Article
Oncology
Petra J. van Houdt, Hina Saeed, Daniela Thorwarth, Clifton D. Fuller, William A. Hall, Brigid A. McDonald, Amita Shukla-Dave, Ernst S. Kooreman, Marielle E. P. Philippens, Astrid L. H. M. W. van Lier, Rick Keesman, Faisal Mahmood, Catherine Coolens, Teodor Stanescu, Jihong Wang, Neelam Tyagi, Andreas Wetscherek, Uulke A. van der Heide
Summary: QIBs derived from MRI techniques have the potential for personalized cancer treatment, with MRI-guided radiotherapy systems allowing for high-frequency imaging and reduced patient burden. Understanding the correlation between QIBs collected during MRIgRT and clinical outcomes is crucial, as technical validation plays an important role in this process.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Michael D. Chuong, Roberto Herrera, Adeel Kaiser, Muni Rubens, Tino Romaguera, Diane Alvarez, Rupesh Kotecha, Matthew D. Hall, James McCulloch, Antonio Ucar, Fernando DeZarraga, Santiago Aparo, Sarah Joseph, Horacio Asbun, Ramon Jimenez, Govindarajan Narayanan, Alonso N. Gutierrez, Kathryn E. Mittauer
Summary: This retrospective analysis evaluated the outcomes of induction chemotherapy followed by ablative A-SMART treatment for inoperable PDAC. The results showed promising preliminary efficacy in terms of local control and survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Colton Ladbury, Arya Amini, Amanda Schwer, An Liu, Terence Williams, Percy Lee
Summary: Magnetic resonance-guided radiotherapy (MRgRT) combines an onboard MRI scanner with radiation delivery technology, enabling real-time low-field or high-field MRI acquisition and improving soft tissue delineation, adaptive treatment, and motion management. Research has shown that MRgRT can effectively shrink treatment margins, decrease toxicity in certain cancers, and improve oncologic outcomes in others, while also enabling clear soft tissue delineation and gating for specific indications. The use of MRgRT has the potential to significantly improve patient outcomes and quality of life. This narrative review aims to discuss the rationale for MRgRT, current and future technology, existing studies, and future directions and challenges associated with the advancement of MRgRT.
Article
Oncology
Sebastian Regnery, Carolin Buchele, Fabian Weykamp, Moritz Pohl, Philipp Hoegen, Tanja Eichkorn, Thomas Held, Jonas Ristau, Carolin Rippke, Laila Koenig, Michael Thomas, Hauke Winter, Sebastian Adeberg, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: This study explores the benefit of adaptive magnetic resonance-guided stereotactic body radiotherapy for lung tumors, particularly ultracentral lung tumors. The results show that plan adaptation can effectively improve the shortcomings of predicted plans and reduce the risk of exceeding maximum dose and violating organ-at-risk constraints.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyuan Chen, Xiangyu Ma, Xuena Yan, Fei Luo, Siran Yang, Zekun Wang, Runye Wu, Jianyang Wang, Ningning Lu, Nan Bi, Junlin Yi, Shulian Wang, Yexiong Li, Jianrong Dai, Kuo Men
Summary: This study proposes a personalized auto-segmentation framework for online delineation of prostate cancer using MRIgART, and the results show that the proposed method improves the segmentation accuracy compared to the population model.
Article
Oncology
Hsin-Hua Lee, Chun-Yen Wang, Shan-Tzu Chen, Tzu-Ying Lu, Cheng-Han Chiang, Ming-Yii Huang, Chih-Jen Huang
Summary: This research aimed to analyze the electron stream effect (ESE) during magnetic resonance image guided radiotherapy (MRgRT) for breast cancer patients. It was found that a 0.35T MR-Linac caused redundant doses to the skin of the chin and the neck. Adding a 1cm thick bolus efficiently decreased the unnecessary dose caused by ESE.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
John Michael Bryant, Joseph Weygand, Emily Keit, Ruben Cruz-Chamorro, Maria L. Sandoval, Ibrahim M. Oraiqat, Jacqueline Andreozzi, Gage Redler, Kujtim Latifi, Vladimir Feygelman, Stephen A. Rosenberg
Summary: Stereotactic body radiotherapy (SBRT) is an effective radiation therapy technique that shortens treatment courses by using daily image guidance. Magnetic resonance imaging (MRI) improves soft-tissue visualization for better tumor targeting. MR-guided SBRT (MRgSBRT) with a combined MRI and linear accelerator offers superior soft-tissue visualization, real-time assessment, and online adaptive replanning.
