Article
Endocrinology & Metabolism
Yuan Zhou, Zhuo Xu, Yuanyi Wang, Qiang Song, Ruofeng Yin
Summary: This study investigates the role of MALAT1 in osteogenic differentiation and cell apoptosis in osteoporosis. MALAT1 upregulates the expression of Bmp4, Col1a1, and Spp1, enhances ALP activity, and inhibits apoptosis. MALAT1 promotes osteogenic differentiation and inhibits cell apoptosis through the miR-485-5p/WNT7B axis, suggesting its potential as a target for alleviating osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Yongxian Cao, Feng Zhang, Haotian Wang, Chunhua Bi, Jinpeng Cui, Fenghai Liu, Huazheng Pan
Summary: Research has shown that MALAT1 and Nova1 are upregulated in doxorubicin-resistant HCC tissues and cells, while miR-3129-5p expression is decreased. Knockdown of MALAT1 regulates doxorubicin resistance of HCC cells by inhibiting proliferation, migration, invasion, and promoting apoptosis, with Nova1 being a target gene of miR-3129-5p that can reverse the effects of miR-3129-5p expression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Juanjuan Dai, Ning Zhou, Rui Wu, Jing Du, Shuang Miao, Kaikai Gong, Lijuan Yang, Weiwei Chen, Xuelin Li, Chen Li, Yan Wu
Summary: This study found that MALAT1 is upregulated in lung carcinoma cells, and its suppression can block cancer cell proliferation, invasion, and migration, as well as inhibit UBE2C expression. Additionally, MALAT1 regulates UBE2C expression by sponging miR-491-5p, affecting the progression of lung carcinoma.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Ophthalmology
Anjun Tan, Tianrong Li, Libo Ruan, Jingjing Yang, Yuanyuan Luo, Ling Li, Xinan Wu
Summary: This study investigated the role of Malat1 in diabetic retinopathy (DR), revealing that Malat1 regulates hRMEC dysfunction by modulating the miR-205-5p/VEGF-A pathway under high glucose conditions. The findings provide valuable insights for exploring new therapeutic targets for DR.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Zhe Zhao, Jianquan Liu, Zhiqin Deng, Xiaoqiang Chen, Wencui Li
Summary: This study found that MALAT1 regulates the tenogenic differentiation of TDSCs by regulating the miR-378a-3p/MAPK1 axis, indicating that this axis may be a promising avenue for the treatment of tendinopathy.
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Tian Liang, Tong Lu, Weiwei Jia, Runze Li, Min Jiang, Yu Jiao, Yuchen Wang, Shanshan Cong, Xinyan Jiang, Lina Dong, Yingyu Zhou, Guangmei Zhang, Dan Xiao
Summary: This study elucidated the role and downstream mechanism of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of pyroptosis in cervical cancer cells. The findings demonstrated that lncRNA MALAT1 was upregulated in cervical carcinoma cells and its knockdown induced pyroptosis-mediated cell death, while its overexpression blocked lipopolysaccharide-induced pyroptosis. The study also identified the involvement of the microRNA-124/sirtuin 1 axis in mediating the effects of lncRNA MALAT1 on cervical cancer cell pyroptosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chengnan Tian, Shuo Hu, Junjian Yu, Wentong Li, Peijun Li, Huanlei Huang
Summary: This study revealed that PVT1 promotes cardiac fibrosis by increasing HCN1 expression through sponging miR-145. These findings suggest that targeting PVT1 may be a potential therapeutic option for cardiac fibrosis and cardiac diseases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Oncology
Jing-Jin Yang, Wei-Xia Peng, Mei-Biao Zhang
Summary: This study investigated the role of lncRNA KCNQ1OT1 in osteogenic differentiation of bone marrow mesenchymal stem cells. The results showed that KCNQ1OT1 can upregulate the expression of RICTOR by inhibiting miR-205-5p, thus promoting osteogenesis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yingzhi Gu, Yuxing Bai
Summary: This study aimed to determine whether lncRNA MALAT1 promotes the osteogenic differentiation of human PDLSCs in vitro. The results showed that MALAT1 regulates human PDLSC differentiation by regulating the miR-93-5p/SMAD5 axis.
Article
Multidisciplinary Sciences
Weiping Xia, Xiang Chen, Zewu Zhu, Hequn Chen, Bingsheng Li, Kangning Wang, Li Huang, Zhi Liu, Zhi Chen
Summary: The study found that lncRNA MALAT1 promotes the process of renal interstitial fibrosis through the miR-124-3p/ITGB1 signaling pathway, suggesting its potential as a therapeutic target for RIF.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Haozi Huang, Guowei Zhang, Zhenying Ge
Summary: The overexpression of MALAT1 in diabetic rats and HG-treated cells may exacerbate renal fibrosis and cell damage via the miR-2355-3p/IL6ST axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin Yue, Wen-ying Wu, Ma Dong, Meng Guo
Summary: MALAT1 is highly expressed in breast cancer tissues and cells, promoting proliferation, migration, invasion, and doxorubicin resistance. Through targeting miR-570-3p, MALAT1 plays a pivotal role in regulating breast cancer progression and drug resistance.
BIOMEDICAL JOURNAL
(2021)
Article
Cell Biology
Gang Han, Quanyi Guo, Ning Ma, Wenzhi Bi, Meng Xu, Jinpeng Jia, Wei Wang
Summary: This study revealed that BCRT1 is significantly upregulated in osteosarcoma specimens and plays a role in promoting cell growth, cell cycle progression, EMT, and inflammatory mediator secretion. The elevated expression of BCRT1 decreases miR-1303 expression and enhances FGF7 expression in osteosarcoma cells, contributing to oncogenic progression. The findings suggest that BCRT1 acts as an oncogene in osteosarcoma progression.
Article
Cell Biology
Kechun Yang, Yun Xue, Xiaoya Gao
Summary: XIST levels were found to be elevated in the serum of AS patients and ox-LDL-treated AS cell models. XIST depletion restrained cell proliferation and induced apoptosis in AS cell models, while miR-599 was identified as a direct downstream target of XIST reversing the effects of XIST knockdown on AS progression. XIST was also shown to increase TLR4 expression by serving as a ceRNA of miR-599, implicating the XIST/miR-599/TLR4 axis in AS development.