Article
Oncology
Javier A. Menendez, Adriana Papadimitropoulou, Travis Vander Steen, Elisabet Cuyas, Bharvi P. Oza-Gajera, Sara Verdura, Ingrid Espinoza, Luciano Vellon, Inderjit Mehmi, Ruth Lupu
Summary: The study highlights the critical role of fatty acid synthase (FASN) in HER2-driven tamoxifen resistance and suggests that FASN inhibition could be a novel therapeutic approach to restore tamoxifen sensitivity in endocrine-resistant breast cancer.urther research using next-generation FASN inhibitors may be therapeutically relevant in countering resistance to tamoxifen in FASN-overexpressing ER+/HER2+ breast carcinomas.
Article
Oncology
Jiale Qin, Lvlan Ye, Xiangqiong Wen, Xiang Zhang, Yuqin Di, Zhihui Chen, Ziyang Wang
Summary: Despite the success of immunotherapy and molecular targeted therapy, chemotherapy remains the most commonly used treatment for tumor patients. However, tumor cells often develop chemoresistance during chemotherapy, limiting its effectiveness. Alterations in lipid metabolism may play a role in the development of chemoresistance. Therefore, this review provides an overview of fatty acid metabolism and its impact on chemoresistance mechanisms, as well as the potential of targeting fatty acid metabolism as a therapeutic strategy to overcome drug resistance.
Article
Biochemistry & Molecular Biology
Helena Muley, Karmele Valencia, Josefina Casas, Bea Moreno, Luis Botella, Fernando Lecanda, Rut Fado, Nuria Casals
Summary: Breast cancer is the most common malignancy in women worldwide, and chemoresistance is a major obstacle to patient survival. CPT1C expression has been found to be associated with plasma membrane remodelling and drug resistance in breast cancer cells, suggesting its potential as a predictive biomarker for breast cancer chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Marcin Herok, Bartosz Wawrzynow, Marta J. Maluszek, Maciej B. Olszewski, Alicja Zylicz, Maciej Zylicz
Summary: MDM2 plays a crucial role in cancer development, involved in DNA repair inhibition and chemoresistance acquisition. Inhibiting MDM2 expression can reduce the chemoresistance of tumor cells.
Review
Pharmacology & Pharmacy
Chang Liu, Changfeng Li, Yuanda Liu
Summary: Pancreatic cancer is a highly malignant disease with hidden onset and early metastasis. Chemotherapy is the primary treatment, but chemoresistance has become an urgent clinical problem. Recent studies have shown that metabolic reprogramming, including glucose, lipid, and amino acid metabolism, plays a crucial role in tumorigenesis and drug tolerance. Additionally, mitochondria, as central players in nutrient and energy metabolism, are also involved in drug resistance development. This review summarizes the metabolic changes during pancreatic cancer progression, their impact on chemoresistance, and current studies on metabolic inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Gulnihal Ozcan
Summary: The molecular characterization of breast cancer has led to the development of endocrine therapies in ER+/HER2- breast cancer, increasing response rates. However, taxane-based neoadjuvant chemotherapy remains crucial for locally advanced cancers with high recurrence risk. Predicting chemoresistance and deselecting patients who will not benefit from chemotherapy is important, and current multigene assays have limitations. This study identified PTCH1 and CTNNB1 as robust and cost-effective predictors in developing countries to guide chemotherapy decisions in high-risk ER+/HER2- breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiang Li, Qidong Xia, Can Di, Chunni Li, Hang Si, Boxuan Zhou, Shubin Yu, Yihong Li, Jingying Huang, Yiwen Lu, Min Huang, Huixin Liang, Xinwei Liu, Qiyi Zhao
Summary: Targeting CD96 in tumor cells has potential for cancer therapy, as discovered in clinical breast cancer samples. CD96 expression in tumor cells is correlated with poor prognosis, and CD96(+) cancer cell subpopulations display characteristics of breast cancer stem cells and chemoresistance. Inhibition of CD96 in tumor cells enhances chemotherapeutic response in a patient-derived tumor xenograft model.
