Mechanisms of Action of Hypomethylating Agents: Endogenous Retroelements at the Epicenter
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Title
Mechanisms of Action of Hypomethylating Agents: Endogenous Retroelements at the Epicenter
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-03-09
DOI
10.3389/fonc.2021.650473
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Note: Only part of the references are listed.- Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3− T cells represents a potential antitumor mechanism of azacitidine
- (2021) Eleftheria Lamprianidou et al. Blood Advances
- Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity are Linked to Clinical Responses to 5-Azacytidine
- (2020) Hitoshi Ohtani et al. CANCER RESEARCH
- Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
- (2020) Özgen Deniz et al. Nature Communications
- Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
- (2020) Parinaz Mehdipour et al. NATURE
- OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug
- (2019) Shuvojit Banerjee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transposable elements drive widespread expression of oncogenes in human cancers
- (2019) Hyo Sik Jang et al. NATURE GENETICS
- Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled
- (2019) Jan Philipp Bewersdorf et al. Expert Review of Anticancer Therapy
- Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine
- (2019) Myrna R. Nahas et al. BRITISH JOURNAL OF HAEMATOLOGY
- Genetics of MDS
- (2019) Seishi Ogawa BLOOD
- Multifaceted modes of action of azacytidine: a riddle wrapped up in an enigma
- (2019) Eleftheria Lamprianidou et al. LEUKEMIA & LYMPHOMA
- Azacytidine failure revisited: an appraisal based on real life data from the MDS registry of the Hellenic Myelodysplastic Syndrome Study Group (HMDS).
- (2019) IOANNIS KOTSIANIDIS Mediterranean Journal of Hematology and Infectious Diseases
- The emerging role of epigenetic therapeutics in immuno-oncology
- (2019) Michael J. Topper et al. Nature Reviews Clinical Oncology
- The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation of Azacitidine) in Patients with Acute Myeloid Leukemia (AML) in First Remission
- (2019) Andrew H. Wei et al. BLOOD
- Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes
- (2019) Guillermo Montalban-Bravo et al. LEUKEMIA
- Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression
- (2019) Anastasiya Kazachenka et al. Genome Medicine
- LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
- (2018) Wanqiang Sheng et al. CELL
- Intrinsic Immunity Shapes Viral Resistance of Stem Cells
- (2018) Xianfang Wu et al. CELL
- The Immune Landscape of Cancer
- (2018) Vésteinn Thorsson et al. IMMUNITY
- Nucleosidic DNA demethylating epigenetic drugs – A comprehensive review from discovery to clinic
- (2018) Khushboo Agrawal et al. PHARMACOLOGY & THERAPEUTICS
- Counseling patients with higher-risk MDS regarding survival with azacitidine therapy: are we using realistic estimates?
- (2018) Amer M. Zeidan et al. Blood Cancer Journal
- Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells
- (2018) Minmin Liu et al. CANCER RESEARCH
- How I treat MDS after hypomethylating agent failure
- (2018) Valeria Santini BLOOD
- Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome
- (2018) Kevin K. Leung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transposable Element Expression in Acute Myeloid Leukemia Transcriptome and Prognosis
- (2018) Anthony R. Colombo et al. Scientific Reports
- ADAR1 Editing and its Role in Cancer
- (2018) Li-Di Xu et al. Genes
- Somatic SETBP1 mutations in myeloid neoplasms
- (2017) Hideki Makishima INTERNATIONAL JOURNAL OF HEMATOLOGY
- Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia
- (2017) Trinna L. Cuellar et al. JOURNAL OF CELL BIOLOGY
- RNA editing signature during myeloid leukemia cell differentiation
- (2017) C Rossetti et al. LEUKEMIA
- CDK4/6 inhibition triggers anti-tumour immunity
- (2017) Shom Goel et al. NATURE
- Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer
- (2017) George Kassiotis et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Immunological effects of hypomethylating agents
- (2017) Katherine E. Lindblad et al. Expert Review of Hematology
- Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes
- (2017) Ashwin Unnikrishnan et al. Cell Reports
- Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells
