Article
Multidisciplinary Sciences
Xiao Zhang, Junping Hong, Ling Zhong, Qian Wu, Shanshan Zhang, Qianying Zhu, Haiwen Chen, Dongmei Wei, Rui Li, Wanlin Zhang, Xinyu Zhang, Guosong Wang, Xiang Zhou, Junyu Chen, Yinfeng Kang, Zhenghui Zha, Xiaobing Duan, Yang Huang, Cong Sun, Xiangwei Kong, Yan Zhou, Yanhong Chen, Xiaoping Ye, Qisheng Feng, Shaowei Li, Tong Xiang, Song Gao, Mu-Sheng Zeng, Qingbing Zheng, Yixin Chen, Yi-Xin Zeng, Ningshao Xia, Miao Xu
Summary: This study identified two neutralizing antibodies that effectively neutralize EBV infection and provide protection against EBV-induced lymphoproliferative disorders in humanized mice. The antibodies inhibit membrane fusion through interference with gB-cell interaction and activation, offering potential targets for antiviral therapies and vaccines.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Dermatology
Serena Shimshak, Christina Dai, Nneka Comfere, Olayemi Sokumbi
Summary: This study aims to further characterize the clinicopathologic features of primary cutaneous T-cell lymphoma (CTCL) in solid organ transplant recipients (SOTR). The study found that CTCL is rare among SOTR, with the folliculotropic mycosis fungoides (FMF) subtype being more common compared to other CTCL.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Jwa Hoon Kim, Hyungwoo Cho, Heungsup Sung, Ah Ra Jung, Yoon Sei Lee, Sang-wook Lee, Jin-Sook Ryu, Eun Jin Chae, Kyoung Won Kim, Jooryung Huh, Chan-Sik Park, Dok Hyun Yoon, Cheolwon Suh
Summary: This study suggests that positive plasma EBV DNA is a stronger predictor for survival prognosis in patients with PTLD-DLBCL after transplantation compared to EBER or WB EBV DNA positivity, indicating its significant unfavorable impact on progression-free survival and overall survival.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Paola Chabay
Summary: EBV+ DLBCL, NOS is a new category with varying incidence rates among different populations, influencing tumor microenvironment and patient survival. EBV can alter genetic composition of tumor cells and affect recruitment of immune cells.
Article
Multidisciplinary Sciences
Linlin Zhang, Mengjia Liu, Meng Zhang, Junhong Ai, Jiao Tian, Ran Wang, Zhengde Xie
Summary: Infectious mononucleosis (IM) is an acute syndrome associated with primary Epstein-Barr virus (EBV) infection. The exact pathogenic mechanism of IM remains unclear and there is currently no effective treatment. B cells and NK cells play important roles in IM, while the balance between CD4+ T cells and CD8+ T cells is crucial for lifelong control of the disease. Transcriptome sequencing of different cell populations involved in IM can help understand their functions and pathogenic mechanisms.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Oncology
Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
Summary: ENKTCL is an aggressive lymphoma associated with EBV infection, characterized by activation of the JAK-STAT pathway and mutations in genes like BCOR, DDX3X and TP53. Differences in EBV strains and LMP1 variants among populations provide insights into the pathogenesis and genetics of ENKTCL. The genetic landscape of ENKTCL highlights mechanisms of lymphomagenesis and potential therapeutic targets.
Article
Immunology
Lili Cheng, Qi Song, Mengke Liu, Yan Wang, Hongmei Yi, Ying Qian, Pengpeng Xu, Shu Cheng, Chaofu Wang, Li Wang, Weili Zhao
Summary: PBL is a rare and aggressive hematological malignancy that commonly occurs in immune incompetent patients, with no specific standard treatment currently available. In some cases, immune therapy may be a potential treatment option for PBL, providing new insights into its management.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Junhun Cho, Eojin Kim, Sang Eun Yoon, Seok Jin Kim, Won Seog Kim
Summary: This study investigated the pathologic differences of EBV-positive DLBCL in different age and immune status groups. The results showed that EBV-positive DLBCL exhibited similar pathologic characteristics in these three groups, but TET2 and LILRB1 gene mutations were more frequent in elderly patients.
