Article
Chemistry, Medicinal
Gul Fatma Yarim, Murat Yarim, Mahmut Sozmen, Ayris Gokceoglu, Ali Ertekin, Yonca Betil Kabak, Efe Karaca
Summary: This study investigated the potential preventive and therapeutic effects of nobiletin in an EAE mouse model, showing that nobiletin modulates the expressions of proinflammatory and antiinflammatory cytokines in the brain and spinal cord in a dose-dependent manner. These findings suggest that nobiletin has the ability to attenuate inflammation in EAE mouse model, but further clinical studies are needed to support these experimental results.
Review
Biochemistry & Molecular Biology
Paulina Czajka-Francuz, Sylwia Cison-Jurek, Aleksander Czajka, Maciej Kozaczka, Jerzy Wojnar, Jerzy Chudek, Tomasz Francuz
Summary: Tumor microenvironment (TME) consists of tumor, stromal, and immune cells interacting with each other. Early and advanced colorectal tumors have different structures and altered levels of serum cytokines. The crosstalk among TME infiltrating cells can influence patients' prognosis by shifting the balance towards immune suppression or pro-inflammatory, antitumor responses. Understanding TME processes could aid in therapeutic planning and accurate patient prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shuang Lu, Xingyu Wei, Huan Zhu, Zhi Hu, Meiling Zheng, Jiali Wu, Cheng Zhao, Shuang Yang, Delong Feng, Sujie Jia, Hongjun Zhao, Ming Zhao
Summary: This study revealed that defective METTL3 in CD4(+) T cells contributes to the pathogenesis of SLE by promoting abnormal activation and imbalanced differentiation of effector T cells. Inhibition of METTL3 leads to increased activation of CD4(+) T cells and altered differentiation of effector T cells, especially Treg cells, aggravating the lupus-like phenotype in mice. These findings suggest that METTL3 could be a potential therapeutic target for intervention in SLE.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
M. Amelie Jule, J. Kacie Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, L. Maria Taylor, Julie Ng, A. James Lederer, M. Siobhan Case, H. Margaret Chang, M. Ezra Cohen, Fatma Dedeoglu, M. Melissa Hazen, S. Jonathan Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, S. Mindy Lo, Esra Meidan, E. Jordan Roberts, F. Mary Beth Son, P. Robert Sundel, Y. Pui Lee, Talal Chatila, A. Peter Nigrovic, A. Lauren Henderson
Summary: Oligoarticular juvenile idiopathic arthritis (oligo JIA) is characterized by Th1 polarization, particularly prominent in CD4+ T cells, while not compromising the regulatory identity of Tregs. Single-cell RNA-Seq revealed heterogeneous effector and regulatory subpopulations in synovial fluid, including IFN-induced Tregs, peripheral helper T cells, and cytotoxic CD4+ T cells.
Article
Pediatrics
Wei Quan, Jingnan An, Gang Li, Guanghui Qian, Meifang Jin, Chenxi Feng, Si Li, Xiaozhong Li, Yunyun Xu, Xiaohan Hu
Summary: This study identified significantly elevated levels of IL-2, IL-10, and IL-21 in cSLE patients compared to healthy controls, with a positive correlation to disease activity. This suggests potential new approaches for regulating T lymphocyte subsets in cSLE diagnosis.
Review
Medicine, General & Internal
Heiko Pfister
Summary: Neutrophil granulocytes, as a central component of the innate immune system, have gained significant attention in recent years due to their newly discovered biological effector functions and their involvement in various pathological conditions. They can modulate immune and target cells through the release of extracellular vesicles and DNA fibers, but excessive release or inefficient clearance can cause severe damage.
Article
Rheumatology
Ali Duarte-Garcia, Mehmet Hocaoglu, Maria Valenzuela-Almada, Shirley-Ann Osei-Onomah, Jesse Y. Dabit, Alain Sanchez-Rodriguez, Stephanie Q. Duong, Rachel E. Giblon, Hannah E. Langenfeld, Graciela S. Alarcon, Charles G. Helmick, Cynthia S. Crowson
Summary: The incidence and prevalence of systemic lupus erythematosus (SLE) are increasing in the US population, potentially due to the rising ethnic diversity. However, the severity of SLE and the survival gap between SLE and the general population have remained unchanged over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Gastroenterology & Hepatology
Kazumichi Abe, Rei Suzuki, Masashi Fujita, Manabu Hayashi, Atsushi Takahashi, Hiromasa Ohira
Summary: This study identified EV-miR-557 in serum as a potential biomarker for autoimmune hepatitis (AIH) and demonstrated its association with diagnostic and relapse markers. The findings suggest that EV-miR-557 may have potential as a therapeutic target for AIH.
