Article
Environmental Sciences
Taru Goyal, Prasenjit Mitra, Preeti Singh, Raghumoy Ghosh, Shailja Sharma, Praveen Sharma
Summary: Human exposure to cadmium can lead to severe health effects, with recent studies suggesting a link to epigenetic alterations through miRNA expression changes. In a study of occupationally cadmium-exposed workers, it was found that blood cadmium levels were significantly higher in exposed individuals, with changes in immune cell populations and cytokine profiles. Specifically, miR-221 was significantly upregulated in the exposed group and showed a correlation with immune alterations. These findings suggest miR-221 as a potential candidate for further exploration of the mechanism underlying cadmium toxicity.
Review
Biochemistry & Molecular Biology
Bartosz Lenda, Marta Zebrowska-Nawrocka, Grzegorz Turek, Ewa Balcerczak
Summary: Gliomas, particularly glioblastoma, are aggressive brain tumors with limited treatment options and poor prognosis. Although gliomas do not undergo classical epithelial to mesenchymal transition (EMT), EMT-like processes contribute to their invasive nature and intracranial metastasis. Various EMT transcription factors have been described to play important roles in glioma progression, with a focus on molecules like SNAI, TWIST, and ZEB. This review highlights the impact of miRNA, lncRNA, and other epigenetic modifications on the regulation of EMT transcription factors in gliomas, emphasizing the need to uncover the molecular mechanisms and identify novel therapeutic targets for improved diagnosis and prognosis of glioma patients.
Review
Oncology
Karolina Seborova, Radka Vaclavikova, Lukas Rob, Pavel Soucek, Pavel Vodicka
Summary: Although advances have been made in cancer research, efficient predictive biomarkers for ovarian cancer progression and metastasis remain elusive. This review critically discusses recent findings on non-coding RNAs and DNA methylation as promising novel biomarkers in ovarian cancer. Identifying molecular changes in primary tumors and their metastases can help reveal the nature of metastatic development and provide early biomarkers for prognosis and disease progression. Regulatory elements from non-coding RNA families appear to play a role in these processes and may serve as potential molecular biomarkers for patient prognosis.
Review
Biochemistry & Molecular Biology
Kanishka Kumar, Sudha Anjali, Shailja Sharma
Summary: Lead exposure can have detrimental health effects, and histone modifications have been found to play a significant role in lead toxicity. However, research in this field is still lacking and further exploration is needed.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Neelu Batra, Michelle M. L. Tran, Jing-Xin Qiu, Theodore Wun, Primo N. Lara, Xiang Hu, Ai-Xi Yu, Ai-Ming Yu
Summary: A novel platform for in vivo fermentation production of humanized recombinant ncRNA molecules was developed, demonstrating their important roles in cellular processes and anti-tumor activities. The technology represents a unique addition to conventional technologies for basic research and drug development.
Review
Public, Environmental & Occupational Health
Claudia Gundacker, Martin Forsthuber, Tamas Szigeti, Reka Kakucs, Vicente Mustieles, Mariana F. Fernandez, Elizabeth Bengtsen, Ulla Vogel, Karin Sorig Hougaard, Anne Thoustrup Saber
Summary: Lead (Pb) is a common environmental pollutant with potent toxic effects on human health. Effective biomarkers are needed to assess the relationship between Pb exposure and health outcomes, especially in situations of low to moderate exposure. Further studies are required to validate sensitive and reliable biomarkers for Pb-induced toxicity.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Editorial Material
Microbiology
Eain A. Murphy
Summary: The necessity for viruses to modulate the innate immune response significantly impacts the outcome of viral infections. Viruses encode factors that undermine antiviral responses, with recent research highlighting the impact of virus-encoded noncoding RNAs on key components of the interferon pathway, particularly focusing on Epstein-Barr virus microRNAs.