Article
Dermatology
Ryan Fan, Catherine Baker, Earl J. Glusac, Mina L. Xu, Alejandro A. Gru, Jeffrey M. Cohen
Summary: Primary, acute Epstein-Barr virus (EBV) infection can cause various skin eruptions, including viral exanthem and erythema multiforme. Chronic latent EBV infection rarely leads to lymphoproliferative disorders with cutaneous manifestations, but these disorders do not arise from primary infection. This report presents a case of primary, acute EBV infection with histopathologic features closely resembling aggressive cytotoxic cutaneous T-cell lymphoma.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Review
Medicine, General & Internal
Jose Manuel Martin de Bustamante, Ana Mendoza, Samuel Lopez-Munoz, Eugenia Garcia-Fernandez, Pilar Gomez-Prieto, Victor Jimenez-Yuste
Summary: Recently, a new lymphoproliferative entity called breast implant-associated Epstein-Barr virus positive (EBV+) diffuse large B-cell lymphoma (EBV+ BIA-DLBCL) has been reported. The World Health Organization has categorized it as fibrin-associated large B-cell lymphomas (FA-LBCLs), thus it can be referred to as breast implant-associated fibrin-associated large B-cell lymphomas (BIA-FA-LBCLs). While the association between breast implants and lymphomas has been known for a long time, it has mostly been focused on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). This article describes the first case of BIA-FA-LBCL at a particular center, provides a literature review on its clinical features, diagnosis, and treatment approach, as well as explores the challenges in differential diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Masayo Yamamoto, Motohiro Shindo, Chihiro Sumi, Sho Igarashi, Takeshi Saito, Nodoka Tsukada, Yasumichi Toki, Mayumi Hatayama, Junki Inamura, Kazuya Sato, Yusuke Mizukami, Yoshihiro Torimoto, Toshikatsu Okumura
Summary: The case presented a 69-year-old male patient who developed acquired hemophilia A (AHA) during treatment for Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease (EBV-T/NK-LPD). The patient's AHA improved with higher dose prednisolone treatment, achieving complete remission after 13 months of low-dose prednisolone maintenance. It is speculated that EBV-infected and proliferating monoclonal NK cells might have modulated the immune system and produced autoantibodies against factor VIII, leading to the development of AHA in this patient with EBV-T/NK-LPD.
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Biology
Wesley Soo I. Hoo, Kaylie Higa, Alison A. McCormick
Summary: This study successfully developed a mouse B cell line expressing latent membrane protein 1 and demonstrated that vaccination protected mice against B cell tumors expressing latent membrane protein 1. This research provides a potential for studying vaccine immunotherapy in cancer patients.
Article
Pathology
Tasuku Kawano, Yuta Tsuyuki, Yuka Suzuki, Kazuyuki Shimada, Seiichi Kato, Taishi Takahara, Mayuko Mori, Masato Nakaguro, Ayako Sakakibara, Shigeo Nakamura, Akira Satou
Summary: Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is a rare disease with unique clinicopathologic features and biological behavior. Patients with PA-DLBCL can be classified into different subgroups, and significant differences in prognosis were observed among these subgroups. Factors such as immune senescence, iatrogenic immunodeficiency, and immune evasion were found to contribute to the development of PA-DLBCL.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Multidisciplinary Sciences
Thomas Sommermann, Tomoharu Yasuda, Jonathan Ronen, Tristan Wirtz, Timm Weber, Ulrike Sack, Rebecca Caeser, Jingwei Zhang, Xun Li, Van Trung Chu, Anna Jauch, Kristian Unger, Daniel J. Hodson, Altuna Akalin, Klaus Rajewsky
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Tomoharu Yasuda, Yuichi Saito, Chisato Ono, Kazuhiko Kawata, Akemi Baba, Yoshihiro Baba
Summary: The CD19-iCre mouse model, with a T2A-iCre sequence inserted into the Cd19 locus, shows more effective Cre recombination in early B cell development compared to CD19-Cre mice. The B lineage-specific recombination in CD19-iCre mice is more stringent than that in Mb1-iCre mice. Additionally, the CD19-iCre model demonstrates superior deletion efficiency in IL10-floxed mice compared to CD19-Cre mice, making it a valuable tool for highly efficient gene targeting specific to the B cell compartment.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Tetsuya Sakurai, Mutsuko Kukimoto-Niino, Kazufumi Kunimura, Nana Yamane, Daiji Sakata, Ryosuke Aihara, Tomoharu Yasuda, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshinori Fukui, Takehito Uruno
Summary: DOCK8 is a critical guanine-nucleotide exchange factor for the development and function of white blood cells, playing a vital role in spatial control of Cdc42 activity during interstitial leukocyte migration by binding to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). The DHR-1 domain of DOCK8 contains basic residues that are responsible for stereospecific recognition of phosphoinositides, essential for its function.
LIFE SCIENCE ALLIANCE
(2021)
Article
Genetics & Heredity
Akihiro Nita, Akinobu Matsumoto, Ronghao Tang, Chisa Shiraishi, Kazuya Ichihara, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Gaku Tsuji, Masutaka Furue, Bumpei Katayama, Toshiyuki Ozawa, Teruasa Murata, Teruki Dainichi, Kenji Kabashima, Atsushi Hatano, Masaki Matsumoto, Keiichi I. Nakayama
Summary: Although long noncoding RNAs (lncRNAs) are typically not translated into proteins, some lncRNAs contain small ORFs that can be translated. TINCR-encoded ubiquitin-like protein (TUBL) accelerates keratinocyte proliferation and plays a key role in skin homeostasis and regeneration after injury.
