Article
Neurosciences
Tao Zhong, Jingkuan Wei, Kunhua Wu, Liangjun Chen, Fenqiang Zhao, Yuchen Pei, Ya Wang, Hongjiang Zhang, Zhengwang Wu, Ying Huang, Tengfei Li, Li Wang, Yongchang Chen, Weizhi Ji, Yu Zhang, Gang Li, Yuyu Niu
Summary: In this study, longitudinal brain atlases and associated tissue probability maps were constructed based on structural MRI scans from typically-developing cynomolgus macaques, providing dense time-points during infancy and addressing the lack of temporally densely-sampled atlases for non-human primates.
Article
Neurosciences
B. Riffault, R. Cloarec, H. Rabiei, M. Begnis, D. C. Ferrari, Yehezkel Ben-Ari
Summary: This study provides the first 3D atlases of the cholinergic and catecholaminergic systems in the mouse brain from embryonic day 12 to post-natal day 8 using tissue clearing, immunohistochemistry, lightsheet microscopy, and a multiresolution registration technique. The findings show a logarithmic scale increase of choline acetyltransferase and tyrosine hydroxylase positive neurons from E18 to P8 in several brain structures. Moreover, there are abrupt modifications in the developmental trajectory of many brain structures during the transition from E18 to P0.
Article
Computer Science, Software Engineering
D. R. Bukenberger, K. Buchin, M. Botsch
Summary: Voronoi diagrams and their computation are well known in the Euclidean L-2 space. Our novel algorithm allows for the construction of generalized L-infinity Voronoi diagrams, supporting individually oriented sites and generating weighted diagrams with anisotropic weight vectors for individual sites.
COMPUTER GRAPHICS FORUM
(2022)
Review
Chemistry, Multidisciplinary
Shameel Thurakkal, David Feldstein, Raul Perea-Causin, Ermin Malic, Xiaoyan Zhang
Summary: This study discusses the recent progress in constructing heterostructures using black phosphorus nanosheets, emphasizing different types of interactions and various applications. It also highlights the challenges and future research aspects in these heterostructures based on BPNS.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yueyuan Xiao, Yang Ling, Kuixing Wang, Shijie Ren, Yanhang Ma, Longyu Li
Summary: A 3D covalent organic framework (COF-904) was successfully constructed by inter-digitating 2D hcb nets using imine condensation reactions. The single-crystal structure of COF-904 was resolved, revealing the formation of complex extended frameworks from simple molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Neurosciences
Joel D. Hahn, Larry W. Swanson, Ian Bowman, Nicholas N. Foster, Brian Zingg, Michael S. Bienkowski, Houri Hintiryan, Hong-Wei Dong
Summary: This study presents flatmaps of the mouse, rat, and human brain, with enhanced representations of the nervous system components and different stages of rat brain development. These flatmaps serve as a neuroscience toolbox for researchers, facilitating comparative analysis of brain data.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Thermodynamics
Shima Soleimani, Steven Eckels, Matthew Campbel
Summary: This study investigates the effects of micro-fin design on heat transfer and friction factors, and evaluates the potential of a data-mining model as a surrogate for computational fluid dynamic (CFD) models in 2D and 3D micro-fin tubes.
APPLIED THERMAL ENGINEERING
(2022)
Article
Biology
Jun Takatoh, Jae Hong Park, Jinghao Lu, Shun Li, P. M. Thompson, Bao-Xia Han, Shengli Zhao, David Kleinfeld, Beth Friedman, Fan Wang
Summary: This study developed a new method to track premotor circuits in the adult mouse, revealing unique spatial organizations of different premotor circuits and identifying premotor neurons that simultaneously innervate multiple motor nuclei.
Article
Computer Science, Interdisciplinary Applications
Temitope Akanbi, Jiansong Zhang
Summary: This study proposes a framework for converting existing 2D bridge drawings into 3D information models and further into industry foundation class files. Experimental results show that the framework can generate high-quality 3D models from PDF bridge drawings in a semi-automated fashion, using only 3.33% of the time required by the current state-of-the-art method.