Article
Environmental Sciences
Wenzhen Li, Haozhe Zhang, Zhaomin Chen, Yueqing Tao, Xuezan Huang, Weihong Chen, Dongming Wang
Summary: This study suggests that occupational noise exposure is positively associated with blood pressure, and miRNA-92a-3p partially mediates the association between occupational noise exposure and diastolic blood pressure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Biotechnology & Applied Microbiology
S. Shome, R. L. Jernigan, D. C. Beitz, S. Clark, E. D. Testroet
Summary: The study reveals that bovine milk contains a significant number of ncRNAs with putative regulatory targets associated with immune and developmental functions important for neonatal bovine health. Processing significantly affects ncRNA expression values, but overall abundance values of miRNA samples are not greatly impacted.
Review
Behavioral Sciences
Abraham Hernandez-Coro, Beatriz Eugenia Sanchez-Hernandez, Sergio Montes, Juan Carlos Martinez-Lazcano, Edith Gonzalez-Guevara, Francisca Perez-Severiano
Summary: Lead is a common pollutant that interacts with cells and tissues, causing behavioral and physiological alterations, as well as biochemical and epigenetic changes at a neurotransmitter level, leading to negative impacts on behavior and learning.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Marine & Freshwater Biology
Gregory P. Toth, David C. Bencic, John W. Martinson, Robert W. Flick, David L. Lattier, Mitchell S. Kostich, Weichun Huang, Adam D. Biales
Summary: This study aimed to develop novel methodologies to expand the panel of gene expression-based biomarkers, including responses to estrogens, and to evaluate the potential of small non-coding RNAs as biomarkers. The research findings showed that miRNA and piRNA could respond to estrogen exposure, indicating the need for further investigation into their regulatory roles in the estrogenic response.
AQUATIC TOXICOLOGY
(2021)
Review
Medicine, Research & Experimental
Jia Liu, Shan Song, Rong Zhao, He-Yi Zhang, Sheng-Xiao Zhang
Summary: Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial tissue inflammation, irreversible joint damage, and severe physical impairment. Non-coding RNAs (ncRNAs) are important regulators that are incapable of encoding proteins but play a crucial role in the pathogenesis of RA by mediating fundamental cellular processes. Several confirmed ncRNAs have been identified as prospective biomarkers for diagnosing and treating RA. This paper aims to elucidate the role of ncRNAs in the pathogenesis of RA and propose new ideas for the diagnosis and treatment of this condition.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Qiannan-Di, Qianqian-Jiang, Jiahui-Sun, Haowei-Fu, Qian-Xu
Summary: This study investigates the mechanisms underlying liver injury caused by nonylphenol (NP) exposure. The findings suggest that the upregulation of lncRNA PVT1 leads to increased expression of necroptosis-related proteins, promoting necroptosis. Additionally, the study reveals that lncRNA PVT1 can bind to DNMT1 via EZH2 and enhance methylation at the ZBP1 promoter, further promoting necroptosis. These findings provide valuable insights into the molecular mechanisms of liver injury and contribute to the evaluation of NP biosafety.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Behavioral Sciences
Dietrich van Calker, Tsvetan Serchov
Summary: Psychiatric disorders pose a significant burden on global healthcare systems, with genetic and epigenetic modifications potentially playing important roles in their pathogenesis. However, there is still limited understanding of these mechanisms, indicating a need for further research in this area.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Plant Sciences
Leidy Alves dos Santos, Bruno Lemos Batista, Allan Klynger da Silva Lobato
Summary: This study found that foliar application of 24-epibrassinolide (EBR) under high magnesium concentration can alleviate the negative effects of magnesium stress on soybean photosynthesis. EBR protects against oxidative stress, delays chlorophyll degradation, and improves magnesium content and photochemical efficiency.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Plant Sciences
Camille Ferreira Maia, Ynglety Cascaes Pereira, Breno Ricardo Serrao da Silva, Bruno Lemos Batista, Allan Klynger da Silva Lobato
Summary: This study demonstrated that 24-epibrassinolide can mitigate oxidative damage against the photosynthetic apparatus in tomato leaves under excess nickel stress by upregulating the antioxidant system, improving leaf anatomy and stomatal performance.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Cell Biology
Caroline M. S. Marques, Rafael N. Gomes, Tatiana Pedron, Bruno L. Batista, Giselle Cerchiaro
Summary: The study investigates the involvement of cellular prion protein (PrPC) in neuroprotection under oxidative stress. The presence of PrPC showed resistance to oxidative stress in astrocytes, and PrPC plays a role in metal homeostasis and prevents protein aggregation. Additionally, PrPC can translocate SOD1 to cell nuclei under oxidative stress, potentially controlling DNA damage. Overall, the study suggests that PrPC activates cellular response and defense against oxidative stress, protecting neurons and ensuring astrocyte functionality.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yan Zhou, Jose Russo, Jose Rueff, Marcelo A. M. Pires, Guilherme Bezerra de Castro
Summary: Population study reveals that Xavante Indians have distinct genetic compositions and extremely low risk of breast cancer, providing new insights for breast cancer research.