Article
Pharmacology & Pharmacy
Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai
Summary: GPR3 is immediately induced by T cell stimulation and plays an important role in suppressing effector T cell activation.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Shintaro Mise, Akinobu Matsumoto, Keisuke Shimada, Toshiaki Hosaka, Masatomo Takahashi, Kazuya Ichihara, Hideyuki Shimizu, Chisa Shiraishi, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Toru Ide, Yoshihiro Izumi, Takeshi Bamba, Tomomi Kimura-Someya, Mikako Shirouzu, Haruhiko Miyata, Masahito Ikawa, Keiichi Nakayama
Summary: This study identifies two small peptides encoded by a testes-specific lncRNA, Gm9999, that are crucial for male fertility in mice. These peptides interact with VDAC and play a critical role in the formation of the mitochondrial sheath in spermatozoa.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Yasuo Kitajima, Ryoka Tsukahara, Shohei Nakamoto, Tomoharu Yasuda
Summary: This study compared two methods for isolating lymphocytes during muscle regeneration and found that the CD45-magnetic bead method had a higher efficiency in isolating T cells, B cells, and myogenic cells from injured muscle tissues.
Article
Geriatrics & Gerontology
Yuma Sugiyama, Tanenobu Harada, Yuka Kamei, Tomoharu Yasuda, Tomoji Mashimo, Akihiko Nishikimi, Mitsuo Maruyama
Summary: Senescent cells play a role in aging-related malfunctions and pathologies, but it remains unclear whether current models accurately reflect physiological senescence. This study developed a novel approach to eliminate p16-expressing cells and generated a new knock-in model, p16hCD2 mice, and an inducer called hCD2-SAP. The study confirmed p16-associated hCD2 expression in various tissues and found that targeting p16positive senescent cells partially restored aging-related phenotypes in T lymphocytes.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Cell Biology
Kentaro Inoue, Tomoharu Yasuda, Yoshihiro Baba, Tadashi Yamamoto, Tomohiro Kurosaki, Hisaaki Shinohara
Summary: In this study, the influence of TRAF6 on CBM formation and TAK1 and IKK activities was investigated using TRAF6-deficient DT40 B cells. Mathematical model analysis showed that TRAF6 contributes to the positive regulation of IKK activation via TAK1, and negatively regulates CARMA1 binding to Bcl10.
Article
Multidisciplinary Sciences
Wiebke Winkler, Carlota Farre Diaz, Eric Blanc, Hanna Napieczynska, Patrick Langner, Marvin Werner, Barbara Walter, Brigitte Wollert-Wulf, Tomoharu Yasuda, Arnd Heuser, Dieter Beule, Stephan Mathas, Ioannis Anagnostopoulos, Andreas Rosenwald, Klaus Rajewsky, Martin Janz
Summary: By targeting the expression of genes involved in MM subgroup-specific chromosomal translocations into mouse GC B cells, we have generated distinct MM-like disease models that recapitulate key features of human tumors, which provides insights into the pathogenesis and therapeutic vulnerabilities of different MM subgroups.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Kiyomi Shitaoka, Akifumi Higashiura, Yohei Kawano, Akima Yamamoto, Yoko Mizoguchi, Takao Hashiguchi, Norihisa Nishimichi, Shiyu Huang, Ayano Ito, Shun Ohki, Miyuki Kanda, Tomohiro Taniguchi, Rin Yoshizato, Hitoshi Azuma, Yasuo Kitajima, Yasuyuki Yokosaki, Satoshi Okada, Takemasa Sakaguchi, Tomoharu Yasuda
Summary: Broadly neutralizing antibodies against SARS-CoV-2 variants, including Omicron, were found in long-term hospitalized convalescent patients infected with early SARS-CoV-2 strain B.1.1, and their mechanisms were identified through crystal structures. The decrease in antibody efficacy against mutated SARS-CoV-2 spike RBD explains breakthrough infections and reinfections by Omicron variants. Therefore, eliciting RBD-specific B cells in the longitudinal germinal center reaction provides potent immunity against emerging wide range of SARS-CoV-2 variants.
COMMUNICATIONS BIOLOGY
(2023)
Article
Immunology
Hitoshi Azuma, Yohei Kawano, Kiyomi Shitaoka, Takahiro Kawahara, Ayano Ito, Akifumi Higashiura, Yasuo Kitajima, Shun Ohki, Tomoharu Yasuda
Summary: The multiple amino acid replacements in the receptor-binding domain (RBD) of the Omicron variant of SARS-CoV-2 weaken the effectiveness of antibodies elicited by current booster vaccines. There is a concern regarding the original antigenic sin negative aspect of the immune response that needs to be addressed. However, our study shows that vaccination with Omicron-specific antigens can induce a broad range of neutralizing antibodies against Omicron variants, even in individuals previously vaccinated with the original antigen.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Biology
Koshi Imami, Tomoharu Yasuda
