Article
Endocrinology & Metabolism
Simon Chang, Jesper Just, Anne Skakkebaek, Emma B. Johannsen, Jens Fedder, Claus H. Gravholt, Anna-Marie B. Muenster
Summary: Men with Klinefelter syndrome (KS) have an increased risk of thrombosis and are in need of testosterone replacement therapy (TRT) to alleviate their hypogonadism. This study aimed to evaluate the effects of 18 months of TRT on hemostasis in KS and identify genes associated with the prothrombotic phenotype. The results showed that KS patients have fibrinolytic impairment and an increased risk of thrombosis. However, TRT can reduce body fat and fibrinogen levels, thereby attenuating the prothrombotic profile and improving the fibrinolytic impairment in KS patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Yen-Chieh Tu, Yi-Hsueh Liu, Szu-Chia Chen, Ho-Ming Su
Summary: The prevalence of hyperuricemia in Taiwan remains high, particularly in men. The correlation between metabolic syndrome (MetS) and hyperuricemia has been studied, and this observational cohort study further explores the association between MetS and new-onset hyperuricemia.
Article
Andrology
Simon Chang, Ole Halfdan Larsen, Anne-Mette Hvas, Anne Skakkebaek, Claus Hojbjerg Gravholt, Anna-Marie Bloch Munster
Summary: This study found that platelet aggregation in men with Klinefelter syndrome (KS) was normal before and after testosterone replacement therapy (TRT), and does not support an independent role of platelets in driving cardiovascular risk in KS.
Article
Psychiatry
Yolanda Sanchez-Carro, Alejandro de la Torre-luque, Christina Vassou, Pilar Lopez-Garcia, Ekavi Georgousopoulou, Christos Pitsavos, Jose Luis Ayuso-Mateos, Demostenes Panagiotakos
Summary: This study found that elevated symptoms of depression and anxiety are associated with inflammatory alterations in the concurrent relationship, as well as an increased risk of metabolic diseases at a 10-year follow-up.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Julia Uhanova, Meaghan O'Brien, Gerald Minuk, Robert Tate
Summary: Chronic liver disease and MetS independently increase the relative risk of mortality; the magnitude of the effect is greater in CLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Ya-Chin Huang, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Jer-Ming Chang, Hung-Chun Chen
Summary: The habit of betel nut chewing in Taiwan is significantly associated with metabolic syndrome (MetS) and its components, and long-term betel nut chewing is related to the development of MetS.
Article
Biochemical Research Methods
Rongmei Huang, Yi Hong, Yike Wu, Weifeng Li, Wenlan Liu
Summary: We developed a new LC-MS/MS method for simultaneous determination of serum testosterone and free testosterone levels. The method is simple to perform and can be applied in clinical practice, providing important information for diagnosis, treatment, and monitoring of androgen-related diseases.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychiatry
Salla Karjula, Riikka K. Arffman, Laure Morin-Papunen, Stephen Franks, Marjo-Riitta Jarvelin, Juha S. Tapanainen, Jouko Miettunen, Terhi T. Piltonen
Summary: The study found that women with Polycystic Ovary Syndrome (PCOS) have a three-fold increased risk for psychotic disorders and exhibit more severe symptoms. This suggests that PCOS should be taken into consideration in psychiatric care.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Health Care Sciences & Services
Hsuan Chiu, Mei-Yueh Lee, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen
Summary: The study investigated the associations between MetS risk factors and bone mineral density in a longitudinal study of Taiwanese population, revealing a significant correlation between MetS and bone density.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Robert M. Geraghty, Paul Cook, Paul Roderick, Bhaskar Somani
Summary: The study suggests that kidney stone formers are at an increased risk of developing metabolic syndrome compared to non-formers, potentially indicating an underlying metabolic abnormality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wei-Yu Su, I-Hua Chen, Yuh-Ching Gau, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Szu-Chia Chen, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Summary: The study found significant associations between metabolic syndrome and high values of obesity-related indices except LAP with high baseline eGFR and a rapid decline in renal function.
