Article
Obstetrics & Gynecology
Israel Yoles, Eyal Sheiner, Tamar Wainstock
Summary: First pregnancy without GDM complicated by hypertensive disorders, perinatal mortality, maternal obesity, and fetal macrosomia was associated with an increased risk for GDM in the subsequent pregnancy. Women with these complications may benefit from early detection of GDM in their subsequent pregnancy.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Public, Environmental & Occupational Health
Himanshu Nayak, Rajendra Gadhavi, Bhavin Solanki, Bhagyalaxmi Aroor, Hemant Gameti, Kalpita S. Shringarpure, Jayun Joshi, Zuveriya Kazi
Summary: This study aimed to implement a community-based screening and awareness-raising project for gestational diabetes in Ahmedabad, India. By training medical personnel to screen pregnant women, a high prevalence of gestational diabetes was found, indicating the need for implementing this project on a larger scale.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2022)
Article
Medicine, General & Internal
Teresa A. Hillier, Kathryn L. Pedula, Keith K. Ogasawara, Kimberly K. Vesco, Caryn E. S. Oshiro, Suzanne L. Lubarsky, Jan Van Marter
Summary: In this study comparing one-step screening with two-step screening for gestational diabetes mellitus, the one-step approach resulted in more diagnoses of gestational diabetes mellitus but did not have a significant impact on the incidence of adverse perinatal and maternal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hui Wang, Weiqin Si, Leifen Shen, Jian Chen
Summary: This study aimed to identify and establish a prediction model for the risk factors of gestational diabetes mellitus (GDM). Through classification of 210 pregnant women registered at the Huzhou Maternal and Child Health Care Hospital, it was found that education level, pre-pregnancy BMI, family history of hypertension, family history of diabetes, history of macrosomia, history of GDM, TPOAb (+), and levels of FT3, HbA1c, and Hb were the risk factors for GDM. These findings may be beneficial for predicting GDM.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, General & Internal
Xiaocui Li, Xinru Liu, Yan Zuo, Jiejun Gao, Yan Liu, Wei Zheng
Summary: The incidence of GDM in PCOS patients is high, with age, body mass index, insulin resistance index, testosterone, and other factors being independent risk factors for GDM. There are significant differences in complications between the GDM group and the no-GDM group.
Article
Medicine, General & Internal
Ele Hanson, Inge Ringmets, Anne Kirss, Maris Laan, Kristiina Rull
Summary: The diagnosis rate of gestational diabetes mellitus is increasing year by year, and pregnant women with GDM risk factors are at risk of increased weight gain and delivering large-for-gestational-age (LGA) newborns, even with normal OGTT results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yumei Wei, Juan Juan, Rina Su, Geng Song, Xu Chen, Ruiqin Shan, Ying Li, Shihong Cui, Shangrong Fan, Ling Feng, Zishan You, Haixia Meng, Yan Cai, Cuilin Zhang, Huixia Yang
Summary: This study investigates the prevalence of gestational diabetes mellitus (GDM) recurrence and its associated risk factors in China. The findings show that factors such as age, pre-pregnancy BMI, and OGTT levels during the first pregnancy are associated with GDM recurrence. Preconception counseling is important for preventing GDM recurrence in women with a history of GDM.
CHINESE MEDICAL JOURNAL
(2022)
Article
Endocrinology & Metabolism
Sang Youn You, Kyungdo Han, Seung-Hawn Lee, Mee Kyoung Kim
Summary: The study found that NAFLD is associated with an increased risk of insulin-requiring GDM, with higher FLI scores (30-59 and >=60) showing higher rates of GDM. This association was more prominent in subjects without metabolic syndrome.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Environmental Sciences
Zhigang Li, Rongrong Xu, Zhanshan Wang, Nianfeng Qian, Yan Qian, Jianhao Peng, Xiaojing Zhu, Chen Guo, Xiaoqian Li, Qiujin Xu, Yongjie Wei
Summary: This study found that ozone exposure, especially in the first month before pregnancy, is associated with an increased risk of gestational diabetes mellitus (GDM). The odds of GDM also increase with increasing ozone concentration. These findings highlight the importance of stricter air pollution controls to improve the health of pregnant women and their offspring.