SCIENTIFIC REPORTS
(2023)
Article
Agronomy
Breno Ricardo Serrao da Silva, Elaine Maria Silva Guedes Lobato, Leidy Alves dos Santos, Rodrigo Mendes Pereira, Bruno Lemos Batista, Mohammed Nasser Alyemeni, Parvaiz Ahmad, Allan Klynger da Silva Lobato
Summary: The purpose of this research was to investigate the negative effects of salt stress on soybean plants in terms of anatomical, morphological, nutritional, physiological, and biochemical parameters. The study found that concentrations of 50 to 200 mM Na+ significantly reduced the levels of K, Ca, and Mg in the plants, and had negative effects on photosynthesis, gas exchange, and photosynthetic pigments, which were likely caused by oxidative stress. Interestingly, at concentrations below 100 mM Na+, there were changes in epicuticular wax deposition, stomatal quantity and morphology, and leaf epidermis thickness in soybean plants. Overall, significant deleterious effects were observed in soybean plants under salt stress conditions above 100 mM Na+.
Article
Public, Environmental & Occupational Health
Alda Neis Miranda Araujo, Isabelle Nogueira Leroux, Danielle Zildeana Sousa Furtado, Ana Paula Sacone da Silva Ferreira, Bruno Lemos Batista, Heron Dominguez Torres Silva, Evangelos Handakas, Nilson Antonio Assuncao, Kelly Polido Kaneshiro Olympio
Summary: Occupational exposure to potentially toxic elements in informal jewelry production can have adverse health effects on workers. This study used proteomic and metabolomic analyses to assess the impact of these exposures on workers' exposome in Limeira city, Brazil. The results showed high levels of Sn and Cu in welders' blood, as well as correlations between certain proteins and blood PTE levels. Additionally, pathway analysis revealed seven metabolic pathways potentially disturbed by the informal work. These findings highlight the harmful effects of PTE exposure in the jewelry production industry.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Nanoscience & Nanotechnology
Joao Conde, Robert Langer, Jose Rueff
Summary: Since the early 1990s, the combination of genetics and nanomedicine has become a game changer in the medical field, offering promising advancements in treating diseases such as cancer and infectious or genetic diseases. The key to this revolution lies in the evolving world of messenger RNA and its 'cues'.
NATURE NANOTECHNOLOGY
(2023)
Article
Engineering, Chemical
Marta C. Coelho, Soudabeh Ghalamara, Ricardo Pereira, Antonio S. Rodrigues, Jose A. Teixeira, Manuela E. Pintado
Summary: This study focused on developing a zero waste strategy for the by-products of winemaking, specifically grape pomace. The phytochemical properties of the by-products were identified and characterized, and a green extraction method called ohmic heating was applied. The study found that red grape pomace contains more bioactive compounds compared to white grape pomace.
Article
Food Science & Technology
Marta C. Coelho, Celia Costa, Dalila Roupar, Sara Silva, A. Sebastiao Rodrigues, Jose A. Teixeira, Manuela E. Pintado
Summary: Several studies have shown that prebiotics and probiotics have positive effects on gut microbiota. This study aimed to assess the fermentability of tomato flour obtained through different extraction methods and its impact on specific microbiota groups. The results showed that the tomato flour could support the growth of Bifidus longum, and different strains of probiotics had different responses to the flour depending on their carbohydrate profiles. The study also found correlations between microbial growth, short-chain fatty acids, and the different extraction methods.
