Article
Neurosciences
Michele Bailo, Nicolo Pecco, Marcella Callea, Paola Scifo, Filippo Gagliardi, Luca Presotto, Valentino Bettinardi, Federico Fallanca, Paola Mapelli, Luigi Gianolli, Claudio Doglioni, Nicoletta Anzalone, Maria Picchio, Pietro Mortini, Andrea Falini, Antonella Castellano
Summary: This study evaluates an innovative PET and MRI approach for assessing hypoxia, perfusion, and tissue diffusion in high-grade gliomas (HGGs) and derives a combined map for clustering of intra-tumor heterogeneity. The results demonstrate a reliable correlation between the PET and MRI habitat maps and histopathological features, indicating the importance of understanding tumor heterogeneity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia C. Carmona-Bozo, Roido Manavaki, Ramona Woitek, Turid Torheim, Gabrielle C. Baxter, Corradina Caraco, Elena Provenzano, Martin J. Graves, Tim D. Fryer, Andrew J. Patterson, Fiona J. Gilbert
Summary: Through combined (18)F-FMISO-PET/MRI, we found a relationship between hypoxia and vascular function in breast cancer, highlighting the heterogeneity within tumour regions. Hypoxia was positively correlated with lesion size, but negatively correlated with DCE-MRI parameters.
EUROPEAN RADIOLOGY
(2021)
Review
Medicine, General & Internal
Tineke van de Weijer, Martijn P. G. Broen, Rik P. M. Moonen, Ann Hoeben, Monique Anten, Koos Hovinga, Inge Compter, Jochem A. J. van der Pol, Cristina Mitea, Toine M. Lodewick, Arnaud Jacquerie, Felix M. Mottaghy, Joachim E. Wildberger, Alida A. Postma
Summary: Gliomas, the most frequent primary brain tumors, have prognosis and treatment dependent on grade and molecular markers. Multi-parametric MRI and F-18-FET PET imaging techniques are valuable for the evaluation of gliomas.
Article
Oncology
Ye Cheng, Shuangshuang Song, Yukui Wei, Geng Xu, Yang An, Jie Ma, Hongwei Yang, Zhigang Qi, Xinru Xiao, Jie Bai, Lixin Xu, Zeliang Hu, Tingting Sun, Leiming Wang, Jie Lu, Qingtang Lin
Summary: This study established accurate diagnostic criteria for gliomas based on FET-PET and DWI, identifying correlations between different gene mutations and imaging values, providing higher diagnostic accuracy for high-grade gliomas with IDH1, hTERT, and EGFR mutations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Roberta Fusco, Vincenza Granata, Mauro Mattace Raso, Paolo Vallone, Alessandro Pasquale De Rosa, Claudio Siani, Maurizio Di Bonito, Antonella Petrillo, Mario Sansone
Summary: The study aimed to differentiate benign and malignant breast lesions by combining BOLD-MRI, DCE-MRI, and DW-MRI, but found that the combined use of these imaging techniques did not provide a significant improvement compared to using DCE-MRI alone. An interesting result was the negative correlation between R-2* and D.
Article
Biochemistry & Molecular Biology
David Gergo Nagy, Imre Fedorcsak, Attila Gyorgy Bago, Georgina Gati, Janos Martos, Peter Szabo, Hajnalka Rajnai, Istvan Kenessey, Katalin Borbely
Summary: Amino acid PET/CT outperforms enhanced MRI in sensitivity and negative predictive value for the primary diagnosis of primary malignant brain tumors, but is inferior in terms of specificity.
Review
Oncology
Wynton B. Overcast, Korbin M. Davis, Chang Y. Ho, Gary D. Hutchins, Mark A. Green, Brian D. Graner, Michael C. Veronesi
Summary: This review discusses the latest advances in brain tumor imaging, focusing on the complementary nature of MRI and PET imaging techniques, as well as the advantages of advanced MRI techniques and the specificity of PET in tumor diagnosis.
CURRENT ONCOLOGY REPORTS
(2021)
Review
Medicine, General & Internal
Giulia Santo, Riccardo Laudicella, Flavia Linguanti, Anna Giulia Nappi, Elisabetta Abenavoli, Vittoria Vergura, Giuseppe Rubini, Roberto Sciagra, Gaspare Arnone, Orazio Schillaci, Fabio Minutoli, Sergio Baldari, Natale Quartuccio, Sotirios Bisdas
Summary: This comprehensive review evaluates the utility of amino acid PET radiotracers compared to MRI in assessing glioma recurrence. The study found that amino acid PET provides complementary and comparable information to standard modalities, making it an essential tool for differentiation between tumor recurrence and other entities.
