Article
Biotechnology & Applied Microbiology
Jie Yang, Yaqin Fan, Beibei Xie, Dan Yang
Summary: This study investigated the molecular mechanisms of GJB1 in ovarian cancer through RNA-Seq and bioinformatics analysis, identifying upstream regulatory factors, downstream pathways, and potential drugs targeting GJB1. The results will help accelerate drug development and improve outcomes for ovarian cancer patients.
ONCOTARGETS AND THERAPY
(2021)
Article
Genetics & Heredity
Hong-Yan Cai, Si-Ru Chen, Yu Wang, Juan-Juan Jiao, Jun Qiao, Christian Holscher, Zhao-Jun Wang, Sheng-Xiao Zhang, Mei-Na Wu
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disease that worsens with age. Dysregulation of long non-coding RNAs (lncRNAs) and the associated competing endogenous RNA (ceRNA) network may be linked to the occurrence and development of AD. RNA sequencing identified 358 differentially expressed genes (DEGs), including 302 differentially expressed mRNAs (DEmRNAs) and 56 differential expressed lncRNAs (DElncRNAs). The constructed ceRNA network includes 4 lncRNAs, 4 microRNAs, and 2 mRNAs. Functional enrichment analysis revealed the involvement of DEmRNAs in AD-related biological functions. Co-expressed DEmRNAs in humans and mice were validated using real-time quantitative polymerase chain reaction (qRT-PCR). The findings provide insights into AD-related pathological mechanisms and can contribute to improving AD diagnosis and treatment.
Article
Cell Biology
Ricardo Coelho, Alessandra Tozzi, Muriel Disler, Flavio Lombardo, Andre Fedier, Monica Nunez Lopez, Florian Freuler, Francis Jacob, Viola Heinzelmann-Schwarz
Summary: PARP inhibitors have shown outstanding benefits in the treatment of epithelial ovarian cancer, especially in patients with BRCA1/2 mutations or defects in the homologous recombination repair system. This study identified ATM, MUS81, NBN, BRCA2, and RAD51B as predictive markers for olaparib response and highlighted CDK12 as a potential therapeutic target in EOC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
John B. Liao, William R. Gwin, Renata R. Urban, Katie M. Hitchcock-Bernhardt, Andrew L. Coveler, Doreen M. Higgins, Jennifer S. Childs, Hania N. Shakalia, Ron E. Swensen, Sasha E. Stanton, Anna Tinker, Tanya A. Wahl, Richard G. Ancheta, Kathryn F. McGonigle, James Y. Dai, Mary L. Disis, Barbara A. Goff
Summary: The study evaluated the activity and safety of pembrolizumab with carboplatin in recurrent platinum-resistant ovarian cancer, showing that this treatment approach had modest activity and good tolerability. A ratio of peripheral T-cell exhaustion to radiographic tumor burden may help identify patients who are more likely to benefit from this chemoimmunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Bo Ding, Zheng Ye, Han Yin, Xin-Yi Hong, Song-Wei Feng, Jing-Yun Xu, Yang Shen
Summary: This study reveals the regulatory role of tumor exosomes on cancer-associated fibroblast (CAF) in ovarian cancer, showing that ovarian cancer-derived exosomes can promote the proliferation and migration of CAF through the H19/miR-29c-3p/LOXL2-COL1A1 pathway, leading to tumor growth. This finding provides a theoretical basis for the development of therapeutic regimens targeting fibroblasts in ovarian cancer.
Review
Cell Biology
Komal Imran, Muhammad Javed Iqbal, Rameesha Abid, Muhammad Mushtaq Ahmad, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: This review focuses on the functional and tumor progression role of miRNA-3652 in ovarian cancer. miRNA-3652 is involved in regulating ovarian cancer cell proliferation, migration, and invasion, and its dysregulation is associated with altered expression of critical genes involved in tumor growth and metastasis. Additionally, miRNA-3652 expression levels are correlated with clinical stages, prognosis, and response to therapy in ovarian cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang, Xipeng Wang
Summary: The study identified a novel pseudogene, lnc-CTSLP8, in ovarian cancer with significantly elevated expression in metastatic tumor tissues. Overexpression of lnc-CTSLP8 promoted ovarian cancer growth in vitro and in vivo, enhanced autophagy and EMT, and upregulated CTSL1 as a competitive endogenous RNA. Moreover, inhibition of CTSL1 and overexpression of miR-199a-5p reversed the effects of lnc-CTSLP8 overexpression, suggesting its potential as a therapeutic target for metastatic ovarian cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ruizhuo Ouyang, Jinyao Liu, Shen Wang, Weilun Zhang, Kai Feng, Conghao Liu, Baolin Liu, Yuqing Miao, Shuang Zhou
Summary: To develop new anti-cancer drugs more efficiently and reduce side effects, virtual drug screening was performed targeting G-quadruplexes, resulting in the identification of 23 hit compounds as potential anticancer drugs. Shape feature similarity (SHAFTS) method was used to calculate the three-dimensional similarity of molecules and narrow down the range of potential compounds. Molecular docking was then utilized for final screening and to explore the binding between each compound and different G-quadruplex structures. Three selected compounds (1, 6, and 7) exhibited promising anticancer characteristics in treating lung cancer cells, demonstrating the great application potential of virtual screening in drug development.
