Article
Pharmacology & Pharmacy
Ying Xing, Weiwei Xue, Yuhao Teng, Zhichao Jin, Xiaolong Tang, Zirui Li, Yue Hu, Ruiping Wang, Jun Qian
Summary: This study explored the pharmacological actions and mechanisms of Raddeanin A (RA) in non-small-cell lung cancer (NSCLC) using network pharmacology. The potential targets of RA for NSCLC therapy, such as SRC, MAPK1, and STAT3, were identified. Enrichment analyses indicated the involvement of these targets in regulating cell death, MAPK cascade, Ras signaling pathway, and PI3K/AKT signaling pathway. Experimental results showed that RA effectively inhibited proliferation, induced apoptosis, and induced autophagy in A549 lung cancer cells and downregulated the activity of the PI3K/AKT/mTOR pathway. Overall, this study revealed the antitumor effects and underlying mechanisms of RA on apoptosis and autophagy in A549 cells, suggesting its potential as an effective antineoplastic agent.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jiaming He, Wenkan Zhang, Xiaozhong Zhou, Weiqi Yan, Zhan Wang
Summary: Aloin inhibited osteosarcoma proliferation by inhibiting the PI3K/AKT/mTOR pathway, increasing autophagic flux, and promoting the apoptosis of osteosarcoma cells.
Article
Cell Biology
Hui Deng, Jing Jiang, Jie Shu, Meng Huang, Qing-Lian Zhang, Li-Juan Wu, Wen-Kui Sun
Summary: Bavachinin (BVC), a natural small molecule derived from the Chinese herb Fructus Psoraleae, displays multiple pharmacological effects and may serve as a potential drug candidate for the treatment of rheumatoid arthritis (RA). This study identified BVC targets and RA-related targets, and found that BVC primarily acts through the PPARG/PI3K/AKT signaling pathway to inhibit cell proliferation, migration, and inflammatory cytokine production, while promoting cell apoptosis. In vivo experiments showed that BVC alleviated joint injury and inflammation in CIA mice. These findings provide a theoretical foundation for the development of RA therapies.
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Dermatology
Min Zhou, Hao Zhang, Hairen Chen, Baiwen Qi
Summary: This study reveals that adiponectin protects skeletal muscle from ischemia-reperfusion injury through the miR-21/PI3K/Akt signaling pathway by inhibiting inflammatory response, apoptosis, and autophagy.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, Research & Experimental
Abulaiti Abulizi, Jimilihan Simayi, Maimaitiming Nuermaimaiti, Mengyuan Han, Sendaer Hailati, Ziruo Talihati, Nulibiya Maihemuti, Muhadaisi Nuer, Nawaz Khan, Kayisaier Abudurousuli, Dilihuma Dilimulati, Nuerbiye Nueraihemaiti, Nicholas Moore, Ainiwaer Wumaier, Wenting Zhou
Summary: In this study, the effective components and underlying mechanisms of Quince (Cydonia oblonga Mill, COM) extract against atherosclerosis were identified. Using UHPLC-Q-TOF-MS/MS, 14 serum components of COM extract were identified. Network pharmacology analysis predicted 573 targets, including 224 atherosclerosis-specific targets. The key targets included GSK3 beta, ESR1, EGFR, and HSP90AA1, and the key signaling pathway was the PI3K-Akt signaling pathway. COM extract exhibited hypolipidemic, anti-oxidative, anti-inflammatory, anti-thrombotic, and vascular endothelium protective effects in a rat model of atherosclerosis. These effects may be related to the inhibition of the EGFR/PI3K/AKT/GSK-3 beta signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Zheng Jin, Wenbo Zhang, Yuan Luo, Xiushen Li, Lijin Qing, Qiang Zuo, Junfeng Fang, Wei Wu
Summary: This study elucidated the mechanisms of QRHX in preventing or treating myocardial infarction in a rat model by activating the PI3K/Akt signaling pathway to promote autophagy, inhibit inflammatory factor expression, and reduce myocardial fibrosis. The findings provide a scientific basis for further research and validation of QRHX as a potential therapeutic for myocardial infarction.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Plant Sciences
