Article
Medicine, General & Internal
A. W. Thille, A. Gacouin, Remi Coudroy, Stephan Ehrmann, Jean-Pierre Frat, Mai-Anh Nay, Christophe Guitton, Damien Contou, Guylaine Labro, Jean Reignier, Gael Pradel, Gaetan Beduneau, Laurence Dangers, Clement Saccheri, Gwenael Prat, Guillaume Lacave, Nicholas Sedillot, Nicolas Terzi, Beatrice La Combe, Jean-Paul Mira, Antoine Romen, Marie-Ange Azais, Anahita Rouze, Jerome Devaquet, Agathe Delbove, Martin Dres, Jeremy Bourenne, Alexandre Lautrette, Joe de Keizer, Stephanie Ragot, Jean-Pierre Frat
Summary: For patients at high risk of extubation failure, using pressure-support ventilation (PSV) or a T-piece for spontaneous-breathing trials did not result in significantly different ventilator-free days at day 28.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
John Selickman, Charikleia S. Vrettou, Spyros D. Mentzelopoulos, John J. Marini
Summary: ARDS is a complex respiratory syndrome, and COVID-19-related ARDS presents with unique clinical features due to the specific pathobiology of SARS-CoV-2. Treatment strategies for C-ARDS may need to be tailored based on these distinctive characteristics.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Maria Consuelo Bachmann, Pablo Cruces, Franco Diaz, Vanessa Oviedo, Mariela Goich, Jose Fuenzalida, Luis Felipe Damiani, Roque Basoalto, Yorschua Jalil, David Carpio, Niki Hamidi Vadeghani, Rodrigo Cornejo, Maximiliano Rovegno, Guillermo Bugedo, Alejandro Bruhn, Jaime Retamal
Summary: Spontaneous breathing during the early stage of acute respiratory failure can lead to lung injury, but this can be prevented by early application of controlled mechanical ventilation. However, late application of controlled mechanical ventilation is ineffective in preventing lung injury in a lung collapse model.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Ines Dufour, Alexis Werion, Leila Belkhir, Anastazja Wisniewska, Marie Perrot, Julien De Greef, Gregory Schmit, Jean Cyr Yombi, Xavier Wittebole, Pierre-Francois Laterre, Michel Jadoul, Ludovic Gerard, Johann Morelle
Summary: Studies have shown that low serum uric acid levels are common among COVID-19 patients and are associated with disease severity and progression to respiratory failure requiring mechanical ventilation.
Review
Medicine, General & Internal
Po-Lan Su, Zhanqi Zhao, Yen-Fen Ko, Chang-Wen Chen, Kuo-Sheng Cheng
Summary: Acute respiratory distress syndrome (ARDS) is characterized by rapid-deteriorating lung injury. Vigorous spontaneous breathing may aggravate lung injury. Increased lung stress and pendelluft are important mechanisms of patient self-inflicted lung injury.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Marta Molinero, Ivan D. Benitez, Jessica Gonzalez, Clara Gort-Paniello, Anna Moncusi-Moix, Fatima Rodriguez-Jara, Maria C. Garcia-Hidalgo, Gerard Torres, J. J. Vengoechea, Silvia Gomez, Ramon Cabo, Jesus Caballero, Jesus F. Bermejo-Martin, Adrian Ceccato, Laia Fernandez-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menendez, Ana Motos, Oscar Penuelas, Jordi Riera, Antoni Torres, Ferran Barbe, David de Gonzalo-Calvo
Summary: This study analyzed the miRNA profile of bronchial aspirate samples from COVID-19 and non-COVID-19 patients, and identified prognostic biomarkers and molecular pathways related to fatal outcomes and adverse events in critically ill patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Mohamed Badr, Bruno De Oliveira, Khaled Abdallah, Ashraf Nadeem, Yeldho Varghese, Dnyaseshwar Munde, Shameen Salam, Baraa Abduljawad, Khaled Saleh, Hussam Elkambergy, Ahmed Taha, Ahmed Bayrlee, Ali Wahla, Jamil Dibu, Rehan Haque, Fadi Hamed, Nadeem Rahman, Jihad Mallat
Summary: The study showed that methylprednisolone was independently associated with increased ventilator-free days and shortened hospital length of stay in patients with COVID-19 ARDS. However, the combination of methylprednisolone and tocilizumab was associated with a higher rate of positive blood cultures. Further trials are needed to evaluate the benefits and safety of methylprednisolone in moderate or severe COVID-19 ARDS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Medicine, General & Internal
