Article
Immunology
Marco Caminati, Gabriella Guarnieri, Veronica Batani, Elena Scarpieri, Anita Finocchiaro, Fulvia Chieco-Bianchi, Gianenrico Senna, Andrea Vianello
Summary: This study evaluated the safety, tolerability, and impact of the mRNA SARS-CoV-2/COVID-19 vaccine on disease control and quality of life in severe asthma patients. Among 253 patients, no serious adverse events were detected, with less than 20% reporting side effects, and significant improvements in asthma control and quality of life were observed post-vaccination.
Article
Medicine, General & Internal
I. O. Rosas, N. Brau, M. Waters, R. C. Go, B. D. Hunter, S. Bhagani, D. Skiest, M. S. Aziz, N. Cooper, I. S. Douglas, S. Savic, T. Youngstein, L. Del Sorbo, A. Cubillo Gracian, D. J. De la Zerda, A. Ustianowski, M. Bao, S. Dimonaco, E. Graham, B. Matharu, H. Spotswood, L. Tsai, A. Malhotra
Summary: In this randomized trial involving hospitalized patients with severe Covid-19 pneumonia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Virology
Oleksandr Valentynovych Oliynyk, Marta Rorat, Olena Vadymivna Strepetova, Serhij Oleksandrovych Dubrov, Vitaliy Grygorovych Guryanov, Yanina Volodymyrivna Oliynyk, Oleksii Serhijovych Kulivets, Anna Slifirczyk, Wojciech Barg
Summary: This study aimed to investigate the clinical efficacy of sildenafil in patients with severe COVID-19 and pulmonary arterial hypertension (PAH). The results showed that sildenafil group had lower one-week mortality, intubation rate, and length of ICU stay compared to the placebo group. Therefore, sildenafil should be considered as an add-on therapy in patients with severe COVID-19 and PAH.
Article
Public, Environmental & Occupational Health
Abeer Al-Baadani, Nazik Eltayeb, Eid Alsufyani, Salma Albahrani, Shareefah Basheri, Hawra Albayat, Enas Batubara, Sulafa Ballool, Ayed Al Assiri, Fahad Faqihi, Ali B. Musa, Asirvatham A. Robert, Nisreen Alsherbeeni, Fatehi Elzein
Summary: The study found that treatment with tocilizumab (TCZ) was associated with a lower likelihood of death in COVID-19 patients, despite potentially higher infection rates and a slightly longer hospital stay.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Immunology
Ladan Abbasian, Negar Toroghi, Hamid Rahmani, Hossein Khalili, Malihe Hasannezhad, Fereshteh Ghiasvand, Sirous Jafari, Mohammadreza Salehi, Faeze Salahshour, Mahsa Azadbakhsh Kanaf Gorabi, Fateme Alizade, Sara Ghaderkhani, Maryam Nakhostin
Summary: This study compared the efficacy and safety of methylprednisolone, tocilizumab, and dexamethasone in the treatment of severe COVID-19. Results showed no significant differences in clinical response time, improvement rate of oxygen saturation and CRP, need for ICU admission, and 28-day mortality among the three groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Abolghasem Allahyari, Mohsen Seddigh-Shamsi, Mahmoud Mahmoudi, Saeid Amel Jamehdar, Mahnaz Amini, Mahnaz Mozdourian, Zahra Javidarabshahi, Saeed Eslami Hasan Abadi, Shahram Amini, Alireza Sedaghat, Maryam Emadzadeh, Mohammad Moeini Nodeh, Hossein Rahimi, Alireza Bari, Zahra Mozaheb, Mostafa Kamandi, Sajad Ataei Azimi, Mojtaba Abrishami, Arezoo Akbarian, Parisa Ataei, Negin Allahyari, Sepideh Hasanzadeh, Neda Saeedian