Article
Oncology
Amaresha Shridhar Konar, Akash Deelip Shah, Ramesh Paudyal, Maggie Fung, Suchandrima Banerjee, Abhay Dave, Vaios Hatzoglou, Amita Shukla-Dave
Summary: This study aims to characterize brain metastases using T1 and T2 maps generated from newer, rapid, synthetic MRI. The results demonstrate the potential of T1 and T2 metric values to characterize brain metastases and normal tissues. This information could be useful for diagnosis and research of brain metastases.
Article
Oncology
M. P. W. Intven, S. R. de Mol van Otterloo, S. Mook, P. A. H. Doornaert, E. N. de Groot-van Breugel, G. G. Sikkes, M. E. Willemsen-Bosman, H. M. van Zijp, R. H. N. Tijssen
Summary: This study evaluates the feasibility and implementation of MR-guided radiotherapy for rectal cancer on a 1.5T MR-linac. Results show that daily online adaptation of the CTV can reduce margins effectively and achieve good treatment outcomes. The treatment process takes about 48 minutes per fraction.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jing Yang, Jie Feng, Sugeun Yang, Yikai Xu, Zheyu Shen
Summary: In recent years, exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) have emerged as promising T-1 contrast agents for magnetic resonance imaging (MRI) due to their advantages over traditional contrast agents and conventional magnetic nanoparticles. This review summarizes the synthesis methods, surface modifications, T-1-MRI visual strategies, and imaging-guided cancer therapies of ES-MIONs, aiming to attract extensive interest from researchers and promote their involvement in the development of ES-MIONs based nanoplatforms for tumor theranostics.
Article
Engineering, Biomedical
Artur Weidner, Christina Stengl, Fabian Dinkel, Stefan Dorsch, Carlos Murillo, Steffen Seeber, Regula Gnirs, Armin Runz, Gernot Echner, Christian P. Karger, Oliver Jaekel
Summary: This study presents a custom developed abdominal phantom for end-to-end tests in image-guided radiotherapy treatment planning scenarios. The phantom demonstrates anthropomorphic T1 and T2 relaxation times as well as HU numbers, and also simulates physiological motion patterns.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Sebastian Regnery, Efthimios Katsigiannopulos, Philipp Hoegen, Fabian Weykamp, Elisabetta Sandrinia, Thomas Held, Maximilian Deng, Tanja Eichkorn, Carolin Buchele, Carolin Rippke, Katharina Renkamp, Laila Koenig, Kristin Lang, Michael Thomas, Hauke Winter, Sebastian Adeberg, Sebastian Klueter, Juergen Debus, Juliane Hoerner-Rieber
Summary: This study analyzed data from 36 patients who received stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) for ultracentral lung tumors (ULT). The results suggest that SMART treatment may be effective for ULTs, but it carries a higher risk of toxicities.
Review
Oncology
Paul B. Romesser, Neelam Tyagi, Christopher H. Crane
Summary: Stereotactic ablative body radiotherapy (SABR) is an effective treatment for CRC liver metastases, but advanced radiation techniques are needed for safe and efficacious treatment. MR-guided adaptive radiation therapy (MRgART) is a promising new technology that can overcome the challenges of liver SABR and facilitate safe tumor dose escalation.