Manbong Heo, Jong Hwan Jeong, Sunmi Ju, Seung Jun Lee, Yi Yeong Jeong, Jong Deog Lee, Jung-Wan Yoo
Summary: This study compared the clinical features and outcomes of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and non-SARS-CoV-2 respiratory viruses associated acute respiratory distress syndrome (ARDS). The study found that although there were no significant differences in mortality rates between the two groups, patients with SARS-CoV-2 had longer duration of mechanical ventilation and hospital stay.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Samar Shurbaji, Ibrahim M. El-Sherbiny, Maha Alser, Isra H. Ali, Haya Kordi, Ameena Al-Sadi, Anton Popelka, Fatiha Benslimane, Magdi Yacoub, Huseyin C. Yalcin
Summary: The study demonstrates that NO-releasing nanoparticles can effectively prevent or reduce inflammation and cell injuries caused by ARDS, which is particularly important for treating severe ARDS caused by COVID-19 infection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Krista Stephens, Nathan Mitchell, Sean Overton, Joseph E. Tonna
Summary: This study investigated the transition from mechanical ventilation to spontaneous ventilation in ECMO patients, specifically focusing on changes in breathing patterns. The findings suggest that patients with low compliance experience increased tidal volumes, higher respiratory rates, and other significant changes during this transition. These changes in ventilatory parameters may be associated with worsened lung injury and warrant further prospective study.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yolanda M. Lopez-Fernandez, Amelia Martinez-de-Azagra, Jose M. Gonzalez-Gomez, Cesar Perez-Caballero Macarron, Maria Garcia-Gonzalez, Julio Parrilla-Parrilla, Maria Minambres-Rodriguez, Paula Madurga-Revilla, Ana Gomez-Zamora, Patricia Rodriguez-Campoy, Juan Mayordomo-Colunga, Laura Butragueno-Laiseca, Rocio Nunez-Borrero, Jesus M. Gonzalez-Martin, Arthur S. Slutsky, Jesus Villar
Summary: This study found that children with AHRF due to SARS-CoV2 infection had fewer comorbidities and better oxygenation than patients with non-COVID-19 AHRF. Progression to severe PARDS was rarely observed in children with COVID-19 in this study.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Laura Pasin, Dario Gregori, Tommaso Pettenuzzo, Alessandro De Cassai, Annalisa Boscolo, Nicolo Sella, Giulia Lorenzoni, Federico Geraldini, Elisa Pistollato, Vito Marco Ranieri, Giovanni Landoni, Paolo Rosi, Paolo Navalesi
Summary: This study compared the outcomes of COVID-19 patients with hypoxemic acute respiratory failure (hARF) who received either non-invasive ventilation (NIV) or direct intubation. The results showed that attempting a trial of NIV prior to intubation in COVID-19 patients significantly reduced in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Kyeong Tae Kim, Jennifer Knopp, J. Geoffrey Chase
Summary: This study introduces two model-based non-invasive methods for quantifying spontaneous breathing effort in invasively ventilated patients. The results demonstrate consistent metrics between the two methods, providing computationally simple and cost-effective ways to estimate patient-specific lung mechanics.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Respiratory System
Claudia Crimi, Alberto Noto, Fabiana Madotto, Mariachiara Ippolito, Santi Nolasco, Raffaele Campisi, Stefano De Vuono, Giuseppe Fiorentino, Ioannis Pantazopoulos, Athanasios Chalkias, Alessandro Libra, Alessio Mattei, Raffaele Scala, Enrico M. Clini, Begum Ergan, Manel Lujan, Joao Carlos Winck, Antonino Giarratano, Annalisa Carlucci, Cesare Gregoretti, Paolo Groff, Andrea Cortegiani
Summary: Among patients with COVID-19 pneumonia and mild hypoxaemia, the use of HFNO did not significantly reduce the likelihood of escalation of respiratory support.