Summary: The study evaluated the safety and efficacy of convalescent plasma therapy for severe COVID-19 cases with ARDS, showing that early administration of convalescent plasma can contribute to the treatment of severe COVID-19 patients with mild or moderate ARDS by reducing mortality rate, disease severity, ICU stay, and need for intubation while increasing oxygenation levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Michele Bartoletti, Lorenzo Marconi, Luigia Scudeller, Livia Pancaldi, Sara Tedeschi, Maddalena Giannella, Matteo Rinaldi, Linda Bussini, Ilaria Valentini, Anna Filomena Ferravante, Antonella Potalivo, Elisa Marchionni, Giacomo Fornaro, Renato Pascale, Zeno Pasquini, Massimo Puoti, Marco Merli, Francesco Barchiesi, Francesca Volpato, Arianna Rubin, Annalisa Saracino, Tommaso Tonetti, Paolo Gaibani, Vito Marco Ranieri, Pierluigi Viale, Francesco Cristini
Summary: The study aimed to evaluate the efficacy of corticosteroids in treating COVID-19 patients. Results showed that corticosteroid treatment did not significantly reduce 30-day mortality overall, but in patients with PO2/FiO2 < 200 mm Hg at admission, corticosteroid treatment was associated with a lower risk of 30-day mortality.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Yi Li, Yan Zhang, Rongli Lu, Minhui Dai, Minxue Shen, Jianchu Zhang, Yanhui Cui, Ben Liu, Fengyu Lin, Lingli Chen, Duoduo Han, Yifei Fan, Yanjun Zeng, Wen Li, Sha Li, Xiang Chen, Haitao Li, Pinhua Pan
Summary: This study found that in severe COVID-19 patients, survivors showed an increasing trend in LDL-C, TC, HDL-C, and apoA-I, while non-survivors showed a decreasing trend. The concentrations of HDL-C and apoA-I were inversely correlated with CRP, length of hospital stay of survivors, and disease severity scores. High CRP/HDL-C ratio was significantly associated with an increase in mortality and a poor prognosis.
CLINICA CHIMICA ACTA
(2021)
Article
Immunology
Saborni Chakraborty, Joseph Gonzalez, Karlie Edwards, Vamsee Mallajosyula, Anthony S. Buzzanco, Robert Sherwood, Cindy Buffone, Nimish Kathale, Susan Providenza, Markus M. Xie, Jason R. Andrews, Catherine A. Blish, Upinder Singh, Haley Dugan, Patrick C. Wilson, Tho D. Pham, Scott D. Boyd, Kari C. Nadeau, Benjamin A. Pinsky, Sheng Zhang, Matthew J. Memoli, Jeffery K. Taubenberger, Tasha Morales, Jeffrey M. Schapiro, Gene S. Tan, Prasanna Jagannathan, Taia T. Wang
Summary: COVID-19 is often characterized by a hyperinflammatory syndrome, and disease severity is associated with specific antibody structures that enhance inflammatory responses.
Article
Immunology
Ali Ameri, Masoomeh Frouz Asadi, Ava Ziaei, Majid Vatankhah, Omid Safa, Manoochehr Kamali, Mohammad Fathalipour, Masoumeh Mahmoodi, Soheil Hassanipour
Summary: The study evaluated the efficacy and safety of oral melatonin in patients with COVID-19-induced pneumonia. The results showed that melatonin significantly reduced mortality rate and requirement of IMV, as well as shortened hospitalization and time to clinical status improvement.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olga Kalinina, Alexey Golovkin, Ekaterina Zaikova, Arthur Aquino, Vadim Bezrukikh, Olesya Melnik, Elena Vasilieva, Tatiana Karonova, Igor Kudryavtsev, Evgeny Shlyakhto
Summary: This study investigated the levels of cytokines in patients with moderate and severe COVID-19 and found elevated levels of pro-inflammatory factors, chemokines, anti-inflammatory factors, and growth factors. Patients with severe disease had higher levels of FGF-2/FGF-basic, IL-1 beta, and IL-7 compared to healthy donors. Pneumonia lung injury was positively correlated with levels of EGF, IP-10, and MCP-3, and negatively correlated with IL-12 p40. Pro-inflammatory factors were negatively correlated with the frequency of circulating Th17-like cells and follicular Th cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Rania M. Sarhan, Hadeer S. Harb, Ahmed E. Abou Warda, Mounir M. Salem-Bekhit, Faiyaz Shakeel, Sami Ali Alzahrani, Yasmin M. Madney, Marian S. Boshra