Article
Cell Biology
Xiaofang Tan, Yang Shao, Yue Teng, Siyu Liu, Weijian Li, Lu Xue, Yuepeng Cao, Chongqi Sun, Jinhong Zhang, Jing Han, Xiaoli Wu, Hanzi Xu, Kaipeng Xie
Summary: The study revealed that PCAT6 is overexpressed in ovarian cancer and correlates with advanced stages and poor survival rates. PCAT6 interacts with miR-143-3p to modulate the expression of TAK1, contributing to the proliferation and invasion of ovarian cancer cells. The findings suggest that PCAT6 could serve as a potential therapeutic target for ovarian cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Jian Zhao, Xiaofeng Song, Tianyi Xu, Qichang Yang, Jingjing Liu, Bin Jiang, Jing Wu
Summary: Increasing lncRNA-associated competing triplets play crucial roles in cancer, forming a regulatory network closely related to processes like cell division and the cell cycle.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Multidisciplinary
Zi-Ying Zhou, Xiao-Yang Han, Lian-Qi Sun, Si-Yan Li, Si-Tu Xue, Zhuo-Rong Li
Summary: This study demonstrates the association between FOXM1 protein and drug resistance in ovarian cancer, and identifies DZY-4 as a potential inhibitor with high affinity and anti-tumor effects, making it a potential treatment option for ovarian cancer.
FRONTIERS IN CHEMISTRY
(2022)
Article
Medicine, General & Internal
Jingya Xu, Wenya Liu, Ruiqi Li, Youmin Wang
Summary: This study explored the significance of LINC02082 and LOC105369812 in the differential diagnosis of papillary thyroid carcinoma and benign nodules. The results showed that LOC105369812 could be used to differentiate malignant thyroid nodules, while LINC02082 had lower diagnostic value.
Article
Biochemistry & Molecular Biology
Margareta Pernar Kovac, Vanja Tadic, Juran Kralj, George E. Duran, Alessia Stefanelli, Darija Stupin Polancec, Sanja Dabelic, Niko Bacic, Maja T. Tomicic, Petra Heffeter, Branimir I. Sikic, Anamaria Brozovic
Summary: This study investigated resistance to platinum and taxane-based chemotherapy in ovarian cancer cells and the role of TUBB3 in therapy response prediction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Genetics & Heredity
Dongyu Huang, Runzhi Wang, Lewei Tian, Hui Wang
Summary: A prognostic model centered around JARID2, consisting of long non-coding RNAs, has been identified through bioinformatics analysis. The PKD1P6/miR-424-5p/JARID2 axis has been revealed to play a role in promoting cell proliferation in ovarian cancer. JARID2 shows exciting potential as a novel biomarker.
Article
Oncology
Yuanyuan Li, Han Lei, Rihan Hai, Guang Shu, Wenguang Yan, Gang Yin
Summary: This study found that HOXC10 is upregulated in ovarian cancer and is associated with carboplatin resistance. Further investigation revealed that HOXC10 can promote the expression of ABCC3 by upregulating beta-catenin, resulting in decreased sensitivity of cells to carboplatin. These findings suggest that the expression of HOXC10/ABCC3 could serve as a novel biomarker for predicting carboplatin resistance and prognosis in ovarian cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Yan-Ming Xu, Dan-Dan Wu, Wei Zheng, Fei-Yuan Yu, Feng Yang, Yue Yao, Yuan Zhou, Yick-Pang Ching, Andy T. Y. Lau
Article
Environmental Sciences
Feng Yang, Wenhui Qiu, Rongzhen Li, Jiaqi Hu, Shusheng Luo, Ting Zhang, Xin He, Chunmiao Zheng
Article
Environmental Sciences
Wenhui Qiu, Shuai Liu, Feng Yang, Peiyao Dong, Ming Yang, Minghung Wong, Chunmiao Zheng
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Environmental Sciences
Wenhui Qiu, Xinjie Liu, Feng Yang, Rongzhen Li, Ying Xiong, Caixia Fu, Guanrong Li, Shuai Liu, Chunmiao Zheng
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Genetics & Heredity
Feng Yang, Shaoyi Cai, Li Ling, Haiji Zhang, Liang Tao, Qin Wang
Summary: The study identified prognostic markers and potential drug-repurposing for CRC through bioinformatics analysis, offering new therapeutic options for CRC patients.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Feng Yang, Ziyu Zhao, Haiji Zhang, Liping Zhou, Liang Tao, Qin Wang
Summary: The study used zebrafish as a model to investigate the toxicity of BPS and found that excess ROS production may trigger multiple toxic effects. Pathway enrichment analysis and protein-protein network analysis identified key pathways and interaction proteins associated with BPS exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Li-Xia Fan, Liang Tao, Yong-Chang Lai, Shao-Yi Cai, Zi-Yu Zhao, Feng Yang, Ri-Ya Su, Qin Wang
Summary: This study investigates the role of gap junctions and connexins in the autophagy of cervical cancer cells. It is found that connexin 32 promotes autophagy by activating the AMP-activated protein kinase pathway, leading to the inhibition of apoptosis in cervical cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Feng Yang, Xutao Chen, Hui Zhang, Guo-Dong Zhao, Huifei Yang, Jiang Qiu, Siyan Meng, Penghan Wu, Liang Tao, Qin Wang, Gang Huang
Summary: BK polyomavirus (BKPyV) infection has a significant impact on the prognosis of kidney transplant recipients, but effective antiviral treatment is currently lacking. This study demonstrated the renal-cell-type tropism of BKPyV, with proximal tubule cells being the most susceptible. Furthermore, the study identified potential antiviral targets and provided insights for the development of new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
