Article
Polymer Science
Qunhao Wang, Mei Li, Zhuo Zheng, Yan Niu, Xiaolin Xue, Chenghong Ao, Wei Zhang, Canhui Lu
Summary: In this study, a novel wound dressing with high drug loading capacity and sustained drug release properties was successfully fabricated by electropinning of cellulose followed by polyethylenimine (PEI)-functionalization. The grafted PEI chains on the surface of electrospun cellulose nanofibers provided numerous active amino groups, leading to enhanced adsorption performance against the anionic drug of sodium salicylate (NaSA). The NaSA-loaded cellulose-PEI could continuously release the drug for 12 hours in simulated body fluid (SBF), demonstrating the versatility of cellulose-PEI as an advanced wound dressing with drug carrier functionalities.
Article
Materials Science, Multidisciplinary
Weijie Xu, Xin Gao, Huaping Tan, Shengke Li, Tianle Zhou, Jianliang Li, Yong Chen
Summary: This study aims to develop a polysaccharide-based hydrogel dressing with self-healing ability and sustained antibacterial function for wound healing. The dressing shows good elasticity and sustained release performance, and it also supports the survival and proliferation of stem cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Polymer Science
Lili Deng, Kangkang Ou, Jiaxin Shen, Baoxiu Wang, Shiyan Chen, Huaping Wang, Song Gu
Summary: A natural self-healing hydrogel based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) was developed in this study. The hydrogel showed good self-healing properties and cytocompatibility, indicating its potential in wound healing and tissue repair.
Article
Biochemistry & Molecular Biology
Gabriela Isopencu, Iuliana Deleanu, Cristina Busuioc, Ovidiu Oprea, Vasile-Adrian Surdu, Mihaela Bacalum, Roberta Stoica, Anicuta Stoica-Guzun
Summary: Bacterial cellulose (BC) is a biopolymer studied intensively for biomedical applications. However, it lacks antimicrobial activity and has limited water retention capacity. To address these limitations, BC composites with carboxymethyl cellulose (CMC) and turmeric extract (TE) were developed using citric acid (CA) as the crosslinking agent. These composites showed high swelling degrees, adsorbing exudate from chronic wounds, and exhibited potential antibacterial properties against Escherichia coli, Staphylococcus aureus, and Candida albicans. The composites were also found to be non-toxic to fibroblast cells, making them promising candidates for wound dressing applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Paper & Wood
Nghi Thi-Phuong Nguyen, Huy Hoang Nguyen, Hoan Ngoc Doan, Kien Trung Pham, Khiem Van Nguyen, Binh Thanh Vu, Tin Dai Luong, Bach Thang Phan, Hanh Kieu Thi Ta, Ngoc Quyen Tran, Tuan-Ngan Tang, Nhi Ngoc-Thao Dang, Thi-Hiep Nguyen
Summary: The study found that adding chitosan oligosaccharide to bacterial cellulose membranes can improve their hemostatic properties, although it may decrease the mechanical strength of the membranes. The modified bacterial cellulose membrane with 2 w/v% chitosan oligosaccharide solution (BC-COS2) demonstrated excellent hemostasis promotion in in vitro and in vivo experiments.
Article
Chemistry, Applied
Daria Ciecholewska-Jusko, Anna Zywicka, Adam Junka, Radoslaw Drozd, Peter Sobolewski, Pawel Migdal, Urszula Kowalska, Monika Toporkiewicz, Karol Fijalkowski
Summary: This study introduces a novel ex situ modification method for bacterial cellulose (BC) polymer, significantly enhancing its water absorption capacity through a single and cost-effective crosslinking process. The optimized crosslinked BC showed superior water capacity compared to modern commercial dressings, making it a potentially valuable material for super-absorbent dressings designed for chronic wounds.
CARBOHYDRATE POLYMERS
(2021)
Review
Biotechnology & Applied Microbiology
Nour Fatema, Ruben Michael Ceballos, Chenguang Fan
Summary: This review highlights the advances and future prospects of cellulose as a biomaterial. It focuses on the applications of nanofibrillated, nanocrystalline, and bacterial cellulose as biomaterials in the field of biomedicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Guihua Yang, Zhikun Zhang, Kefeng Liu, Xingxiang Ji, Pedram Fatehi, Jiachuan Chen
Summary: A novel pH-responsive hydrogel (RPC/PB) was developed for the treatment of bacterial-infected wounds. The hydrogel exhibited excellent mechanical properties, self-healing ability, and adhesion performance. It showed pH-responsive drug release behavior in the acidic wound microenvironment. Additionally, the hydrogel showed biocompatibility, antioxidant effect, antibacterial activity, skin tissue regeneration, and wound closure capabilities.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Suphatchaya Lamkhao, Sujitra Tandorn, Praput Thavornyutikarn, Komsanti Chokethawai, Gobwute Rujijanagul, Kriangkrai Thongkorn, Parkpoom Jarupoom, Chamnan Randorn
Summary: This study focuses on the formulation of environmentally friendly blended materials based on carboxymethyl cellulose for advanced interactive wound dressing. The hydrogels produced showed excellent swelling properties, improved surface mechanical properties, and high cell viability, indicating their potential for wound healing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Sam Swingler, Abhishek Gupta, Hazel Gibson, Marek Kowalczuk, Grazyna Adamus, Wayne Heaselgrave, Iza Radecka
Summary: This study explored the incorporation of thymoquinone within bacterial cellulose using cyclodextrins as a solubilizing agent for hydrophobic compounds. The resulting inclusion complex was found to be soluble in water, thermally stable, and capable of being loaded into the bacterial cellulose matrix, with potential application in pharmaceutically active wound dressings.