Article
Health Care Sciences & Services
Li-Wei Chen, Cheng-Hung Chien, Chih-Lang Lin, Rong-Nan Chien
Summary: This study conducted a longitudinal community-based prospective study on the impact of H. pylori infection on metabolic parameters, finding that HBA1c was associated with new H. pylori infection and BMI was linked to H. pylori loss. Serial analyses within group 3 revealed increased HBA1c and HDL values, but decreased cholesterol and WBC values associated with H. pylori infection loss.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sabine Naessen, Malin Eliasson, Kerstin Berntorp, Margareta Kitlinski, Penelope Trimpou, Emily Amundson, Sofia Thunstrom, Bertil Ekman, Jeanette Wahlberg, Anders Karlsson, Magnus Isaksson, Ingrid Bergstrom, Carina Levelind, Inger Bryman, Kerstin Landin-Wilhelmsen
Summary: This study investigated the prevalence of autoimmune diseases in Turner syndrome (TS). The results showed that more than half of TS women developed hypothyroidism, mainly autoimmune, during the follow-up period. It is recommended to raise awareness of vitamin B-12 deficiency and celiac disease in TS women throughout their lives.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Christina M. Dieli-Conwright, Louise Wong, Sarah Waliany, Joanne E. Mortimer
Summary: Metabolic syndrome components, body composition, and biomarkers continued to worsen within 4-5 years after chemotherapy in breast cancer survivors. Factors such as body weight, body fat, lipids, glucose metabolism, and inflammation showed significant increases.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Review
Environmental Sciences
Vicente Mustieles, Ria K. Balogh, Marta Axelstad, Parisa Montazeri, Sandra Marquez, Martine Vrijheid, Monica K. Draskau, Camilla Taxvig, Francisco M. Peinado, Tamar Berman, Hanne Frederiksen, Mariana F. Fernandez, Anne Marie Vinggaard, Anna-Maria Andersson
Summary: This study comprehensively evaluated the safety issues of BP-3 and BP-1 in the human body and found that they have endocrine disrupting properties. HBM studies showed that North Americans have potential exposure levels 10 to 20 times higher than Europeans and Asians. Therefore, it is recommended to use commercially available sunscreens with inorganic UV filters for susceptible populations.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Cecilie S. Uldbjerg, Youn-Hee Lim, Elvira Braeuner, Anders Juul
Summary: There is a lack of evidence on the long-term and general health of males with gynecomastia. This study found that males with idiopathic gynecomastia have a higher risk of future disease, especially endocrine diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Clara Lundetoft Clausen, Trine Holm Johannsen, Niels Erik Skakkebaek, Hanne Frederiksen, Camilla Koch Ryrso, Arnold Matovu Dungu, Maria Hein Hegelund, Daniel Faurholt-Jepsen, Rikke Krogh-Madsen, Birgitte Lindegaard, Allan Linneberg, Line Lund Karhus, Anders Juul, Thomas Benfield
Summary: This study aimed to investigate the concentrations of pituitary-gonadal hormones in COVID-19 patients and their associations with inflammation, severe respiratory failure, and mortality. The results showed that reduced testosterone concentrations were associated with severe respiratory failure in men with COVID-19, while reduced LH and FSH concentrations were associated with severe respiratory failure in women with COVID-19.
ENDOCRINE CONNECTIONS
(2023)
Review
Endocrinology & Metabolism
Claus H. Gravholt, Alberto Ferlin, Joerg Gromoll, Anders Juul, Armin Raznahan, Sophie van Rijn, Alan D. Rogol, Anne Skakkebaek, Nicole Tartaglia, Hanna Swaab
Summary: The 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and 47,XYY syndrome was held in Leiden, the Netherlands, from September 12-14, 2022. This review focuses on the new data presented at the workshop and the scientific and clinical trajectories discussed. It highlights the deficiencies in knowledge and identifies areas for future research, particularly in the genetics and genomics of supernumerary sex chromosome syndromes. The workshop also addressed the challenges of transitioning, the pervasive neurocognitive changes in these syndromes, and the need for improved healthcare systems and guidelines.
ENDOCRINE CONNECTIONS
(2023)
Article
Oncology
P. L. Jorgensen, M. Kreiberg, N. Jorgensen, A. Juul, P. S. Oturai, C. Dehlendorff, J. Lauritsen, T. Wagner, J. Rosenvilde, G. Daugaard, C. R. Medici, N. R. Jorgensen, M. Bandak
Summary: The aim of this study was to evaluate the metabolic profile and bone mineral density (BMD) changes in testicular cancer survivors with mild Leydig cell insufficiency after 12 months of testosterone replacement therapy (TRT). The results showed that TRT did not significantly affect BMD, but it resulted in a small increase in N-terminal propeptide of type 1 procollagen (P1NP), which had little clinical significance.
Article
Medicine, General & Internal
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study investigated the role of circulating AMH in men and found that low serum AMH is associated with severely impaired gonadal function. Vitamin D supplementation had no effect on serum AMH.
