Journal
ACS CATALYSIS
Volume 11, Issue 6, Pages 3268-3292Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c05580
Keywords
alkylation; unactivated alkyl halides; C-H activation; (hetero)arenes; transition metals
Categories
Funding
- SERB, New Delhi, India [EMR/2016/000989]
- CSIRNew Delhi
Ask authors/readers for more resources
This review summarizes the transition-metal-catalyzed alkylations of C-H bonds on various arenes and heteroarenes using unactivated alkyl halides until October 2020. The review is divided into two major sections based on the substrates utilized for alkylation: alkylation of arenes and alkylation of heteroarenes. Substantial progress has been made in direct alkylation using primary, secondary, and tertiary alkyl halides as well as methylation and fluoroalkylation.
Alkylation represents an important organic transformation in molecular science to develop privileged alkylated arenes and heteroarenes. Especially, the direct C-H bond alkylation using unactivated alkyl halides is a straightforward and attractive approach from both the step-economy and chemoselectivity perspectives. Substantial progress has been made in the direct alkylation using primary, secondary, and tertiary alkyl halides along with the methylation and fluoroalkylation. This Review broadly summarizes the transition-metal-catalyzed alkylations of C-H bonds on various arenes and heteroarenes with unactivated alkyl halides until October 2020. On the basis of the substrates utilized for alkylation, the Review is divided into two major sections: alkylation of arenes and alkylation of heteroarenes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available