HEPATOLOGY RESEARCH
(2022)
Article
Microbiology
Leah S. Hohman, Zhirong Mou, Matheus B. Carneiro, Gabriel Ferland, Rachel M. Kratofil, Paul Kubes, Jude E. Uzonna, Nathan C. Peters
Summary: Intracellular infection with Leishmania major results in concomitant immunity mediated by CD4(+) Th1 cells. The timing and interaction between Th1 cells and infected monocytes play a critical role in protective immunity. Activation of phagocytic host cells by preactivated Th1 cells at the time of infection is essential for successful immune response.
Review
Immunology
Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Shinichi Sato
Summary: This article outlines the role of B cells in the development of systemic sclerosis (SSc), including their involvement in autoimmune abnormalities, pro-inflammatory actions, and inhibitory functions. Studies have found B-cell depletion therapy to be effective for SSc.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
T. Bozic, G. Sersa, S. Kranjc Brezar, M. Cemazar, B. Markelc
Summary: The study indicates that gene therapy can alter the distribution of inflammatory cells in the tumor microenvironment and enhance immune system activation. However, further optimization of dosing schedule is needed to achieve better treatment outcomes.
BIOELECTROCHEMISTRY
(2021)
Article
Immunology
Lauren Goldschen, Jack Ellrodt, Hermioni L. Amonoo, Candace H. Feldman, Siobhan M. Case, Karestan C. Koenen, Laura D. Kubzansky, Karen H. Costenbader
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by unpredictable disease flares. A connection between posttraumatic stress disorder (PTSD) and the development of SLE has been identified, suggesting that stress-related disorders alter susceptibility to SLE. Perturbations in the autonomic nervous system, neuroendocrine system, and at the genomic level may cause and sustain immune dysregulation, contributing to the development and propagation of SLE in those predisposed genetically.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Yi-Rou Wu, Chung-Hsi Hsing, Chiao-Juno Chiu, Hsin-Yi Huang, Yu-Hsiang Hsu
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown etiology that affects multiple organ systems. Dysregulation of cytokines, particularly IL-1 and IL-10 families, plays a vital role in immune activation and self-tolerance in the pathogenesis of SLE. These cytokines could be potential targets for therapeutic intervention in SLE.
Article
Medicine, Research & Experimental
Carmen Bobeica, Elena Niculet, Mihaela Craescu, Cristian Onisor, Florin Bujoreanu, Miruna Luminita Draganescu, Ioana Alina Halip, Laura Gheuca-Solovastru
Summary: Epidemiological research on systemic sclerosis (SSc) in the southeast region of Romania reveals a higher prevalence of female patients, with the majority coming from urban areas, and most suffering from the diffuse subset of the disease. Further studies on larger patient populations in various countries are needed to identify epidemiological similarities and differences, as well as to develop new experimental models for future research.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Li-Juan Wang, Jie Zhu, Xiu-Juan Wu, Ting Li, Chun-Jiao Yang, Xi-Xiong Kang, Hong-Liang Zhang, Guo-Jun Zhang
Summary: This study aimed to observe the effect of Toll-like receptor 4 (TLR4) deficiency on clinical severity and expression of Th1/Th2/Th17-associated cytokines in experimental autoimmune neuritis (EAN). It was found that TLR4 deficiency could attenuate the clinical severity and delay the onset of EAN. Additionally, the production of IL-17A was significantly lower in the TLR4 KO mice with EAN compared to their WT counterparts.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Rheumatology
Ana Matas-Garcia, Alfredo Guillen-Del-Castillo, Boris Kisluk, Albert Selva-O'Callaghan, Gerard Espinosa, Sergio Prieto-Gonzalez, Pedro Moreno Lozano, Gloria Garrabou, Josep Maria Grau-Junyent, Carmen Pilar Simeon-Aznar, Jose C. Milisenda
Summary: This study analyzed the clinico-serological and histological phenotypes of SSc patients with associated myopathy. The patients were divided into two subgroups based on histological findings: fibrosing and inflammatory. Significant differences were found in clinical data, antibody profile, electrophysiologic studies, treatment response, mortality, and survival between the two groups.
Article
Rheumatology
G. Pires da Rosa, E. Ferreira, B. Sousa-Pinto, P. Bettencourt, G. Espinosa, R. Cervera
Summary: This study analyzed a cohort of patients with laboratory criteria for anti-phospholipid syndrome (APS) but only presenting "non-criteria" clinical manifestations. The patients were compared with definite APS patients. The results showed that these "clinical non-criteria" patients had mainly hematological and neurological involvements, with significant treatment use. Some patients may progress to future systemic lupus erythematosus (SLE).
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Giuseppe Barilaro, Carlo Della Rocca, Alexandra Esteves, Ricard Cervera, Gerard Espinosa
Summary: This study analyzed the association between the average 'adjusted' Global APS Score (aGAPSS) and the change in Damage Index for APS (DIAPS) in patients with thrombotic and non-thrombotic APS. The results showed that a higher average aGAPSS value was associated with an increase in DIAPS during follow-up, suggesting that the average aGAPSS score can predict the increase in DIAPS.