Summary: The effectiveness of tocilizumab-hydroxychloroquine (TCZ-HCQ) and tocilizumab-remdesivir (TCZ-RMV) combinations were observed in the treatment of severe COVID-19 patients. However, the TCZ-RMV group had a higher incidence of ICU or mechanical ventilation and a greater risk of cardiac and thrombotic events.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Hashaam Akhtar, Sundas Khalid, Fazal-Ur-Rahman, Sabahat Ali, Maham Afridi, Yousef S. Khader, Faheem Hassan, Nasim Akhtar, Muhammad Mujeeb Khan, Aamer Ikram
Summary: The study found that in patients with severe/critical COVID-19, age over 60, presence of hypertension, heart disease, kidney disease, and late admission (over 5 days) were significant predictors of mortality. The study highlights the importance of timely provision of appropriate medical interventions in controlling COVID-19-related mortality.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Cell & Tissue Engineering
Martin Grumet, Jason Sherman, Barry S. Dorf
Summary: Patients with severe COVID-19 experience cytokine storm, and treatment with mesenchymal stromal cells (MSC) appears to be effective in reducing morbidity and mortality. MSC respond to pro-inflammatory cytokines by releasing anti-inflammatory factors and mobilizing immune cells. Clinical trials and literature reports show that MSC can improve survival, oxygenation, and reduce pro-inflammatory markers in COVID-19 patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Letter
Medicine, General & Internal
Wentao Sang, Feng Xu
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Tangxing Jiang, Yanyan Ma, Jiaqi Zheng, Chunyi Wang, Kai Cheng, Chuanbao Li, Feng Xu, Yuguo Chen
Summary: In mainland China, the signing rate of DNR orders is low, and the establishment of DNR orders is associated with demographics and comorbidity characteristics.
Article
Construction & Building Technology
Shaohua Zhao, Hao Wang, Hui Chen, Shaohua Wang, Juan Ma, Dandan Zhang, Lin Shen, Xiaorong Yang, Yuguo Chen
Summary: Understanding the global spatiotemporal variation in household air pollution from solid fuels (HAP)-related ischemic heart disease (IHD) burden is crucial for reducing IHD burden and controlling HAP exposure. This study analyzed the numbers and rates of IHD mortality and disability-adjusted life years (DALYs) attributed to HAP at global, regional, and national levels. In 2019, IHD attributed to HAP resulted in 511,170 deaths and 13.18 million DALYs globally. The burden rates were higher in males, increased with age, and varied greatly across the world. Despite a decline in HAP-related IHD burden globally, some low-income countries experienced an undesirable increase. Sustained and comprehensive efforts are needed to control HAP and reduce IHD burden in countries with a high or increasing burden.
Letter
Infectious Diseases
Mei Yin, Yue Zheng, Lu Zhang, Weidong Qin, Hui Han, Dawei Wu, Hao Wang
JOURNAL OF INFECTION
(2022)
Article
Nutrition & Dietetics
Kai Zhang, Weidong Qin, Yue Zheng, Jiaojiao Pang, Ning Zhong, Jianchun Fei, Yu Li, Xiangdong Jian, Xinguo Hou, Zhao Hu, Chen Li, Hao Wang, Yuguo Chen
Summary: Malnutrition was common among patients with early-stage COVID-19, and it contributed to the occurrence of low TLC, which in turn was an independent risk factor for severe disease.
