Article
Biology
Samuel J. Barnes, Georg B. Keller, Tara Keck
Summary: This study used two-photon imaging to observe changes in neuronal synaptic calcium signals in awake mice, revealing that spines correlated with intrinsic network activity undergo TNF-α-dependent homeostatic enhancement, while spines responsive to sensory stimulation do not. Following sensory deprivation, global sensory-evoked responses increased, despite identified sensory inputs not strengthening.
Review
Neurosciences
Jane Yang, Steven A. Prescott
Summary: Neurons maintain homeostasis by adjusting ion channel expression levels through negative feedback. Degeneracy and pleiotropy play important roles in homeostatic regulation, where degeneracy enables compensatory changes in multiple channels and pleiotropy complicates regulation by affecting multiple properties. Understanding feedback loops and their interactions provides insight into the failure modes of homeostatic regulation, which can aid in developing more effective treatments for chronic neurological disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biology
Dina Simkin, Kelly A. Marshall, Carlos G. Vanoye, Reshma R. Desai, Bernabe Bustos, Brandon N. Piyevsky, Juan A. Ortega, Marc Forrest, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Steven J. Lubbe, John J. Millichap, Alfred L. George, Evangelos Kiskinis
Summary: Mutations in the KCNQ2 gene result in neonatal epileptic encephalopathy with severe seizures and neurodevelopmental impairments. Patient-derived neurons show specific functional properties that can be replicated in control neurons by chronically inhibiting the M-current. Dyshomeostatic mechanisms exacerbate KCNQ2 loss-of-function in patient iPSC-derived neurons.
Article
Biology
Shruti Thapliyal, Kristin L. Arendt, Anthony G. Lau, Lu Chen, Dion K. Dickman
Summary: Homeostatic synaptic plasticity is a mechanism that adjusts synaptic strength to maintain network stability. This study reveals that synaptic signaling through retinoic acid and its receptor, RAR alpha, regulates presynaptic neurotransmitter release to achieve homeostatic adjustment.
Article
Neurosciences
Carola I. Radulescu, Nazanin Doostdar, Nawal Zabouri, Leire Melgosa-Ecenarro, Xingjian Wang, Sadra Sadeh, Pavlina Pavlidi, Joe Airey, Maksym Kopanitsa, Claudia Clopath, Samuel J. Barnes
Summary: The study reveals dysregulation of neuronal activity control in the visual cortex of older adults, with downregulation of plasticity mechanisms leading to higher synaptic strengthening and activity levels following overstimulation. Overstimulation disrupts cognitive performance in older animals but not younger animals.
NATURE NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Cheng-Shih Chen, Edmund Cheung So, Sheng-Nan Wu
Summary: The hyperpolarization-activated cation current (I-h) is a slowly activating current involved in generating electrical activity in various cells. Different compounds or herbal drugs can impact the magnitude and gating kinetics of I-h. These compounds or herbal drugs have regulatory effects on cellular function by perturbing I-h.
Article
Neurosciences
Benjamin Liu, Michael J. Seay, Dean V. Buonomano
Summary: Research shows that different subpopulations of neurons in the complex cortical circuits can form neuronal ensembles with shared functional connectivity through chronic optogenetic stimulation. These ensembles exhibit changes such as decreased voltage correlation, synaptic decoupling between stimulated and nonstimulated populations, and decreased firing rate during Upstates in the stimulated population. These findings help understand the mechanisms of creating ensembles within cortical circuits through chronic patterned stimulation and demonstrate the preservation of functional distinct ensembles during Upstates through differential firing rates and correlations.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Mickael Zbili, Sylvain Rama, Maria-Jose Benitez, Laure Fronzaroli-Molinieres, Andrzej Bialowas, Norah Boumedine-Guignon, Juan Jose Garrido, Dominique Debanne
Summary: Blocking excitatory synaptic receptors leads to an increase in synaptic transmission and intrinsic excitability in the CA3 region, with intrinsic plasticity mediated by a reduction in Kv1.1 channel density. Activity-deprived neurons show down-regulation of axonal Kv1.1 channels, resulting in functional synergy between synaptic strength and intrinsic excitability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Lior Bar, Lia Shalom, Jonathan Lezmy, Asher Peretz, Bernard Attali
Summary: This study examined the bidirectional homeostatic plasticity induced by M-channel inhibition in hippocampal neurons. The results showed that excitatory and inhibitory neurons exhibited different adaptations to chronic alterations in neuronal excitability, with excitatory neurons showing homeostatic changes in excitability while inhibitory neurons did not.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yang Wang, Jingran Lin, Jiarui Li, Lu Yan, Wenwen Li, Xingzhi He, Huan Ma
Summary: Activity-dependent changes in protein expression are crucial for neuronal plasticity. Homeostatic synaptic up-scaling, induced primarily by neuronal inactivity, involves autophagy and the regulation of key synaptic proteins. The turnover mechanism of synaptic proteins in this process remains unclear.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Alexandra Ptakova, Michal Mitro, Lucie Zimova, Viktorie Vlachova
Summary: TRPC5 is a cold-sensitive channel protein, and its sensitivity is determined by the phosphorylation status of the protein and intracellular calcium homeostasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Kathryn Lynn Carzoli, Georgios Kogias, Jessica Fawcett-Patel, Siqiong June Liu
Summary: Carzoli et al. demonstrate that fear memory formation is driven by activity in cerebellar interneurons, which involves an increase in intrinsic excitability specific to learning and the loss of endocannabinoid-HCN signaling. This highlights the significance of moving beyond traditional investigations of memory formation focused on synaptic plasticity.
Article
Computer Science, Artificial Intelligence
Juan P. Dominguez-Morales, Stefano Buccelli, Daniel Gutierrez-Galan, Ilaria Colombi, Angel Jimenez-Fernandez, Michela Chiappalone
Summary: The accurate identification of burst events is crucial in various fields, yet existing methods in literature are not widely adopted. A novel neuromorphic approach for real-time burst detection proposed in this study shows similar results to current state-of-the-art methods, suggesting potential advantages over conventional techniques.
Article
Clinical Neurology
Lena H. Nguyen, Youfen Xu, Travorn Mahadeo, Longbo Zhang, Tiffany Lin, Heather A. Born, Anne E. Anderson, Angelique Bordey
Summary: Hyperactivation of the mTOR pathway during foetal neurodevelopment leads to focal malformation of cortical development and intractable epilepsy. Dysregulated cap-dependent translation downstream of mTOR signalling is involved in the formation of these developmental abnormalities. Modifying translation in juvenile mice with focal malformation of cortical development can reverse neuronal abnormalities and reduce seizures, suggesting potential therapeutic opportunities for treating these disorders in children.
Article
Neurosciences
Brian C. Baculis, Harish Kesavan, Amanda C. Weiss, Edward H. Kim, Gregory C. Tracy, Wenhao Ouyang, Nien-Pei Tsai, Hee Jung Chung
Summary: Homeostatic plasticity refers to the mechanisms that neurons use to stabilize themselves in response to prolonged and unstable changes in network activity. This study found that prolonged activity blockade reduces the activity of ERK1/2 and subsequently decreases the activation of BDNF receptor, TrkB. This leads to a decrease in KCNQ3 expression and a reduction in K(v)7.3 density at the AIS. These findings suggest a potential signaling pathway that links prolonged activity blockade to homeostatic control of BDNF-TrkB signaling and K(v)7.3 density.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)