Article
Immunology
Stanislas Faguer, Matthieu Groh, Francois Vergez, Mathilde Hunault-Berger, Nicolas Duployez, Yves Renaudineau, Carle Paul, Guillaume Lefevre, Jean-Emmanuel Kahn
Summary: Alternatives are required for CD3(-) CD4(+) lymphocytic-variant hypereosinophilic syndrome patients who do not respond well to high-dose steroids or conventional therapies. This study reports successful treatment of five L-HES patients with cutaneous involvement and persistent eosinophilia by using JAK inhibitors. Complete clinical remission was achieved in all patients within three months, and adverse events were not observed during follow-up. Prospective clinical trials are needed to further investigate the use of JAK inhibitors in L-HES.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Caroline Carle, Yannick Degboe, Adeline Ruyssen-Witrand, Marina I. Arleevskaya, Cyril Clavel, Yves Renaudineau
Summary: T cells play a crucial role in the development of rheumatoid arthritis (RA). A comprehensive review based on the analysis of the Immune Epitope Database (IEDB) was conducted to better understand the contribution of T cells to RA. It was found that an immune CD8+ T cell senescence response is present in RA and inflammatory diseases, driven by viral antigens and self-apoptotic peptides. Additionally, pro-inflammatory CD4+ T cells in RA are selected by MHC class II and immunodominant peptides derived from molecular chaperones, host peptides, and bacterial cross-reactive peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Mohamed-Yacine Khitri, Alessandra Bartoli, Georgina Maalouf, Alban Deroux, Carlo Salvarani, Giacomo Emmi, Omer Karadag, Gerard Espinosa, Mathilde Leclercq, Gabriele Simonini, Mathieu Vautier, Patrice Cacoub, David Saadoun
Summary: This study evaluated the efficacy of tocilizumab in patients with refractory Behcet disease. The results showed that 83% of patients responded to tocilizumab, with 60% achieving complete response and 23% achieving partial response. Tocilizumab also significantly reduced steroid dosage and the need for concomitant disease-modifying antirheumatic drugs. However, a small number of patients experienced mild to moderate side effects and serious adverse events.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Georgia Lattanzi, Francesco Strati, Angelica Diaz-Basabe, Federica Perillo, Chiara Amoroso, Giulia Protti, Maria Rita Giuffre, Luca Iachini, Alberto Baeri, Ludovica Baldari, Elisa Cassinotti, Michele Ghidini, Barbara Galassi, Gianluca Lopez, Daniele Noviello, Laura Porretti, Elena Trombetta, Eleonora Messuti, Luca Mazzarella, Giandomenica Iezzi, Francesco Nicassio, Francesca Granucci, Maurizio Vecchi, Flavio Caprioli, Federica Facciotti
Summary: iNKT cells are a significant portion of effector T-cells in the intestine and have potential for cancer immunotherapy. However, their role in colorectal cancer (CRC) is controversial, limiting their therapeutic use. This study found that iNKT cells are enriched in tumor lesions and are induced by the pathobiont Fusobacterium nucleatum to express IL-17 and GM-CSF. This induces the recruitment of neutrophils with suppressive functions, which can be overcome by activating iNKT cells with α-galactosylceramide. The co-infiltration of iNKT cells and neutrophils correlates with negative clinical outcomes, highlighting the importance of iNKT cells in CRC.
MUCOSAL IMMUNOLOGY
(2023)
Article
Rheumatology
Francois Gaillard, Delphine Bachelet, Cecile Couchoud, Cedric Laouenan, Katell Peoc'h, Quentin Simon, Nicolas Charles, Noemie Jourde-Chiche, Eric Daugas
Summary: This study found that lupus activity decreases after the initiation of maintenance dialysis, but non-severe and severe lupus flares still occur. It emphasizes the importance of continued follow-up of lupus patients by specialists after dialysis initiation.
