Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking
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Title
Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking
Authors
Keywords
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Journal
Scientific Reports
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-03-01
DOI
10.1038/s41598-021-84380-w
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Note: Only part of the references are listed.- TIMER2.0 for analysis of tumor-infiltrating immune cells
- (2020) Taiwen Li et al. NUCLEIC ACIDS RESEARCH
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- Carrageenan: A Wonder Polymer from Marine Algae for Potential Drug Delivery Applications
- (2019) Dilshad Qureshia et al. CURRENT PHARMACEUTICAL DESIGN
- Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh)
- (2019) I.P. Shanura Fernando et al. ENVIRONMENTAL RESEARCH
- Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
- (2019) Richa Mehra et al. MOLECULAR BIOLOGY REPORTS
- Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells
- (2019) Ying-Ju Lin et al. PHYTOMEDICINE
- Cytotoxic activity of the seaweed compound fucosterol, alone and in combination with 5-fluorouracil, in colon cells using 2D and 3D culturing
- (2019) Alice A. Ramos et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- Molecular Docking: Shifting Paradigms in Drug Discovery
- (2019) Luca Pinzi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Therapeutic Effects of Fucoidan: A Review on Recent Studies
- (2019) Sibusiso Luthuli et al. Marine Drugs
- Marine Natural Products: A Source of Novel Anticancer Drugs
- (2019) Shaden A. M. Khalifa et al. Marine Drugs
- Investigating the regulation mechanism of baicalin on triple negative breast cancer’s biological network by a systematic biological strategy
- (2019) Kailin Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile
- (2019) Marzia Vasarri et al. JOURNAL OF ETHNOPHARMACOLOGY
- Effect of miR-21 on Apoptosis in Lung Cancer Cell Through Inhibiting the PI3K/ Akt/NF-κB Signaling Pathway in Vitro and in Vivo
- (2018) Bing Zhou et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Steered Molecular Dynamics Simulation in Rational Drug Design
- (2018) Phuc-Chau Do et al. Journal of Chemical Information and Modeling
- Impact of Nivolumab versus Docetaxel on Health-Related Quality of Life and Symptoms in Patients with Advanced Squamous Non–Small Cell Lung Cancer: Results from the CheckMate 017 Study
- (2018) Martin Reck et al. Journal of Thoracic Oncology
- The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non‑small cell lung cancer (Review)
- (2018) Yao Chen et al. Molecular Medicine Reports
- Fucosterol exhibits selective antitumor anticancer activity against HeLa human cervical cell line by inducing mitochondrial mediated apoptosis, cell cycle migration inhibition and downregulation of m-TOR/PI3K/Akt signalling pathway
- (2018) Hongye Jiang et al. Oncology Letters
- MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway
- (2018) Jun Jiang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway
- (2018) Ho Lee et al. Nutrients
- The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone
- (2018) Bing-jie Wang et al. Toxins
- Molecular Docking: Challenges, Advances and Its Use in Drug Discovery Perspective
- (2018) Surovi Saikia et al. CURRENT DRUG TARGETS
- Fucosterol exerts antiproliferative effects on human lung cancer cells by inducing apoptosis, cell cycle arrest and targeting of Raf/MEK/ERK signalling pathway
- (2018) Zhangfan Mao et al. PHYTOMEDICINE
- Application of reverse docking for target prediction of marine compounds with anti-tumor activity
- (2017) Fangling Chen et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial
- (2017) Toyoaki Hida et al. LANCET
- Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial
- (2017) Julie R Brahmer et al. LANCET ONCOLOGY
- Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties
- (2017) Sónia Santos et al. Marine Drugs
- PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database
- (2017) Xia Wang et al. NUCLEIC ACIDS RESEARCH
- Potential anti-inflammatory natural products from marine algae
- (2016) I.P. Shanura Fernando et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Enhancing the Enrichment of Pharmacophore-Based Target Prediction for the Polypharmacological Profiles of Drugs
- (2016) Xia Wang et al. Journal of Chemical Information and Modeling
- The marine biodiscovery pipeline and ocean medicines of tomorrow
- (2016) Marcel Jaspars et al. JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM
- Cancer statistics, 2015
- (2015) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects
- (2015) Xing-Hua Zhen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Fucosterol protects cobalt chloride induced inflammation by the inhibition of hypoxia-inducible factor through PI3K/Akt pathway
- (2015) Zhengwang Sun et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Protective effect of fucosterol isolated from the edible brown algae,Ecklonia stoloniferaandEisenia bicyclis, ontert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury
- (2015) Jae Sue Choi et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Fucosterol attenuates lipopolysaccharide-induced acute lung injury in mice
- (2015) Yuexia Li et al. JOURNAL OF SURGICAL RESEARCH
- Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials
- (2015) James Chih-Hsin Yang et al. LANCET ONCOLOGY
- Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
- (2015) Zamal Ahmed et al. Nature Communications
- PI3K/AKT signaling pathway and cancer: an updated review
- (2014) Miriam Martini et al. ANNALS OF MEDICINE
- Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer
- (2014) Claudia Fumarola et al. BIOCHEMICAL PHARMACOLOGY
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- (2014) Noga Kozer et al. BIOCHEMISTRY
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- (2014) Xiao-Jiaoyang Li et al. JOURNAL OF ETHNOPHARMACOLOGY
- First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer
- (2014) Benjamin J. Solomon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lung cancer chemoprevention: current status and future prospects
- (2013) Robert L. Keith et al. Nature Reviews Clinical Oncology
- Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways
- (2012) Xiuxia Li et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Valuable compounds in macroalgae extracts
- (2012) Paula B. Andrade et al. FOOD CHEMISTRY
- Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
- (2012) Rafael Rosell et al. LANCET ONCOLOGY
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- How Many Species Are There on Earth and in the Ocean?
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- PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach
- (2010) Xiaofeng Liu et al. NUCLEIC ACIDS RESEARCH
- Discovery of drug mode of action and drug repositioning from transcriptional responses
- (2010) F. Iorio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ErbB receptors and signaling pathways in cancer
- (2009) Nancy E Hynes et al. CURRENT OPINION IN CELL BIOLOGY
- Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship
- (2009) Julian R. Molina et al. MAYO CLINIC PROCEEDINGS
- Evaluation of Molecular Docking Using Polynomial Empirical Scoring Functions
- (2008) Raquel Dias et al. CURRENT DRUG TARGETS
- Grb2 signaling in cell motility and cancer
- (2008) Alessio Giubellino et al. EXPERT OPINION ON THERAPEUTIC TARGETS
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