JOURNAL OF COMPUTING IN CIVIL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Xuran Wang, David Choi, Kathryn Roeder
Summary: Developed a method called locCSN that estimates cell-specific networks (CSNs) for each cell, preserving information about cellular heterogeneity. The CSNs can reveal gene communities better than traditional measures and can identify differential network genes that do not differ in gene expression. By analyzing the gene networks in fetal brain cells and comparing CSNs between case and control subjects, intriguing patterns in gene coexpression were revealed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Computer Science, Interdisciplinary Applications
S. Boopathiraja, V. Punitha, P. Kalavathi, V. B. Surya Prasath
Summary: With the rapid development and utilization of medical technology in the era of big data, efficient and robust data compression models are required to handle the huge amount of medical imaging data. Researchers have proposed numerous compression mechanisms and algorithms in the past two decades to address this challenge, with this work providing a detailed overview of existing computational compression methods in the field of medical imaging data.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2022)
Article
Computer Science, Artificial Intelligence
Javid Dadashkarimi, Amin Karbasi, Qinghao Liang, Matthew Rosenblatt, Stephanie Noble, Maya Foster, Raimundo Rodriguez, Brendan Adkinson, Jean Ye, Huili Sun, Chris Camp, Michael Farruggia, Link Tejavibulya, Wei Dai, Rongtao Jiang, Angeliki Pollatou, Dustin Scheinost
Summary: Open-source neuroimaging datasets offer large sample sizes and promote generalization efforts, but releasing preprocessed data limits user choices. To address this, CAROT is introduced to find a mapping between different atlases, allowing already processed connectomes to be easily reused in a wide range of analyses. CAROT can reconstruct connectomes from various atlases without needing raw data.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Engineering, Biomedical
Sarah Frisken, Nazim Haouchine, Rose Du, Alexandra J. Golby
Summary: This work presents a new method for reconstructing patient-specific 3D brain vasculature from a pair of 2D DSA image sequences, aiming to provide high resolution visualization of blood vessels. By augmenting vessel centerlines with mathematical algorithm, the method achieved a significant reduction in 'ghosting' artifacts during reconstruction process.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Maryam Sadeghi, Arnau Ramos-Prats, Pedro Neto, Federico Castaldi, Devin Crowley, Pawel Matulewicz, Enrica Paradiso, Wolfgang Freysinger, Francesco Ferraguti, Georg Goebel
Summary: To accurately investigate the anatomical organization of neural circuits in the brain, it is crucial to map experimental brain data onto a standardized coordinate system. We propose a computational tool called AMBIA that can accurately map 2D mouse brain slices onto a 3D brain model with minimal human intervention. The tool performs at a human expert level in terms of localization and registration.
Article
Mathematics, Interdisciplinary Applications
Yuanyuan Si, Hongjun Liu, Yuehui Chen
Summary: Some weaknesses of 1D chaotic maps in cryptography can be solved by using a higher-dimensional chaotic map called 3D exponential hyperchaotic map (3D-EHCM), which has better dynamic properties.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2022)
Article
Public, Environmental & Occupational Health
Allyson J. Gallant, Paul Flowers, Karen Deakin, Nicola Cogan, Susan Rasmussen, David Young, Lynn Williams
Summary: This study aimed to enhance influenza vaccination uptake among adults with chronic respiratory conditions by using the Behaviour Change Wheel (BCW) to specify intervention content. The study identified barriers and enablers to vaccination through focus groups, interviews, and surveys. Factors such as perceptions of vaccine side effects, time constraints, and fear of needles were found to be common barriers, while enablers included protection from influenza, reminders, and support from others. Based on the findings, the study proposed a suite of multi-level intervention components involving diverse actors, recipients, and settings to enhance vaccination uptake.
PSYCHOLOGY & HEALTH
(2023)
Article
Pediatrics
Elizabeth M. A. Henderson, David Tappin, David Young, Donata Favretto, Helen Mactier
Summary: This study aimed to examine the correlation between postnatal maternal self-report of alcohol consumption during pregnancy and PEth concentration measured from dried blood spot (DBS) obtained on day 5 of life. However, the study found that PEth concentration measured from DBS obtained on day 5 of life does not reliably identify modest prenatal alcohol exposure (PAE) after 36 weeks' gestation from maternal self-report.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Chemistry, Organic
Da-Liang Zhu, Jie Li, Qi Wu, Yanqing Wang, David J. Young, Hong-Xi Li
Summary: The efficient etherification of alcohols with aryl bromides can be promoted by sodium tert-butoxide at room temperature. This simple procedure offers a practical pathway to aryl alkyl ethers in good yields without the need for any transition metal species.