Letter
Respiratory System
A. Verduri, J. Hewitt, B. Carter, R. Tonelli, E. Clini, B. Beghe
Letter
Critical Care Medicine
Roberto Tonelli, Andrea Cortegiani, Riccardo Fantini, Luca Tabbi, Ivana Castaniere, Giulia Bruzzi, Stefano Busani, Lorenzo Ball, Enrico Clini, Alessandro Marchioni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Virology
Cristina Mussini, Alessandro Cozzi-Lepri, Marianna Meschiari, Erica Franceschini, Giulia Burastero, Matteo Faltoni, Giacomo Franceschi, Vittorio Iadisernia, Sara Volpi, Andrea Dessilani, Licia Gozzi, Jacopo Conti, Martina Del Monte, Jovana Milic, Vanni Borghi, Roberto Tonelli, Lucio Brugioni, Elisa Romagnoli, Antonello Pietrangelo, Elena Corradini, Massimo Girardis, Stefano Busani, Andrea Cossarizza, Enrico Clini, Giovanni Guaraldi
Summary: This observational cohort study evaluated the mortality rate of severe COVID-19 pneumonia patients treated with glucocorticoids + tocilizumab. The study found that the combination therapy was associated with a lower mortality rate, especially in patients with high CRP levels. These results suggest that the CRP level prior to treatment initiation may serve as an important indicator for the use of this treatment regimen.
Article
Medicine, General & Internal
Emanuela Biagioni, Elena Ferrari, Ilenia Gatto, Lucia Serio, Carlotta Farinelli, Irene Coloretti, Marta Talamonti, Martina Tosi, Marianna Meschiari, Roberto Tonelli, Claudia Venturelli, Cristina Mussini, Enrico Clini, Mario Sarti, Andrea Cossarizza, Stefano Busani, Massimo Girardis
Summary: The aim of this study was to evaluate the effectiveness of introducing Selective Digestive Decontamination (SDD) in a structured protocol for ventilator-associated pneumonia (VAP) prevention in reducing VAP occurrence without affecting antibiotic resistance. The study included adult COVID-19 patients requiring invasive mechanical ventilation (IMV) in three Italian COVID-19 intensive care units (ICUs) from February 22, 2020, to March 8, 2022. SDD, consisting of tobramycin sulfate, colistin sulfate, and amphotericin B, was introduced in the VAP prevention protocol from late April 2021. The occurrence of VAP decreased by 7.7% in patients who received SDD compared to those who did not. Multivariate analysis showed that the use of SDD significantly reduced VAP occurrence. This observational study suggests that incorporating SDD in a structured protocol for VAP prevention can effectively reduce VAP occurrence in COVID-19 patients without impacting antibiotic resistance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Francesco Mattioli, Edoardo Serafini, Alessandro Andreani, Gaia Cappiello, Daniele Marchioni, Massimo Pinelli, Roberto Tonelli, Enrico Clini, Alessandro Marchioni
Summary: This paper presents a case report of bronchoscopic fistula closure using autologous fascia lata graft placement in a patient with pulmonary squamous cell carcinoma. The esophageal stent was retained due to the high risk associated with its removal. After 7 months of treatment, no recurrence of tracheoesophageal fistula was observed.
