Article
Multidisciplinary Sciences
Mohammad Hazaymeh, Ronja Loeber-Handwerker, Katja Doering, Tammam Abboud, Dorothee Mielke, Veit Rohde, Vesna Malinova
Summary: Approximately 25% of glioblastomas show corpus callosum infiltration at diagnosis, which is associated with poor prognosis. The extent of corpus callosum involvement ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial.
SCIENTIFIC REPORTS
(2022)
Review
Cell & Tissue Engineering
Sijia Li, Lihua Dong, Zhenyu Pan, Guozi Yang
Summary: Background: Glioblastoma, a common and aggressive adult brain tumor, has a high recurrence rate and low survival rate despite conventional treatment. Accumulating evidence suggests that the subventricular zone, which contains neural stem cells and glioma stem cells, plays a crucial role in recurrence and treatment resistance.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Charles P. Couturier, Javad Nadaf, Zhaorong Li, Salma Baig, Gabriele Riva, Phuong Le, Daan J. Kloosterman, Jean Monlong, Andriniaina Nkili Meyong, Redouane Allache, Theresa Degenhard, Mariam Al-Rashid, Marie-Christine Guiot, Guillaume Bourque, Jiannis Ragoussis, Leila Akkari, Francisco J. Quintana, Kevin Petrecca
Summary: Using single-cell RNA sequencing, researchers found that there are multiple neural lineages in new and recurrent glioblastoma, with an enrichment of cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences. They also discovered that neural stem cells (NSCs) in the subventricular zone (SVZ) of glioblastoma patients harbored glioblastoma chromosomal anomalies and were likely the cells of origin. Additionally, they observed that radiotherapy induced similar gene signatures in mesenchymal cancer cells and TME reactive astrocytes in a myeloid-dependent manner.
Article
Oncology
Jee Ye Kahng, Byung-Hee Kang, Soon-Tae Lee, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Jae-Kyung Won, Sung-Hye Park, Jaeman Son, Joo Ho Lee
Summary: This study investigated the relationship between neural stem cells (NSCs) in the subventricular zone (SVZ) and glioblastoma (GBM), as well as the impact of radiotherapeutic strategies. The results showed that GBM patients without SVZ involvement had longer progression-free survival, while patients with GBM in contact with NSCs showed better prognosis after NSC irradiation. This study is of great significance for understanding the origin and treatment of GBM.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Anna Lozano-Urena, Esteban Jimenez-Villalba, Alejandro Pinedo-Serrano, Antonio Jordan-Pla, Martina Kirstein, Sacri R. Ferron
Summary: In GBM, GSCs with tumor potential may originate from NSCs or dedifferentiation of somatic cells through genetic and epigenetic changes. Dysregulation of genomic imprinting, including LOI, is common in tumors, and understanding similarities in imprinting regulation between NSCs and GBM cells may help identify molecular players in GBM development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Jordan Phillipps, Emily S. Norton, Paula Schiapparelli, Rawan Al-Kharboosh, Jordina Rincon-Torroella, Stephanie Jeanneret, Teresa Corona, Jose Segovia, Mark E. Jentoft, Kaisorn L. Chaichana, Yan W. Asmann, Alfredo Quinones-Hinojosa, Hugo Guerrero-Cazares
Summary: This study investigated the effect of CSF on GBM gene expression and the role of CSF-induced SERPINA3 gene in GBM malignancy in vitro and in vivo. The results showed that SERPINA3 plays a key role in GBM malignancy and its inhibition leads to a better outcome for patients.
Article
Oncology
S. Comas, E. Luguera, J. Molero, C. Balana, A. Estival, S. Castaner, C. Carrato, C. Hostalot, P. Teixidor, S. Villa
Summary: This study suggests that tumor proximity to the subventricular zone (SVZ) is an independent prognostic factor for poor progression-free survival (PFS) in glioblastoma patients. Tumors contacting the SVZ were associated with more aggressive recurrences and a higher rate of contralateral relapses.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Summary: The study found that TUSC2 protein expression is reduced in glioblastoma compared to normal brain due to protein destabilization. NEDD4-mediated polyubiquitination is a novel mechanism for TUSC2 degradation in glioblastoma. TUSC2 loss promotes glioblastoma progression through upregulation of Bcl-xL and its knockout gene signature predicts poor patient survival.