Article
Immunology
Elise Van Breedam, Tamariche Buyle-Huybrecht, Jonas Govaerts, Pieter Meysman, Andrea Bours, Marlies Boeren, Julia Di Stefano, Thalissa Caers, Hans De Reu, Laura Dirkx, Jolien Schippers, Esther Bartholomeus, Marielle Lebrun, Catherine Sadzot-Delvaux, Paulina Rybakowska, Marta E. Alarcon-Riquelme, Concepcion Maranon, Kris Laukens, Peter Delputte, Benson Ogunjimi, Peter Ponsaerts
Summary: Using hiPSC-derived neural cell models, the study investigated the interactions between VZV and neural cells. It was found that macrophages were unable to mount an antiviral immune response in VZV-infected hiPSC-neurons. Further analysis suggested the involvement of other cell types in orchestrating an efficient antiviral immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Jose Manuel Mascaro, Ignasi Rodriguez-Pinto, Gabriela Poza, Anna Mensa-Vilaro, Julian Fernandez-Martin, Luis Caminal-Montero, Gerard Espinosa, Jose Hernandez-Rodriguez, Marina Diaz, Joana Rita-Marques, Raimon Sanmarti, Santos Castaneda, Dolores Colunga, Ruben Coto-Hernandez, Patricia Fanlo, Jose Ignacio Elejalde, Segundo Bujan, Ignasi Figueras, Francisco Manuel Marco, Mariano Andres, Silvia Suarez, Andres Gonzalez-Garcia, Xavier Fusta-Novell, Clara Garcia-Belando, Ana Granados, Maria Teresa Fernandez-Figueras, Neus Quilis, Maria Orriols-Caba, Ricardo Gomez de la Torre, Maria Cinta Cid, Georgina Espigol-Frigole, Alba Alvarez-Abella, Eztizen Labrador, Maria Rozman, Monica Lopez-Guerra, Paola Castillo, Jose R. Alamo-Moreno, Eva Gonzalez-Roca, Susana Plaza, Virginia Fabregat, Rocio Lara, Esther F. Vicente-Rabaneda, Sonia Tejedor-Vaquero, Giuliana Magri, Nuria Bonet, Manuel Solis-Moruno, Andrea Cerutti, Oscar Fornas, Ferran Casals, Jordi Yague, Juan Arostegui
Summary: Thirty patients with adult-onset autoinflammatory diseases were definitively diagnosed with VEXAS syndrome through genetic analyses. Patients presented with late-onset disease and symptoms including cutaneous lesions, fever, pulmonary manifestations, and arthritis. The UBA1 variants were detected in both hematopoietic and non-hematopoietic tissues.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Dermatology
Bianca Bergamini, Julien Seneschal, Kristin J. Meyers, Frederick Durand, Ewa Haladyj, Gerard Espinosa, Jacob P. Thyssen
Summary: A total of 117 pregnancies with exposure to baricitinib were analyzed, and the clinical outcomes were found to be comparable to other targeted therapies for immune-mediated diseases or general population.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yves Renaudineau, Wesley Brooks, Julie Belliere
Summary: Lupus nephritis is the most severe organ manifestation of systemic lupus erythematosus. Efforts have been made to characterize the different steps of the disease and develop biomarkers for early diagnosis, disease monitoring, and preventing complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Guillaume Dorcet, Marie Benaiteau, Jeremie Pariente, Fabienne Ory-Magne, Emmanuel Cheuret, Marie Rafiq, Wesley Brooks, Benedicte Puissant-Lubrano, Francoise Fortenfant, Yves Renaudineau, Chloe Bost
Summary: This study aimed to explore the correlation between several biomarkers and the clinical course of autoimmune encephalitis (AIE). The results showed that the decrease in YKL-40 and MMP-9A at the protein level was associated with AIE remission, and the decrease in NfL and NfH levels in the serum was also associated with AIE remission. The study suggests that YKL-40 can be used as a biomarker to evaluate disease activity and therapeutic response in AIE.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Immunology
Silvia Martinez-Rivera, Helene Guet-Revillet, Fabrice Herin, Guillaume Martin-Blondel, Marcel Miedouge, Laura Billon, Emmanuel Treiner, Yves Renaudineau
Summary: The study evaluated the use of QTF-TB and mycobacterial infection testing to differentiate MTC exposure from active disease. QTF-TB had limited ability to distinguish between LTBI and active MTC disease, but a cut-off value of 4.4 IFN-gamma IU/mL showed the best diagnostic performance for MTC detection. Antibodies were detected in active MTC disease cases using the humoral assay, but not in LTBI or negative QTF-TB cases.
Article
Critical Care Medicine
Davide Mangioni, Mauro Panigada, Emanuele Palomba, Chiara Bobbio, Liliane Chatenoud, Laura Alagna, Jacopo Fumagalli, Andrea Gori, Anna Grancini, Amedeo Guzzardella, Andrea Lombardi, Caterina Matinato, Andrea Meli, Antonio Muscatello, Laura Porretti, Mara Tomasello, Elena Trombetta, Luca Valenti, Alessandra Bandera, Giacomo Grasselli
Summary: Differences in microbial sampling at VAP suspicion in COVID-19 ICU patients could lead to high variability in VAP incidence and microbiological findings. Concordance between ETA and BAL was limited by over 20% of ETA positive and BAL negative samples, while BALFAPPP showed high sensitivity but limited specificity when evaluating in-panel targets only. These factors should be considered when comparing results of cohorts with different sampling methods.