Article
Oncology
Yikun Xu, Binshu Chai, Xianyi Wang, Zong Wu, Zhitao Gu, Xiaomin Liu, Yiqi Zhao, Tangbing Chen, Zhongliang Ma, Qiangling Sun
Summary: In this study, low expression of miR-199a-5p in NSCLC sera samples was found, and miR-199a-5p was demonstrated to suppress cell proliferation, migration, and cell cycle arrest in NSCLC cell lines by targeting SLC2A1. This study suggests that miR-199a-5p can inhibit glucose metabolism in NSCLC and provides a novel approach for clinical treatments of NSCLC.
Article
Biochemistry & Molecular Biology
Daniele Lettieri-Barbato, Katia Aquilano, Carolina Punziano, Giuseppina Minopoli, Raffaella Faraonio
Summary: Cell senescence plays critical roles in various aspects of organism life, including tissue development, homeostasis, tumor suppression, and aging-related diseases. Oxidative stress, caused by inadequate detoxification of reactive oxygen/nitrogen species, is a major driver of senescence. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, are important regulators of cellular processes, including oxidative stress responses and senescence.
Review
Plant Sciences
K. Bharathan Sruthi, Athira Menon, P. Akash, Eppurath Soniya
Summary: Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides without coding potential. Recent research shows that lncRNAs can code for micropeptides, which are generated from small open reading frames (smORFs) and found in short mRNAs and non-coding RNAs. Although micropeptides play critical roles in plant development and stress, only a few functions have been verified so far.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Myoung-Hee Kang, Tae-Keun Kim, Chan-Gi Pack, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Summary: Exosomal miR-1260b promotes angiogenesis in HUVECs and metastasis in NSCLC by targeting HIPK2, and may serve as a potential prognostic marker for lung cancer.
CELL DEATH & DISEASE
(2021)
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Review
Oncology
Mohammad Roshani, Ghazaleh Baniebrahimi, Mahboubeh Mousavi, Noushid Zare, Reza Sadeghi, Reza Salarinia, Amirhossein Sheida, Danial Molavizadeh, Sara Sadeghi, Farzaneh Moammer, Mohammad Reza Zolfaghari, Hamed Mirzaei
Summary: Exosomal lncRNAs play a crucial role in the biology of gastrointestinal cancer and can be utilized as biomarkers for diagnosis, prognosis, and potential treatment targets.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Lina Ma, Zhang Zhang
Summary: This comment provides an overview of the types and features of lncRNA databases worldwide, and discusses their contribution to lncRNA research.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Guo, Bolun Zhou, Liang Zhao, Qilin Huai, Fengwei Tan, Qi Xue, Fang Lv, Shugeng Gao, Jie He
Summary: This study identified an exLR-based signature that accurately predicts immunotherapeutic responses and prognosis in NSCLC patients before neoadjuvant immunotherapy.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Cell Biology
Yanlei Yang, Suying Liu, Chengmei He, Zhilei Chen, Taibiao Lyu, Liuting Zeng, Li Wang, Fengchun Zhang, Hua Chen, Robert Chunhua Zhao
Summary: MSCs are promising candidates for stem cell-based therapies due to their properties of self-renewal, multi-differentiation, immunoregulation, and tissue maintenance. Long non-coding RNAs (lncRNAs) play a major role in regulating homeostasis and differentiation functions in MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tongyan Liu, Chencheng Han, Panqi Fang, Hongyu Zhu, Siwei Wang, Zhifei Ma, Quanli Zhang, Wenjia Xia, Jie Wang, Lin Xu, Rong Yin
Summary: The translation discusses the resistance mechanisms in NSCLC targeted therapy, including the role of lineage plasticity; Lineage plasticity can drive cells to a new cell identity independent of the drug-targeted pathway, serving as a mechanism of TKI resistance in NSCLC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xuefeng Hao, Minghang Zhang, Meng Gu, Ziyu Wang, Shijie Zhou, Weiying Li, Shaofa Xu
Summary: The study evaluated the clinical significance and role of BZRAP1-AS1 in non-small-cell lung cancer (NSCLC). It was found that BZRAP1-AS1 expression was lower in tumor tissues and associated with clinical characteristics and prognosis. Overexpression of BZRAP1-AS1 inhibited cell proliferation and migration in NSCLC. BZRAP1-AS1 may serve as a diagnostic marker and therapeutic target for NSCLC.
Article
Medicine, Research & Experimental
Wenhua Xue, Zhibo Shen, Lifeng Li, Yuanyuan Zheng, Dan Yan, Quancheng Kan, Jie Zhao
Summary: The study showed that upregulation of NSD2 in esophageal squamous cell carcinoma (ESCC) is associated with cisplatin resistance, which is mediated by the stimulation of long non-coding RNA MACC1-AS1. High levels of MACC1-AS1 are significantly correlated with reduced overall survival of ESCC patients.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Medicine, Research & Experimental
Yajie Liao, Xudong Wu, Mengyu Wu, Yuan Fang, Jie Li, Weiqiang Tang
Summary: Lung cancer is the second most common cancer globally and the leading cause of tumor-related mortality. Angiogenesis, a critical feature in cancer development, is a promising target for lung cancer treatment. Non-coding RNAs (ncRNAs) have been found to play crucial roles in tumor angiogenesis, and this review focuses on discussing the regulatory functions of different ncRNAs in lung cancer angiogenesis, including downstream targets and signaling pathways. The potential applications of ncRNAs as biomarkers or novel anti-angiogenic tools in lung cancer are also explored.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Jianfei Tang, Xiaodan Fang, Juan Chen, Haixia Zhang, Zhangui Tang
Summary: Oral squamous cell carcinoma (OSCC) is a highly lethal malignancy worldwide, with long non-coding RNAs (lncRNAs) playing crucial regulatory roles in OSCC by influencing tumor initiation and progression. This review discusses the functions, molecular mechanisms, and interactions with the tumor microenvironment of lncRNAs in OSCC, highlighting their potential as diagnostic, prognostic, and therapeutic targets. Furthermore, it explores lncRNA-targeted therapeutic techniques such as CRISPR-Cas9 and immune checkpoint therapies to target lncRNAs and the PD-1/PD-L1 axis, presenting future perspectives in OSCC therapy that require further research for clinical applications.