FRONTIERS IN SURGERY
(2023)
Review
Geriatrics & Gerontology
Alessia Verduri, Ben Carter, Ceara Rice, James Laraman, Eleanor Barton, Enrico Clini, Nick A. Maskell, Jonathan Hewitt
Summary: This article investigates the prevalence and impact of frailty in adult patients with interstitial lung disease (ILD), asthma, and pleural disease. The prevalence of frailty in asthma was found to be 9.5%, and in ILD, it was 48%. The study also found that frail ILD patients have an increased risk of long-term mortality.
Article
Respiratory System
Irene Coloretti, Carlotta Farinelli, Emanuela Biagioni, Ilenia Gatto, Elena Munari, Lorenzo Dall'Ara, Stefano Busani, Marianna Meschiari, Roberto Tonelli, Cristina Mussini, Giovanni Guaraldi, Andrea Cossarizza, Enrico Clini, Massimo Girardis
Summary: This retrospective study investigates whether the outcomes of COVID-19 patients admitted to the ICU improved with the progressive knowledge and development of therapeutic strategies. The study found that despite the increasing understanding of the disease and specific treatments, there was no significant improvement in mortality rates between different waves of the pandemic. However, the hospital mortality rate was reduced in the third wave.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Infectious Diseases
Simone Campani, Marta Talamonti, Lorenzo Dall'Ara, Irene Coloretti, Ilenia Gatto, Emanuela Biagioni, Martina Tosi, Marianna Meschiari, Roberto Tonelli, Enrico Clini, Andrea Cossarizza, Giovanni Guaraldi, Cristina Mussini, Mario Sarti, Tommaso Trenti, Massimo Girardis
Summary: The study aimed to evaluate the association of PCT and CRP with secondary infections acquired during ICU stay in critically ill COVID-19 patients. The results showed that PCT and CRP values were associated with infections acquired during the ICU stay and can be used to support the diagnosis of these infections.
Article
Medicine, General & Internal
Alessia Laneri, Stefania Cerri, Giovanni Della Casa, Antonio Moretti, Andreina Manfredi, Marco Sebastiani, Enrico Clini, Carlo Salvarani
Summary: This case report highlights the challenges in differentiating COVID-19 sequelae with fibrotic features from preexisting pSS-ILD. A wait and see approach was taken, and the patient's clinical symptoms and radiologic manifestations eventually resolved.
CASE REPORTS IN MEDICINE
(2023)
Article
Virology
Valeria Caciagli, Irene Coloretti, Marta Talamonti, Carlotta Farinelli, Ilenia Gatto, Emanuela Biagioni, Mario Sarti, Erica Franceschini, Marianna Meschiari, Cristina Mussini, Roberto Tonelli, Enrico Clini, Massimo Girardis, Stefano Busani
Summary: CMV reactivation is common in critically ill COVID-19 patients with prior CAPA diagnosis. Basal immunosuppression before COVID-19 appears to be the primary independent variable affecting CMV reactivation in patients with CAPA. Furthermore, the association of CAPA+CMV versus CAPA alone appears to impact ICU length of stay and secondary bacterial infections but not mortality.
Article
Critical Care Medicine
Roberto Tonelli, Salvatore Grasso, Andrea Cortegiani, Lorenzo Ball, Ivana Castaniere, Luca Tabbi, Riccardo Fantini, Dario Andrisani, Filippo Gozzi, Antonio Moretti, Giulia Bruzzi, Linda Manicardi, Stefania Cerri, Anna Valeria Samarelli, Giulia Raineri, Francesco Murgolo, Andrea Carzoli, Rossella Di Mussi, Stefano Busani, Raffaella Rizzoni, Giacomo Grasselli, Enrico Clini, Alessandro Marchioni
Summary: This study aims to investigate the physiological effects of lung-protective ventilation in patients with AE-ILD-UIP and compare it with primary ARDS. The findings indicate that, unlike patients with primary ARDS, adjusting positive end-expiratory pressure to achieve a positive transpulmonary pressure significantly worsened lung mechanics in mechanically ventilated AE-ILD-UIP patients.