Xiaoyi Qi, Yonglan Chen, Sha Liu, Li Liu, Zehui Yu, Ling Yin, Lu Fu, Mingming Deng, Sicheng Liang, Muhan Lu
Summary: This study revealed the antimetastatic effect of SAG on melanoma and identified the underlying molecular mechanisms through the inhibition of the PI3K-AKT signaling pathway. Results showed that SAG inhibited the proliferation, migration, and invasion of melanoma cells and effectively suppressed tumor growth in a xenograft model. These findings offer a theoretical foundation for the clinical application of SAG in antitumor therapy.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dengren Li, Kuipeng Yu, Feng Feng, Yang Zhang, Fang Bai, Yimeng Zhang, Nan Sun, Jiahui Fan, Lei Liu, Huimin Yang, Xiangdong Yang
Summary: This study found that hydroxychloroquine (HCQ) can alleviate inflammation and cell apoptosis caused by renal fibrosis by inhibiting the activation of the PI3K/AKT and NF-kB pathways, improving the epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) deposition in renal tubular epithelial cells. This provides theoretical evidence for the treatment of renal fibrosis with HCQ.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Tengyun Ma, Panwang Liu, Jiangping Wei, Meihuan Zhao, Xingxing Yao, Xiaohong Luo, Shijun Xu
Summary: The research demonstrated that imperatorin significantly inhibits the growth of ectopic endometrium in experimental endometriosis rats. It may regulate inflammatory response and cellular function by primarily affecting multiple pathways. Imperatorin is considered a significant multi-target natural active ingredient for treating endometriosis.
Article
Plant Sciences
Yi Han, Shujia Guo, Yunpeng Li, Jiani Li, Linfangzi Zhu, Yuwen Liu, Yufei Lv, Dong Yu, Lan Zheng, Caihong Huang, Cheng Li, Jiaoyue Hu, Zuguo Liu
Summary: The study findings suggest that berberine (BBR) has potential therapeutic effects for dry eye disease (DED), as it can rescue impaired corneal epithelium cells, ameliorate dry eye symptoms, suppress inflammation, protect the ocular surface, and inhibit specific pathways.
Article
Pharmacology & Pharmacy
Xue-hao Cheng, Xue-xin Yang, He-rong Cui, Bei-bei Zhang, Ke-dian Chen, Xiao-yun Yang, Jing-yi Jiao, Ya-wen Du, Qi Zhang, Jia-xin Zheng, Wei Xie, Fei-fei Li, Hai-min Lei
Summary: Chuanxiong promotes angiogenesis in vivo and in vitro by regulating the PI3K/AKT/Ras/MAPK pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Hui Shan, Xin Zhang, Yalu Mi, Jihui Jia, Bo Wang, Qing Yang
Summary: This study identifies eriodictyol as the most effective anti-gastric cancer flavonoid from Polygoni orientalis Fructus (POF) and investigates its potential targets in gastric cancer. Eriodictyol exhibits inhibitory effects on gastric cancer cell viability, suppresses colony formation, induces cell apoptosis, and inhibits tumor growth in vivo. Network pharmacology analysis suggests that the PI3K/AKT signaling pathway may be a potential target for eriodictyol in gastric cancer.
Article
Medicine, Research & Experimental
Jiangtao Ma, Maolin Ye, Ying Li, Shuang Chai, Hong Huang, Xiaohang Lian, Hongxing Huang
Summary: This study investigated the effect and mechanism of Zhuanggu Zhitong Capsule (ZGZT) in osteosarcopenia (OS) rats. Results showed that ZGZT could effectively improve the phenotypes of OS by up-regulating the PI3K/Akt/Bcl2 signaling pathway. This suggests that ZGZT may be a new treatment option for OS prevention and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Cheng-long Huo, Bing Wang, Xuewen Zhang, Zhen-Gang Sun
Summary: Skimmianine (Ski) has a protective effect against liver ischemia/reperfusion (I/R) injury by activating the PI3K-AKT pathway and reducing oxidative stress, apoptosis, and inflammation.
SCIENTIFIC REPORTS
(2023)
