An old friend who has overstayed their welcome: the ALSFRS-R total score as primary endpoint for ALS clinical trials

Plateaus in amyotrophic lateral sclerosis progression: results from a population‐based cohort

(2020) R. Vasta et al.   EUROPEAN JOURNAL OF NEUROLOGY

Current trends in the clinical trial landscape for amyotrophic lateral sclerosis

(2020) Ruben P.A. van Eijk et al.   CURRENT OPINION IN NEUROLOGY

Group sequential designs for clinical trials with bivariate endpoints

(2020) Junxiao Hu et al.   STATISTICS IN MEDICINE

Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

(2020) Sabrina Paganoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS

(2020) Jeremy M. Shefner et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Frequent self‐assessments in ALS Clinical Trials: worthwhile or an unnecessary burden for patients?

(2020) Ruben P. A. Eijk   Annals of Clinical and Translational Neurology

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

(2019) Leonard H. van den Berg et al.   NEUROLOGY

Evidence for a multimodal effect of riluzole in patients with ALS?

(2019) Adriaan D de Jongh et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Development and assessment of the inter-rater and intra-rater reproducibility of a self-administration version of the ALSFRS-R

(2019) Leonhard A Bakker et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Development and Validation of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS)

(2019) Christina N. Fournier et al.   JAMA Neurology

Assessment of bulbar function in amyotrophic lateral sclerosis: validation of a self-report scale (Center for Neurologic Study Bulbar Function Scale)

(2018) R. A. Smith et al.   EUROPEAN JOURNAL OF NEUROLOGY

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

(2018) Ton Fang et al.   LANCET NEUROLOGY

Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open-Access ALS Clinical Trials cohort

(2018) Nimish J. Thakore et al.   MUSCLE & NERVE

Deconstructing progression of amyotrophic lateral sclerosis in stages: a Markov modeling approach

(2018) Nimish J. Thakore et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

(2018) Ruben P.A. van Eijk et al.   Clinical Epidemiology

Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial

(2017) Richard Smith et al.   Neurotherapeutics

Predicting functional decline and survival in amyotrophic lateral sclerosis

(2017) Mei-Lyn Ong et al.   PLoS One

What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis

(2016) James Rooney et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

How common are ALS plateaus and reversals?

(2015) Richard S. Bedlack et al.   NEUROLOGY

Clinical Measures of Disease Progression in Amyotrophic Lateral Sclerosis

(2015) Seward B. Rutkove   Neurotherapeutics

A further Rasch study confirms that ALSFRS-R does not conform to fundamental measurement requirements

(2015) Franco Franchignoni et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The PRO-ACT database: Design, initial analyses, and predictive features

(2014) N. Atassi et al.   NEUROLOGY

Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients

(2014) Hazuki Watanabe et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale

(2014) Rubika Balendra et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis

(2013) Adriano Chiò et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Evidence of multidimensionality in the ALSFRS-R Scale: a critical appraisal on its measurement properties using Rasch analysis

(2013) Franco Franchignoni et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Combined Assessment of Function and Survival (CAFS): A new endpoint for ALS clinical trials

(2013) James D. Berry et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Comparison of analysis approaches for phase III clinical trials in amyotrophic lateral sclerosis

(2012) Brian C. Healy et al.   MUSCLE & NERVE

Composite Variables

(2012) Mi-Kyung Song et al.   NURSING RESEARCH

Through the looking glass: understanding non-inferiority

(2011) Jennifer Schumi et al.   Trials

Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial

(2009) Matthew R Sydes et al.   Trials