Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Han Na Jung, Min-Ju Kim, Hwi Seung Kim, Woo Je Lee, Se Hee Min, Ye-Jee Kim, Chang Hee Jung
Summary: This study investigated the age-related association between low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD). The results showed a positive association between LDL-C and ASCVD risk across all age groups, and individuals aged 75 and above with higher LDL-C levels still had an increased risk of ASCVD. Therefore, managing LDL-C is crucial for the prevention of primary ASCVD in the elderly population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Ronald M. Krauss
Summary: Levels of small, dense low-density lipoprotein (sdLDL) particles have been associated with risk of atherosclerotic cardiovascular disease (ASCVD). There is sufficient evidence to suggest measuring sdLDL for assessing and managing cardiovascular disease risk.
CURRENT OPINION IN LIPIDOLOGY
(2022)
Article
Medicine, General & Internal
In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
Summary: The study found that the risk of MACE incidence decreased in statin users, but increased for low-risk statin users, with no significant relationship identified for intermediate and borderline risk groups. The risk of MACE incidence decreased only in the high CVD risk group among statin users.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Harold Superko, Brenda Garrett
Summary: Despite statin use and LDL-C reduction, residual cardiovascular disease event risk remains. Abnormal lipoprotein size and density distribution, known as lipoprotein heterogeneity, contributes to this residual risk. Recent clinical trial evidence reinforces the importance of LDL heterogeneity measurement and its impact on CHD risk prediction and outcomes.
Article
Biochemistry & Molecular Biology
Gediz Dogay Us, Sohail Mushtaq
Summary: The study demonstrates that high-dose intake of omega-3 fatty acids in combination with statins has a positive effect on improving lipid profiles in hyperlipidemic patients, particularly in reducing LDL III, non-HDL-C, TG, and VLDL-C. Further research is needed to validate these findings.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Endocrinology & Metabolism
Yaxin Wang, Gabriella Bulloch, Yu Huang, Yingying Liang, Zijing Du, Guanrong Wu, Ying Fang, Yijun Hu, Xianwen Shang, Zhuoting Zhu, Xiayin Zhang, Xiaohong Yang, Honghua Yu
Summary: This study aimed to assess the association between atherosclerotic cardiovascular disease (ASCVD) risk factors and incident ASCVD events in individuals with type 2 diabetes (T2D) and microvascular complications. The study found that higher levels of HDL-C were associated with a decreased risk of ASCVD, while each 10 nmol/L increase in lipoprotein(a) (Lp(a)) levels was associated with an increased risk of ASCVD.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Cardiac & Cardiovascular Systems
Fatemeh Omidi, Maryam Rahmannia, Amir Hashem Shahidi Bonjar, Parsa Mohammadsharifi, Mohammad Javad Nasiri, Tala Sarmastzadeh
Summary: Our study conducted a systematic review to examine the effectiveness of Ezetimibe in lowering LDL-C levels and its impact on coronary atherosclerotic plaques in individuals with ACD. The results showed that combining Ezetimibe with statins led to a greater decrease in LDL-C levels compared to using statins alone. Additionally, this intervention strategy was effective in reducing the volume of dense calcification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Xiaona Wang, Liang Wang, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Ping Ye
Summary: In the Chinese cohort, elevated levels of sdLDL-C are associated with major adverse cardiovascular events and serve as an independent risk factor. Hypertension combined with high levels of sdLDL-C further increases the risk of MACEs.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Marenao Tanaka, Tatsuya Sato, Keisuke Endo, Masafumi Inyaku, Kazuma Mori, Itaru Hosaka, Takuma Mikami, Yukinori Akiyama, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi
Summary: A disorder of lipid metabolism is involved in cardiovascular diseases including hypertension. A high level of small dense low-density lipoprotein cholesterol (sdLDL-C) is a strong risk factor for atherosclerotic cardiovascular disease. However, the association between sdLDL-C and hypertension has not been fully investigated.