Article
Biochemistry & Molecular Biology
Jonathan Isacco Battistini, Valentina Mastrorilli, Vittoria Nicolis di Robilant, Daniele Saraulli, Sara Marinelli, Stefano Farioli Vecchioli
Summary: Traumatic brain injury (TBI) is a common cause of death and disability worldwide, with no effective treatments available. Recent studies have suggested that adult neurogenesis may be a new approach to counteract post-traumatic neurodegeneration. It has been shown that long-term running can enhance adult neurogenesis and promote neuroregeneration and functional recovery after injury. These findings suggest that running could be a promising method to increase neural stem cells and improve endogenous neuroregenerative responses following brain trauma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ting-Chun Lin, Yi-Chieh Tsai, Yun-An Chen, Tai-Horng Young, Chung-Che Wu, Yung-Hsiao Chiang, Chia-Hsin Kao, Abel Po-Hao Huang, Yi-Hua Hsu, Kai-Yun Chen, Li-Kai Tsai
Summary: This study investigated the role of brain-derived neurotrophic factor (BDNF) in post-ICH neurogenesis using a rodent model and patients with ICH. The results showed that the BDNF concentration in cerebrospinal fluid (CSF) was positively correlated with neurogenesis-promoting capacity. This suggests that BDNF plays an important role in regulating neurogenesis after ICH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Vicente Llorente, Pedro Velarde, Manuel Desco, Maria Victoria Gomez-Gaviro
Summary: This review summarizes the latest research on neural stem cells and their canonical niches, including their structure, behaviors, and role in neural diseases.
Review
Oncology
Hyun Jung Kim, Jung Won Park, Jeong Ho Lee
Summary: This study explores the pathogenesis and cell-of-origin of glioblastoma (GBM). It is suggested that GBM may originate from somatic mutations in neural stem cells and glial precursor cells. Further research will aid in understanding the evolution of GBMs and developing effective targets for treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Summary: Glioblastoma (GBM) shares common signaling pathways involving TIM-3, an immune checkpoint, between tumor and non-tumor cells. The study reveals that TIM-3 in glioma cells not only regulates the malignant behaviors of glioma cells but also induces macrophage migration and transition to an anti-inflammatory/protumorigenic phenotype through the TIM-3/IL6 signal. Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
Article
Oncology
Jan Remsik, Jessica A. Wilcox, N. Esther Babady, Tracy A. McMillen, Behroze A. Vachha, Neil A. Halpern, Vikram Dhawan, Marc Rosenblum, Christine A. Iacobuzio-Donahue, Edward K. Avila, Bianca Santomasso, Adrienne Boire
Summary: Cancer patients with neurologic sequelae of COVID-19 have meningeal inflammatory cytokines without viral neuroinvasion, mainly driven by type II interferon and correlated with the degree of neurological dysfunction. The neuroinflammatory process persists weeks after recovery from acute respiratory infection, leading to long-term neurocognitive dysfunction. Anti-inflammatory treatments may play a role in managing neurological complications of COVID-19 infection.
Article
Cell Biology
Vashendriya V. V. Hira, Remco J. Molenaar, Barbara Breznik, Tamara Lah, Eleonora Aronica, Cornelis J. F. Van Noorden
Summary: The study indicates that in glioblastoma patients, GSCs can exist in the subventricular zone at a distance from the tumor, maintaining a stable state through intratumoral hypoxic niches, which renders them resistant to radiotherapy and chemotherapy. These GSCs may contribute to tumor recurrence after therapy.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Oncology
Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Jordan Phillipps, Emily S. Norton, Paula Schiapparelli, Rawan Al-Kharboosh, Jordina Rincon-Torroella, Stephanie Jeanneret, Teresa Corona, Jose Segovia, Mark E. Jentoft, Kaisorn L. Chaichana, Yan W. Asmann, Alfredo Quinones-Hinojosa, Hugo Guerrero-Cazares
Summary: This study investigated the effect of CSF on GBM gene expression and the role of CSF-induced SERPINA3 gene in GBM malignancy in vitro and in vivo. The results showed that SERPINA3 plays a key role in GBM malignancy and its inhibition leads to a better outcome for patients.
Article
Multidisciplinary Sciences
Keila Alvarado-Estrada, Lina Marenco-Hillembrand, Sushila Maharjan, Valerio Luca Mainardi, Yu Shrike Zhang, Natanael Zarco, Paula Schiapparelli, Hugo Guerrero-Cazares, Rachel Sarabia-Estrada, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana
Summary: Cancer cells circulating in the blood vessels can survive and lead to increased metastatic disease under the pressure of circulation. Specific transition phenotypes of cancer cells play a critical role in their survival and metastatic potential in the circulatory system.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Cesar A. Garcia, Adip G. Bhargav, Mieu Brooks, Paola Suarez-Meade, Sujan K. Mondal, Natanael Zarco, Karim ReFaey, Mark Jentoft, Erik H. Middlebrooks, Matija Snuderl, Anna Carrano, Hugo Guerrero-Cazares, Paula Schiapparelli, Rachel Sarabia-Estrada, Alfredo Quinones-Hinojosa
Summary: The study functionally characterized six patient-derived GBM cell lines and established sex-specific preclinical models, showing that GBM cell lines of different sexes exhibited differential growth rates and survival times in mice.
