Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain

(2014) Lintao Qu et al.   BRAIN

What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain?

(2014) Clifford J. Woolf   PAIN

Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesion

(2014) Kendall Mitchell et al.   PAIN

Three functionally distinct classes of C-fibre nociceptors in primates

(2014) Matthew Wooten et al.   Nature Communications

High concentration capsaicin for treatment of peripheral neuropathic pain: effect on somatosensory symptoms and identification of treatment responders

(2013) Johanna Höper et al.   CURRENT MEDICAL RESEARCH AND OPINION

Treatment of peripheral neuropathic pain by topical capsaicin: Impact of pre-existing pain in the QUEPP-study

(2013) C.G. Maihöfner et al.   EUROPEAN JOURNAL OF PAIN

Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing

(2013) C. Brenneis et al.   JOURNAL OF NEUROSCIENCE

TRPV1, but not TRPA1, in Primary Sensory Neurons Contributes to Cutaneous Incision-Mediated Hypersensitivity

(2013) Marie E Barabas et al.   Molecular Pain

Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo

(2013) Sophia Vrontou et al.   NATURE

Reappraising neuropathic pain in humans—how symptoms help disclose mechanisms

(2013) Andrea Truini et al.   Nature Reviews Neurology

Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: Implications for pain and memory

(2013) Elizabeth J. Rahn et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons

(2013) Asami Naka et al.   PAIN

The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons

(2012) Jie Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch

(2012) Eric S. McCoy et al.   PLoS One

Role of Peptidergic Nerve Terminals in the Skin: Reversal of Thermal Sensation by Calcitonin Gene-Related Peptide in TRPV1-Depleted Neuropathy

(2012) Yu-Lin Hsieh et al.   PLoS One

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

(2011) P. Anand et al.   BRITISH JOURNAL OF ANAESTHESIA

The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons

(2011) Isabelle Bachy et al.   DEVELOPMENTAL BIOLOGY

Spinal cord injury, dendritic spine remodeling, and spinal memory mechanisms

(2011) Andrew M. Tan et al.   EXPERIMENTAL NEUROLOGY

Pain perception in humans: use of intraepidermal electrical stimulation: Figure 1

(2011) Koji Inui et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Pain Unmasks Heterosynaptic Facilitation in Lamina I Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord

(2011) C. Torsney   JOURNAL OF NEUROSCIENCE

Neural Correlates of Heterotopic Facilitation Induced after High Frequency Electrical Stimulation of Nociceptive Pathways

(2011) Emanuel N van den Broeke et al.   Molecular Pain

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity

(2011) Doreen B. Pfau et al.   PAIN

Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats

(2011) Jordi Serra et al.   PAIN

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients

(2011) Andreas Binder et al.   PLoS One

Phenotypic Switching of Nonpeptidergic Cutaneous Sensory Neurons following Peripheral Nerve Injury

(2011) Ting Wang et al.   PLoS One

Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat

(2010) Li-Jun Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers

(2010) Michael Ragé et al.   CLINICAL NEUROPHYSIOLOGY

Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain

(2010) A. Akbar et al.   GUT

A Randomized, Controlled, Open-Label Study of the Long-Term Effects of NGX-4010, a High-Concentration Capsaicin Patch, on Epidermal Nerve Fiber Density and Sensory Function in Healthy Volunteers

(2010) William R. Kennedy et al.   JOURNAL OF PAIN

Low intensity intra-epidermal electrical stimulation can activate Aδ-nociceptors selectively

(2010) A. Mouraux et al.   PAIN

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

(2010) C. Maier et al.   PAIN

Ovarian hormones and pain response: A review of clinical and basic science studies

(2009) Vincent T. Martin   Gender Medicine

Short-Term Synaptic Plasticity in the Nociceptive Thalamic-Anterior Cingulate Pathway

(2009) Bai-Chuang Shyu et al.   Molecular Pain

Unmyelinated afferents in human skin and their responsiveness to low temperature

(2009) Mario Campero et al.   NEUROSCIENCE LETTERS

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn

(2008) Li-Jun Zhou et al.   EXPERIMENTAL NEUROLOGY

TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

(2008) Jeffrey J. Lawson et al.   JOURNAL OF PAIN

Differential Changes in TRPV1 Expression After Trigeminal Sensory Nerve Injury

(2008) Hyun Yeong Kim et al.   JOURNAL OF PAIN

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study

(2008) Miroslav Backonja et al.   LANCET NEUROLOGY

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy

(2008) D. M. Simpson et al.   NEUROLOGY

The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation

(2008) Thomas Klein et al.   PAIN

Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision

(2008) Ratan K. Banik et al.   PAIN