Article
Oncology
Yuxiang Liu, Bining Yang, Xinyuan Chen, Ji Zhu, Guangqian Ji, Yueping Liu, Bo Chen, Ningning Lu, Junlin Yi, Shulian Wang, Yexiong Li, Jianrong Dai, Kuo Men
Summary: This study developed efficient segmentation methods for MRIgART and CBCTgART, utilizing personalized modeling to improve the segmentation accuracy of adaptive radiotherapy (ART), and achieved better or comparable performance.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Adham Hijab, Boris Tocco, Ian Hanson, Hanneke Meijer, Christina Junker Nyborg, Anders Smedegaard Bertelsen, Robert Jan Smeenk, Gillian Smith, Jeff Michalski, Brian C. Baumann, Shaista Hafeez
Summary: Radiotherapy plays a significant role in both curative and palliative treatment of bladder cancer, but faces technical challenges such as poor tumor visualization and bladder size variability. Magnetic resonance imaging (MRI) is favored for tumor visualization and staging, and the integration of MRI scanning with linear accelerator in MR-Linac systems allows for real-time plan adaptation during treatment, potentially improving outcomes for bladder cancer patients. However, robust evidence is needed to determine if MR-guided radiotherapy translates into better patient outcomes before widespread clinical implementation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Munoz, Igor Olaciregui-Ruiz, Gunnar Norberg, Uulke A. van der Heide, Anton Mans
Summary: The study compared the performance of the new EPID with conventional EPIDs and ionization chambers, finding that the GEM EPID showed good dosimetric performance, with linearity and dose rate dependence within 1%, demonstrating a more water-equivalent response compared to conventional EPIDs. The experimental results for transmission response and off-axis response were also better for the GEM EPID compared to conventional EPIDs.
Editorial Material
Oncology
Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dietmar Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Steffen Lock, Birgitte Offersen, Jens Overgaard, David I. Thwaites, Albert J. van der Kogel, Uulke A. van der Heide, Vincenzo Valentini, Michael Baumann
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Marjaneh Taghavi, Femke Staal, Fernando Gomez Munoz, Farshad Imani, David B. Meek, Rita Simoes, Lisa G. Klompenhouwer, Uulke A. van der Heide, Regina G. H. Beets-Tan, Monique Maas
Summary: The study developed a machine learning radiomics model to predict local tumor progression in patients with colorectal liver metastases after thermal ablation treatment. The model showed a high concordance index in the validation set, providing a valuable predictive tool for clinical practice.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Victoria Y. Yu, Jani Keyrilainen, Sami Suilamo, Ilyes Beslimane, Alex Dresner, Aleksi Halkola, Uulke A. Van der Heide, Neelam Tyagi
Summary: The study validated a synthetic computed tomography (sCT) software for general pelvis anatomy in radiotherapy, showing good soft tissue contrast and dosimetric accuracy, suitable for MRI-only workflow.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Engineering, Biomedical
Tessa N. van de Lindt, Martin F. Fast, Wouter van den Wollenberg, Jochem Kaas, Anja Betgen, Marlies E. Nowee, Edwin Pm Jansen, Christoph Schneider, Uulke A. van der Heide, Jan-Jakob Sonke
Summary: The 4D-MRI guided strategy demonstrated excellent performance in all workflow tests, including 4D-MRI scanning, tumor registration with CT images, calculation of daily tumor mid-position misalignment, plan adaptation, and adapted plan delivery, in preparation for clinical introduction on the Unity MR-linac.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Cedric Draulans, Floris Pos, Robert J. Smeenk, Linda Kerkmeijer, Wouter V. Vogel, James Nagarajah, Marcel Janssen, Cindy Mai, Stijn Heijmink, Marloes van der Leest, Patrik Zamecnik, Raymond Oyen, Sofie Isebaert, Frederik Maes, Steven Joniau, Martina Kunze-Busch, Robin De Roover, Gilles Defraene, Uulke A. van der Heide, Karolien Goffin, Karin Haustermans
Summary: The study assessed the intermodality and intertracer variability of PSMA PET and bpMRI for gross tumor volume delineation in prostate cancer. Results showed significant differences in overlap favoring PSMA PET over bpMRI, and variations between different tracers.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marjaneh Taghavi, Femke C. R. Staal, Rita Simoes, Eun K. Hong, Doenja M. J. Lambregts, Uulke A. van der Heide, Regina G. H. Beets-Tan, Monique Maas
Summary: This study aimed to investigate whether an existing machine-learning model based on radiomics features of pre-ablation CT images can predict the development of new CRLM. The results showed that both the original and newly developed models were unable to accurately predict the occurrence of new CRLM.
