Journal
BRAIN AND BEHAVIOR
Volume 11, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/brb3.2100
Keywords
Alzheimer' s disease; amyloid β ‐ protein; ApoE; cholinergic neurons; Estrogen; Genistein; neural regeneration; oxidative stress; SERMs; tau protein
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Funding
- Education Department of Jilin Province [JJKH20180107KJ]
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With the aging of the world population, the incidence of Alzheimer's disease is increasing. Studies have shown that genistein can improve brain function, protect nerves, and potentially delay and treat AD without the side effects of estrogen.
Along with the aging of the world population, the incidence rate of Alzheimer's disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. Studies have shown that estrogen has a positive effect on AD, but estrogen has the side effect of leading to tumors. Recent in vivo studies have shown that genistein, one of the selective estrogen receptor modulators (SERMs), can improve brain function through the blood-brain barrier (BBB), antagonize the toxicity of amyloid beta-protein (A beta), that is, to inhibit neurotoxicity due to aggregation of beta amyloid protein, and have neuroprotective effects. In addition, the use of Gen can avoid the risk of endometrial cancer and breast cancer caused by estrogen therapy while exerting an estrogen-like effect, which has some potential for the delay and treatment of AD.
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