Article
Oncology
Hui Ma, Jing Zhao, Shaoyu Liu, Dingxiang Xie, Zhanwen Zhang, Dahong Nie, Fuhua Wen, Zhiyun Yang, Ganghua Tang
Summary: This study aimed to explore the potential application of F-18-trifluoromethylated D-cysteine (S-[F-18]CF3-D-CYS) in evaluating glioma using orthotopic C6 glioma models. The results showed that S-[F-18]CF3-D-CYS PET performed well in the diagnosis and evaluation of glioma, suggesting its potential as a valuable tool in the clinical management of gliomas.
FRONTIERS IN ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
R. Laudicella, N. Quartuccio, G. Argiroffi, P. Alongi, L. Baratto, E. Califaretti, V Frantellizzi, G. De Vincentis, A. Del Sole, L. Evangelista, S. Baldari, S. Bisdas, Francesco Ceci, Andrei Iagaru
Summary: The current use of non-amino acid PET radiopharmaceuticals for assessing perfusion, angiogenesis, hypoxia, neuroinflammation, cell proliferation, tumor invasiveness, and other biological features in glioma patients is limited. Further exploration of investigational PET radiopharmaceuticals and studies validating their potential are necessary for clinical translation in glioma assessment.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, Research & Experimental
Nabil A. Siddiqui, Hailey A. Houson, Nitin S. Kamble, Jose R. Blanco, Robert E. O'Donnell, Daniel J. Hassett, Suzanne E. Lapi, Nalinikanth Kotagiri
Summary: The need for accurate and rapid identification of bacteria in the human body for diverse biomedical objectives is increasing. The development of a copper-64-labeled bacterial metal chelator, yersiniabactin, utilizes a highly conserved metal acquisition pathway for noninvasive and selective imaging of bacteria. This simplified strategy combines metal attachment and cell recognition functions into the same molecule, enabling the identification of specific bacterial populations, monitoring antibiotic treatment outcomes, and tracking bacteria in diverse niches in vivo.
Review
Pharmacology & Pharmacy
Anh Thu Nguyen, Hee-Kwon Kim
Summary: Hypoxia, a common feature of solid tumors, can induce many cancer characteristics and is associated with metastases and resistance to therapy. Non-invasive imaging methods using hypoxia-targeting radiopharmaceuticals have been used for tumor hypoxia detection and therapy. Nitroimidazoles, which can selectively bind to intracellular macromolecules under hypoxic conditions, have been the focus of PET and SPECT radiotracer development for imaging and treatment of hypoxic tumors. This review summarizes the development of novel PET and SPECT radiotracers containing nitroimidazoles, including their physicochemical properties, cellular uptake values, biodistribution, and imaging results.
Article
Radiology, Nuclear Medicine & Medical Imaging
K. J. Paprottka, S. Kleiner, C. Preibisch, F. Kofler, F. Schmidt-Graf, C. Delbridge, D. Bernhardt, S. E. Combs, J. Gempt, B. Meyer, C. Zimmer, B. H. Menze, I Yakushev, J. S. Kirschke, B. Wiestler
Summary: By fully automated analysis of [F-18]-FET-PET and MRI data, including deep learning algorithms, successful differentiation of tumor progression and treatment-related changes in 77% of cases was achieved, demonstrating the potential application value of this method in patients with glioma.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Lelio Guida, Vittorio Stumpo, Jacopo Bellomo, Christiaan Hendrik Bas van Niftrik, Martina Seboek, Moncef Berhouma, Andrea Bink, Michael Weller, Zsolt Kulcsar, Luca Regli, Jorn Fierstra
Summary: This first part of the review series provides an overview and critical discussion of the hemodynamic imaging applications in diffuse gliomas and highlights the challenges and limitations in current standard neuroimaging.
