Article
Biochemistry & Molecular Biology
Susan T. Veissi, Tijmen van den Berge, Joanna A. E. van Wijk, Thea van der Velden, Rene Classens, Lynn Lunsonga, Rick Brockotter, Charlotte Kaffa, Sander Bervoets, Bart Smeets, Lambertus P. W. J. van den Heuvel, Michiel F. Schreuder
Summary: Levamisole exerts beneficial effects on podocytes in iNS by stabilizing the actin cytoskeleton in a glucocorticoid receptor-dependent manner.
Article
Biochemistry & Molecular Biology
Cindy Karouta, Robert Kucharski, Kristine Hardy, Kate Thomson, Ryszard Maleszka, Ian Morgan, Regan Ashby
Summary: Research on inhibiting myopia in animals has shown significant overlap in retinal molecular changes, with transcription factors playing a key role in growth regulation. These findings suggest that a defined set of transcriptome changes in the retina is crucial for regulating eye growth.
Article
Multidisciplinary Sciences
Balazs Gocz, Eva Rumpler, Miklos Sarvari, Katalin Skrapits, Szabolcs Takacs, Imre Farkas, Veronika Csillag, Sarolta H. Trinh, Zsuzsanna Bardoczi, Yvette Ruska, Norbert Solymosi, Szilard Poliska, Zsuzsanna Szoke, Lucia Bartoloni, Yassine Zouaghi, Andrea Messina, Nelly Pitteloud, Ross C. Anderson, Robert P. Millar, Richard Quinton, Stephen M. Manchishi, William H. Colledge, Erik Hrabovszky
Summary: This study provides a comprehensive characterization of the estrogen-dependent kisspeptin neuron transcriptome and sheds light on the molecular mechanisms of ovary-brain communication, which is important for genetic research on human fertility disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Shihao Xu, Chengwei Zhu, Jiachun Jiang, Cheng Hui, Ping Wang, Jingwei Hong, Shiping Yang, Zhongshan Li, Xiaobing Wang
Summary: This study aimed to develop non-invasive diagnosis methods for primary Sjo & BULL;gren's syndrome (pSS) by integrating classic clinical indexes, major salivary gland ultrasonography (SGUS), and gene expression profiles. Differentially expressed genes (DEGs) enriched in defense response to virus and type I interferon production pathways were identified in glands and blood. Four upregulated DEGs common in glands and blood were identified as hub genes. A random forest model trained with SGUS, antiSSA/Ro60, keratoconjunctivitis sicca tests, and gene expression levels of MX1 and RSAD2 achieved comparable pSS diagnosis accuracy to the golden standard method.
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Chieh Chen, Yung-Che Chou, Chia-Yi Hsu, Eing-Mei Tsai, Tze-Kiong Er
Summary: In this study, RNA sequencing analysis was used to identify a potential pathogenic gene of endometriosis. The differentially expressed genes were found to be enriched in several signaling pathways, providing new insights into the underlying mechanisms of endometriosis.
Article
Genetics & Heredity
Miao Yuqing, Gao Shang, Gao Qing, Wang Jiyang, Li Ruihao, Chen Zuoguan, Diao Yongpeng, Wu Zhiyuan, Li Yongjun
Summary: This study used bulk RNA sequencing to explore the alterations of mRNA in Takayasu arteritis (TA) and found the critical roles of interleukins in its pathogenesis. Smooth muscle cells may also participate in the vessel wall reconstruction at the late stage of TA.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Taihei Suzuki, Masayuki Iyoda, Nobuhiro Kanazawa, Shohei Tachibana, Hirokazu Honda
Summary: Inhibition of PCSK9 can improve kidney disease by reducing urinary albumin and ameliorating podocytopathy through regulating lipid uptake and inflammation signaling pathways. This study suggests that targeting PCSK9 may serve as a potential therapeutic strategy for kidney disease.