Article
Urology & Nephrology
Veerle H. Groen, Karin Haustermans, Floris J. Pos, Cedric Draulans, Sofie Isebaert, Evelyn M. Monninkhof, Robert J. Smeenk, Martina Kunze-Busch, Johannes C. J. de Boer, Jochem van der Voort van Zijp, Linda G. W. Kerkmeijer, Uulke A. van der Heide
Summary: The FLAME trial demonstrates that focal dose escalation to intraprostatic lesions in external beam radiotherapy can improve local failure-free survival and regional + distant metastasis-free survival.
Article
Oncology
Alice Couwenberg, Uulke van der Heide, Tomas Janssen, Baukelien van Triest, Peter Remeijer, Corrie Marijnen, Jan-Jakob Sonke, Marlies Nowee
Summary: The master protocol trial design aims to improve efficiency in the development of innovations in radiation oncology. This article describes a master protocol for studying the feasibility of MR-guided adaptive radiotherapy techniques/software.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Eline D. Hessen, Sebastian Makocki, Uulke A. van der Heide, Bas Jasperse, Lotte J. Lutkenhaus, Emmy Lamers, Eugene Damen, Esther G. C. Troost, Gerben R. Borst
Summary: The study demonstrated that anatomical changes during radiotherapy in glioblastoma patients may affect dose coverage, but only a small number of patients experienced potentially clinically relevant underdosage as a result.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Anouk Corbeau, Remi A. Nout, Jan Willem M. Mens, Nanda Horeweg, Jeremy Godart, Ellen M. Kerkhof, Sander C. Kuipers, Mariette I. E. van Poelgeest, Judith R. Kroep, Ingrid A. Boere, Helena C. van Doorn, Mischa S. Hoogeman, Uulke A. van der Heide, Hein Putter, Marij J. P. Welters, Sjoerd H. van der Burg, Carien L. Creutzberg, Stephanie M. de Boer
Summary: Chemoradiation with photon radiotherapy is effective for locally advanced cervical cancer, but leads to treatment-related toxicity. Proton therapy reduces undesired dose to organs, and the PROTECT trial aims to compare side effects between photon and proton therapy for LACC.
Article
Oncology
Chavelli M. Kensen, Anja Betgen, Lisa Wiersema, Femke P. Peters, Mutamba T. Kayembe, Corrie A. M. Marijnen, Uulke A. van der Heide, Tomas M. Janssen
Summary: Online adaptive MRI-guided radiotherapy allows for dose escalation to multiple targets in rectal cancer. The adapt-to-shape (ATS) workflow provides the smallest margins for treatment, making it the recommended approach for safe dose escalation.
Article
Oncology
Catarina Dinis Fernandes, Annekoos Schaap, Joan Kant, Petra van Houdt, Hessel Wijkstra, Elise Bekers, Simon Linder, Andries M. Bergman, Uulke van der Heide, Massimo Mischi, Wilbert Zwart, Federica Eduati, Simona Turco
Summary: Prostate cancer is a global health burden and multi-parametric magnetic resonance imaging is recommended for diagnosis. By studying imaging characteristics and genomic information from tumor biopsies, it may be possible to non-invasively detect aggressive tumor characteristics. This study found significant correlations between imaging features and tumor aggressiveness, as well as links between diagnostic images and genomic information of the tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Myriam G. Jaarsma-Coes, Teresa A. Ferreira, Petra J. van Houdt, Uulke A. van der Heide, Gregorius P. M. Luyten, Jan-Willem M. Beenakker
Summary: The study successfully addressed the challenges specific to imaging intraocular masses, enabling accurate ocular DCE-MRI. The results showed improved concentration curve quality after registration, with significant differences observed in T-1 values between melanotic and amelanotic lesions. This eye-specific analysis method could potentially aid in the diagnosis, prognosis, and follow-up of uveal melanoma.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