Article
Endocrinology & Metabolism
Daryl J. Selen, Tanayott Thaweethai, Carolin C. M. Schulte, Sarah Hsu, Wei He, Kaitlyn James, Anjali Kaimal, James B. Meigs, Camille E. Powe
Summary: Gestational glucose intolerance (GGI), an abnormal initial gestational diabetes mellitus (GDM) screening test without a GDM diagnosis, is associated with an increased risk of future diabetes. Individuals with GGI have a higher risk of developing diabetes compared to those with normal glucose tolerance during pregnancy. Routine clinical data can be used to identify this unrecognized group who may benefit from enhanced diabetes screening and prevention.
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Antonio Ceriello, Francesco Prattichizzo
Summary: Studies suggest that variability of risk factors such as blood pressure, plasma lipids, and weight may play a role in diabetes complications, with potential additive effects. While causality of variability is uncertain, monitoring risk factor variability in clinical practice could improve quality of care.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Ares Blanco, Carmen Lambert, Manuel Fernandez-Sanjurjo, Paula Morales-Sanchez, Pedro Pujante, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Edelmiro Menendez Torre, Elias Delgado
Summary: The aim of this study was to investigate the glucose tolerance status after 15 years of pregnancy in women diagnosed with gestational diabetes mellitus (GDM) and to assess the long-term effect of GDM on circulating miRNA profile. The study included 30 randomly selected women diagnosed with GDM during 2005-2006, and glucose tolerance was measured using the National Diabetes Data Group criteria. Four miRNAs were analyzed in the plasma of women 15 years after the diagnosis of GDM. The study found that 50% of women had some degree of glucose intolerance 15 years after the diagnosis of GDM, which was directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed significantly increased levels of circulating hsa-miR-24-3p. Thus, initial weight and BMI, along with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Gwendolyn Patience Mensah, Dalena (R. M. ) van Rooyen, Wilma ten Ham-Baloyi
Summary: This study aimed to develop evidence-based recommendations for screening and nursing management of gestational diabetes mellitus (GDM) in Ghana. Qualitative interviews and literature review were conducted to develop the recommendations. The recommendations include early screening and diagnosis of GDM, and involvement of women with GDM and their significant others during pregnancy, intrapartum and postpartum management. These recommendations provide valuable guidance for midwives managing GDM in Ghana.
Article
Medicine, General & Internal
Lingwang An, Yanlei Wang, Chenxiang Cao, Tao Chen, Yonghong Zhang, Linhui Chen, Shuhong Ren, Manni Tang, Fenglian Ma, Xianglan Li, Shuang Yuan, Wenhui Zhao, Yaujiunn Lee, Jianzhong Xiao
Summary: This study evaluated ASCVD risk factors in type 2 diabetes patients from primary diabetes clinics in China and found low control rates, indicating a need for comprehensive intervention and management of ASCVD risk factors, with a focus on global management, weight loss, and smoking cessation.
Article
Infectious Diseases
Kah Yee Tai, Jasbir Dhaliwal, Vinod Balasubramaniam
Summary: The study revealed significant genetic marker differences between populations, indicating varying resistance or susceptibility to malaria. The Mann-Whitney U test proved robust in analyzing genetic markers in large-scale data, offering an alternative method for exploring genetic markers in complex diseases. The findings hold promise for genetic marker analysis and can be replicated for analyzing new data.