LABORATORY INVESTIGATION
(2023)
Article
Urology & Nephrology
Yizhen Chen, Aicheng Yang, Yuansheng Hou, Longhui Liu, Jiehua Lin, Xiaodan Huang, Jundu Li, Xusheng Liu, Fuhua Lu, Qizhan Lin, Haifeng Yang, Shuling Yue, Shujun Jiang, Lixin Wang, Chuan Zou
Summary: Nephrotic syndrome (NS) and nephrotic-range proteinuria (NRP) are uncommon in IgA nephropathy (IgAN) and have distinct clinicopathological characteristics. Podocytes play an important role in both types. NS is associated with more severe lesions and foot process effacement (FPE) compared to NRP. NRP is an independent risk factor for renal progression, while moderate FPE (MFPE) is associated with a better prognosis in NRP patients without obvious chronic renal lesions.
Article
Plant Sciences
Pranjali A. Gedam, Kiran Khandagale, Dhananjay Shirsat, A. Thangasamy, Onkar Kulkarni, Abhijeet Kulkarni, Swaranjali S. Patil, Vitthal T. Barvkar, Vijay Mahajan, Amar Jeet Gupta, Kiran P. Bhagat, Yogesh P. Khade, Major Singh, Suresh Gawande
Summary: This study identified differentially expressed genes (DEGs) through transcriptome analysis in two onion genotypes (Acc. 1666 and W-344) with contrasting responses to waterlogging stress. The proteins coded by these DEGs regulate key biological processes such as phytohormone production, antioxidant enzymes, programmed cell death, and energy production. The results provide valuable molecular information for improving stress tolerance and developing waterlogging tolerant onion varieties.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Nathan Maren, Fangzhou Zhao, Rishi Aryal, Darren Touchell, Wusheng Liu, Thomas Ranney, Hamid Ashrafi
Summary: Reproduction in grasses involves complex gene regulatory networks and developmental processes. This research identified differentially expressed transcripts associated with floral induction, inflorescence development, and seed development in T. ravennae, providing insights into the molecular regulation of reproductive development and laying a foundation for future studies in genome annotation, functional genomics, gene family evolutionary studies, comparative genomics, and precision breeding.
Review
Chemistry, Physical
Yingwen Chen, Jia Song, Qingyu Ruan, Xi Zeng, Lingling Wu, Linfeng Cai, Xuanqun Wang, Chaoyong Yang
Summary: Cells are fundamental building blocks of biological systems, and studying single cells can provide insights into cell diversity and disease processes. Single-cell RNA sequencing technologies allow cellular heterogeneity to be dissected at unprecedented resolution.
Article
Agronomy
Heng Sun, Yanling Liu, Junyu Ma, Yunmeng Wang, Heyun Song, Juanjuan Li, Xianbao Deng, Dong Yang, Juan Liu, Minghua Zhang, Yaqian Xiong, Mei Yang
Summary: The study revealed that starch and protein content in lotus seeds increased while soluble sugar content decreased during postharvest storage, leading to increased hardness and reduced sweetness. Transcriptome analysis identified DEGs and enrichment of pathways related to starch and sucrose metabolism. Most DEGs involved in energy metabolic pathways were down-regulated, and changes in starch and soluble sugar content were associated with altered enzyme activity. Additionally, plant hormone levels such as auxins, jasmonates, and salicylic acid increased during postharvest storage, demonstrating activation of signaling pathways at the transcriptional level.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Genetics & Heredity
Zhuoyi Liao, Tian Zhao, Ningxiang Wang, Jiaqi Chen, Weibin Sun, Juan Wu
Summary: Periodontal Ehlers-Danlos syndrome (pEDS) is a rare genetic disorder characterized by severe early-onset periodontitis and other symptoms. This study used transcriptome profiling to identify molecular mechanisms and potential treatment targets for pEDS. The analysis revealed differential gene expression in monocytes of pEDS patients, particularly genes related to inflammation response and immune response.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Enbo Wang, Wenju Lu, Haiying Liang, Xumeng Zhang, Shaojie Huo, Xiqiang Song, Jian Wang, Ying Zhao
Summary: Dacrydium pectinatum, an endangered gymnosperm species dominant in tropical montane rain forests, undergoes female cone development in six stages influenced by hormone levels. Our study provides insights into cone development and hormone-induced female cone induction.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Junqi Chen, Shengliang Yuan, Jie Zhou, Xiuye Huang, Wenjia Wu, Yiwen Cao, Hong Liu, Qinghong Hu, Xiaojie Li, Xueping Guan, Simin Yin, Jiaying Jiang, Yuan Zhou, Jiuyao Zhou
Summary: This study investigated the therapeutic effects and potential mechanisms of Danshen injection (DSI) on nephrotic syndrome (NS). The results demonstrated that DSI activated podocyte autophagy and reduced apoptosis via the PI3K/AKT/mTOR signaling, ultimately attenuating NS.