HYPERTENSION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Federica Galimberti, Manuela Casula, Elena Olmastroni
Summary: The retention of apoB-containing lipoproteins in the subendothelial layer is crucial for the development of atherosclerotic processes. Recent evidence suggests that the number of atherogenic particles trapped in the arterial lumen, rather than their lipid content, plays a key role in this process. Hence, apoB level is proposed as a better indicator than LDL-cholesterol for assessing cardiovascular disease risk, particularly in specific patient subgroups. Routine measurement of both LDL-cholesterol and apoB is essential for estimating overall cardiovascular risk, evaluating residual risk, and monitoring therapeutic effectiveness.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Hematology
Gissette Reyes-Soffer, Henry N. Ginsberg, Lars Berglund, P. Barton Duell, Sean P. Heffron, Pia R. Kamstrup, Donald M. Lloyd-Jones, Santica M. Marcovina, Calvin Yeang, Marlys L. Koschinsky
Summary: High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular diseases. Genetic factors determine 70% to 90% of interindividual heterogeneity in Lp(a) levels. There is a lack of standardized assays, diagnostic guidelines, and targeted treatments for lowering Lp(a). Understanding the genetic and biological basis for variation in Lp(a) levels in different populations is crucial.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Akshyaya Pradhan, Ravninder Kuka, Pravesh Vishwakarma, Wahid Ali, Marco Alfonso Perrone, Ferdinando Iellamo, Gaurav Chaudhary, Sharad Chandra, Rishi Sethi, Sudhanshu Dwivedi, Varun Narain, R. K. Saran
Summary: In ACS patients, age, sex, diabetes, smoking, and the severity of coronary artery disease did not significantly affect sd-LDL levels. However, prior statin usage was associated with lower sd-LDL levels, and diabetic patients had higher sd-LDL/lb-LDL ratios.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Michael J. Wilkinson, Norman E. Lepor, Erin D. Michos
Summary: Management of elevated low-density lipoprotein cholesterol (LDL-C) is crucial for preventing atherosclerotic cardiovascular disease (ASCVD) and reducing ASCVD events. Statins are recommended as the first-line therapy for LDL-C reduction, while nonstatin lipid-lowering therapy can be added for intensive LDL-C lowering in high-risk patients. However, many high-risk patients fail to meet LDL-C thresholds despite guideline recommendations. This review explores the challenges of LDL-C lowering and proposes a new approach to ASCVD risk assessment and treatment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Virginia Fisher, Paola Sebastiani, L. Adrienne Cupples, Ching-Ti Liu
Summary: AnnoRE utilizes GWAS summary statistics, local genotype correlation structure, and functional annotation to prioritize the most plausible causal SNPs in trait-associated loci. This method improves upon previous fine-mapping approaches by allowing for differential shrinkage via random effects in a multiple regression model, avoiding assumptions on the number of causal SNPs per locus.
HUMAN MOLECULAR GENETICS
(2022)
Article
Mathematical & Computational Biology
Yuh-Jenn Wu, Yu-Chieh Cheng, Chieh Chiang, Li-Hsueh Cheng, Ching-Ti Liu, Chin-Fu Hsiao
Summary: Globalized drug development studies, such as multiregional clinical trials (MRCTs), play a significant role in expediting drug development and supporting drug registration in different regions. However, the heterogeneity in variability across regions presents a challenge in MRCTs, and it is essential to consider this heterogeneous variability in the design and evaluation of such trials for ensuring consistency in treatment effects.
STATISTICS IN MEDICINE
(2022)
Article
Infectious Diseases
Hiroaki Ikezaki, Hideyuki Nomura, Nobuyuki Shimono
Summary: This study evaluated the anti-spike IgG levels in Japanese healthcare workers six months after receiving the BNT162b2 vaccine. The results showed that older individuals and daily alcohol drinkers had substantially lower levels of anti-spike IgG, suggesting the need for an additional vaccine dose for these at-risk categories.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Kosaku Sasaki, Masayuki Murata, Keiji Nakamura, Yuji Matsumoto, Yuko Nakashima, Sho Yamasaki, Azusa Ota, Satoshi Hiramine, Koji Takayama, Hiroaki Ikezaki, Kazuhiro Toyoda, Eiichi Ogawa, Nobuyuki Shimono
Summary: This study reports a case of a COVID-19 patient who developed heparin-induced thrombocytopenia (HIT), a possible complication of anticoagulant therapy with heparin, along with pulmonary artery thrombus. The patient's respiratory failure improved after switching to the direct oral anticoagulant apixaban.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Ching-Ti Liu, Timothy Tsai, Brett T. Allaire, Mary L. Bouxsein, Marian T. Hannan, Thomas G. Travison, Douglas P. Kiel
Summary: This study examines the association between changes in visceral adipose tissue (VAT) over 6 years and paraspinal muscle density, finding that greater accumulation of VAT is associated with lower muscle density.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamanos, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, J-MICC Study group
Summary: This study found that higher BMI in the Japanese population is causally associated with various cardiometabolic traits including high blood pressure, triglycerides, uric acid, low high-density-lipoprotein cholesterol, and eGFR. However, there was no significant association between genetic risk scores for BMI and individual-level cardiometabolic traits.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chloe Sarnowski, Matthew P. Conomos, Ramachandran S. Vasan, James B. Meigs, Josee Dupuis, Ching-Ti Liu, Aaron Leong
Summary: The effects of genetic burden on obesity risk and cardiovascular disease differ based on birth year, with individuals born after 1960 being more strongly affected. This suggests that the impact of genetics on obesity and cardiovascular risks may be amplified in the increasingly obesogenic environment.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Mathematical & Computational Biology
Loraine Liping Seng, Ching-Ti Liu, Jingli Wang, Jialiang Li
Summary: Mendelian randomization is a technique that uses genetic variants to examine the causal effect of a modifiable exposure on a trait. A model average estimator is proposed to overcome the difficulty of high-dimensionality, which involves using different subsets of instruments to predict the exposure and weighting the submodels' predictions using penalization. The estimator's practical performance is examined in numerical studies and applied to a real genetic dataset investigating the relationship between stature and blood pressure.
