Journal
ONCOLOGY LETTERS
Volume 21, Issue 4, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2021.12559
Keywords
exosomes; pancreatic cancer; proliferation; migration; invasion; mechanisms
Categories
Ask authors/readers for more resources
The review discusses the potential role of exosomes in pancreatic cancer and their clinical applications, as well as the impact of their molecular mechanisms and functions on cancer cells.
Pancreatic cancer (PC) is a malignant tumour of the human digestive system that has a poor prognosis. Exosomes contain proteins and nucleic acids, and constitute a class of extracellular vesicles defined as membrane-bound nanovesicles of endocytic origin, with a diameter of 40-150 nm. Exosomes are potential diagnostic markers of PC; however, their roles in cancer initiation and progression remain unclear. Previous studies have focused on the molecular mechanisms and functions of exosomes that allow them to accelerate PC cell proliferation, migration and invasion. The present review discusses the interactions between exosomes and the pathophysiology of PC. The potential clinical applications of exosomes are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available