Review
Psychology, Clinical
San Lee, Keum Hwa Lee, Kyung Mee Park, Sung Jong Park, Won Jae Kim, Jinhee Lee, Andreas Kronbichler, Lee Smith, Marco Solmi, Brendon Stubbs, Ai Koyanagi, Louis Jacob, Andrew Stickley, Trevor Thompson, Elena Dragioti, Hans Oh, Andre R. Brunoni, Andre F. Carvalho, Joaquim Radua, Suk Kyoon An, Kee Namkoong, Eun Lee, Jae Il Shin, Paolo Fusar-Poli
Summary: Errors in data extraction may account for discrepancies in previous meta-analyses on the association between depression and inflammatory biomarkers.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Rheumatology
Gabriele Gamerith, Finn Mildner, Peter A. Merkel, Kristina Harris, Laura Cooney, Noha Lim, Robert Spiera, Philip Seo, Carol A. Langford, Gary S. Hoffman, E. William St Clair, Fernando C. Fervenza, Paul Monach, Steven R. Ytterberg, Duvuru Geetha, Arno Amann, Dominik Wolf, Ulrich Specks, John H. Stone, Andreas Kronbichler
Summary: This study investigated the predictive role of soluble immune checkpoints (sICPs) in patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). The study found that in patients treated with rituximab, low concentrations of sLag-3 and high concentrations of sCD27 were associated with treatment failure, while high concentrations of sTim-3, sCD27, and sBTLA at baseline predicted relapse in patients reaching remission. These results suggest that sICPs could play a role in personalized treatment approaches for AAV.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Andreas Kronbichler, Milena Bond, Christian Dejaco
Summary: This editorial discusses the reclassification of previously diagnosed GPA patients using the 2022 ACR/EULAR classification criteria.
Article
Pediatrics
Mallory L. Downie, Sanjana Gupta, Melanie M. Y. Chan, Omid Sadeghi-Alavijeh, Jingjing Cao, Rulan S. Parekh, Carmen Bugarin Diz, Agnieszka Bierzynska, Adam P. Levine, Ruth J. Pepper, Horia Stanescu, Moin A. Saleem, Robert Kleta, Detlef Bockenhauer, Ania B. Koziell, Daniel P. Gale
Summary: A genetic risk score can help classify patients with INS presenting in different ways when monogenic causes are excluded.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Balazs Odler, Annette Bruchfeld, Jennifer Scott, Duvuru Geetha, Mark A. Little, David R. W. Jayne, Andreas Kronbichler
Summary: This review focuses on the kidney survival of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). It discusses the potential for kidney recovery, the influence of various factors, and the potential improvement in prediction through modern approaches such as kidney biopsies, blood and urine markers, and patient characteristics. The review emphasizes the need for well-studied surrogate markers to predict renal outcome in AAV and highlights the limitations of traditional markers. It suggests that refinement of existing markers and the incorporation of novel approaches could significantly improve prognostication.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Frank B. Cortazar, John L. Niles, David R. W. Jayne, Peter A. Merkel, Annette Bruchfeld, Huibin Yue, Thomas J. Schall, Pirow Bekker
Summary: In the ADVOCATE trial, avacopan showed better improvement of eGFR compared to prednisone in treating ANCA-associated vasculitis, especially in patients with baseline eGFR <= 20 ml/min/1.73 m2.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Pediatrics
Hee Sun Baek, Min Ji Park, Ji Yeon Song, Seong Heon Kim, Hee Gyung Kang, Yo Han Ahn, Kyoung Hee Han, Heeyeon Cho, Keum Hwa Lee, Jae Il Shin, Young Seo Park, Joo Hoon Lee, Eujin Park, Eun Mi Yang, Min Hyun Cho
Summary: This study aimed to assess the association between changes in serum total cholesterol levels and the progression of CKD in children. The results showed that very high serum total cholesterol is a significant risk factor for the progression of CKD in children.