STATISTICS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Peitao Wu, Josee Dupuis, Ching-Ti Liu
Summary: We propose a nonparametric additive quantile regression method with network regularization to incorporate known network information, aiming to identify genomic risk factors of higher BMI.
STATISTICS IN MEDICINE
(2023)
Article
Cell Biology
Fabrice J. F. Laroche, Sheng Li, Ning Shen, Soo Kyung Hwang, Gina Nguyen, Wenling Yu, Chen Khuan Wong, Ryan J. J. Quinton, Jason N. N. Berman, Ching-Ti Liu, Anurag Singh, Neil J. J. Ganem, Sam Thiagalingam, Hui Feng
Summary: Hyperactive sphingosine 1-phosphate (S1P) signaling is associated with poor prognosis of triple-negative breast cancer (TNBC). The phosphorylation of S1P receptor 1 (S1P1) at threonine 236 (T236) plays a critical role in TNBC dissemination and invasion. Inhibiting the phosphorylation of S1P1 T236 using AKT inhibitors or an S1P1 functional antagonist suppresses TNBC cell migration and tumor invasion.
Article
Medical Laboratory Technology
Hiroaki Ikezaki, Norihiro Furusyo, Masumi Ai, Mitsuyo Okazaki, Takuji Kohzuma, Jun Hayashi, Nobuyuki Shimono, Ernst J. Schaefer
Summary: This study evaluated the association between lipoprotein subclasses and maximum cIMT levels, finding that elevated LDL-2 and -3 cholesterol were related to higher cIMT levels, suggesting the importance of smaller LDL particle cholesterol values in atherosclerosis prevention.
CLINICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Hiroaki Ikezaki, Hideyuki Nomura, Nobuyuki Shimono
Summary: The efficacy of COVID-19 vaccination in the elderly is hindered by immunosenescence. This study found a positive correlation between mitochondrial DNA levels and vaccine-induced immunity, suggesting that maintaining mitochondrial DNA levels may improve immunosenescence in the elderly.
Article
Endocrinology & Metabolism
Shylaja Srinivasan, Peitao Wu, Josep M. Mercader, Miriam S. Udler, Bianca C. Porneala, Traci M. Bartz, James S. Floyd, Colleen Sitlani, Xiquing Guo, Jeffrey Haessler, Charles Kooperberg, Jun Liu, Shahzad Ahmad, Cornelia van Duijn, Ching-Ti Liu, Mark O. Goodarzi, Jose C. Florez, James B. Meigs, Jerome Rotter, Stephen S. Rich, Josee Dupuis, Aaron Leong
Summary: In large biobank samples, a common variant polygenic score (PS) for type 1 diabetes (T1D) was not consistently associated with the prevalence of type 2 diabetes (T2D). However, possible heterogeneity in T2D cannot be ruled out and future studies are needed to further investigate subphenotyping.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Biochemical Research Methods
Xiaoyu Zhang, Ching-Ti Liu
Summary: This article introduces an information-incorporated clustering method that utilizes existing information from previous studies to improve disease subtyping and biomarker identification. The method is validated through simulation studies and real data analysis, and demonstrates better performance compared to other clustering methods.
Review
Statistics & Probability
Xiaoyu Zhang, Zhenwei Zhou, Hanfei Xu, Ching-Ti Liu
Summary: Integrative multi-omics clustering is an unsupervised method aimed at providing a comprehensive understanding of disease mechanisms and biological processes. Due to statistical and computational challenges, the methods are categorized into three general categories and further classified based on the main statistical strategy used in clustering under each category.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL STATISTICS
(2022)