Article
Biotechnology & Applied Microbiology
Feng Wang, Shuguang Wang, Liping Nan, Jiawei Lu, Ziqi Zhu, Jintao Yang, Dong Zhang, Junjian Liu, Xiao Zhao, Desheng Wu
Summary: Wound injuries can lead to serious consequences, and the use of biomedical hydrogels as wound dressings has shown great potential in accelerating wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Saharman Gea, Imam Budi Putra, Dharma Lindarto, Khatarina Meldawati Pasaribu, Yanggi Saraswati, Myrtha Karina, Ronn Goei, Alfred Iing Yoong Tok
Summary: Diabetic foot ulcer is a common complication of diabetes mellitus. This study focused on the development of BC/Z. acanthopodium microencapsulated wound dressing composites and evaluated their potential as a DFU wound dressing. The results showed that the wound dressings exhibited good antibacterial effect and accelerated the wound closure process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Mehdi Farokhi, Fatemeh Mottaghitalab, Mercedeh Babaluei, Yasamin Mojarab, Subhas C. Kundu
Summary: Skin injuries, especially chronic wounds, remain a significant healthcare problem. Recent developments in multifunctional wound dressings aim to improve wound repair.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jun Zhao, Peng Qiu, Yue Wang, Yufan Wang, Jianing Zhou, Baochun Zhang, Lihong Zhang, Dongxia Gou
Summary: As promising biomaterials, hydrogels are widely used in wound repairing due to their ability to absorb and retain water without dissolving or losing their three-dimensional structure. Chitosan and its derivatives have gained attention in this field for their unique molecular structure and diverse biological activities. This review systematically introduces the mechanism of wound healing and analyzes the role of chitosan in different stages of wound repair. Intelligent and drug-loaded chitosan-based hydrogels are discussed, along with the challenges and prospects for future development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Olga Luneva, Roman Olekhnovich, Mayya Uspenskaya
Summary: A wide range of skin diseases necessitates the search for alternative and effective treatment options, particularly for various types of wounds. This review examines the advantages and methods of bilayer dressings in wound treatment and skin tissue regeneration, focusing on hydrogel-based materials. The use of such materials can provide unique properties, such as antimicrobial, adhesion, and hemostasis capabilities, as well as drug delivery and self-healing abilities.
Article
Chemistry, Medicinal
Enas Al-Ani, Wayne Heaselgrave
Summary: The aim of this study was to investigate the potential of thymol to inhibit Candida biofilm formation and improve its biocompatibility with hydroxypropyl methylcellulose (HPMC) and poloxamer 407 (P407) as drug carriers. Thymol showed concentration-dependent biofilm inhibition, and its inhibitory effect was enhanced when combined with HPMC. The Thymol-P407 combination completely inhibited biofilm formation, but its antibiofilm effect decreased as the Candida biofilms matured. Thymol had a significant negative effect on the viability of HEK 293 cells, but when P407 was present, the cell viability increased significantly. The thymol-P407 combination showed a superior inhibitory effect on biofilm formation and better biocompatibility with human cell lines, suggesting its potential for medical use in preventing Candida biofilm formation.
Article
Polymer Science
Joanna Brzeska, Grzegorz Jasik, Wanda Sikorska, Barbara Mendrek, Jakub Karczewski, Marek Kowalczuk, Maria Rutkowska
Summary: This paper presents the results of testing the susceptibility to degradation in soil of branched polyesterurethane (PUR) based on poly([R,S]-3-hydroxybutyrate) (R,S-PHB), modified with poly([D,L]-lactide) (PLA) and starch (St). The study found that these materials underwent enzymatic degradation caused by microorganisms in the soil, resulting in changes in surface morphology while having minimal changes in molecular weight, chemical structure, and thermal properties.
