Review
Biochemistry & Molecular Biology
Ingrid Sidibe, Fatima Tensaouti, Margaux Roques, Elizabeth Cohen-Jonathan-Moyal, Anne Laprie
Summary: Glioblastoma is the most frequent malignant primitive brain tumor in adults. Advanced magnetic resonance imaging techniques and radiomics analysis can help differentiate pseudoprogression from true progression, and provide predictive models for diagnosis, prognosis, and therapeutic response.
Article
Oncology
Morgan Michalet, Olivier Riou, Jeremy Cottet-Moine, Florence Castan, Sophie Gourgou, Simon Valdenaire, Pierre Debuire, Norbert Ailleres, Roxana Draghici, Marie Charissoux, Carmen Llacer Moscardo, Marie-Pierre Farcy-Jacquet, Pascal Fenoglietto, David Azria
Summary: This study evaluates the late tolerance and biochemical recurrence-free survival of MRgRT treatment in patients with local-only recurrence. The data showed excellent acute tolerance with no grade >2 toxicities. However, an increase in dysuria and polyuria was observed after treatment. The biochemical recurrence-free survival decreased over time, with 65% of patients experiencing biochemical recurrence at 12 months.
Review
Oncology
Clara Le Fevre, Jean-Marc Constans, Isabelle Chambrelant, Delphine Antoni, Caroline Bund, Benjamin Leroy-Freschini, Roland Schott, Helene Cebula, Georges Noel
Summary: This review presents various imaging techniques and potential imaging biomarkers to differentiate pseudoprogression from true progression, improving diagnostic accuracy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Wouter H. T. Teunissen, Chris W. Govaerts, Miranda C. A. Kramer, Jeremy A. Labrecque, Marion Smits, Linda Dirven, Anouk van der Hoorn
Summary: The meta-analysis evaluated the diagnostic accuracy of different MRI techniques for treatment response assessment in patients with brain metastasis. The results showed that a combination of techniques had the highest diagnostic accuracy in differentiating tumor progression from treatment induced abnormalities.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Paul Rogowski, Rieke von Bestenbostel, Franziska Walter, Katrin Straub, Lukas Nierer, Christopher Kurz, Guillaume Landry, Michael Reiner, Christoph Josef Auernhammer, Claus Belka, Maximilian Niyazi, Stefanie Corradini
Summary: This study retrospectively assessed the feasibility and early results of online adaptive MR-guided radiotherapy for liver tumors using a 0.35T hybrid MR-Linac. The treatment was successfully completed in all cases, with no local failure or ≥ grade two toxicity observed after a median follow-up of five months. Early results show promising outcomes for MR-linac based oMRgRT in the treatment of primary and secondary liver tumors.
Article
Oncology
Aliya Anil, Ashley M. Stokes, Renee Chao, Leland S. Hu, Lea Alhilali, John P. Karis, Laura C. Bell, C. Chad Quarles
Summary: In this study, the optimal standardized rCBV threshold for the single-dose, dual-echo protocol was determined to generate FTB maps that match those derived from the reference standard, double-dose, single-echo protocol. The results showed a strong correlation between the mean tumor sRCBV values obtained from the two protocols. The study also demonstrated that dual-echo DSC-MRI acquisitions enable robust single-dose sRCBV and FTB mapping, providing pulse sequence parameter flexibility.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hanna Meister, Thomas Look, Patrick Roth, Steve Pascolo, Ugur Sahin, Sohyon Lee, Benjamin D. Hale, Berend Snijder, Luca Regli, Vidhya M. Ravi, Dieter Henrik Heiland, Charles L. Sentman, Michael Weller, Tobias Weiss
Summary: This study demonstrated the generation of mouse and human mRNA-based multifunctional T cells coexpressing a multitargeting CAR and proinflammatory cytokines IL12 and IFN alpha 2, which exhibited enhanced antiglioma activity in vitro and in vivo compared to T cells expressing the CAR or cytokines alone. The coexpression of IL12 and IFN alpha 2 in addition to the CAR promoted a proinflammatory tumor microenvironment and reduced T-cell exhaustion, providing a rationale for future clinical studies with mRNA-based multifunctional CAR T cells in treating malignant brain tumors.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Friederike Hesse, Alan J. Wright, Vencel Somai, Flaviu Bulat, Felix Kreis, Kevin M. Brindle
Summary: The study demonstrates that detecting fumarate metabolism using H-2 MRI can early identify tumor cell death in glioblastoma following chemoradiation, potentially improving the clinical evaluation of treatment response.
Review
Oncology
Mohammadreza Alizadeh, Nima Broomand Lomer, Mobin Azami, Mohammad Khalafi, Parnian Shobeiri, Melika Arab Bafrani, Houman Sotoudeh
Summary: Radiomics, a promising tool that extracts features from medical images, can help differentiate the progression, recurrence, pseudoprogression, and radionecrosis of glioma and glioblastoma multiforme (GBM). It can significantly impact patient care and post-treatment follow-ups.
Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Hanna Ek, Ingrid Fagerstrom Kristensen, Lars Stenberg, Sara Kinhult, Hunor Benedek, Simon Ek, Svend Aage Engelholm, Silke Engelholm, Per Munck af Rosenschold
Summary: This study investigated the characteristics and treatment outcomes of patients selected for proton radiation therapy (PT) for lower-grade gliomas. The study found no difference in the risk of pseudo-progression (PsP) between PT and photon therapy (XRT), and PT was associated with lower rates of fatigue within three months after treatment and better survival outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Liao, Yuan-Cheng Liu, Jiang-Yong Liu, Di Wang, Xin-Feng Liu
Summary: This study aimed to investigate the diagnostic performance of different parameters derived from diffusion-weighted imaging (DWI) models in differentiating tumour progression from pseudoprogression in glioblastoma patients. The results showed that multi-b DWI is a promising method for differentiating tumour progression from pseudoprogression with high diagnostic accuracy. The parameter "a" derived from the stretched-exponential model is the most promising DWI parameter for the prediction of tumour progression in glioblastoma patients.
BMC MEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Oi Lei Wong, JIng Yuan, Yihang Zhou, Siu Ki Yu, Kin Yin Cheung
Summary: This study evaluated the longitudinal acquisition repeatability of MRI radiomics features in a 3D T1-weighted TSE sequence using an ACR-MRI phantom, demonstrating heterogeneous repeatability among different types of radiomics features with shape features being the most repeatable. The most repeatable radiomics feature set identified in this study may assist in selecting reliable radiomics features for future clinical applications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Lewis, Anamaria Guta, Jaeik Shin, Zhen Ji, Jin Sung Kim, Taeho Kim
Summary: Pancreatic cancer treatment with radiotherapy is limited by tolerance issues and difficulties in visualizing tumors. This study used an MR-Linac system to track tumor motion in real-time and developed prediction models using abdominal and diaphragm motion as surrogates. The models can be applied to other abdominothoracic diseases.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Cell Biology
Inge Compter, Danielle B. P. Eekers, Ann Hoeben, Kasper M. A. Rouschop, Bart Reymen, Linda Ackermans, Jan Beckervordersantforth, Noel J. C. Bauer, Monique M. Anten, Pieter Wesseling, Alida A. Postma, Dirk De Ruysscher, Philippe Lambin
Summary: Treatment with chloroquine in combination with radiotherapy and concurrent temozolomide for newly diagnosed glioblastoma showed favorable toxicity and promising overall survival. The maximum tolerated dose was determined to be 200 mg of chloroquine daily. Further clinical studies are supported by these results.