- (2017) Shayda Hemmati et al. Frontiers in Oncology
- ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis
- (2016) Maria Anna Zipeto et al. Cell Stem Cell
- Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment
- (2016) Yan Cui et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine
- (2016) Minmin Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis
- (2016) Kiranmai Gumireddy et al. Nature Communications
- International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts
- (2015) H. Dombret et al. BLOOD
- The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers
- (2015) Leng Han et al. CANCER CELL
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- (2015) Katherine B. Chiappinelli et al. CELL
- The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine
- (2015) P. Miltiades et al. CLINICAL CANCER RESEARCH
- Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis
- (2015) Einav Shoshan et al. NATURE CELL BIOLOGY
- Onco-exaptation of an endogenous retroviral LTR drives IRF5 expression in Hodgkin lymphoma
- (2015) A Babaian et al. ONCOGENE
- RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
- (2015) B. J. Liddicoat et al. SCIENCE
- Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents
- (2015) Erika Héninger et al. Frontiers in Immunology
- Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
- (2015) Huili Li et al. Oncotarget
- Why methylation is not a marker predictive of response to hypomethylating agents
- (2014) M. T. Voso et al. HAEMATOLOGICA
- Endogenous Retroviruses and the Development of Cancer
- (2014) G. Kassiotis JOURNAL OF IMMUNOLOGY
- Endogenous retrovirus induces leukemia in a xenograft mouse model for primary myelofibrosis
- (2014) I. Triviai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genomic impact of transient low-dose decitabine treatment on primary AML cells
- (2013) J. M. Klco et al. BLOOD
- Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents
- (2013) H Yang et al. LEUKEMIA
- Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
- (2013) Christoph Plass et al. NATURE REVIEWS GENETICS
- Concise Drug Review: Azacitidine and Decitabine
- (2013) E. J. B. Derissen et al. ONCOLOGIST
- Epigenetic Reprogramming in Cancer
- (2013) M. L. Suva et al. SCIENCE
- Endogenous retroviruses: acquisition, amplification and taming of genome invaders
- (2013) Marie Dewannieux et al. Current Opinion in Virology
- Cancer Epigenetics: From Mechanism to Therapy
- (2012) Mark A. Dawson et al. CELL
- Human Transposon Tectonics
- (2012) Kathleen H. Burns et al. CELL
- Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia
- (2012) Hagop M. Kantarjian et al. JOURNAL OF CLINICAL ONCOLOGY
- Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
- (2012) Gillian I Rice et al. NATURE GENETICS
- LINE-1 Elements in Structural Variation and Disease
- (2011) Christine R. Beck et al. Annual Review of Genomics and Human Genetics
- Endogenous retrovirus sequences as a novel class of tumor-specific antigens: an example of HERV-H env encoding strong CTL epitopes
- (2011) Christina S. Mullins et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Outcome of High-Risk Myelodysplastic Syndrome After Azacitidine Treatment Failure
- (2011) Thomas Prébet et al. JOURNAL OF CLINICAL ONCOLOGY
- Failure of Hypomethylating Agent–Based Therapy in Myelodysplastic Syndromes
- (2011) Tapan M. Kadia et al. SEMINARS IN ONCOLOGY
- Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting
- (2009) L. I. Sanchez-Abarca et al. BLOOD
- Epigenetic mechanisms of regulation of Foxp3 expression
- (2009) G. Lal et al. BLOOD
- An operational definition of epigenetics
- (2009) S. L. Berger et al. GENES & DEVELOPMENT
- Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
- (2009) Pierre Fenaux et al. LANCET ONCOLOGY
- Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients
- (2008) F. Wang-Johanning et al. CANCER RESEARCH
- Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
- (2008) Carlo Stresemann et al. INTERNATIONAL JOURNAL OF CANCER
- Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells
- (2008) Yoshiyuki Takahashi et al. JOURNAL OF CLINICAL INVESTIGATION
- Azacytidine causes complex DNA methylation responses in myeloid leukemia
- (2008) C. Stresemann et al. MOLECULAR CANCER THERAPEUTICS
- Deregulation of Signaling Pathways in Acute Myeloid Leukemia
- (2008) Claudia Scholl et al. SEMINARS IN ONCOLOGY
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