. A minimal concentration of 12.5% was found to effectively eradicate both Gram-negative and Gram-positive bacteria.
Article
Engineering, Biomedical
Liliana Liverani, Anna Liguori, Paola Zezza, Chiara Gualandi, Maurizio Toselli, Aldo R. Boccaccini, Maria Letizia Focarete
Summary: This study presents electrospun fibers loaded with bioactive glasses (BG) as well as unloaded fibers for comparison. It is proposed that the interaction between triethoxysilane groups and silanol groups at the BG particle surface leads to additional crosslinking points, enhancing the shape memory properties of the fibers. The presence of BG particles not only confers bioactivity to the fibers but also promotes the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests show that adding BG particles does not inhibit cell viability. This novel approach expands the versatility and suitability of PCL-based composite fibers for various biomedical applications.
BIOACTIVE MATERIALS
(2022)
Article
Polymer Science
Golestan Salimbeigi, Renata Nunes Oliveira, Garrett Brian McGuinness
Summary: This study combines synthetic polymer with natural antibacterial propolis and uses response surface methodology to model the dependence of fiber diameter distribution on process parameters. It identifies statistically significant parameters and targets parameters capable of forming small diameter fibers.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Benlin Sun, Lei Hou, Binbin Sun, Yu Han, Yunqing Zou, Juexin Huang, Yanan Zhang, Chuanliang Feng, Xiaoqiu Dou, Feng Xu
Summary: Chiral hybrid scaffolds prepared by electrospinning show potential in promoting endothelial remodeling in tissue-engineered vascular grafts, offering new insights for the treatment of cardiovascular diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Henry T. Hsueh, Renee Ti Chou, Usha Rai, Wathsala Liyanage, Yoo Chun Kim, Matthew B. Appell, Jahnavi Pejavar, Kirby T. Leo, Charlotte Davison, Patricia Kolodziejski, Ann Mozzer, HyeYoung Kwon, Maanasa Sista, Nicole M. Anders, Avelina Hemingway, Sri Vishnu Kiran Rompicharla, Malia Edwards, Ian Pitha, Justin Hanes, Michael P. Cummings, Laura M. Ensign
Summary: Sustained drug delivery strategies through peptide engineering can provide long-term therapeutic effects for chronic ocular diseases. By utilizing multifunctional peptides with melanin binding properties, a sustained-release depot in the eye can be achieved. In this study, the peptide-drug conjugate HR97, coupled with brimonidine, showed a prolonged intraocular pressure reduction for up to 18 days after a single intracameral injection in rabbits. The engineered multifunctional peptide-drug conjugates offer a promising approach for sustained therapeutic delivery in the eye and beyond.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
Gianluca Viscusi, Elena Lamberti, Vittoria Vittoria, Giuliana Gorrasi
Summary: In this study, nano fibrous membranes core-shell of PLA and PCL encapsulating curcumin were fabricated using coaxial electrospinning technique. Morphology, physical properties, and curcumin release were studied, showing a possibility of fine tuning of drug release depending on the required application. Mechanical performances and barrier properties of the membranes were found to be dependent on the fibers' composition and morphology.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Polymer Science
Roberto Cescato, Daniele Rigotti, Haroon Mahmood, Andrea Dorigato, Alessandro Pegoretti
Summary: The research successfully utilized electrospun PCL mesh to improve the performance of epoxy composites, enhancing the self-healing efficiency.
Article
Polymer Science
Kemal Cetin
Summary: Poly(e-caprolactone)/polyethyleneimine nanofibers were fabricated and catalase was immobilized via coordination of Cu2+ ions, showing improved thermal and storage stability compared to free catalase. The immobilized nanofibers also demonstrated significant reusability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Medicine, Research & Experimental
Safiullah Khan, Muhammad Naeem Aamir, Asadullah Madni, Nasrullah Jan, Arshad Khan, Abdul Jabar, Hassan Shah, Muhammad Abdur Rahim, Ahsan Ali
Summary: The study successfully developed lipid polymer hybrid nanoparticles for delivering 5-fluorouracil, demonstrating sustained release and enhanced anti-cancer efficacy. The system shows potential for targeted chemotherapy delivery and minimizing toxic side effects.
