Article
Environmental Sciences
Sofie Svanholm, Moa Safholm, Nanna Brande-Lavridsen, Erika Larsson, Cecilia Berg
Summary: The study utilized the model frog Xenopus tropicalis to investigate the effects of propiconazole exposure on endocrine perturbations and subsequent adverse effects. It was found that propiconazole increased brain aromatase activity and accelerated metamorphosis in tadpoles, indicating a stimulatory effect on the thyroid system. However, at puberty, hepatic and reproductive effects were evident, suggesting persistent disruption of metabolism and male reproductive function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Anuj Kumar Pandey, Vandana Sharma, Kristipati Ravi Ram
Summary: Insect pollinators, crucial for agriculture and ecosystems, are declining due to human-made chemicals. This study develops an ex vivo assay system using transgenic Drosophila males to evaluate the effects of environmental chemicals on ecdysone receptor activity, crucial for male fertility. The assay demonstrates the specific and sensitive modulation of ecdysone receptor activity by different classes of environmental chemicals, and links the endocrine disruption to reduced fertility in vivo.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Angelico Mendy, Susan M. Pinney
Summary: This study is the first to report an association between exposure to neonicotinoids and decreased serum testosterone levels in humans. Neonicotinoids, despite being harmful to honeybees, are considered safe for mammals. Future research is necessary to confirm these findings.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Michala R. Birch, Mathias Johansen, Niels E. Skakkebaek, Anna-Maria Andersson, Anders Rehfeld
Summary: This study found that various pesticides can interfere with normal Ca2+ signaling in human sperm cells, affecting sperm function and viability. These effects can occur at low nanometer concentrations and when pesticides are used alone or in combination with other environmental chemicals.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Christina Stern, Sarah Schwarz, Gerit Moser, Silvija Cvitic, Evelyn Jantscher-Krenn, Martin Gauster, Ursula Hiden
Summary: During pregnancy, the placenta plays a crucial role in regulating maternal physiology by secreting a variety of hormones and proteins. Maternal insulin resistance increases to supply glucose for the developing fetus, with a compensation in beta-cell mass and function. Sex differences may influence placenta-derived hormones and proteins, impacting the regulation of maternal glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Kelsey R. Pool, Faustine Chazal, Jeremy T. Smith, Dominique Blache
Summary: Phytoestrogens have an impact on reproductive health and can influence reproductive capacity in various species. Our understanding of the mechanisms linking phytoestrogens and compromised reproduction in sheep is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Environmental Sciences
Tao Huang, Yuanhui Zhao, Jia He, Hongguang Cheng, Christopher J. Martyniuk
Summary: Azole fungicides have been shown to disrupt the endocrine system in fish, particularly affecting the HPG, HPT, and HPA axis. Some azoles have well-documented endocrine disruptor effects, while others lack data, revealing a knowledge gap in understanding azole toxicity. Further studies are needed to focus on non-steroid endocrine pathways, mechanisms of neuroendocrine disruption, and transgenerational effects of azoles on fish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Food Science & Technology
Chenyan Hu, Yachen Bai, Jing Li, Baili Sun, Lianguo Chen
Summary: Methylparaben (MeP), commonly used in daily products as a preservative, has become a concerning aquatic pollutant. This study exposed adult zebrafish to different concentrations of MeP to investigate its reproductive toxicity. The results showed that MeP exposure affected gonad development, disrupted hormone balance, and led to developmental deficits in offspring. This study provides insight into the antiestrogenic activity and reproductive toxicity of MeP.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Marine & Freshwater Biology
Tianyu Wang, Shanshan Wu, Jianjie Chen, Lijuan Li, Jinling Cao
Summary: This study investigated the alleviating effects of sesamin on thyroid endocrine disruption caused by fluoride in zebrafish. Sesamin significantly improved growth performance and reduced mortality rate in adults, while also improving hatching rate and body length and alleviating spinal curvature and cyst formation in embryos and larvae. It also alleviated damage to thyroid tissues, reduced oxidative stress, improved thyroid hormone imbalance, and reversed the expression of endocrine-related genes.
AQUATIC TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elif I. Erguc, Alev Tascioglu-Aliyev, Bita Entezari, Hande Gurer-Orhan
Summary: Endocrine disruptors are exogenous chemicals that interfere with the normal function of endogenous hormones. These chemicals, including pharmaceuticals, phytoestrogens, natural hormones, pesticides, plasticizers, can have potential toxic effects depending on their biotransformation.
CURRENT DRUG METABOLISM
(2021)
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Nurul Amalina Khairul Hasni, Zurahanim Fasha Anual, Siti Aishah Rashid, Syahidiah Syed Abu Thahir, Yuvaneswary Veloo, Khor Sok Fang, Mohamad Iqbal Mazeli
Summary: Contamination of water systems in Malaysia with endocrine disrupting chemicals (EDCs) is a significant public health concern due to their toxic and widespread nature. This report provides a comprehensive overview of the occurrence and locations of EDCs in water systems, based on a literature search of 41 peer-reviewed articles. Most studies focused on pharmaceuticals, pesticides, hormones, mixed compounds, and plasticisers. The majority of research was conducted in Peninsular Malaysia, particularly in the central region and Selangor State. The Langat River, Klang River, and Selangor River were frequently studied for EDC contamination in surface waters. Risk assessments generally indicated negligible health risks, except for certain compounds in the Selangor River and combined pharmaceuticals in Putrajaya tap water.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ming Jia, Miaomiao Teng, Sinuo Tian, Jin Yan, Zhiyuan Meng, Sen Yan, Ruisheng Li, Zhiqiang Zhou, Wentao Zhu
Summary: The study found that long-term low-dose exposure to PEN did not significantly affect the growth and spawning of zebrafish, but led to significant changes in important hormones and related gene expressions in zebrafish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Andrea Corrales Vargas, Jorge Penaloza Castaneda, Emelie Rietz Liljedahl, Ana Maria Mora, Jose Antonio Menezes-Filho, Donald R. Smith, Donna Mergler, Brian Reich, Andrew Giffin, Jane A. Hoppin, Christian H. Lindh, Berna van Wendel de Joode
Summary: This study evaluates the effects of pesticide and metal exposures on thyroid function in pregnant women. The findings suggest that certain pesticides and metals are associated with alterations in thyroid hormone levels, potentially leading to hypothyroidism or hyperthyroidism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Nutrition & Dietetics
Anastasia Konstantina Sakali, Alexandra Bargiota, Ioannis G. Fatouros, Athanasios Jamurtas, Djuro Macut, George Mastorakos, Maria Papagianni
Summary: This article summarizes the impact of pesticide residues on the timing of puberty landmarks and their potential effects on the human reproductive system.