SYNTHESIS-STUTTGART
(2023)
Review
Psychiatry
Mara Parellada, Alvaro Andreu-Bernabeu, Monica Burdeus, Antonia San Jose Caceres, Elena Urbiola, Linda L. Carpenter, Nina V. Kraguljac, William M. McDonald, Charles B. Nemeroff, Carolyn I. Rodriguez, Alik S. Widge, Matthew W. State, Stephan J. Sanders
Summary: The aim of this study was to evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms. A systematic review was conducted and 280 articles were included, reporting on 940 biomarkers. However, the studies showed high heterogeneity and there is currently no sufficient evidence for response biomarkers in ASD clinical trials.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Maria Cristina Cioclu, Ilaria Mosca, Paolo Ambrosino, Deborah Puzo, Allan Bayat, Saskia B. Wortmann, Johannes Koch, Vincent Strehlow, Kentaro Shirai, Naomichi Matsumoto, Stephan J. Sanders, Vincent Michaud, Marine Legendre, Antonella Riva, Pasquale Striano, Hiltrud Muhle, Manuela Pendziwiat, Gaetan Lesca, Giuseppe Donato Mangano, Rosaria Nardello, Johannes R. Lemke, Rikke S. Moller, Maria Virginia Soldovieri, Guido Rubboli, Maurizio Taglialatela
Summary: This study describes the phenotypic and genetic features of patients with KCNT2-related developmental epileptic encephalopathy (DEE), and investigates the functional and pharmacological properties of KCNT2 channels carrying novel or previously untested variants. The results expand the phenotypic and genotypic spectrum of KCNT2-related disorders, and highlight the need for targeted therapies based on the molecular phenotype.
ANNALS OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Justin Koesterich, Joon-Yong An, Fumitaka Inoue, Ajuni Sohota, Nadav Ahituv, Stephan J. Sanders, Anat Kreimer
Summary: Autism spectrum disorder (ASD) is influenced by both common and rare genetic variations, with disruptive rare variants in protein-coding regions having a clear impact on symptoms. However, the role of rare non-coding variants, including promoters, remains unclear. In this study, the functional impact of de novo mutations in promoter regions in ASD cases and controls was analyzed using massively parallel reporter assays. Although certain functionally high confidence de novo variants were identified, no differences in functional impact based on ASD diagnostic status were found.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qing Li, Bo-Wei Xu, Yi-Ming Zou, Ru-Jie Niu, Jin-Xiang Chen, Wen-Hua Zhang, David James. Young
Summary: In this study, nanoscale two-dimensional Fe-II- and Co-II-based metal-organic frameworks (NMOFs) were shown to have an anticancer effect in the tumor microenvironment. These NMOFs can catalyze the production of hydroxyl radicals (center dot OH) and O-2 in the presence of H2O2, and consume O-2 to produce singlet oxygen (O-1(2)) through photodynamic therapy. Both center dot OH and O-1(2) are reactive oxygen species (ROS) that inhibit cancer cell proliferation.
Article
Biochemistry & Molecular Biology
Kiyoshi Fujisawa, Yui Kobayashi, Mitsuki Okano, Ryota Iwabuchi, Shiori Kondo, David James Young
Summary: Coordination polymers of transition metal ions, such as silver(I), are important in coordination chemistry. Silver(I) coordination polymers are often insoluble in common solvents, making it difficult to analyze them in solution. However, by using a tetramethyl-substituted bipyrazole ligand, we have synthesized more soluble silver(I) complexes with coordinated ions CF3CO2- and CF3SO3-. We determined the structures of these complexes and studied their solution behavior using various spectroscopic techniques.