MOLECULAR CANCER THERAPEUTICS
(2021)
Editorial Material
Oncology
Esperanza R. Matarredona, Natanael Zarco, Carmen Castro, Hugo Guerrero-Cazares
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Rajappa S. Kenchappa, Athanassios Dovas, Michael G. Argenziano, Christian T. Meyer, Lauren E. Stopfer, Matei A. Banu, Brianna Pereira, Jessica Griffith, Afroz Mohammad, Surabhi Talele, Ashley Haddock, Natanael Zarco, William Elmquist, Forest White, Peter Sims, Vito Quaranta, Peter Sims, Peter Canoll, Steven S. Rosenfeld
Summary: This study reveals a mechanism of resistance to Kif11 inhibitors in glioblastoma, where suppression of apoptosis driven by activation of STAT3 plays a crucial role. Simultaneous inhibition of SRC and EGFR can reverse this resistance and significantly prolong survival in mice. These findings provide a translational actionable approach to overcome Kif11 inhibitor resistance.
Article
Neurosciences
Emily S. Norton, Lauren A. Whaley, Maria Jose Ulloa-Navas, Patricia Garcia-Tarraga, Kayleah M. Meneses, Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Alfredo Quinones-Hinojosa, Jose Manuel Garcia-Verdugo, Hugo Guerrero-Cazares
Summary: This study demonstrates for the first time that glioblastomas (GBMs) proximal to the lateral ventricles (LVs) disrupt the ependymal cell barrier, leading to compromised ependymal cell health and increased interaction between cerebrospinal fluid (CSF) and the tumor. These findings suggest that ependymal cell health and CSF-contained molecules could be potential therapeutic targets in the treatment of GBM.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Clinical Neurology
Oluwaseun O. Akinduro, Paola Suarez-Meade, McKinley Roberts, Stephany Y. Tzeng, Rachel Sarabia-Estrada, Paula Schiapparelli, Emily S. Norton, Ziya L. Gokaslan, Panos Z. Anastasiadis, Hugo Guerrero-Cazares, Jordan J. Green, Alfredo Quinones-Hinojosa
Summary: This study demonstrates that verteporfin-mediated inhibition of YAP can reduce tumorigenicity in lung and breast spinal metastatic cancer cells, offering promising results for potential translation to human clinical trials.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Review
Biochemistry & Molecular Biology
Marissa N. Russo, Lauren A. Whaley, Emily S. Norton, Natanael Zarco, Hugo Guerrero-Cazares
Summary: Glioblastoma (GBM) is the most malignant form of gliomas and the most common and deadly primary brain tumor in adults. The tumor microenvironment (TME), including the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment, plays an important role in GBM biology and tumor maintenance. Extracellular vesicles, such as exosomes and microvesicles, facilitate communication between GBM cells and TME cells, carrying cancerous and non-cancerous cargo. This review highlights the potential of extracellular vesicles as diagnostic and targetable vehicles for GBM.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Oncology
Rea Ravin, Paola Suarez-Meade, Brad Busse, Paul S. Blank, Tito Vivas-Buitrago, Emily S. Norton, Steve Graepel, Kaisorn L. Chaichana, Ludmila Bezrukov, Hugo Guerrero-Cazares, Joshua Zimmerberg, Alfredo Quinones-Hinojosa
Summary: A human-derived brain organotypic model is used to study the migratory properties of GBM IDH-wild type cells, which migrate towards the perivascular space in blood vessels and exhibit changes in migratory parameters upon contact with vascular structures and under hypoxic conditions. This model allows for the evaluation of GBM invasion, taking into consideration the human brain microenvironment when cells are removed from their native niche after surgery.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Luisina B. Ripari, Emily S. Norton, Raquel Bodoque-Villar, Stephanie Jeanneret, Montserrat Lara-Velazquez, Anna Carrano, Natanael Zarco, Carla A. Vazquez-Ramos, Alfredo Quinones-Hinojosa, Carlos De La Rosa-Prieto, Hugo Guerrero-Cazares
Summary: A novel rodent model was used to analyze the bidirectional signaling between GBM tumors and cells within the subventricular zone (SVZ). The study found that GBM tumors located close to the lateral ventricles show increased tumor growth, decreased median survival, and negatively influence the neurogenic and cell division process of the SVZ in adult mice. This model will be invaluable for further investigation into the interactions between GBM and the neurogenic cell populations of the SVZ.
FRONTIERS IN ONCOLOGY
(2021)