Review
Infectious Diseases
Thamil Vaani Komarasamy, Nur Amelia Azreen Adnan, William James, Vinod R. M. T. Balasubramaniam
Summary: Flaviviruses have caused large epidemics and ongoing outbreaks for centuries, but there are currently no approved antiviral drugs against them. Recent advancements in drug repurposing and validation methodologies have shown promise in the development of new antiviral drugs, but there are still limitations and challenges to be addressed.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Infectious Diseases
Vanessa Chong, Jennifer Zi Ling Tan, Valliammai Jayanthi Thirunavuk Arasoo
Summary: Dengue cases have been increasing in recent years, with over 658,301 reported cases originating from Southeast Asia in 2019 alone. Research has shown adverse effects of dengue on pregnant women, but there is insufficient literature on its impact in the SEA region. Through a narrative review, the study describes the effects of dengue on pregnancy and highlights the existing gaps in the literature. The findings emphasize the need for further research on trimester-specific impacts, investigations, and management methods, especially in Southeast Asia.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Obstetrics & Gynecology
Andrew Khai Weyn Ong, Anne Li Yee, Adrian Jing Hong Fong, Valliammai Jayanthi Thirunavuk Arasoo, Amutha Ramadas
Summary: This article provides a systematic review on the effects of Ramadan fasting (RF) on fetal health. The findings suggest potential negative associations between RF and neonatal weight, amniotic fluid index, preterm birth, and growth parameters, but the evidence is not strongly supported. More studies are needed to better understand the relationship between RF and fetal health.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Nutrition & Dietetics
Shaneerra Raajlynn Kaur Sidhu, Chin Wei Kok, Thubasni Kunasegaran, Amutha Ramadas
Summary: Plant-based diets are increasingly popular for their health and environmental benefits. This systematic review analyzed the relationship between plant-based food items and the gut microbiome, as well as the biochemical and anthropometric measurements. The review found evidence of short- to moderate-term beneficial effects of plant-based diets on gut microbiome composition and health measurements, but contradictory results were observed for certain bacteria species. Further interventional studies are needed to explore the relationship between plant-based diets, gut microbiome, and metabolic/inflammatory effects.
Review
Nutrition & Dietetics
Thubasni Kunasegaran, Vinod R. M. T. Balasubramaniam, Valliammai Jayanthi Thirunavuk Arasoo, Uma Devi Palanisamy, Amutha Ramadas
Summary: A systematic review found that dietary intake during pregnancy is associated with changes in gut microbiota, which can have a positive impact on maternal metabolic health. The study highlights the importance of well-designed prospective cohort studies to investigate the effects of dietary changes during pregnancy on gut microbiota.
CURRENT NUTRITION REPORTS
(2023)
Article
Pediatrics
Stephanie R. Lebby, Sangeetha Shyam, Amutha Ramadas, Andrew R. Bohm, Julia C. Hill, Karen L. Fortuna, Stephanie R. Zoltick
Summary: This study examined the prevalence of video and computer game use among US adolescents and the rates of obesity, diabetes, high blood pressure, and high cholesterol. The results showed that frequent video game use was associated with higher BMI and increased risks of obesity, diabetes, high blood pressure, and high cholesterol in adolescents. This suggests that frequent video game use may have negative effects on adolescent health.
JMIR PEDIATRICS AND PARENTING
(2023)
Review
Biochemistry & Molecular Biology
Nur Azizah A. Rahman, Vinod R. M. T. Balasubramaniam, Wei Boon Yap
Summary: The IL-12 family consists of cytokines that play a crucial role in activating host antiviral immunity and preventing excessive immune reactions. IL-12 and IL-23 stimulate T cell proliferation and effector cytokine release, leading to host defense against virus infections. IL-27 and IL-35 have dual functions in regulating cytokine synthesis, T cell proliferation, and viral antigen presentation to enhance virus clearance. The multitasking nature of the IL-12 family makes it a highly important target for antiviral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Geok Pei Lim, Jamuna Rani Appalasamy, Badariah Ahmad, Kia Fatt Quek, Amutha Ramadas
Summary: This scoping review evaluates recent lifestyle interventions delivered on social media for individuals with diabetes and prediabetes. Most interventions were coordinated by a team of multidisciplinary healthcare professionals, lasting for 6 months, and used a combination of videos, texts, images or audio to deliver educational materials. The studies showed improvements in glycosylated hemoglobin (HbA1c) levels, diabetes self-care, and fasting plasma glucose.
CURRENT NUTRITION REPORTS
(2023)
Article
Infectious Diseases
Valliammai Jayanthi Thirunavuk Arasoo, Mariyammah Masalamani, Amutha Ramadas, Nisha Angela Dominic, Darien Daojuin Liew, Robin Wai Jen Sia, Anuradha Wanigaratne, Keshawa Weerawarna, William Lik Loong Wong, Ravichandran Jeganathan
Summary: This case-control study in Malaysia found a higher prevalence of chlamydial infection in women with ectopic pregnancies, with many of them lacking classical risk factors. Additionally, a significant number of patients experienced rupture and substantial blood loss. These findings highlight the need for reevaluation of early pregnancy care.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)