Article
Computer Science, Interdisciplinary Applications
Christoph W. Lerche, Timon Radomski, Philipp Lohmann, Liliana Caldeira, Claudia Regio Brambilla, Lutz Tellmann, Juergen Scheins, Elena Rota Kops, Norbert Galldiks, Karl-Josef Langen, Hans Herzog, N. Jon Shah
Summary: A linearized model for dynamic PET scans of F-18-FET TACs was derived and validated in this study, showing high agreement with measured TACs and small parameter uncertainties. The model demonstrated good diagnostic performance in discriminating between IDH wildtype and IDH mutant gliomas in adult patients. Voxel-wise fitting within a short computation time and comparable classification accuracy to linear fits based on average TAC values were achievable.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Clinical Neurology
Luigi Albano, Marco Losa, Giorgio Spatola, Pietro Panni, Maria Rosa Terreni, Lina Raffaella Barzaghi, Pietro Mortini
Summary: Sellar melanocytomas are benign, slow-growing tumors with a high risk of recurrence. This study reported two cases treated at the same institute, with one undergoing gross total resection and the other undergoing subtotal resection followed by gamma knife radiosurgery.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Natale Quartuccio, Federica Agugliaro, Pierpaolo Alongi, Letterio Sturiale, Gaspare Arnone, Salvatore Corrao
Summary: This systematic review compared lymphoscintigraphy and MRI techniques for the diagnosis of peripheral lymphedema and found inconclusive evidence on the superiority of one imaging technique over the other. Further studies are needed to compare the accuracy of these imaging modalities.
CURRENT MEDICAL IMAGING
(2023)
Article
Oncology
Giuseppe Minniti, Paolo Tini, Martina Giraffa, Luca Capone, Giorgio Raza, Ivana Russo, Elisa Cinelli, PierCarlo Gentile, Alessandro Bozzao, Sergio Paolini, Vincenzo Esposito
Summary: The purpose of this study was to analyze recurrence patterns in glioblastoma (GBM) patients after standard chemoradiation using different target volume delineation strategies. 207 GBM patients who recurred after standard chemoradiation were evaluated. Recurrent lesions were classified as in-field, marginal, or distant, and a theoretical plan with a reduced margin was created for comparison.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Paolo Tini, Mariya Yavoroska, Maria Antonietta Mazzei, Clelia Miracco, Luigi Pirtoli, Miriam Tomaciello, Francesco Marampon, Giuseppe Minniti
Summary: In this study, the prognostic role of Ki-67/MIB-1-LI in IDHwt GBM patients was retrospectively investigated, and a positive correlation between Ki-67/MIB-1-LI expression < 15% and overall survival was found. This correlation was independent of patient age, Karnofsky performance status scale, extent of surgery, and O6-MeG-DNA methyltransferase promoter methylation status.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Oncology
Tamara Ius, Giovanni Sabatino, Pier Paolo Panciani, Marco Maria Fontanella, Roberta Ruda, Antonella Castellano, Giuseppe Maria Vincenzo Barbagallo, Francesco Belotti, Riccardo Boccaletti, Giuseppe Catapano, Gabriele Costantino, Alessandro Della Puppa, Francesco Di Meco, Filippo Gagliardi, Diego Garbossa, Antonino Francesco Germano, Maurizio Iacoangeli, Pietro Mortini, Alessandro Olivi, Federico Pessina, Fabrizio Pignotti, Giampietro Pinna, Antonino Raco, Francesco Sala, Francesco Signorelli, Silvio Sarubbo, Miran Skrap, Giannantonio Spena, Teresa Somma, Carmelo Sturiale, Filippo Flavio Angileri, Vincenzo Esposito
Summary: The aim of this article is to provide an overview of the current trends and technical tools to achieve maximal safe resection in adult patients with Grade 4 Glioma. The results show that the use of Dexamethasone and avoidance of prophylaxis with anti-seizure medications are important in improving overall survival.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Luigi Albano, Silvia Basaia, Daniele Emedoli, Roberta Balestrino, Edoardo Pompeo, Lina Raffaella Barzaghi, Antonella Castellano, Andrea Falini, Sandro Iannaccone, Pietro Mortini, Massimo Filippi, Federica Agosta
Summary: This study aimed to assess the resting-state functional connectivity between thalamic ventral intermediate nucleus (Vim) and the rest of the brain before and after thalamotomy in Parkinson's disease (PD) patients. The results showed that the functional connectivity between Vim and visual areas increased before treatment and was restored after 1 year of treatment. Furthermore, the reduction in connectivity between left Vim and left visual cortex was associated with the improvement of tremor symptoms.
JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Luigia Brugliera, Sandro Iannaccone, Gianluca Nocera, Paolo Cimino, Giuseppe D'Angelo, Pietro Mortini, Paolo Capodaglio, Alfio Spina
JOURNAL OF NEUROSURGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Daniela Prosperi, Luciano Carideo, Vincenzo Marcello Russo, Rosaria Meucci, Giuseppe Campagna, Secondo Lastoria, Alberto Signore
Summary: Pulmonary carcinoids (PCs) are neuroendocrine neoplasms that can be classified as typical or atypical. The combination of Ga-68-SSA PET/CT and [F-18]FDG PET/CT is essential for the correct management of these tumors, with [F-18]FDG playing a particularly important role in the clinical practice of aggressive atypical carcinoids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Matteo Figini, Antonella Castellano, Michele Bailo, Marcella Callea, Marcello Cadioli, Samira Bouyagoub, Marco Palombo, Valentina Pieri, Pietro Mortini, Andrea Falini, Daniel C. Alexander, Mara Cercignani, Eleftheria Panagiotaki
Summary: The aim of this study was to expand the VERDICT-MRI framework to model brain tumors and characterize cellular and vascular features. Diffusion MRI data were collected from 21 patients with different types of brain tumors. Different diffusion models were fitted and compared based on their ability to characterize key tumor components. The best-performing model showed agreement with histology and had potential for differentiating tumor types and sub-regions.
Letter
Clinical Neurology
Valentina Pieri, Giulia Berzero, Rosina Paterra, Laura Ferre, Alessandro Tomelleri, Corrado Campochiaro, Federica Esposito, Teresa Calimeri, Maria Giulia Cangi, Nazario Pio Tenace, Andres Jose Maria Ferreri, Antonella Castellano, Maurizio Barbera, Nicoletta Anzalone, Lorenzo Gabriel Gay, Lorenzo Bello, Maurizio Colecchia, Maurilio Ponzoni, Gaetano Finocchiaro, Massimo Filippi
JOURNAL OF NEUROLOGY
(2023)
Review
Oncology
Andrea Romano, Giulia Moltoni, Antonella Blandino, Serena Palizzi, Allegra Romano, Giulia de Rosa, Lara De Blasi Palma, Cristiana Monopoli, Alessia Guarnera, Giuseppe Minniti, Alessandro Bozzao
Summary: Stereotactic radiosurgery is an important treatment for brain metastases, but it can cause brain changes that are difficult to distinguish from disease progression. This review evaluates the most effective imaging techniques for assessing radiation-induced changes and distinguishing them from tumor growth.
Article
Clinical Neurology
Marco Riva, Stephen M. Wilson, Ruofan Cai, Antonella Castellano, Kesshi M. Jordan, Roland G. Henry, Maria Luisa Gorno Tempini, Mitchel S. Berger, Edward F. Chang
Summary: Electrocortical stimulation mapping (ECS) was used during awake surgery in 6 patients to investigate sentence-level processing. Stimulation of the inferior frontal gyrus disrupted comprehension of passive sentences in all subjects, while simpler tasks remained unaffected. These findings suggest the presence of language regions that contribute differently to sentence processing, and sentence-level tasks are best for identifying them. The functional consequences of resecting these sites need further investigation.
JOURNAL OF NEUROSURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerome Hodel, Meike W. Vernooij, Mona K. Beyer, Mariasavina Severino, Xavier Leclerc, Alain Creange, Abir Wahab, Neesmah Badat, Sarah Toledano, Luc van den Hauwe, Ana Ramos, Antonella Castellano, Alexandre Krainik, Tarek Yousry, Alex Rovira
Summary: This study evaluated compliance with recommendations in imaging for multiple sclerosis (MS). The results showed that while MS imaging practices are relatively consistent across Europe, there is still partial adherence to recommendations.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Raphael Bodensohn, Sebastian H. Maier, Claus Belka, Giuseppe Minniti, Maximilian Niyazi
Summary: In the past year, there have been improvements in cancer treatment, especially for cancers that have spread throughout the body. However, treating tumors that spread to the brain, causing brain metastases, is still a challenge. Local treatments like stereotactic radiosurgery are important for addressing brain metastases.
Review
Obstetrics & Gynecology
Mariano Catello Di Donna, Natale Quartuccio, Vincenzo Giallombardo, Letterio Sturiale, Annachiara Arnone, Rosaria Ricapito, Giulio Sozzi, Gaspare Arnone, Vito Chiantera
Summary: This meta-analysis suggests that the use of ICG and PL, alone or in combination, is favored over blue dye for the detection of sentinel lymph nodes in vulvar cancer. Future studies may investigate the combined approach for achieving the highest detection rate in patients with vulvar cancer.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)