Renaming NAFLD to MAFLD: Could the LDE System Assist in This Transition?

Our understanding of fatty liver syndromes and their relationship with the metabolic syndrome has improved over recent decades and, paralleling this, we are now at the dawn of the NAFLD (nonalcoholic fatty liver disease) to MAFLD (metabolic-associated fatty liver disease) transition. The pitfalls of NAFLD diagnosis, together with disappointing results in therapeutic trials, and the inconsistencies and risks inherent in a negative definition (such as nonalcoholic) as opposed to a positive one (i.e., metabolic) are predicted to facilitate the proposed renaming of NAFLD to MAFLD. However, a premature change of terminology would not necessarily address major unmet needs in this area, and may even become counterproductive. As an aid to selecting more homogeneous cohorts of patients, I propose the LDE (Liver, Determinants, Extra-hepatic) classification system which, in principle, may help to assess the natural course of disease as well as the efficacy of novel drugs in patients with NAFLD/MAFLD.

Automated summary

As our understanding of fatty liver syndromes and their association with metabolic syndrome improves, the transition from NAFLD to MAFLD is approaching. However, a premature change in terminology may not necessarily address major unmet needs.