Article
Biochemistry & Molecular Biology
James Hillier, Gemma J. Allcott, Laura A. Guest, Wayne Heaselgrave, Alex Tonks, Myra E. Conway, Amy L. Cherry, Steven J. Coles
Summary: This study provides evidence suggesting that the CXXC motif of cytosolic branched-chain aminotransferase (BCAT1) may contribute to buffering reactive oxygen species (ROS) levels inside acute myeloid leukemia (AML) cells, impacting on ROS-mediated processes in the development of AML.
Article
Ophthalmology
Noor Alantary, Wayne Heaselgrave, Scott Hau
Summary: This study correlated the different forms of Acanthamoeba on ex vivo confocal microscopy (EVCM) with in vivo confocal microscopy (IVCM) and cultured positive cases of Acanthamoeba keratitis. EVCM and IVCM showed good correlation, and cyst morphology changed with imaging depth.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Valeriy Demchenko, Yevgen Mamunya, Serhii Kobylinskyi, Sergii Riabov, Krystyna Naumenko, Svitlana Zahorodnia, Olga Povnitsa, Nataliya Rybalchenko, Maksym Iurzhenko, Grazyna Adamus, Marek Kowalczuk
Summary: The green synthesis of silver-containing nanocomposites based on polylactide (PLA) was carried out through mechanical and in situ methods. The resulting nanocomposites were analyzed for their structure, properties, and antimicrobial, antiviral, and cytotoxic activities. It was found that the average size of silver nanoparticles in the PLA was influenced by the synthesis method, with smaller nanoparticles (3.7 nm) obtained through the in situ method. The nanocomposites exhibited antimicrobial activity against various bacteria and fungi, with increased activity at higher nanoparticle concentrations. Nanocomposites obtained through the mechanical method did not show antimicrobial activity.
Article
Food Science & Technology
Roberta Tolve, Fideline Laure Tchuenbou-Magaia, Lucia Sportiello, Federico Bianchi, Iza Radecka, Fabio Favati
Summary: The development of fortified healthy pleasant foods presents a challenge for the food industry due to their susceptibility to oxidative rancidity. A comparative study was conducted to investigate the oxidative stability and predict the shelf-life of a newly developed no added sugar chocolate spread. The study found that the presence of magnesium-calcium carbonate nanoparticles may enhance lipid oxidation.
Article
Food Science & Technology
Maria Di Cairano, Fideline Laure Tchuenbou-Magaia, Nicola Condelli, Nazarena Cela, Constance Chizoma Ojo, Iza Radecka, Simon Dunmore, Fernanda Galgano
Summary: This study determined the glycemic index (GI) of gluten-free biscuits formulated with alternate flours, resistant starch, and sucrose replacers using in vivo methods. It also compared the in vivo GI values with the predicted glycemic index (pGI) from in vitro digestibility-based protocols commonly used by researchers. The results showed that the correlation between GI and pGI was dependent on food formulation, suggesting that pGI data may not be suitable for classifying food products according to their GI.
Review
Polymer Science
Zinnia Mansoor, Fideline Tchuenbou-Magaia, Marek Kowalczuk, Grazyna Adamus, Georgina Manning, Mattia Parati, Iza Radecka, Habib Khan
Summary: The application of mulch films in agriculture is important for preserving soil moisture and preventing weed growth. However, the use of plastic mulch films has raised concerns about plastic pollution and health hazards. As a result, there has been a growing research focus on finding biodegradable alternatives. Despite the potential benefits, finding a suitable biodegradable polymer for mulch films involves balancing factors such as mechanical properties, cost, and biodegradability.
Review
Biochemistry & Molecular Biology
Diana-Andreea Blaj, Marek Kowalczuk, Cristian Peptu
Summary: Cyclodextrins are cyclic oligosaccharides with unique properties due to their structural architecture, and mass spectrometry techniques have played a crucial role in characterizing these compounds. This review focuses on the application of mass spectrometry methods, such as MALDI MS, ESI MS, and tandem mass spectrometry, in studying the structural features and processes associated with esterified cyclodextrins (ECDs).
Editorial Material
Polymer Science
Alicja Utrata-Wesolek, Barbara Trzebicka, Jerzy Polaczek, Iza Radecka, Marek Kowalczuk
Review
Biotechnology & Applied Microbiology
Brian Johnston, Grazyna Adamus, Anabel Itohowo Ekere, Marek Kowalczuk, Fideline Tchuenbou-Magaia, Iza Radecka
Summary: This review article discusses the potential use of various polymeric materials, such as PE, PP, PS, and PET, in the production of bioplastics through microbial cultivation. It provides up-to-date information on microbial strains used in the biodegradation of polyolefins and reviews metabolic pathways and challenges in plastic waste valorization. The article highlights the importance of oxidative degradation and microbial-based processes in microbiology and biotechnology to reduce the environmental impact of plastic waste.
BIOENGINEERING-BASEL
(2022)