Article
Plant Sciences
Zhu Zhu, Liao Cui, Jing Yang, Chi Teng Vong, Yuanjia Hu, Jianbo Xiao, Ging Chan, Zhiwei He, Zhangfeng Zhong
Summary: The study investigated the anticancer effects of asiatic acid in doxorubicin-resistant breast cancer cells and found that asiatic acid induced cell death through multiple pathways, including ROS production, ATP reduction, and modulation of adaptive immunity via intrinsic apoptosis, AMPK, PD-L1, and NF-kappa B pathways. Additionally, asiatic acid enhanced the sensitivity of doxorubicin-resistant cells to doxorubicin by improving P-gp function.
Article
Chemistry, Analytical
Yangcenzi Xie, Yu Wen, Xiaoming Su, Chao Zheng, Ming Li
Summary: A machine learning-driven surface-enhanced Raman spectroscopy (SERS)-integrated strategy is developed for label-free detection of cellular HER2, achieving high accuracy in cell identification and classification for HER2+ breast cancer. The combination of label-free SERS detection and machine learning-driven analysis enables longitudinal monitoring of therapeutic efficacy, aiding in decision-making and management.
ANALYTICAL CHEMISTRY
(2022)
Article
Pathology
Chuntao Tian, Ying Liu, Yixiong Liu, Peizhen Hu, Shenglong Xie, Yu Guo, Hui Wang, Zhiyong Zhang, Liuyang Du, Binhua Lei, Yingping Wang, Lingfei Xue, Dong Zhang, Jing Su, Xiaotong Zhang, Ruiwen Zhang, Jiaohong Chen, Xiangqian Zhang, Ligang Chen, Mingyang Li, Qingge Jia, Junyang Song, Jin Liu
Summary: The study found that UCHL1 was overexpressed in TNBC tissues and was associated with poor prognosis. UCHL1 promoted cancer stemness and enhanced the migration and invasion ability of TNBC cells. These findings suggest that UCHL1 may play a crucial role in the malignant progression of TNBC and could be a potential therapeutic target for TNBC patients.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Cell Biology
Ruixue Yang, Mei Yi, Bo Xiang
Summary: Chemotherapy is an important treatment for cancer, but drug resistance is a major obstacle. Aberrant lipid metabolism is closely related to drug resistance, and novel therapeutic strategies targeting lipid metabolism show promise in overcoming resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Miku Sato, Narumi Harada-Shoji, Takafumi Toyohara, Tomoyoshi Soga, Masatoshi Itoh, Minoru Miyashita, Hiroshi Tada, Masakazu Amari, Naohiko Anzai, Shozo Furumoto, Takaaki Abe, Takashi Suzuki, Takanori Ishida, Hironobu Sasano
Summary: The study found that L-type amino acid transporter-1 (LAT1) plays an important role in therapeutic resistance and clinical outcomes of breast cancer. Glucose and amino acid metabolism were closely related, and in vitro experiments showed that LAT1 promoted amino acid uptake for energy production. Oncometabolites and branched-chain amino acids were also key players in energy production and drug resistance in chemotherapeutic-treated MCF-7 cells.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Wanfu Wu, Margaret Warner, Li Wang, Wei-Wei He, Ruipeng Zhao, Xiaoxiang Guan, Cindy Botero, Bo Huang, Charlotte Ion, Charles Coombes, Jan-Ake Gustafsson
Summary: Comparing gene expression profiles of malignant parts and normal adjacent parts of TNBC breasts revealed that CYP-mediated pathways may drive TNBC. However, despite being expressed in TNBC, ER13 is unlikely to be a tumor suppressor as its absence of main tethering partners renders it ineffective on genes related to proliferation and inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Medicine, General & Internal
Ron Bose, Cynthia X. Ma
Summary: A recent study suggests that HER2-mutated breast cancer may develop resistance to drugs that inhibit the tyrosine kinase domain of HER2 through developing mutations in HER3, which enhance the dimerization between HER2 and HER3. The HER3 mutations augment signaling. This study supports a specific approach to overcoming mutant-HER3-mediated resistance.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yirong Zhang, Yajie Shen, Weiqing Wei, Wenhan Wang, Daiji Jiang, Yizhuo Ren, Zijing Peng, Qiuju Fan, Jinke Cheng, Jiao Ma
Summary: SIRT3 SUMOylation plays a critical role in regulating chemoresistance in AML by modulating HES1-dependent FAO. Targeted interventions towards SIRT3 SUMOylation and FAO may improve chemotherapies for AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)