Journal
ADVANCED SCIENCE
Volume 8, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/advs.202002499
Keywords
artificial dendritic cell and extracellular vesicle; biomimetic drug delivery; engineered immune cell; immune cell membrane; nanomedicine
Categories
Funding
- Academy of Finland [317042]
- HiLIFE Research Funds
- Sigrid Juselius Foundation
- Academy of Finland (AKA) [317042, 317042] Funding Source: Academy of Finland (AKA)
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In recent decades, diverse immune cells have been explored for their potential as therapeutic and diagnostic cell-based microrobots for challenging disorders. These systems leverage the unique characteristics and functions of immune cells to address a variety of diseases.
Over the past decades, considerable attention has been dedicated to the exploitation of diverse immune cells as therapeutic and/or diagnostic cell-based microrobots for hard-to-treat disorders. To date, a plethora of therapeutics based on alive immune cells, surface-engineered immune cells, immunocytes' cell membranes, leukocyte-derived extracellular vesicles or exosomes, and artificial immune cells have been investigated and a few have been introduced into the market. These systems take advantage of the unique characteristics and functions of immune cells, including their presence in circulating blood and various tissues, complex crosstalk properties, high affinity to different self and foreign markers, unique potential of their on-demand navigation and activity, production of a variety of chemokines/cytokines, as well as being cytotoxic in particular conditions. Here, the latest progress in the development of engineered therapeutics and diagnostics inspired by immune cells to ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, and infectious diseases is reviewed, and finally, the perspective for their clinical application is delineated.
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