Article
Endocrinology & Metabolism
Mette K. Andersen, Lars Angquist, Jette Bork-Jensen, Anna E. Jonsson, Sara E. Stinson, Camilla H. Sandholt, Malte Thodberg, Laura Maarit Pikkupeura, Emily L. Ongstad, Niels Grarup, Arne Astrup, Oluf Pedersen, Kristine Williams, Romain Barres, Thorkild I. A. Sorensen, Allan Linneberg, Joseph Grimsby, Christopher J. Rhodes, Torben Hansen
Summary: The association between FTO rs9939609 and obesity is modified by physical activity and insulin sensitivity, and these modifications are independent. High physical activity and insulin sensitivity can attenuate the effect of the FTO rs9939609 A allele on BMI. Moreover, greater physical activity and insulin sensitivity may weaken the associations between the FTO rs9939609 A allele and all-cause mortality and certain cardiometabolic outcomes. The FTO rs9939609 A allele is associated with higher expression of FTO in skeletal muscle.
Article
Endocrinology & Metabolism
Josephine H. Li, Laura N. Brenner, Varinderpal Kaur, Katherine Figueroa, Philip Schroeder, Alicia Huerta-Chagoya, Miriam S. Udler, Aaron Leong, Josep M. Mercader, Jose C. Florez, Magic Investigators, Diab Prevent Program DPP Res Grp
Summary: This study aimed to explore the genetic variation that influences the response to common glucose-lowering medications in individuals at risk of type 2 diabetes. The researchers identified five significant genetic variants associated with metformin or glipizide response, including two variants specific to individuals of African ancestry. Additionally, they found associations between type 2 diabetes-associated variants and glycaemic response.
Article
Environmental Sciences
Elvira V. Brauner, Cecilie S. Uldbjerg, Astrid L. Beck, Youn-Hee Lim, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Tina K. Jensen
Summary: This study investigated the relationship between maternal paraben concentrations in second trimester urine and birth size of the offspring, specifically looking at sex-specific associations. The findings revealed that higher maternal exposure to n-butylparaben was associated with lower birth size in female offspring, while no significant relationship was observed in male offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Sucharitha Chadalavada, Jaakko Reinikainen, Jonas Andersson, Augusto Di Castelnuovo, Licia Iacoviello, Pekka Jousilahti, Line Lund Karhus, Allan Linneberg, Stefan Soderberg, Hugh Tunstall-Pedoe, Karim Lekadir, Nay Aung, Magnus T. T. Jensen, Kari Kuulasmaa, Teemu J. J. Niiranen, Steffen E. E. Petersen
Summary: This study confirms that women with type 1 diabetes have a higher risk of heart failure compared to men, but there is no significant difference in risk according to sex for type 2 diabetes patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Kamil Demircan, Richard Christian Jensen, Thilo Samson Chillon, Tina Kold Jensen, Qian Sun, Steen Joop Bonnema, Julian Hackler, Tim I. M. Korevaar, Dorte Glintborg, Lutz Schomburg, Marianne Skovsager Andersen
Summary: This study found that low serum selenium levels during pregnancy, particularly low selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3) activity, were associated with an increased risk of gestational diabetes mellitus (GDM) and large for gestational-age offspring. Offering selenium status assessment during pregnancy can identify high-risk women for GDM who may benefit from selenium substitution.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Obstetrics & Gynecology
Camilla V. B. Palm, Anja F. Dreyer, Henriette Boye, Jan S. Jorgensen, Chunsen Wu, Frederik D. Hojsager, Tina K. Jensen, Dorte Glintborg, Marianne S. Andersen
Summary: This study found associations between maternal testosterone levels and birth anthropometrics in offspring. Higher levels of maternal testosterone were linked to lower birth weight, length, and abdominal circumference in boys, but no associations were found in girls.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Developmental Biology
Alexander S. Busch, Juan Manuel Paturlanne, Nina Neuhaus, Joachim Wistuba, Stefan Schlatt, Anders Juul, Heymut Omran
Summary: Minipuberty is a transient activity period of the hypothalamic-pituitary-gonadal axis in the postnatal and infant period, playing a significant role in the development and maturation of male reproductive function. It has no apparent impact on future fertility potential in females. This review comprehensively explores the effects of minipuberty on male reproductive function, presents suitable animal models for studying minipuberty, discusses the short- and long-term effects, and outlines future research directions.
Article
Environmental Sciences
Valentina Rosolen, Elisa Giordani, Marika Mariuz, Maria Parpinel, Vicente Mustieles, Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Kirsten Baken, Greet Schoeters, Ovnair Sepai, Eva Sovcikova, Lucia Fabelova, Jiri Kohoutek, Tina Kold Jensen, Adrian Covaci, Maarten Roggeman, Lisa Melymuk, Jana Klanova, Argelia Castano, Marta Esteban Lopez, Fabio Barbone
Summary: The knowledge about the effects of organophosphate flame retardants on children's neurodevelopment is limited. This research aimed to evaluate the association between exposure to these flame retardants and children's neurodevelopment. The study found a small, negative trend between neurodevelopment and exposure to BDCIPP and DPHP, but the evidence is limited. Further investigations are needed to explore the timing of exposure and the effect of other metabolites.