PEDIATRIC NEPHROLOGY
(2023)
Review
Virology
Hyunju Yon, Hyoin Shin, Jae Il Shin, Jung U. Shin, Youn Ho Shin, Jinseok Lee, Sang Youl Rhee, Ai Koyanagi, Louis Jacob, Lee Smith, Seung Won Lee, Masoud Rahmati, Suhana Ahmad, Wonyoung Cho, Dong Keon Yon
Summary: A systematic review and meta-analysis of monkeypox infection revealed common clinical features including rash, chills, fever, and lymphadenopathy. This study provides important data on the pathophysiology and epidemiology of monkeypox infections.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Biochemical Research Methods
Carlos Ramirez R. Medina, Ibrahim Ali, Ivona Baricevic-Jones, Aghogho Odudu, Moin A. Saleem, Anthony D. Whetton, Philip A. Kalra, Nophar Geifman
Summary: Using SWATH-MS analysis, we identified 25 biomarkers associated with progression in chronic kidney disease (CKD), which are related to subtype classification and disease-relevant pathways. These findings provide important leads for prevention and treatment of CKD.
CLINICAL PROTEOMICS
(2023)
Editorial Material
Urology & Nephrology
Ilay Berke Mentese, Andreas Kronbichler
CLINICAL KIDNEY JOURNAL
(2023)
Article
Immunology
Marc Xipell, Gema M. Lledo, Allyson C. Egan, Farah Tamirou, Cristina Serrano del Castillo, Jordi Rovira, Jose A. Gomez-Puerta, Adriana Garcia-Herrera, Ricard Cervera, Andreas Kronbichler, David R. W. Jayne, Hans-Joachim Anders, Frederic Houssiau, Gerard Espinosa, Luis F. Quintana
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance against nuclear and cytoplasmic self-antigens, induction of immunity, and tissue inflammation. Lupus nephritis (LN) is a common complication of SLE, affecting around 30% of patients at disease onset and up to 50-60% within the first 10 years. This review focuses on the pathogenic mechanisms of SLE, the immunological pathways of kidney damage in LN, and the rationale for the treatment of LN.
AUTOIMMUNITY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Sung-Eun Choi, Soo Bin Lee, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Beom Jin Lim, Sang-Won Lee
Summary: This study investigated the predictive value of histopathological classification and histologic lesion scores in the progression to end-stage kidney disease (ESKD) in patients with ANCA-associated vasculitis-glomerulonephritis (AAV-GN). The study found that a high global glomerulitis score was an independent predictor of ESKD progression, and the sclerotic class had the worst renal prognosis among the histopathological classes.
SCIENTIFIC REPORTS
(2023)
Review
Psychiatry
Heeyeon Kim, Jae Han Kim, Junghwan Kim, Jong Yeob Kim, Samuele Cortese, Lee Smith, Ai Koyanagi, Joaquim Radua, Paolo Fusar-Poli, Andre F. Carvalho, Gonzalo Salazar de Pablo, Jae Il Shin, Keun-Ah Cheon, Marco Solmi
Summary: The study aimed to summarize the evidence on sleep alterations in medication-naive children and adolescents with autism spectrum disorder (ASD). Sixteen observational studies were included, with a total of 981 ASD patients and 1220 typically developing individuals. The results showed that medication-naive ASD patients had significantly poorer sleep quality compared to the typically developing group, with longer sleep latency, reduced sleep efficiency, difficulties in initiating and maintaining sleep, and sleep hyperhidrosis.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
Meeting Abstract
Pediatrics
Jihyun Kim, Yo Han Ahn, Jeesu Min, Kyung Hee Han, Seong Heon Kim, Hee Yeon Cho, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Hee Gyung Kang, Hae Il Cheong
PEDIATRIC NEPHROLOGY
(2023)
Article
Oncology
Ji Hyun Park, Su-Jin Shin, Nara Jeon, Beom Jin Lim
Summary: This study investigated the clinicopathologic features of patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and compared the utility of digital image analysis and eyeball estimation for determining the Ki-67 labeling index. The results showed that eyeball estimation yielded comparable results to digital image analysis. Age, tumor size, lymphovascular invasion, nodal metastasis, and distant metastasis were found to be significantly associated with short overall survival.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2023)