FRONTIERS IN NUTRITION
(2022)
Article
Hematology
Jian Zhang, Xiangkai Zhao, Yunyun Guo, Zhiping Liu, Shujian Wei, Qiuhuan Yuan, Haixia Shang, Wentao Sang, Sumei Cui, Tonghui Xu, Kehui Yang, Jialin Guo, Chang Pan, Jiali Wang, Jiaojiao Pang, Tianrui Han, Yuguo Chen, Feng Xu
Summary: The ALDH2 rs671 mutation is a risk factor for the development and prognosis of atherosclerotic cardiovascular diseases. This study uncovers the important role of the ALDH2-Rac2 axis in efferocytosis during atherosclerosis, providing a potential direction for therapeutic strategies in cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Infectious Diseases
Hao Wang, Shaohua Zhao, Shengjun Wang, Yue Zheng, Shaohua Wang, Hui Chen, Jiaojiao Pang, Juan Ma, Xiaorong Yang, Yuguo Chen
Summary: The spatiotemporal patterns of encephalitis and its associated risk factors were estimated at the national, regional, and global levels. The study found that while the burden of encephalitis has decreased over the past 30 years, there was a plateau in the decline since 2011-2013. The burden varied in different regions, calling for differentiated management strategies.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Shaohua Fan, Min Si, Nana Xu, Meichen Yan, Mingmin Pang, Guangfeng Liu, Jibin Gong, Hao Wang
Summary: The MATESHIP study aims to evaluate the application of mNGS technology in the treatment of SCAP in immunocompromised patients. The study hypothesizes that mNGS-guided treatment can improve clinical outcomes, reduce the degree of organ dysfunction, and decrease antimicrobial agent usage.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Xiaorong Yang, Hui Chen, Yue Zheng, Sifeng Qu, Hao Wang, Fan Yi
Summary: The global burden of urinary tract infections (UTIs) has increased over the past three decades, with a significant rise in mortality rate and disability-adjusted life years. Higher socio-demographic index (SDI) regions have experienced higher incidence rates and burden rates, while low SDI countries have seen a decline in burden rates. There is no significant difference in mortality and disability rates between sexes. The burden of UTIs increases with age, particularly in higher SDI regions and among individuals over 60 years old.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Yang Mao, Nana Xu, Meichen Yan, Mingmin Pang, Xinyue Zhang, Haigang Wang, Juan Du, Dawei Wu, Hao Wang
Summary: This study aimed to explore the factors that drive physicians to choose prolonged infusion of β-lactam antibiotics in septic patients. The results showed that multidrug-resistant bacterial infection and septic shock were independent factors associated with prolonged infusion. However, the use of prolonged infusion had a survival benefit independent of disease severity, especially in less severe sepsis cases.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Huiruo Liu, Hang Yin, Zhen Wang, Qiuhuan Yuan, Feng Xu, Yuguo Chen, Chuanbao Li
Summary: Rho A/ROCK1 signaling promotes calcified aortic valves disease through modulation of VICs metabolism.
CELL DEATH & DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiajun Zhang, Xiaoxing Li, Rui Tian, Mengzhi Zong, Xinghua Gu, Feng Xu, Yuguo Chen, Chuanbao Li
Summary: This retrospective cohort study found that the use of cerebral embolic protection during transcatheter aortic valve replacement (TAVR) for patients with bicuspid aortic valve stenosis was associated with a lower incidence of in-hospital stroke without increasing the cost of hospitalization or the risk of vascular complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Jiaqi Zheng, Chuanzhu Lv, Wen Zheng, Guoqiang Zhang, Huiqiong Tan, Yu Ma, Yimin Zhu, Chaoqian Li, Xiaotong Han, Shengtao Yan, Chang Pan, Jianbo Zhang, Yaping Hou, Chunyi Wang, Yuan Bian, Rugang Liu, Kai Cheng, Jingjing Ma, Zhaolei Zheng, Ruixue Song, Mingjie Wang, Jianhua Gu, Bryan McNally, Marcus Eng Hock Ong, Yuguo Chen, Feng Xu
Summary: This study aimed to comprehensively describe the incidence, process of care, and outcomes of out-of-hospital cardiac arrest (OHCA) in China. The findings revealed a high burden of EMS-assessed OHCA with a low proportion of resuscitation attempts, calling for national efforts to improve patient care and outcomes.
LANCET PUBLIC HEALTH
(2023)
Article
Immunology
Wenchao Zhang, Mei Yin, Wei Li, Nana Xu, Haining Lu, Weidong Qin, Hui Han, Chen Li, Dawei Wu, Hao Wang
Summary: Glucocorticoid aerosol therapy is associated with increased risk of A. baumannii isolation in ventilator patients, which in turn is independently associated with 30-day mortality. Physicians should be cautious when prescribing glucocorticoid aerosol therapy, considering the potential risk of A. baumannii infection.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Emergency Medicine
Chang Pan, Jiao-jiao Pang, Kai Cheng, Feng Xu, Yu-guo Chen
Summary: Over the past decade, there has been a significant increase in emergency department visits and pre-hospital emergency care utilization in China, accompanied by a notable rise in the number of emergency physicians and beds. However, challenges such as overcrowding, prolonged length of stay, poor work environment, and work exhaustion persist in China's emergency medical service system.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2021)
