Journal
FRONTIERS IN CHEMISTRY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.628316
Keywords
asymmetrical porphyrins; detonation nanodiamonds; silver nanoparticles; staphylococcal biofilms; photodynamic antimicrobial therapy
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Funding
- Department of Science and Technology (DST) Innovation through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [62620]
- National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]
- Rhodes University
- Organization for Women in Science for the Developing World (OWSD)
- Swedish International Development Cooperation Agency (Sida)
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The metalated porphyrin derivatives showed red-shifted absorption wavelength and high singlet oxygen quantum yield, making them effective for photodynamic antimicrobial chemotherapy. Conjugation to nanohybrids enhanced the antibacterial and anti-biofilm activities on multi-drug resistant S. aureus strain compared to Ps alone, suggesting potential as antimicrobial agents in biofilm treatment.
New asymmetrical porphyrin derivatives containing a p-hydroxyphenyl moiety and p-acetylphenyl moieties along with their functionalized silver-detonation nanodiamonds nanohybrids were characterized and their photophysicochemical properties were established. The study provides evidence that the metalated porphyrin derivatives were red-shifted in absorption wavelength and possessed high singlet oxygen quantum yield comparative to the unmetalated core, thus making them suitable agents for photodynamic antimicrobial chemotherapy. As a result of conjugation to detonation nanodiamonds and silver nanoparticles, these compounds proved to be more effective as they exhibited stronger antibacterial and anti-biofilm activities on the multi-drug resistant S. aureus strain due to synergetic effect, compared to Ps alone. This suggests that the newly prepared nanohybrids could be used as a potential antimicrobial agent in the treatment of biofilms caused by S. aureus strain.
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