Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma

(2020) Joji Nagasaki et al.   Blood Advances

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

(2019) Shawn J. Rice et al.   LUNG CANCER

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of PD-1 Blockade in Cancer Immunotherapy

(2019) Xiaomo Wu et al.   Computational and Structural Biotechnology Journal

Functional systemic CD4 immunity is required for clinical responses to PD‐L1/PD‐1 blockade therapy

(2019) Miren Zuazo et al.   EMBO Molecular Medicine

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

(2018) Frederick Arce Vargas et al.   CANCER CELL

A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy

(2018) Xuexiang Du et al.   CELL RESEARCH

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

(2017) Alice O. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

PD1 signal transduction pathways in T cells

(2017) Hugo Arasanz et al.   Oncotarget

The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer

(2017) Elena Niccolai et al.   Frontiers in Immunology

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Reversing T-cell Dysfunction and Exhaustion in Cancer

(2016) H. M. Zarour   CLINICAL CANCER RESEARCH

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Validation of biomarkers to predict response to immunotherapy in cancer: Volume I — pre-analytical and analytical validation

(2016) Giuseppe V. Masucci et al.   Journal for ImmunoTherapy of Cancer

The paradoxical role of IL-10 in immunity and cancer

(2015) Mark H. Mannino et al.   CANCER LETTERS

A Transendocytosis Model of CTLA-4 Function Predicts Its Suppressive Behavior on Regulatory T Cells

(2015) Tie Zheng Hou et al.   JOURNAL OF IMMUNOLOGY

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity

(2014) M. Oft   Cancer Immunology Research

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology