Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.617308
Keywords
protein aggregation; light scattering; protein stability; protein denaturation; neurological disorders
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Funding
- SERB, Department of Science and Technology [PDF/2015/001090]
- Indian Council of Medical Research [45/34/2018-BIO/BMS]
- UGC-SAP
- DST-PURSE Delhi University
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N-acetylaspartate (NAA) plays a crucial role in modulating protein aggregation, suppressing aggregation and solubilizing preformed aggregates.
Deposition of toxic protein inclusions is a common hallmark of many neurodegenerative disorders including Alzheimer's disease, Parkinson disease etc. N-acetylaspartate (NAA) is an important brain metabolite whose levels got altered under various neurodegenerative conditions. Indeed, NAA has been a widely accepted biological marker for various neurological disorders. We have also reported that NAA is a protein stabilizer. In the present communication, we investigated the role of NAA in modulating the aggregation propensity on two model proteins (carbonic anhydrase and catalase). We discovered that NAA suppresses protein aggregation and could solubilize preformed aggregates.
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