Article
Multidisciplinary Sciences
Laurent Gole, Feng Liu, Kok Haur Ong, Longjie Li, Hao Han, David Young, Gabriel Pik Liang Marini, Aileen Wee, Jingmin Zhao, Huiying Rao, Weimiao Yu, Lai Wei
Summary: This study utilized image analysis to predict the irreversibility of liver fibrosis in hepatitis C patients. The researchers found that collagen aggregation pattern and thickness were strongly associated with the reversibility of fibrosis. These findings have important implications for early prediction and treatment of hepatitis C.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Chelsea Lowther, Elise Valkanas, Jessica L. Giordano, Harold Z. Wang, Benjamin B. Currall, Kathryn O'Keefe, Emma Pierce-Hoffman, Nehir E. Kurtas, Christopher W. Whelan, Stephanie P. Hao, Ben Weisburd, Vahid Jalili, Jack Fu, Isaac Wong, Ryan L. Collins, Xuefang Zhao, Christina A. Austin-Tse, Emily Evangelista, Gabrielle Lemire, Vimla S. Aggarwal, Diane Lucente, Laura D. Gauthier, Charlotte Tolonen, Nareh Sahakian, Christine Stevens, Joon-Yong An, Shan Dong, Mary E. Norton, Tippi C. Mackenzie, Bernie Devlin, Kelly Gilmore, Bradford C. Powell, Alicia Brandt, Francesco Vetrini, Michelle Divito, Stephan J. Sanders, Daniel G. Macarthur, Jennelle C. Hodge, Anne O'Donnell-Luria, Heidi L. Rehm, Neeta L. Vora, Brynn Levy, Harrison Brand, Ronald J. Wapner, Michael E. Talkowski
Summary: Short-read genome sequencing (GS) has shown a higher diagnostic yield compared to standard-of-care tests for assessing autism spectrum disorder (ASD) and fetal structural anomalies (FSAs). GS outperforms karyotype, chromosomal microarray (CMA), and exome sequencing (ES) in terms of diagnostic variant identification, and when capturing copy-number variants from exome data, GS and ES have similar diagnostic yields. GS has the potential to significantly increase the diagnostic yield for unselected FSAs. Overall, GS is a promising first-tier diagnostic approach for ASD and FSAs.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Kiyoshi Fujisawa, Aoba Yamada, Moeka Koyama, David James Young
Summary: Tridentate, planar nitrogen containing ligands based on pyridine and pyrazoles were synthesized and their solid-state structures were analyzed. Copper(II) chlorido and trifluoromethanesulfonato complexes were formed with these ligands and their coordination geometries were studied. The UV-Vis spectra of the complexes showed pi-pi* transition band red-shift and d-d transition bands at similar energy, indicating structural changes in the solution-state. EPR spectroscopy supported the findings.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Organic
Da-Liang Zhu, Jie Li, David James Young, Yanqing Wang, Hong-Xi Li
Summary: This paper presents a mild strategy for aminating aryl halides with anilines using dual photoredox and nickel catalysis. Thioxanthen-9-one, an inexpensive and readily available compound, greatly enhanced this cross-coupling reaction, yielding a diverse range of diarylamines in good yields (41-93%) at room temperature. The reaction could be performed under compact fluorescent lamp light or sunlight and was tolerant of various functional groups. It was successfully applied to the synthesis of natural products and drug molecules, even at a gram-scale. The mechanism involves several steps including oxidative addition, transmetalation, energy transfer, and reductive elimination.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
You-Hui Zhao, Hai-Yan Li, David James Young, Xiangqian Cao, Da-Liang Zhu, Zhi-Gang Ren, Hong-Xi Li
Summary: Earth-abundant copper(I) coordination complexes have been developed as visible-light photocatalysts for the intermolecular atom-transfer radical addition reactions. Four heteroleptic bis-chelate Cu(I) complexes were synthesized and showed broad absorption in the visible spectrum. These complexes facilitated efficient reactions with CBr4, CCl3Br, and CHI3, yielding high product yields up to 91%. The substitution on the phpz ligand had a significant impact on the absorption, emission, redox potential, and photocatalytic activity.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Zhi-Hao Zhang, Jia-Lu Ge, Yan Li, Qing Li, Pin-Pin Ma, Xiao-Yan Tang, Wen-Hua Zhang, David J. Young
Summary: Developing porous materials for efficient capture of I-2 is important for the sequestration and storage of radioactive iodine towards clean nuclear energy. In this study, three structurally identical two-dimensional (2D) metal-organic frameworks (MOFs) were prepared, and one of the MOFs showed the highest adsorption capacity for I-2.
Article
Biochemistry & Molecular Biology
Shan He, Yixiao Wu, Yang Zhang, Xuan Luo, Christopher T. Gibson d Jingrong Gao, Jingrong Gao, Matt Jellicoe, Hao Wang, David J. Young, Colin L. Raston
Summary: Biodegradable cellulose films derived from kombucha, processed using a vortex fluidic device, show increased mechanical strength due to intense micromixing and high shear stress of the liquid film. The films retain their biodegradability and degrade within 5 days.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