Article
Materials Science, Biomaterials
Patricia Coimbra, Joao P. Freitas, Teresa Goncalves, Maria H. Gil, Margarida Figueiredo
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Chemistry, Physical
Patricia Coimbra, Marta S. N. Coelho, Jose A. F. Gamelas
SURFACE AND INTERFACE ANALYSIS
(2019)
Review
Health Policy & Services
Maria Luisa Bouwman, Joao Jose Simoes Sousa, Maria Eugenia Tavares Pina
HEALTH POLICY AND TECHNOLOGY
(2020)
Article
Materials Science, Paper & Wood
M. G. Simoes, P. Coimbra, A. S. Carreira, M. M. Figueiredo, M. H. Gil, P. N. Simoes
Article
Ophthalmology
Helena P. Filipe, Dimitriya Bozukova, Andreia Pimenta, Ana Paula Vieira, Andreia Sofia Oliveira, Raquel Galante, Ana Topete, Mar Masson, Patricia Alves, Patricia Coimbra, M. Helena Gil, A. Jorge Guiomar, Jose Mata, Rogerio Colaco, Benilde Saramago, Liliana Werner, Nick Mamalis, Ana Paula Serro
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2019)
Article
Biochemistry & Molecular Biology
Joana Couto, Artur Figueirinha, Maria Teresa Batista, Antonio Paranhos, Carla Nunes, Lidia Maria Goncalves, Joana Marto, Manuel Fitas, Pedro Pinto, Helena Margarida Ribeiro, Maria Eugenia Pina
Article
Materials Science, Biomaterials
Henrique Batista, Joao P. Freitas, Alexandra Abrunheiro, Teresa Goncalves, Maria H. Gil, Margarida Figueiredo, Patricia Coimbra
Summary: A localized gentamicin sulfate delivery system with controlled release kinetics was developed using composite electrospun fibers, with the ability to manipulate the PLA/PLGA blend composition for tailored release of GS for at least three weeks. The antibacterial effect against Staphylococcus aureus was confirmed for all produced fibers containing GS, showing potential for the prevention/management of osteomyelitis.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Raquel Sousa, Artur Figueirinha, Maria Teresa Batista, Maria Eugenia Pina
Summary: Cymbopogon citratus, a perennial grass used as a condiment, has shown antioxidant, anti-inflammatory and gastroprotective activities. Developing oral dosage forms from its extract as a functional food with antioxidant properties could contribute significantly to preventing diseases related to oxidative stress. The formulated extract could serve as a valuable antioxidant product.
Article
Chemistry, Multidisciplinary
Ricardo O. Almeida, Adriana Moreira, Daniela Moreira, Maria E. Pina, Maria G. V. S. Carvalho, Maria G. Rasteiro, Jose A. F. Gamelas
Summary: This study demonstrates a successful method of obtaining cellulose-rich materials from the wood of an invasive tree species, utilizing appropriate ionic liquids and deep eutectic solvents. The treated wood can be used to produce cationic wood-based polyelectrolytes with potential applications in wastewater treatment, pharmaceutical, and cosmetic products.
Review
Pharmacology & Pharmacy
Cristiana S. A. Bento, Marisa C. Gaspar, Patricia Coimbra, Herminio C. de Sousa, Mara E. M. Braga
Summary: Hydrogels are widely used in biomedicine as drug delivery systems, wound dressings, contact lenses, and tissue engineering scaffolds. However, their high sensitivity to terminal sterilization poses a challenge for researchers. This paper reviews the literature on hydrogel sterilization, covering conventional methods and emerging techniques, as well as considerations for aseptic processing. It also provides a summary of hydrogel materials, network types, and biomedical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Joana Henriques, Joao Pina, Mara E. M. Braga, Ana M. A. Dias, Patricia Coimbra, Herminio C. de Sousa
Summary: This study proposes the development of a new nanosystem for antimicrobial photodynamic therapy with an oxygen-rich environment. The nanosystem, CUR-IL@ncSi, consists of silica nanocapsules containing curcumin dissolved in hydrophobic ionic liquids (ILs) with high oxygen dissolving capacities. CUR-IL@ncSi demonstrated the ability to generate singlet oxygen (O-1(2)) and exhibit antimicrobial effects through photodynamic inactivation. These results suggest the potential use of CUR-IL@ncSi in developing biomedical products with enhanced oxygenation and aPDT capacities.
Article
Food Science & Technology
Patricia Coimbra, Susana Alarico, Nuno Empadinhas, Mara E. M. Braga, Marisa C. Gaspar
Summary: Edible films composed of starch-based materials enriched with agrifood residues were studied for the incorporation of the probiotic Lactobacillus rhamnosus and the addition of inulin as a prebiotic. The films showed varying mechanical properties depending on the composition, but all had water vapor permeabilities within the typical range. Viability of the probiotic during film production was influenced by the pH of the film-forming solutions. Films with agrifood residues had slower loss of probiotic viability during storage, possibly due to the presence of antioxidant compounds. The films were also shown to be free from foodborne pathogens, making them a promising material for probiotic delivery and food packaging.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Food Science & Technology
Patricia Coimbra, Beatriz Marona, Marta H. F. Henriques, Lara Campos, David M. G. S. Gomes, Carla Vitorino, Joao J. S. Sousa, Mara E. M. Braga, Marisa C. Gaspar
Summary: Edible and biodegradable films were developed using starch and agro-industrial residues for food packaging. Films with quince peel showed the greatest flexibility and did not alter the sensory properties of the food, making them promising for food packaging applications.
FOOD PACKAGING AND SHELF LIFE
(2023)