Article
Food Science & Technology
Marta C. C. Coelho, Soudabeh Ghalamara, Debora Campos, Tania Braganca Ribeiro, Ricardo Pereira, Antonio S. Rodrigues, Jose A. Teixeira, Manuela Pintado
Summary: Tomato by-products from processing industries in Portugal have the potential to be reused as a source of bioactive compounds. However, there is a lack of reliable national data on these by-products and their physicochemical properties, which hinders effective waste management planning. In this study, selected Portugal companies were recruited to obtain representative samples of by-products, and their physicochemical composition was evaluated. Additionally, an environmentally friendly method called ohmic heating (OH) was used to explore new safe value-added ingredients from these by-products.
Article
Biochemistry & Molecular Biology
Miguel Tabanez, Ilma R. Santos, Juliane M. Ikebara, Mariana L. M. Camargo, Bianca A. Dos Santos, Bruna M. Freire, Bruno L. Batista, Silvia H. Takada, Rosanna Squitti, Alexandre H. Kihara, Giselle Cerchiaro
Summary: As people age, they become more susceptible to neurodegenerative illnesses such as Alzheimer's disease. This study found that the antioxidant hydroxytyrosol can regulate metal levels and improve learning performance in a rat model of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bruno Costa Gomes, Nuno Peixinho, Rita Pisco, Marta Gromicho, Ana Catarina Pronto-Laborinho, Jose Rueff, Mamede de Carvalho, Antonio Sebastiao Rodrigues
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that causes muscle control loss, muscle atrophy, and death. This study aimed to assess the differential expression of plasma miRNAs in ALS patients and control populations. Although no specific miRNA signature for ALS diagnosis was identified, miR-7-2-3p, miR-26a-1-3p, miR-224-5p, and miR-206 were found to be potential candidates for understanding the pathophysiology of ALS.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francisco Esteves, Cristina M. M. Almeida, Sofia Silva, Ines Saldanha, Philippe Urban, Jose Rueff, Denis Pompon, Gilles Truan, Michel Kranendonk
Summary: A unique cytochrome P450 (CYP) oxidoreductase (CPR) is important for maintaining the activities of human microsomal CYPs. The conformation of the CPR protein influences electron transfers and complex formation with CYPs. Mutations in the hinge region and FD domain of CPR can modulate CYP activities and regiospecificity of reactions in a substrate-dependent manner.
Article
Biochemistry & Molecular Biology
Carolina P. Bernardes, Neife A. G. Santos, Tassia R. Costa, Danilo L. Menaldo, Flavia M. Sisti, Martin K. Amstalden, Diego L. Ribeiro, Lusania M. G. Antunes, Suely V. Sampaio, Antonio C. Santos
Summary: In this study, the snake-venom-based tripeptide BTX-I was chemically modified to enhance its neurotrophic and neuroprotective effects. The ethyl-esterified peptide BTX-II showed significant improvement in promoting neuritogenesis and upregulating proteins and genes associated with cognitive improvements.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Agriculture, Multidisciplinary
Victoria Freitas de Oliveira, Eduardo Venske, Cassia Fernanda Stafen, Fernanda Pollo Paniz, Tatiana Pedron, Rodrigo Mendes Pereira, Ariano Martins de Magalhaes Jr, Luciano Carlos da Maia, Antonio Costa de Oliveira, Bruno Lemos Batista, Camila Pegoraro
Summary: The objective of this study was to map the chromosomal regions responsible for iron accumulation in rice grains in Southern Brazil. Thirteen candidate genes were identified from single nucleotide polymorphisms mapped on chromosomes 1, 5, 6, and 10, some of which are related to iron homeostasis while others have unknown functions or are related to other metabolic processes.
PESQUISA AGROPECUARIA BRASILEIRA
(2023)
